Childhood onset neuropsychiatric disorders in adult eating disorder patients: A pilot study
Abstract
Background Autism spectrum disorders (ASD) have been suggested to be overrepresented in anorexia nervosa. This study aimed to explore the comorbidity of ASD and other childhood onset neuropsychiatric disorders (COND) [attention-deficit/hyperactivity disorder (AD/HD) and tic disorders] in a group of severe eating disorder (ED) patients. Method Thirty female ED patients from a specialist hospital clinic were examined on measures tapping into COND and personality disorders. Results In our group of longstanding ED, 53% had at least one COND diagnosis; 23% had ASD, 17% had AD/HD, and 27% had a tic disorder. Conclusions These preliminary data suggest that COND may be common in patients with severe ED and should be kept in mind when treating these patients.
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A further narrative review identified additional high-risk groups for ADHD, including people with foetal alcohol spectrum disorder, extremely low birth weight, eating disorders such as binge eating disorder, sleep disorders, or problem gambling.
“A further narrative review identified additional groups, for example, people with foetal alcohol spectrum disorder (Lange et al., 2018), extremely low birth weight (Momany et al., 2018), eating disorders such as binge eating disorder (Wentz et al., 2005; Yates et al., 2009), sleep disorders (Cortese et al., 2009; Sedky et al., 2014), or problem gambling (Dowling et al., 2015).”
From The Australian evidence-based clinical practice guideline for attention deficit hyperactivity disorder (2023) · cites this paper as Wentz et al., 2005
The Discussion reports ADHD in a small group of women with severe eating disorders, specifically those with binge-eating/purging anorexia nervosa. It does not establish the claim for binge eating disorder, which is distinct from that anorexia subgroup. The other listed groups are attributed to other citations, not Wentz et al. (LLM, conf=0.88)
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Cites
Wing, L., Leekam, S. R., Libby, S. J., Gould, J., & Larcombe, M. (2002) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00023 · Cited by 694 · cited 1× · see citing works
“For collateral interview, the Diagnostic Interview for Social and Communication Disorders (DISCO) pertaining to ASD diagnoses has shown good validity and reliability [22, 34].”
BackgroundAsperger Syndrome—Some Epidemiological Considerations: A Research Note
Gillberg, I. C., & Gillberg, C. (1989) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1989.tb00275.x · Cited by 603 · see citing works
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Research works printed but not linked: 25
- [2]2. Anckarsäter H, Stahlberg O, Larson T, Hakansson C, Jutblad S-B, Niklasson L, Nydén A, Wentz E, Westergren S, Cloninger C R, Gillberg - C, Rastam M (2005) The impact of ADHD and autism spectrum disorders on temperament, character and personality development. American Journal of Psychiatry. Accepted for publication.
- [3]3. Biederman J, Newcorn J, Sprich S (1991) Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. American Journal of Psychiatry 148: 564-577
- [4]4. Burd L, Kerbeshian J, Wikenheiser M, Fisher W (1986) Prevalence of Gilles de la Tourette syndrome in North Dakota adults. American Journal of Psychiatry 143: 787-788
- [5]5. Demitrack MA, Putnam FW, Brewerton TD, Brandt HA, Gold PW (1990) Relation of clinical variables to dissociative phenomena in eating disorders. American Journal of Psychiatry 147: 1184-1188
- [7]7. First MB, Spitzer RL, Gibbon M, Williams JBW (1997a) Structured Clinical Interview for DSM-IV Axis I DisordersPatient Edition (SCID-I/P, Version 2.0, 4/97 revision). Biometrics Research Department, New York
- [9]9. Gillberg C (1983) Neuropsychiatric aspects of perceptual, motor and attentional deficits in Swedish primary school-children. Journal of Child Psychology and Psychiatry 24: 377-403
- [14]14. Gillberg IC, Råstam M, Gillberg C (1994) Anorexia nervosa outcome: Six-year controlled longitudinal study of 51 cases including a population cohort. Journal of the American Academy of Child and Adolescent Psychiatry 33: 729-739
- [15]15. Howlin P, Udwin O (2002) Outcomes in neurodevelopmental and genetic disorders. Cambridge University Press, New York
- [17]17. Kadesjö B, Gillberg C, Hagberg B (1999) Brief report: autism and Asperger syndrome in seven-year-old children: a total population study. Journal of Autism and Developmental Disorders 29: 327-31
- [18]18. Kadesjö B, Gillberg C (2000) Tourette's disorder: epidemiology and comorbidity in primary school children. Journal of the American Academy of Child and Adolescent Psychiatry 39: 548-55
- [19]19. Kessler RC (2005) Prevalence of adult ADHD in the United States: Results from the National Comorbidity Survey Replication (NCS-R). Psychological Medicine. In press.
