Attention deficit hyperactivity disorder and disordered eating behaviors: Links, risks, and challenges faced
Open accessAbstract
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that often persists in adulthood. It is defined by inattention and/or hyperactivity-impulsivity. ADHD is associated with many comorbidities, including eating disorders (EDs). In the last decade, studies have reported that ADHD is linked with binge EDs, bulimia nervosa, and anorexia nervosa. Many postulates have been proposed to explain the association: 1) impulsive behavior in ADHD patients leads to disordered eating behavior; 2) other psychologic comorbidities present in ADHD patients account for eating behavior; 3) poor eating habits and resulting nutritional deficiencies contribute to ADHD symptoms; and 4) other risk factors common to both ADHD and EDs contribute to the coincidence of both diseases. Additionally, sex differences become a significant issue in the discussion of EDs and ADHD because of the higher incidence of bulimia nervosa and anorexia nervosa in females and the ability of females to mask the symptoms of ADHD. Interestingly, both EDs and ADHD rely on a common neural substrate, namely, dopaminergic signaling. Dopaminergic signaling is critical for motor activity and emotion, the latter enabling the former into a combined motivated movement like eating. This linkage aids in explaining the many comorbidities associated with ADHD. The interconnection of ADHD and EDs is discussed from both a historical perspective and the one based on the revealing nature of its comorbidities.
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TL;DR
This narrative review argues that ADHD and disordered eating behaviors—especially binge eating disorder, bulimia nervosa, obesity, and possibly anorexia nervosa—are strongly linked through shared impulsivity, comorbidity, and dopaminergic pathways. It highlights clinical challenges including sex differences, underdiagnosis of ADHD in girls, and the need for early monitoring of eating and affective symptoms.
Key findings
- ADHD prevalence is reported as ~5.3% in pediatric and 3.4% in adult populations, and ~70% of ADHD patients display at least one other comorbid disorder; the EDs most associated with ADHD are binge eating disorder (BED) and bulimia nervosa (BN), while the AN–ADHD link is described as more controversial.
- In the Raine study of 1,799 adolescents, 115 had ADHD, and ADHD symptoms were associated with a “western” diet (odds ratio [OR] = 2.21); other cited studies link ADHD to unhealthy foods, skipping breakfast/dinner, more than five meals daily, sweetened beverages, and deficiencies in iron, zinc, and omega-3/6 fatty acids.
- Obesity findings include Altfas’s 27.4% ADHD prevalence among obese adults; a 43,297 US adolescent study with adjusted OR = 1.5; and a German sample of 1,633 adults showing ADHD prevalence of 9.3% in obese vs 3.8% overweight and 4.3% normal-weight individuals, with ADHD participants twice as likely to be obese (22.1% vs 10.2%).
- Loss of control eating was higher in children with ADHD (adjusted OR = 12.68); BN is nearly 12 times more common in girls than boys, while pediatric ADHD is estimated to be three times more common in boys than girls, and impulsivity/inattention correlate with BED/BN severity, with depression, anxiety, and oppositional defiant disorder proposed as mediators.
Methods
- Design: narrative literature review described as an “extensive literature review,” synthesizing prior studies; no systematic review, meta-analysis, or primary data collection is described.
- Data/sample: cites clinical, cross-sectional, longitudinal, case, neuroimaging, and genetic studies across child and adult, clinical and community samples; no single sample or search strategy is reported.
- Analysis: narrative synthesis of associations and proposed mechanisms, including impulsivity/executive dysfunction, dopaminergic signaling, psychiatric comorbidity, and sex differences.
Limitations
- Stated: the AN–ADHD link is unclear, with few studies and small numbers of subjects; no study has longitudinally examined the complex interaction from cyclical shifting between ED subtypes and ADHD; early ADHD diagnosis is challenging, and public education may risk overdiagnosis.
- Evident: as a narrative review, it lacks systematic search/inclusion criteria and formal quality assessment, so selection and citation bias cannot be ruled out; many cited associations are cross-sectional, limiting causal inference.
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- Findingown data
In premedicated newly diagnosed ADHD boys, disruptive dietary patterns were accompanied by diminished consumption of fruits and vegetables and increased consumption of sweetened beverages.
“We also found that these disruptive dietary patterns were accompanied by diminished consumption of fruits and vegetables and increased consumption of sweetened beverages.25”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [25] Ptacek R Kuzelova H Stefano GB Disruptive patterns of eating behaviors and associated lifestyles in males with ADHD Med Sci Monit 2014 20 608 613 24727744 PMC3999164
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- Premisecitation
ADHD is associated with many comorbidities, including eating disorders.
“In the last decade, researchers report a significant coincidence of ADHD and eating disorders (EDs).5,8,9”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [5] Nazar BP Pinna CM Coutinho G Review of literature of attention-deficit/hyperactivity disorder with comorbid eating disorders Rev Bras Psiquiatr 2008 30 4 384 389 19142417
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- Premisecitation
Obesity is more prevalent in individuals with ADHD compared to the general population.
“The link between ADHD and disordered eating behavior is evident by the observation that obesity is more prevalent in individuals with ADHD compared to the general population.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [37] Altfas JR Prevalence of attention deficit/hyperactivity disorder among adults in obesity treatment BMC Psychiatry 2002 2 9 17 12227832 PMC130024
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In adults, the incidence of ADHD is similar in both sexes.
“In adults, the incidence of ADHD is similar in both sexes.18”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [18] Quinn PO Madhoo M A review of attention-deficit/hyperactivity disorder in women and girls: uncovering this hidden diagnosis Prim Care Companion CNS Disord 2014 16 3 CC.13r01596 PMC4195638 25317366
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- Premisecitation
A large cross-sectional study of 43,297 US adolescents revealed a statistically significant adjusted OR of 1.5 for the association between ADHD and obesity.
“A large cross-sectional study of 43,297 US adolescents revealed a statistically significant adjusted OR of 1.5.13”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [13] Halfon N Larson K Slusser W Associations between obesity and comorbid mental health, developmental, and physical health conditions in a nationally representative sample of US children aged 10 to 17 Acad Pediatr 2013 13 1 6 13 23200634
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A 33-year longitudinal study of 207 participants found that men who had childhood ADHD had higher BMI and obesity rates.
