G-protein-coupled receptors and signaling networks: emerging paradigms
Abstract
G-protein-coupled receptors (GPCRs) constitute the largest family of cell-surface molecules involved in signal transmission. These receptors play key physiological roles and their dysfunction results in several diseases. Recently, it has been shown that many of the cellular responses mediated by GPCRs do not involve the sole stimulation of conventional second-messenger-generating systems, but instead result from the functional integration of an intricate network of intracellular signaling pathways. Effectors for GPCRs that are independent of G proteins have now also been identified, thus changing the conventional view of the GPCR-heterotrimeric-G-protein-associated effector. The emerging information is expected to help elucidate the most basic mechanism by which these receptors exert their numerous physiological roles, in addition to determining why the perturbation of their function results in many pathological conditions.
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GPCRs are cell membrane receptors for various ligands.
“G protein-coupled receptors (GPCRs) are cell membrane receptors for various ligands.”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [5]
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Rivagorda, M., Romeo-Guitart, D., Blanchet, V., Mailliet, F., Boitez, V., Barry, N., Milunov, D., Siopi, E., Goudin, N., Moriceau, S., et al. (2025) · Nature Aging · doi:10.1038/s43587-024-00791-0 · Cited by 24 · see citing works
G-protein αq participates in the steroid hormone 20-hydroxyecdysone nongenomic signal transduction
Ren, J., Li, X.-R., Liu, P.-C., Cai, M.-J., Liu, W., Wang, J.-X., & Zhao, X.-F. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.08.006 · Cited by 15 · see citing works
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JIANG, P. F., ZHU, T., GAO, J. D., GAO, F., MAO, S. S., ZHAO, W. T., GU, W. Z., & YU, H. M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.021 · Cited by 6 · see citing works
Retracted
- Authors
- Marinissen, M. J., & Gutkind, J. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Gutkind, J.Silvio
- ORCID
- Gutkind, J.Silvio
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 22
- Issue
- 7
- Pages
- 368-376
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W1994816216
- Cited by
- 1,049
- References
- 79
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 29 · 2023: 24 · 2022: 24 · 2021: 37 · 2020: 20 · 2019: 36 · 2018: 25 · 2017: 33 · 2016: 30 · 2015: 35 · 2014: 49 · 2013: 40 · 2012: 44
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- G protein-coupled receptors, intracellular signaling networks, heterotrimeric G proteins, second messenger signaling, receptor-effector coupling, disease
- MeSH terms
- Animals, Cell Nucleus, Humans, Receptors, Cell Surface, Transcription Factors, Signal Transduction, Gene Expression, GTP-Binding Proteins, GTP-Binding Protein alpha Subunits, Gs, GTP-Binding Protein alpha Subunits, Gi-Go, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase Kinases, JNK Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 7, MAP Kinase Kinase 4
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