- [20]20. Lacey JH, Evans CDH (1986) The impulsivist: a multi-impulsive personality disorder. British Journal of Addiction 81: 641-649
- [21]21. Leckman JF, Towbin KE, Ort SI, Cohen DJ (1988) Clinical assessment of the tic disorder severity. In: Cohen DJ, Bruun RD, Leckman JF (eds) Tourette's syndrome & Tic Disorders . Wiley, New York: pp 55-78
- [22]22. Leekam SR, Libby SJ, Wing L, Gould J, Taylor C. (2002) The Diagnostic Interview for Social and Communication Disorders: algorithms for ICD-10 childhood autism and Wing and Gould autistic spectrum disorder. Journal of Child Psychology and Psychiatry 43:327-342
- [23]23. Milberger S, Biederman J, Faraone SV, Murphy J, Tsuang MT (1995) Attention deficit hyperactivity disorder and comorbid disorders: issues of overlapping symptoms. American Journal of Psychiatry 152: 1793-1799
- [25]25. Piran N, Lerner P, Garfinkel PE, Kennedy S H, Brouillette C (1988) Personality disorders in anorexic patients. International Journal of Eating Disorders 7: 589-599
- [26]26. Rasmussen, P, Gillberg C (2000) Natural outcome of ADHD with developmental co-ordination disorder at age 22 years: A controlled, longitudinal, community-based study. Journal of the American Academy of Child and Adolescent Psychiatry 39: 1424-1431
- [27]27. Råstam M, Gillberg C, Garton M (1989) Anorexia nervosa in a Swedish urban region. A population-based study. British Journal of Psychiatry 155: 642-646
- [28]28. Råstam M (1992) Anorexia nervosa in 51 Swedish children and adolescents. Premorbid problems and comorbidity. Journal of the American Academy of Child and Adolescent Psychiatry 31: 819829
- [29]29. Schweickert LA, Strober M, Moskowitz A (1997) Efficacy of methylphenidate in bulimia nervosa comorbid with attentiondeficit hyperactivity disorder: A case report. International Journal of Eating Disorders 21: 299-301
- [30]30. Sokol MS, Gray NS, Goldstein A, Kaye WH (1999) Methylphenidate treatment for bulimia nervosa associated with a - cluster B personality disorder. International Journal of Eating Disorders 25: 233-237
- [31]31. Waller G (1994) Borderline personality disorder and perceived family dysfunction in eating disorders. The Journal of Nervous and Mental Disease 182: 541-546
- [32]32. Wentz Nilsson E, Gillberg C, Gillberg IC, Råstam M (1999) Tenyear follow-up of adolescent-onset anorexia nervosa: Personality disorders. Journal of the American Academy of Child and Adolescent Psychiatry 38: 1389-1395
- [33]33. Wentz E, Gillberg C, Gillberg IC, Råstam M (2001) Ten-year follow-up of adolescent-onset anorexia nervosa: psychiatric disorders and overall functioning scales. Journal of Child Psychology and Psychiatry 42: 613-622