“Also notable was a 33-year longitudinal study of 207 participants, by the same author, which found that men who had childhood ADHD had higher BMI and obesity rates.43”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [43] Cortese S Ramos Olazagasti MA Klein RG Castellanos FX Proal E Mannuzza S Obesity in men with childhood ADHD: a 33-year controlled, prospective, follow-up study Pediatrics 2013 131 6 e1731 e1738 23690516 PMC4074659
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- Premisecitation
A case study reported that a 13-year-old obese boy with ADHD and a melanocortin 4 receptor mutation showed a dramatic decrease in BMI after atomoxetine treatment.
“A case study reported that a 13-year-old obese boy with ADHD (BMI =47.2) and a melanocortin 4 receptor mutation showed a dramatic decrease in BMI after atomoxetine treatment.49”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [49] Pott W Albayrak O Hinney A Hebebrand J Pauli-Pott U Successful treatment with atomoxetine of an adolescent boy with attention deficit/hyperactivity disorder, extreme obesity, and reduced melanocortin 4 receptor function Obes Facts 2013 6 1 109 115 23493066 PMC5644743
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- Premisecitation
ADHD is associated with adverse health outcomes including obesity.
“ADHD is associated with devastating health outcomes: substance abuse, suicide, physical injuries, risky sexual behavior, obesity, diabetes type 2, hypertension, higher health care visits, and early mortality.12,13”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [12] Nigg JT Attention-deficit/hyperactivity disorder and adverse health outcomes Clin Psychol Rev 2013 33 2 215 228 23298633 PMC4322430
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- Premisecitation
Participants with ADHD were twice as likely to be obese than the general population (22.1% vs 10.2%).
“Conversely, the study reported that participants with ADHD were twice as likely to be obese than the general population (22.1% vs 10.2%).41”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [41] de Zwaan M Gruss B Müller A Association between obesity and adult attention-deficit/hyperactivity disorder in a German community-based sample Obes Facts 2011 4 3 204 211 21701236 PMC6444500
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- Premisecitation
Recent studies have found a significant link between ADHD and an abnormal dietary pattern, specifically consumption of junk food and nonadherence to a traditional three-meal daily diet.
“Recent studies have found a significant link between the ADHD and an abnormal dietary pattern, ie, the consumption of “junk food” and nonadherence to a “traditional” three-meal daily diet.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [22] Howard AL Robinson M Smith GJ Ambrosini GL Piek JP Oddy WH ADHD is associated with a “western” dietary pattern in adolescents J Atten Disord 2011 15 5 403 411 20631199
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- Premisecitation
Consumption of food additives and artificial sweeteners has been reported to contribute to abnormal levels of hyperactivity in developing children.
“Consumption of food additives and artificial sweeteners has been reported to contribute to abnormal levels of hyperactivity in developing children.32”
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- Premisecitation
Another Korean study of 12,350 participants reports a significant association between ADHD and unhealthy foods such as soft drinks, westernized fast food, and instant noodles.
“Another Korean study of 12,350 participants reports a significant association between ADHD and unhealthy foods, such as soft drinks, westernized fast food, and instant noodles.24”
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- Premisecitation
In Cortese et al's study, impulsive and inattentive symptoms, but not hyperactive symptoms, mediated the association between childhood ADHD and obesity.
“Notably, their study consisted of 34,653 face-to-face interviews of young adults and also found that impulsive and inattentive symptoms, but not hyperactive symptoms, mediated the association.42”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [42] Cortese S Faraone SV Bernardi S Wang S Blanco C Adult attention-deficit hyperactivity disorder and obesity: epidemiological study Br J Psychiatry 2013 203 1 24 34 23661765 PMC3696877
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- Premisecitation
In that study, patients with combined subtype of ADHD were significantly more likely to be obese and overweight compared to those with only inattentive or only hyperactive symptoms.
“The study also found that the patients with combined subtype of ADHD were significantly more likely to be obese and overweight compared to those with only inattentive or only hyperactive symptoms.45”
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In pediatric populations, ADHD is estimated to be three times more common in boys than in girls.
“In pediatric populations, ADHD is estimated to be three times more common in boys than in girls.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [18] Quinn PO Madhoo M A review of attention-deficit/hyperactivity disorder in women and girls: uncovering this hidden diagnosis Prim Care Companion CNS Disord 2014 16 3 CC.13r01596 PMC4195638 25317366
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- Premisecitation
Iron deficiency and low serum ferritin levels have been linked to ADHD and impaired cognitive behavioral development.
“Iron deficiency and low serum ferritin levels have been linked to ADHD and impaired cognitive behavioral development.27–29”
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- Premisecitation
Arnold et al reported that zinc supplementation decreased the optimal dose of amphetamine treatment.
“Arnold et al reported that zinc supplementation decreased the optimal dose of amphetamine treatment.30,31”
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- Premisecitation
Obesity genes in the pathways of dopaminergic circuitry, such as FTO and melanocortin 4 receptor, have been associated with ADHD.
“Obesity genes in the pathways of dopaminergic circuitry, such as FTO (fat mass–and obesity-associated variant) and melanocortin 4 receptor, have been associated with ADHD.46–48”
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- Premisecitation
Cortese et al found that obese adults were more likely to have had a diagnosis of childhood ADHD.
“Furthermore, Cortese et al found that obese adults were more likely to have had a diagnosis of childhood ADHD in the past.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [42] Cortese S Faraone SV Bernardi S Wang S Blanco C Adult attention-deficit hyperactivity disorder and obesity: epidemiological study Br J Psychiatry 2013 203 1 24 34 23661765 PMC3696877
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- Premisecitation
After treatment of symptoms, weight loss was greater in treated ADHD obese adults compared to non-ADHD obese adults.
“After treatment of symptoms, weight loss was greater in the treated ADHD obese adults compared to non-ADHD obese adults.37”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [37] Altfas JR Prevalence of attention deficit/hyperactivity disorder among adults in obesity treatment BMC Psychiatry 2002 2 9 17 12227832 PMC130024
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- Premisecitation
A cross-sectional study in Poland of boys aged 6-18 years with ADHD demonstrated that overweight status but not obesity was statistically significant in the ADHD group.
