Cited by 179Iron Metabolism and DisordersNeurological diseases and metabolismTrace Elements in Health

Isoforms of ferritin have a specific cellular distribution in the brain

Connor, J. R., Boeshore, K. L., Benkovic, S. A., Menzies, S. L.·1994·Journal of Neuroscience Research

Abstract

Ferritin is the major iron storage protein and accounts for the majority of the iron in the brain. Thus, ferritin is a key component in protecting the brain from iron induced oxidative damage. The high lipid content, high rate of oxidative metabolism, and high iron content combine to make the brain the organ most susceptible to oxidative stress. The role of oxidative damage and disruption of brain iron homeostasis is considered clinically important to normal aging and a potential pathogenic component of a number of neurologic disorders including Alzheimer's disease and Parkinson's disease. Little is known, however, of the mechanism by which the brain maintains iron homeostasis at either the whole organ or cellular level. In this study we report the cellular distribution of the two isoforms of ferritin in the brain of adult subhuman primates. A subset of neurons immunolabel specifically for the H‐chain ferritin protein, whereas cells resembling microglia are immunolabeled only after exposure to the L‐chain ferritin antibody. Only one cell type immunostains for both H‐and L‐chain ferritin; these cells are morphologically similar and have the same distribution pattern as oligodendrocytes. Neither ferritin isoform is usually detected in astrocytes. These data indicate considerable differences in iron sequestration and use between neurons and glia and among neuronal and glial subtypes. This information will be essential in determining the role of each of these cells in maintaining general brain iron homeostasis and the relative abilities of these cells to withstand oxidative stress. © 1994 Wiley‐Liss, Inc.

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Crossref · 10.1002/jnr.490370405

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Authors
Connor, J. R., Boeshore, K. L., Benkovic, S. A., & Menzies, S. L.
Affiliations
Pennsylvania State University (US)
Corresponding author
Connor, J. R.
Venue
Journal of Neuroscience Research
Publisher
Wiley
Published
1994-03
Volume
37
Issue
4
Pages
461-465
ISSN
  • 0360-4012 (ISSN-L)
  • 1097-4547
OpenAlex
W2077740413
Cited by
179
References
26
Citations by year
2026: 3 · 2025: 3 · 2024: 8 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 7 · 2014: 3 · 2013: 6 · 2012: 4
FWCI
2.94
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroscience Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ag009063-03)
  • U.S. Public Health Service
  • National Institute on Aging (AG09063)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
ferritin, brain iron homeostasis, iron storage, oxidative stress, neurons, microglia, oligodendrocytes, astrocytes, subhuman primates, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease
MeSH terms
Animals, Antibodies, Monoclonal, Brain, Brain Chemistry, Ferritins, Homeostasis, Iron, Macaca, Nerve Tissue Proteins, Neurons, Oligodendroglia, Organ Specificity, Microglia

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