- [35]35. Wolff S, Townshend R, McGuire RJ, Weeks DJ (1991) 'Schizoid' personality in childhood and adult l ife II: adult adjustment and the continuity with schizotypal personality disorder. British Journal of Psychiatry 159: 620-629 Table 1: Mean age, age of ED onset, duration of ED, weight, height and BMI of the ED patients | | ED group (n=30) | |------------------------------------|-------------------| | Age, years (SD) | 27.4 (8.4) | | 95% CI | 24.3-30.6 | | Age of ED onset, years (SD) | 18.0 (4.2) | | 95% CI | 16.4-19.5 | | Duration of current ED, years (SD) | 9.5 (8.8) | | 95% CI | 6.2-12.8 | | Duration of any ED, years (SD) | 9.9 (8.7) | | 95% CI | 6.7-13.1 | | Weight, kg (SD) | 55.0 (20.6) | | 95% CI | 47.4-62.7 | | Height, m (SD) | 1.65 (0.06) | | 95% CI | 1.63-1.67 | | BMI, kg/m 2 (SD) | 20.2 (7.4) | | 95% CI | 17.4-23.0 | SD: standard deviation; ED: eating disorder; BMI: body mass index; CI: confidence interval Table 2: Childhood onset neuropsychiatric disorders in ED patients | Type of COND | ED group n=30 | |----------------|-----------------| | ASD | 7 (23%) | | AD/HD | 5 (17%) | | TD/chronic tic | 8 (27%) | | disorder | | | Any COND | 16 (53%) | COND: childhood onset neuropsychiatric disorders; ED: eating disorder, ASD: autism spectrum disorder; AD/HD: attention deficit/hyperactivity disorder ; TD: Tourette's disorder Table 3. PDs in ED patients | Type of PD | ED group (n=30) | |----------------------|-------------------| | Avoidant | 23 | | Dependent | 5 | | Obsessive-compulsive | 18 | | Passive-aggressive | 6 | | Depressive | 23 | | Paranoid | 20 | | Schizotypal | 3 | | Schizoid | 7 | | Histrionic | 4 | | Narcissistic | 2 | | Borderline | 19 | | Antisocial | 3 | | Any PD | 28 | PD: personality disorder; ED: eating disorder
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Zucker, N. L., Losh, M., Bulik, C. M., LaBar, K. S., Piven, J., & Pelphrey, K. A. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.6.976 · Cited by 284 · see citing works
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“, 2018), eating disorders such as binge eating disorder (Wentz et al., 2005; Yates et al., 2009), sleep disorders (Cortese et al.”
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Testa, G., Baenas, I., Vintró-Alcaraz, C., Granero, R., Agüera, Z., Sánchez, I., Riesco, N., Jiménez-Murcia, S., & Fernández-Aranda, F. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072305 · Cited by 22 · see citing works
- Authors
- Wentz, E., Lacey, J. H., Waller, G., Råstam, M., Turk, J., & Gillberg, C.
- Affiliations
- University of Gothenburg (SE)
- St George's Hospital (GB)
- St George's, University of London (GB)
- Venue
- European Child & Adolescent Psychiatry
- Published
- 2005-12
- Volume
- 14
- Issue
- 8
- Pages
- 431-437
- ISSN
- 1018-8827 (ISSN-L)
- 1435-165X
- OpenAlex
- W2071938440
- Cited by
- 130
- References
- 2
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 10 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 11 · 2016: 9 · 2015: 10 · 2014: 4 · 2013: 19 · 2012: 5
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- eating disorders, anorexia nervosa, autism spectrum disorder, attention deficit hyperactivity disorder, tic disorders, personality disorders, comorbidities, female patients
- MeSH terms
- Adolescent, Adult, Feeding and Eating Disorders, Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Female, Humans, Impulsive Behavior, Middle Aged, Personality Disorders, Pilot Projects, Sweden, Tic Disorders, Comorbidity, Age of Onset
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