“A cross-sectional study by a group in Poland examined boys aged 6–18 years who were diagnosed with ADHD and demonstrated that overweight status but not obesity was statistically significant in the ADHD group.44”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [44] Hanć T Słopień A Wolańczyk T ADHD and overweight in boys: cross-sectional study with birth weight as a controlled factor Eur Child Adolesc Psychiatry 2015 24 1 41 53 24633695 PMC4291509
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- Premisecitation
In the Raine study, adolescents with ADHD symptoms were more likely to have a western style diet than a traditional healthy diet (OR=2.21).
“The study found that the subjects with ADHD symptoms were more likely to have a western style diet than a traditional healthy diet (odds ratio [OR] =2.21)”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [22] Howard AL Robinson M Smith GJ Ambrosini GL Piek JP Oddy WH ADHD is associated with a “western” dietary pattern in adolescents J Atten Disord 2011 15 5 403 411 20631199
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- Premisecitation
BN is nearly 12 times more common in girls than boys.
“On the other hand, BN is nearly 12 times more common in girls than boys.78”
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- Premisecitation
Other comorbidities, such as depression, anxiety, and disruptive behavior, were also found to mediate the association between BN and ADHD.
“Other comorbidities, such as depression, anxiety, and disruptive behavior, were also found to mediate the association between BN and ADHD.11”
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- Premisecitation
ADHD patients with predominantly impulsive symptoms have more commitment errors in the go-no-go task.
“ADHD patients with predominantly impulsive symptoms have more commitment errors in the go–no-go task.”
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- Premisecitation
In a larger study of 89 women with ED, Yates et al found that inattentive symptoms of ADHD were common among women with BN.
“In a larger study of 89 women with ED, Yates et al found that inattentive symptoms of ADHD were common among women with BN.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [86] Yates WR Lund BC Johnson C Mitchell J McKee P Attention-deficit hyperactivity symptoms and disorder in eating disorder inpatients Int J Eat Disord 2009 42 4 375 378 19040267
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- Premisecitation
In the same study, participants with symptoms of anxiety and depression showed emotional and binge eating.
“Expectedly, in the same study, participants with symptoms of anxiety and depression showed emotional and binge eating.”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [76] Pauli-Pott U Becker K Albayrak O Hebebrand J Pott W Links between psychopathological symptoms and disordered eating behaviors in overweight/obese youths Int J Eat Disord 2013 46 2 156 163 22987501
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- Premisecitation
The Catechol-O-methyltransferase gene, involved in the dopaminergic pathways of ADHD, was also implicated in BN.
“For example, the Catechol-O-methyltransferase gene, involved in the dopaminergic pathways of ADHD, was also implicated in BN.92”
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- Premisecitation
Mikami et al found that baseline impulsivity symptoms predicted adolescent pathology in a 5-year prospective longitudinal study of ADHD girls aged 6-12 years.
“Notably, among studies of BN, there are two longitudinal studies by Mikami et al in a 5-year prospective longitudinal study of ADHD girls aged 6–12 years.89 Mikami et al found that baseline impulsivity symptoms predicted adolescent pathology.”
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Punitive parenting in childhood also predicted pathological eating behaviors.
“Punitive parenting in childhood also predicted pathological eating behaviors.89”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [89] Mikami AY Hinshaw SP Patterson KA Lee JC Eating pathology among adolescent girls with attention-deficit/hyperactivity disorder J Abnorm Psychol 2008 117 1 225 235 18266500 PMC2930179
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- Premisecitation
Reinblatt et al reported that loss of control eating was much higher in children with ADHD (adjusted OR=12.68).
“Reinblatt et al reported that LOC was much higher in children with ADHD (adjusted OR =12.68).67”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [67] Reinblatt SP Mahone EM Tanofsky-Kraff M Pediatric loss of control eating syndrome: association with attention-deficit/hyperactivity disorder and impulsivity Int J Eat Disord 2015 48 6 580 588 25855370 PMC4607309
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- Premisecitation
Methylphenidate treatment in obese individuals with ADHD resulted in significant weight loss.
“In another study, methylphenidate treatment in obese individuals with ADHD resulted in significant weight loss in obese patients with ADHD.60”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [60] Levy LD Fleming JP Klar D Treatment of refractory obesity in severely obese adults following management of newly diagnosed attention deficit hyperactivity disorder Int J Obes 2009 33 3 326 334 19223848
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- Premisecitation
Symptoms of impulsiveness and inattention correlate with severity of BED symptoms.
“It is found that symptoms of impulsiveness and inattention correlate with severity of BED symptoms.57,58”
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- Premisecitation
Yates et al also confirmed that inattentive symptoms correlated with bulimic behavior and depressive symptoms.
“Furthermore, Yates et al also confirmed that inattentive symptoms correlated with bulimic behavior and depressive symptoms.86”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [86] Yates WR Lund BC Johnson C Mitchell J McKee P Attention-deficit hyperactivity symptoms and disorder in eating disorder inpatients Int J Eat Disord 2009 42 4 375 378 19040267
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- Interpretationcitation
The link between AN and ADHD is not clear despite the hypothesis of a common neural substrate.
“The link between AN and ADHD is not clear despite the hypothesis of a common neural substrate.97–100”
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- Premisecitation
Many studies found that the presence of depressive symptoms in obese adults with ADHD correlated with severity of BED symptoms.
“Many studies found that the presence of depressive symptoms in obese adults with ADHD correlated with severity of BED symptoms.72–75”
Quote in the paperSubstantial claim0 of 4 sources checked- cites [72] Muller A Claes L Wilderjans TF de Zwaan M Temperament subtypes in treatment seeking obese individuals: a latent profile analysis Eur Eat Disord Rev 2014 22 4 260 266 24809764
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- Premisecitation
In a study of 20 women with BN and 20 age-matched controls, symptoms of impulsivity measured with the BIS were significantly higher in the BN group.
“In a study of 20 women with BN and 20 age-matched controls, symptoms of impulsivity measured with the BIS were significantly higher in the BN group.85”
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- Interpretationcitation
Because of impulsiveness, patients with ADHD and BED are not able to inhibit their impulse to eat food, even when faced with the task of dieting and losing weight.
