Cited by 1,049Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology Research

G-protein-coupled receptors and signaling networks: emerging paradigms

Marinissen, Maria Julia, Gutkind, J.Silvio·2001·Trends in Pharmacological Sciences

Abstract

G-protein-coupled receptors (GPCRs) constitute the largest family of cell-surface molecules involved in signal transmission. These receptors play key physiological roles and their dysfunction results in several diseases. Recently, it has been shown that many of the cellular responses mediated by GPCRs do not involve the sole stimulation of conventional second-messenger-generating systems, but instead result from the functional integration of an intricate network of intracellular signaling pathways. Effectors for GPCRs that are independent of G proteins have now also been identified, thus changing the conventional view of the GPCR-heterotrimeric-G-protein-associated effector. The emerging information is expected to help elucidate the most basic mechanism by which these receptors exert their numerous physiological roles, in addition to determining why the perturbation of their function results in many pathological conditions.

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Crossref · 10.1016/s0165-6147(00)01678-3

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Authors
Marinissen, M. J., & Gutkind, J. S.
Affiliations
National Institutes of Health (US)
Corresponding author
Gutkind, J.Silvio
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2001-07
Volume
22
Issue
7
Pages
368-376
ISSN
0165-6147 (ISSN-L)
OpenAlex
W1994816216
Cited by
1,049
References
79
Citations by year
2026: 12 · 2025: 19 · 2024: 29 · 2023: 24 · 2022: 24 · 2021: 37 · 2020: 20 · 2019: 36 · 2018: 25 · 2017: 33 · 2016: 30 · 2015: 35 · 2014: 49 · 2013: 40 · 2012: 44
FWCI
6.18
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
G protein-coupled receptors, intracellular signaling networks, heterotrimeric G proteins, second messenger signaling, receptor-effector coupling, disease
MeSH terms
Animals, Cell Nucleus, Humans, Receptors, Cell Surface, Transcription Factors, Signal Transduction, Gene Expression, GTP-Binding Proteins, GTP-Binding Protein alpha Subunits, Gs, GTP-Binding Protein alpha Subunits, Gi-Go, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase Kinases, JNK Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 7, MAP Kinase Kinase 4

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