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Cited by 17History of Science and MedicineBiographical and Historical AnalysisInorganic and Organometallic Chemistry

Bringing inorganic chemistry to life with inspiration from R. J. P. Williams

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Hill, H. Allen O., Sadler, Peter J.·2016·JBIC Journal of Biological Inorganic Chemistry
DOI 10.1007/s00775-016-1333-3PMC PMC4771813
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Abstract

Our appreciation of the scholarly ideas and thinking of Bob Williams is illustrated here by a few of the areas in which he inspired us. His journey to bring inorganic chemistry to life began with an early interest in analytical chemistry, rationalising the relative stabilities of metal coordination complexes (The Irving-Williams Series), and elucidating the organometallic redox chemistry of vitamin B12. He (and Vallee) recognised that metal ions are in energised (entatic) states in proteins and enzymes, which themselves are dynamic structures of rods and springs. He played a key role in helping Rosenberg to pave the road toward the clinic for the anticancer drug cisplatin. He believed that evolution is not just dependent on DNA, but also on the metallome. Organisms and the environment are one system: does DNA code directly for all the essential elements of life?

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  • The tendency for metal ions in aqueous solution to interact tightly with ligands is summarized in the Irving-Williams series: Mg2+ < Mn2+ < Fe2+ < Co2+ < Ni2+ < Cu2+ (and Cu+) > Zn2+.

    “The tendency for metal ions in aqueous solution to interact tightly with ligands is summarized in the Irving-Williams series21,22 (here augmented with Mg2+ and Cu+): Mg2+ < Mn2+ < Fe2+ < Co2+ < Ni2+ < Cu2+ (and Cu+) > Zn2+.”

    From Metals in Motion: Understanding Labile Metal Pools in Bacteria (2025) · cites this paper as [22]

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Research works printed but not linked: 45

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Authors
Hill, H. A. O., & Sadler, P. J.
Affiliations
  • University of Oxford (GB)
  • University of Warwick (GB)
Corresponding author
Sadler, Peter J.
ORCID
Sadler, Peter J.
Venue
JBIC Journal of Biological Inorganic Chemistry
Publisher
Springer Science and Business Media LLC
Published
2016-02-03
Volume
21
Issue
1
Pages
5-12
ISSN
  • 0949-8257 (ISSN-L)
  • 1432-1327
DOI
10.1007/s00775-016-1333-3
PMC
PMC4771813
OpenAlex
W2271065496
Cited by
17
References
0
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2016: 4
FWCI
13.30
Type
journal article
Language
en
Open access
Licence
Locations
  • JBIC Journal of Biological Inorganic Chemistry (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust
  • Cancer Research UK
  • Engineering and Physical Sciences Research Council
Topics
  • Social Sciences › Arts and Humanities › History and Philosophy of Science › History of Science and Medicine
  • Social Sciences › Arts and Humanities › History › Biographical and Historical Analysis
  • Physical Sciences › Chemistry › Organic Chemistry › Inorganic and Organometallic Chemistry
Keywords
Irving-Williams series, metal complexes, vitamin B12, metalloproteins, metalloenzymes, cisplatin, metallome, evolution, bioinorganic chemistry
MeSH terms
Antineoplastic Agents, Chemistry, Inorganic, History, 20th Century

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