“Because of impulsiveness, patients with ADHD and BED are not able to “inhibit” their impulse to eat food, even when faced the task of dieting and losing weight.56”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [56] Schag K Schonleber J Teufel M Zipfel S Giel KE Food-related impulsivity in obesity and binge eating disorder – a systematic review Obes Rev 2013 14 6 477 495 23331770
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- Premisecitation
LOC eating in childhood may be a predictor of disordered eating behavior in adolescence.
“LOC eating in childhood may be a predictor of disordered eating behavior in adolescence.68”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [68] Tanofsky-Kraff M Yanovski SZ Schvey NA Olsen CH Gustafson J Yanovski JA A prospective study of loss of control eating for body weight gain in children at high risk for adult obesity Int J Eat Disord 2009 42 1 26 30 18720473 PMC2673525
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- Premisecitation
Food addiction has been associated with inattentive impulsive symptoms.
“Food addiction, or eating behavior that involves overconsumption of specific foods that are highly palatable in an addiction-like manner, has also been associated with inattentive impulsive symptoms.”
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- Rests on an assumption: ADHD consists of dopamine and norepinephrine circuits in the brain, which are involved in reward processing.
- Premisecitation
Affective diseases, mainly depression, have been associated with higher incidence of BED.
“Affective diseases, mainly depression, have been associated with higher incidence of BED.”
Quote in the paperSubstantial claim0 of 4 sources checked- cites [72] Muller A Claes L Wilderjans TF de Zwaan M Temperament subtypes in treatment seeking obese individuals: a latent profile analysis Eur Eat Disord Rev 2014 22 4 260 266 24809764
Not checked in the free run.
- cites [73] Nazar BP Suwwan R de Sousa Pinna CM Influence of attention-deficit/hyperactivity disorder on binge eating behaviors and psychiatric comorbidity profile of obese women Compr Psychiatry 2014 55 3 572 578 24246603
Not checked in the free run.
- cites [74] Alfonsson S Parling T Ghaderi A Self-reported symptoms of adult attention deficit hyperactivity disorder among obese patients seeking bariatric surgery and its relation to alcohol consumption, disordered eating and gender Clin Obes 2013 3 5 124 131 25586627
Not checked in the free run.
- cites [75] Khalife N Kantomaa M Glover V Childhood attention-deficit/hyperactivity disorder symptoms are risk factors for obesity and physical inactivity in adolescence J Am Acad Child Adolesc Psychiatry 2014 53 4 425 436 24655652
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- Premisecitation
Pauli-Pott et al reported that ODD symptoms, not ADHD symptoms alone, were associated with disordered eating behaviors.
“Pauli-Pott et al reported that ODD symptoms, not ADHD symptoms alone, were associated with disordered eating behaviors.76,77”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [76] Pauli-Pott U Becker K Albayrak O Hebebrand J Pott W Links between psychopathological symptoms and disordered eating behaviors in overweight/obese youths Int J Eat Disord 2013 46 2 156 163 22987501
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- cites [77] Pauli-Pott U Neidhard J Heinzel-Gutenbrunner M Becker K On the link between attention deficit/hyperactivity disorder and obesity: do comorbid oppositional defiant and conduct disorder matter? Eur Child Adolesc Psychiatry 2014 23 7 531 537 24197170
Not checked in the free run.
- Premisecitation
Girls with ADHD and depressive symptoms were found to be at the highest risk of BN.
“Girls with ADHD and depressive symptoms were found to be at the highest risk of BN.11”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [11] Biederman J Newcorn J Sprich S Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders Am J Psychiatry 1991 148 5 564 577 2018156
Not checked in the free run.
- Interpretationcitation
Patients with ADHD and another psychiatric comorbidity are necessary for the development of BED.
“This suggests that patients with ADHD and another psychiatric comorbidity are necessary for the development of BED.”
Quote in the paperSubstantial claim - Interpretationreasoning
Girls with ADHD and symptoms of depressive, anxiety, and disruptive disorders are at risk of developing BN.
“In summary, girls with ADHD and symptoms of depressive, anxiety, and disruptive disorders are at risk of developing BN.”
Quote in the paperSubstantial claim - Premisecitation
Biederman et al found that girls with ADHD tend to have an earlier onset of menarche.
“Biederman et al found that girls with ADHD tend to have an earlier onset of menarche; however, the reason behind this finding is currently not understood.95”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [95] Biederman J Ball SW Monuteaux MC Surman CB Johnson JL Zeitlin S Are girls with ADHD at risk for eating disorders? Results from a controlled, five-year prospective study J Dev Behav Pediatr 2007 28 4 302 307 17700082
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- Premisecitation
In BED, impulsiveness according to BIS scores correlated with decreased food-specific response inhibition in the prefrontal control network during the go-no-go task.
“It was found that, in BED, impulsiveness according to BIS scores correlated with decreased food-specific response inhibition in the prefrontal control network during the go–no-go task.63”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [63] Hege MA Preissl H Stingl KT Magnetoencephalographic signatures of right prefrontal cortex involvement in response inhibition Hum Brain Mapp 2014 35 10 5236 5248 24845057 PMC6869148
Not checked in the free run.
- Premisecitation
Impulsive behavior is related to avoidance of food in anorexic girls.
“Impulsive behavior is related to avoidance of food in anorexic girls.101”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [101] Stulz N Hepp U Gachter C Martin-Soelch C Spindler A Milos G The severity of ADHD and eating disorder symptoms: a correlational study BMC Psychiatry 2013 13 1 44 50 23375103 PMC3566966
Not checked in the free run.
- Interpretationreasoning
The cyclical nature of the symptoms of both eating disorders and ADHD is a challenge in studying them.
“A challenge in the study of EDs and ADHD is the cyclical nature of the symptoms of both diseases.”
Quote in the paperSubstantial claim - Interpretationcitation
Healthier diets are associated with improved symptomatology.
“Furthermore, unhealthy eating habits as well as food-associated additives, in general, are directly correlated with ADHD and healthier diets have been associated with improved symptomatology.22”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [22] Howard AL Robinson M Smith GJ Ambrosini GL Piek JP Oddy WH ADHD is associated with a “western” dietary pattern in adolescents J Atten Disord 2011 15 5 403 411 20631199
Not checked in the free run.
- Premisecitation
A larger study of 191 patients reports that girls with AN had a higher correlation with ADHD symptomatology than girls with BN.
