Does structural neuroimaging reveal a disturbance of iron metabolism in Parkinson's disease? Implications from MRI and TCS studies
Abstract
A central role of iron in the pathogenesis of Parkinson's disease (PD) has been discussed for many years. Numerous studies using magnetic resonance imaging and transcranial sonography have been performed to detect alterations in tissue iron content of the substantia nigra. This manuscript reviews the findings of this still controversial issue and indicates that specific abnormalities that are suggested to be related to a disturbance of iron homeostasis may play an early role in the pathogenesis of PD.
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Imaging methods such as MRI and transcranial sonography were not able to substantiate the relation between total iron concentration and disease severity because of the absence of accurate quantification for iron content in different brain areas.
“Imaging methods, such as MRI and transcranial sonography, were not able to substantiate the relation between total iron concentration and disease severity because of the absence of accurate quantification for the iron content in different brain areas.104,105”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [105]
An area of increased echogenicity in the substantia nigra can be visualised in about 90% of patients with Parkinson's disease.
“An area of increased echogenicity (ie, propensity to generate ultrasound echo) in the substantia nigra can be visualised in about 90% of patients with Parkinson’s disease.105”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [105]
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The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works
Iron metabolism in the CNS: implications for neurodegenerative diseases
Rouault, T. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3453 · Cited by 496 · see citing works
- Authors
- Gröger, A., & Berg, D.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- Corresponding author
- Gröger, Adriane
- ORCID
- Berg, Daniela
- Venue
- Journal of Neural Transmission
- Published
- 2012-08-09
- Volume
- 119
- Issue
- 12
- Pages
- 1523-1528
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W1964966606
- Cited by
- 34
- References
- 52
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 7
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- Parkinson's disease, iron metabolism, iron homeostasis, substantia nigra, tissue iron content, transcranial ultrasound, magnetic resonance imaging, neurodegeneration pathogenesis
- MeSH terms
- Humans, Iron, Magnetic Resonance Imaging, Parkinson Disease, Substantia Nigra, Ultrasonography, Doppler, Transcranial, Neuroimaging
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