“A larger study of 191 patients reports that girls with AN had a higher correlation with ADHD symptomatology than girls with BN.10”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [10] Fernández-Aranda F Agüera Z Castro R ADHD symptomatology in eating disorders: a secondary psychopathological measure of severity? BMC Psychiatry 2013 13 1 166 173 23758944 PMC3693886
Not checked in the free run.
- Premisecitation
The general trend is that inattentive symptoms of ADHD are more persisting.
“The general trend is that inattentive symptoms are more persisting.103”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [103] Mick E Biederman J Prince J Fischer MJ Faraone SV Impact of low birth weight on attention-deficit hyperactivity disorder J Dev Behav Pediatr 2002 23 1 16 22 11889347
Not checked in the free run.
- Premisecitation
Patients with eating disorders cycle through symptoms of bulimia nervosa, anorexia nervosa, and eating disorders not otherwise specified.
“Patients with EDs have been found to cycle through symptoms of BN, AN, and EDs not otherwise specified.106,107”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [106] Anderluh M Tchanturia K Rabe-Hesketh S Collier D Treasure J Lifetime course of eating disorders: design and validity testing of a new strategy to define the eating disorders phenotype Psychol Med 2009 39 1 105 114 18377676
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- cites [107] Castellini G Lo Sauro C Mannucci E Diagnostic crossover and outcome predictors in eating disorders according to DSM-IV and DSM-V proposed criteria: a 6-year follow-up study Psychosom Med 2011 73 3 270 279 21257978
Not checked in the free run.
- Interpretationcitation
Unhealthy eating habits in general are directly correlated with ADHD.
“Furthermore, unhealthy eating habits as well as food-associated additives, in general, are directly correlated with ADHD and healthier diets have been associated with improved symptomatology.22”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [22] Howard AL Robinson M Smith GJ Ambrosini GL Piek JP Oddy WH ADHD is associated with a “western” dietary pattern in adolescents J Atten Disord 2011 15 5 403 411 20631199
Not checked in the free run.
- Premisecitation
Patients with BN and AN have a distorted body image.
“In addition to depressive symptoms, these patients have a distorted body image.89,90”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [89] Mikami AY Hinshaw SP Patterson KA Lee JC Eating pathology among adolescent girls with attention-deficit/hyperactivity disorder J Abnorm Psychol 2008 117 1 225 235 18266500 PMC2930179
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- cites [90] Mikami AY Hinshaw SP Arnold LE Bulimia nervosa symptoms in the multimodal treatment study of children with ADHD Int J Eat Disord 2010 43 3 248 259 19378318
Not checked in the free run.
- Premisecitation
Predominant symptoms of ADHD may change, persist, or remit throughout the lifetime.
“Investigators have found that predominant symptoms of ADHD may change, persist, or remit throughout the lifetime.104,105”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [104] Hart EL Lahey BB Loeber R Applegate B Frick PJ Developmental change in attention-deficit hyperactivity disorder in boys: a four-year longitudinal study J Abnorm Child Psychol 1995 23 6 729 749 8609310
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- cites [105] Biederman J Mick E Faraone SV Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type Am J Psychiatry 2000 157 5 816 818 10784477
Not checked in the free run.
- Interpretationcitation
Food-associated additives in general are directly correlated with ADHD.
“Furthermore, unhealthy eating habits as well as food-associated additives, in general, are directly correlated with ADHD and healthier diets have been associated with improved symptomatology.22”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [22] Howard AL Robinson M Smith GJ Ambrosini GL Piek JP Oddy WH ADHD is associated with a “western” dietary pattern in adolescents J Atten Disord 2011 15 5 403 411 20631199
Not checked in the free run.
- Interpretationcitation
ADHD is correlated with abnormal BMI ranges known as obesity.
“ADHD is also correlated with pathological eating behaviors that are characterized as mental illnesses, such as, BN, AN as well as abnormal BMI ranges known as obesity.1,13,18”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [1] American Association of Pediatrics Diagnostic and Statistic Manual of Mental Disorders 5th ed Washington DC American Psychiatric Publishing 2013
Not checked in the free run.
- cites [13] Halfon N Larson K Slusser W Associations between obesity and comorbid mental health, developmental, and physical health conditions in a nationally representative sample of US children aged 10 to 17 Acad Pediatr 2013 13 1 6 13 23200634
Not checked in the free run.
- cites [18] Quinn PO Madhoo M A review of attention-deficit/hyperactivity disorder in women and girls: uncovering this hidden diagnosis Prim Care Companion CNS Disord 2014 16 3 CC.13r01596 PMC4195638 25317366
Not checked in the free run.
- Premisecitation
Many risk factors for ADHD are perinatal, for example, prematurity.
“In this regard, many risks factors for ADHD are perinatal, for example, prematurity.103”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [103] Mick E Biederman J Prince J Fischer MJ Faraone SV Impact of low birth weight on attention-deficit hyperactivity disorder J Dev Behav Pediatr 2002 23 1 16 22 11889347
Not checked in the free run.
- Interpretationcitation
ADHD and eating behavior are strongly tied together and correlated throughout age groups.
“ADHD and eating behavior are strongly tied together and correlated throughout age groups.5,8,9”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [5] Nazar BP Pinna CM Coutinho G Review of literature of attention-deficit/hyperactivity disorder with comorbid eating disorders Rev Bras Psiquiatr 2008 30 4 384 389 19142417
Not checked in the free run.
- cites [8] Quinn PO Attention-deficit/hyperactivity disorder and its comorbidities in women and girls: an evolving picture Curr Psychiatry Rep 2008 10 5 419 423 18803916
Not checked in the free run.
- cites [9] Cortese S Angriman M Maffeis C Attention-deficit/hyperactivity disorder (ADHD) and obesity: a systematic review of the literature Crit Rev Food Sci Nutr 2008 48 6 524 537 18568858
Not checked in the free run.
- Interpretationreasoning
ADHD and eating disorders may represent a logical comorbidity.
“Taken together, although ADHD is complex and multifaceted as are EDs, it appears that they may represent a logical comorbidity.”
Quote in the paperSubstantial claim - Premisecitation
COMT data involve ADHD behavioral states and eating disorders.
“This is also somewhat evident from the COMT data, which involve ADHD behavioral states and EDs.110,111”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [110] Mantione KJ Kream RM Stefano GB Catechol-O-methyltransferase: potential relationship to idiopathic hypertension Arch Med Sci 2010 6 3 291 295 22371762 PMC3282503
Not checked in the free run.
- cites [111] Mantione K Kream RM Stefano GB Variations in critical morphine biosynthesis genes and their potential to influence human health Neuro Endocrinol Lett 2010 31 1 11 18 20150871
Not checked in the free run.
- Premisecitation
The symptoms with the highest correlation included novelty seeking, impaired self-directedness, and impaired cooperativeness.
“The symptoms with the highest correlation included novelty seeking, impaired self-directedness, and impaired cooperativeness.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [10] Fernández-Aranda F Agüera Z Castro R ADHD symptomatology in eating disorders: a secondary psychopathological measure of severity? BMC Psychiatry 2013 13 1 166 173 23758944 PMC3693886
Not checked in the free run.
- Premisereasoning
The ratio of ADHD children who seek treatment is ~3:1 (girls to boys).
“This may account for the observation that the ratio of ADHD children who seek treatment is ~3:1 (girls to boys).2”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [2] Polanczyk G de Lima MS Horta BL Biederman J Rohde LA The worldwide prevalence of ADHD: a systematic review and metaregression analysis Am J Psychiatry 2007 164 6 942 948 17541055
Not checked in the free run.
- Interpretationreasoning
Both EDs and ADHD rely on a common neural substrate, namely, dopaminergic signaling.
“Interestingly, both EDs and ADHD rely on a common neural substrate, namely, dopaminergic signaling.”
Quote in the paperNot a substantial claim - Premisecitation
Wentz et al found that in a small study of individuals with EDs, there was a high prevalence of ADHD.
“Similarly, Wentz et al found that in a small study of individuals with EDs, there was a high prevalence of ADHD.102”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [102] Wentz E Lacey JH Waller G Rastam M Turk J Gillberg C Childhood onset neuropsychiatric disorders in adult eating disorder patients. A pilot study Eur Child Adolesc Psychiatry 2005 14 8 431 437 16341499
Not checked in the free run.
- Interpretationcitation
ADHD is correlated with pathological eating behaviors characterized as mental illnesses, such as bulimia nervosa and anorexia nervosa.
“ADHD is also correlated with pathological eating behaviors that are characterized as mental illnesses, such as, BN, AN as well as abnormal BMI ranges known as obesity.1,13,18”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [1] American Association of Pediatrics Diagnostic and Statistic Manual of Mental Disorders 5th ed Washington DC American Psychiatric Publishing 2013
Not checked in the free run.
- cites [13] Halfon N Larson K Slusser W Associations between obesity and comorbid mental health, developmental, and physical health conditions in a nationally representative sample of US children aged 10 to 17 Acad Pediatr 2013 13 1 6 13 23200634
Not checked in the free run.
- cites [18] Quinn PO Madhoo M A review of attention-deficit/hyperactivity disorder in women and girls: uncovering this hidden diagnosis Prim Care Companion CNS Disord 2014 16 3 CC.13r01596 PMC4195638 25317366
Not checked in the free run.
- May combine two claims. 18
- Classified as probably not a substantial claim. 9
May combine two claims.
Findingown dataIn premedicated newly diagnosed ADHD boys, patients with ADHD are more likely to skip breakfast and dinner and have more than five meals throughout the day.
“We found that patients with ADHD are more likely to skip breakfast and dinner and have more than five meals throughout the day.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [25] Ptacek R Kuzelova H Stefano GB Disruptive patterns of eating behaviors and associated lifestyles in males with ADHD Med Sci Monit 2014 20 608 613 24727744 PMC3999164
Not checked in the free run.
Probably not a substantial claim: may not pass S1 (asserted), S3 (load-bearing).
PremisecitationThe prevalence of ADHD in girls is likely higher than reported because girls better mask their symptoms during childhood.
“Compounding these observations some believe that, in reality, the prevalence of ADHD in girls is higher than reported, because of their ability to better “mask” their symptoms during childhood.21”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [21] Quinn P Wigal S Perceptions of girls and ADHD: results from a national survey MedGenMed 2004 6 2 2 15266229 PMC1395774
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationApproximately 70% of ADHD patients display at least one other comorbid disorder or specific neurological problem.
“Previous studies have reported that ~70% of ADHD patients display at least one other comorbid disorder or specific neurological problems.5–7”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [5] Nazar BP Pinna CM Coutinho G Review of literature of attention-deficit/hyperactivity disorder with comorbid eating disorders Rev Bras Psiquiatr 2008 30 4 384 389 19142417
Not checked in the free run.
- cites [6] Goetz M Schwabova J Hlavka Z Cerebellar symptoms are associated with omission errors and variability of response time in children with ADHD J Atten Disord 2014 24412970
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- cites [7] Nováková M Paclt I Ptáček R Kuželová H Hájek I Sumová A Salivary melatonin rhythm as a marker of the circadian system in healthy children and those with attention-deficit/hyperactivity disorder Chronobiol Int 2011 28 7 630 637 21859418
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May combine two claims.
PremisecitationPolyunsaturated fatty acids are involved in neuronal development and have protective effects against ADHD symptoms.
“Similar to zinc, polyunsaturated fatty acids are also involved in neuronal development and have protective effects against ADHD symptoms.33–35”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [33] Mitchell EA Aman MG Turbott SH Manku M Clinical characteristics and serum essential fatty acid levels in hyperactive children Clin Pediatr 1987 26 8 406 411 2439249
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- cites [34] Colter AL Cutler C Meckling KA Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study Nutr J 2008 7 8 19 18275609 PMC2275745
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- cites [35] Richardson AJ Montgomery P The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder Pediatrics 2005 115 5 1360 1366 15867048
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May combine two claims.
PremisecitationMales with ADHD are more likely to externalize their symptoms, and females are more likely to internalize their symptoms.
“Males with ADHD are more likely to externalize their symptoms, and females are more likely to internalize their symptoms.19,20”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [19] Gershon J A meta-analytic review of gender differences in ADHD J Atten Disord 2002 5 143 154 11911007
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- cites [20] Biederman J Faraone SV Spencer T Wilens T Mick E Lapey KA Gender differences in a sample of adults with attention deficit hyperactivity disorder Psychiatry Res 1994 53 1 13 29 7991729
Not checked in the free run.
May combine two claims.
PremisecitationBN and AN are disorders that mainly affect females.
“BN and AN are disorders that mainly affect females.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [78] Surman CB Randall ET Biederman J Association between attention-deficit/hyperactivity disorder and bulimia nervosa: analysis of 4 case-control studies J Clin Psychiatry 2006 67 3 351 354 16649819
Not checked in the free run.
May combine two claims.
PremisecitationThe link between anorexia nervosa (AN) and ADHD is controversial, although some studies suggest an association.
“Although the link between AN and ADHD is more controversial, some studies suggest an association between the two.10”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [10] Fernández-Aranda F Agüera Z Castro R ADHD symptomatology in eating disorders: a secondary psychopathological measure of severity? BMC Psychiatry 2013 13 1 166 173 23758944 PMC3693886
Not checked in the free run.
May combine two claims.
PremisecitationADHD is linked with binge eating disorder (BED) and bulimia nervosa (BN).
“The EDs mostly associated with ADHD are binge eating disorder (BED) and bulimia nervosa (BN).”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [5] Nazar BP Pinna CM Coutinho G Review of literature of attention-deficit/hyperactivity disorder with comorbid eating disorders Rev Bras Psiquiatr 2008 30 4 384 389 19142417
Not checked in the free run.
- cites [8] Quinn PO Attention-deficit/hyperactivity disorder and its comorbidities in women and girls: an evolving picture Curr Psychiatry Rep 2008 10 5 419 423 18803916
Not checked in the free run.
- cites [9] Cortese S Angriman M Maffeis C Attention-deficit/hyperactivity disorder (ADHD) and obesity: a systematic review of the literature Crit Rev Food Sci Nutr 2008 48 6 524 537 18568858
Not checked in the free run.
May combine two claims.
PremisecitationIn an 8-year follow-up, boys and girls with ADHD were at risk with symptoms of BN in mid-adolescence; the association was stronger in girls than in boys.
“It was found that boys and girls with ADHD were at risk with symptoms of BN in mid-adolescence. The association was stronger in girls than in boys.90”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [90] Mikami AY Hinshaw SP Arnold LE Bulimia nervosa symptoms in the multimodal treatment study of children with ADHD Int J Eat Disord 2010 43 3 248 259 19378318
Not checked in the free run.
May combine two claims.
InterpretationcitationADHD and BN share many neural pathways; abnormalities in the frontostriatal circuit may account for the coincidences in these two disorders.
“From a neuroimaging perspective, ADHD and BN share many neural pathways. Abnormalities in these pathways in the frontostriatal circuit may account for the coincidences in these two disorders.93”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [93] Broft A Shingleton R Kaufman J Striatal dopamine in bulimia nervosa: a pet imaging study Int J Eat Disord 2012 45 5 648 656 22331810 PMC3640453
Not checked in the free run.
May combine two claims.
PremisecitationMikami et al found that baseline peer rejection and parent-child relationship predicted eating pathology.
“Interestingly, the group found that baseline peer rejection and parent–child relationship predicted eating pathology.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [89] Mikami AY Hinshaw SP Patterson KA Lee JC Eating pathology among adolescent girls with attention-deficit/hyperactivity disorder J Abnorm Psychol 2008 117 1 225 235 18266500 PMC2930179
Not checked in the free run.
May combine two claims.
PremisecitationDocet et al found that obese patients with ADHD were more likely to have binge eating episodes, to eat snacks between meals, to eat large amounts of food, and to eat in secret.
“For example, Docet et al found that obese patients with ADHD were more likely to have binge eating episodes, to eat snacks between meals, to eat large amounts of food, and to eat in secret.59”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [59] Docet MF Larranaga A Perez Mendez LF Garcia-Mayor RV Attention deficit hyperactivity disorder increases the risk of having abnormal eating behaviours in obese adults Eat Weight Disord 2012 17 2 e132 e136 23010783
Not checked in the free run.
May combine two claims.
PremisecitationSteadman and Knouse found that although impulsivity in ADHD correlates with BED symptoms, impulsivity alone does not mediate the association.
“Steadman and Knouse found that although impulsivity in ADHD correlates with BED symptoms, impulsivity alone does not mediate the association.71”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [71] Steadman KM Knouse LE Is the relationship between ADHD symptoms and binge eating mediated by impulsivity? J Atten Disord 2014 24804686
Not checked in the free run.
May combine two claims.
PremisecitationIn adolescents with BN, there is a high prevalence of suicide attempts, alcohol consumption, and illegal drug use.
“In adolescents with BN, there is a high prevalence of suicide attempts, alcohol consumption, and illegal drug use.91”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [91] Fischer S le Grange D Comorbidity and high-risk behaviors in treatment-seeking adolescents with bulimia nervosa Int J Eat Disord 2007 40 8 751 753 17683094
Not checked in the free run.
Classified as probably not a substantial claim. May combine two claims.
InterpretationreasoningThe link between obesity and ADHD lies in the common symptom of impulsivity; ADHD predisposes an individual to BED due to common impulsivity symptoms.
“Various investigators propose that the link between obesity and ADHD lies in the common symptom of impulsivity. Here, it is surmised that ADHD predisposes an individual to BED, again due to common impulsivity symptoms.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationCo-occurrence of ADHD and obesity has been attributed to common immune and inflammatory processes, common fetal programming mechanisms, and common perinatal risk factors.
“Co-occurrence of ADHD and obesity has also been attributed to common immune and inflammatory processes, common fetal programming mechanisms, and common perinatal risk factors.12,50”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [12] Nigg JT Attention-deficit/hyperactivity disorder and adverse health outcomes Clin Psychol Rev 2013 33 2 215 228 23298633 PMC4322430
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- cites [50] Verlaet AA Noriega DB Hermans N Savelkoul HF Nutrition, immunological mechanisms and dietary immunomodulation in ADHD Eur Child Adolesc Psychiatry 2014 23 7 519 529 24493267
Not checked in the free run.
Classified as probably not a substantial claim.
PremisecitationCortese et al argue that the impulsivity of ADHD patients causes executive dysfunction, which prevents the patient from executing the goal of controlling eating behavior or losing weight.
“Cortese et al argue that the impulsivity of ADHD patients causes executive dysfunction, which prevents the patient from executing the goal of controlling eating behavior or losing weight.14”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [14] Cortese S Comencini E Vincenzi B Speranza M Angriman M Attention-deficit/hyperactivity disorder and impairment in executive functions: a barrier to weight loss in individuals with obesity? BMC Psychiatry 2013 13 286 292 24200119 PMC4226281
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May combine two claims.
PremisecitationCatecholamines, e.g., dopamine, are heavily involved in both motor regulation and emotions, working together to provide the motivation for motor activity, using few chemical messengers in both invertebrates and vertebrates, especially humans.
“It is important to note that catecholamines, eg, dopamine, are heavily involved in both motor regulation and emotions, working together to provide the motivation for motor activity, using few chemical messengers in both invertebrates and vertebrates, especially humans.108”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [108] Stefano GB Kream RM Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution (review) Int J Mol Med 2007 20 6 837 841 17982691
Not checked in the free run.
Probably not a substantial claim: may not pass S4 (based).
Interpretationnone givenIt is a challenge to diagnose ADHD early, regardless of the population.
“This is compounded by the problem that it is a challenge to diagnose ADHD early, regardless of the population.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Premisenone givenMost of the literature on BN and AN suggest that depression may mediate bulimic and anorexic symptoms.
“Most of the literature on BN and AN suggest that depression may mediate bulimic and anorexic symptoms.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S4 (based).
InterpretationreasoningEarly diagnostic indicators for ADHD may be at hand in the form of novel discoveries in gene expression patterns.
“Hence, early diagnostic indicators for ADHD may be at hand in the form of novel discoveries in gene expression patterns.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationThirty-two female patients diagnosed with ED had no correlation between severity of ADHD and severity of ED symptoms; however, there was an association between impulsivity and avoidance of fattening food.
“Thirty-two female patients diagnosed with ED had no correlation between severity of ADHD and severity of ED symptoms; however, there was an association between impulsivity and avoidance of fattening food.101”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [101] Stulz N Hepp U Gachter C Martin-Soelch C Spindler A Milos G The severity of ADHD and eating disorder symptoms: a correlational study BMC Psychiatry 2013 13 1 44 50 23375103 PMC3566966
Not checked in the free run.
Probably not a substantial claim: may not pass S4 (based). May combine two claims.
Premisenone givenDopaminergic signaling is critical for motor activity and emotion, the latter enabling the former into a combined motivated movement like eating.
“Dopaminergic signaling is critical for motor activity and emotion, the latter enabling the former into a combined motivated movement like eating.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Interpretationnone givenAnorexic and bulimic girls are already obsessed and guilty due to their eating behaviors.
“Anorexic and bulimic girls are already obsessed and guilty due to their eating behaviors.”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningADHD comorbidities involve eating disorders, which may result from altered cognitive and emotional neural substrates.
“Thus, it is not a surprise that ADHD comorbidities involve EDs, which may result from altered cognitive and emotional neural substrates.5,11”
- Also stated in: § Conclusion · hedged
“Furthermore, it is not a surprise that ADHD comorbidities involve EDs, which may result from altered cognitive and emotional neural substrates given their dependencies.109”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [5] Nazar BP Pinna CM Coutinho G Review of literature of attention-deficit/hyperactivity disorder with comorbid eating disorders Rev Bras Psiquiatr 2008 30 4 384 389 19142417
Not checked in the free run.
- cites [11] Biederman J Newcorn J Sprich S Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders Am J Psychiatry 1991 148 5 564 577 2018156
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- cites [109] Esch T Kim JW Stefano GB Neurobiological implications of eating healthy Neuro Endocrinol Lett 2006 27 1–2 21 33 16648819
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- Also stated in: § Conclusion · hedged
The paper relies on this without support.
Zinc deficiency, especially in the Middle East, is associated with ADHD.
“Zinc deficiency, especially in the Middle East, has also been associated with ADHD.”
The paper relies on this without support.
ADHD consists of dopamine and norepinephrine circuits in the brain, which are involved in reward processing.
“It is thought that ADHD consists of dopamine and norepinephrine circuits in the brain, which are involved in reward processing.”
The paper relies on this without support.
No study has longitudinally examined the complex interaction that may arise due to cyclical shifting between different subtypes of eating disorders and ADHD.
“No study to our knowledge has longitudinally examined the complex interaction that may arise due to cyclical shifting between different subtypes of EDs and ADHD.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Both ADHD and EDs rely on dopaminergic signaling which makes their cooccurrence a logical comorbidity.
“Both conditions rely on a dopaminergic signaling which makes their cooccurrence a logical comorbidity [182].”
From Separating the Signal from the Noise: How Psychiatric Diagnoses Can Help Discern Food Addiction from Dietary Restraint (2020) · cites this paper as [182]
The ADHD diagnosis indicates the potential for higher levels of impulsivity and the stimulant medications may have appetite dysregulating effects.
“However, the ADHD diagnosis indicates the potential for higher levels of impulsivity and the stimulant medications may have appetite dysregulating effects [182,189,197].”
From Separating the Signal from the Noise: How Psychiatric Diagnoses Can Help Discern Food Addiction from Dietary Restraint (2020) · cites this paper as [182]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Treatment-seeking sex ratio runs opposite to the stated underdiagnosis pattern
MinorThe paper says girls are more likely to mask ADHD symptoms and be underdiagnosed, yet says this accounts for girls outnumbering boys three to one among children seeking treatment. The proposed explanation points in the opposite direction from the reported treatment-seeking ratio.
“This may account for the observation that the ratio of ADHD children who seek treatment is ~3:1 (girls to boys).2”
“There is also a higher level of clinical suspicion of the disorder in boys, which may contribute to underdiagnosis in girls.18,21”
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Self-citationAssociation Between Pubertal Onset and Symptoms of ADHD in Female University Students
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Neurobiological implications of eating healthy.
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Self-citationADHD and growth: questions still unanswered.
Ptáček, R., Kuželová, H., Stefano, G. B., Raboch, J., Kream, R. M., & Goetz, M. (2014) · PubMed · Cited by 15 · see citing works
Self-citationGenetics in Psychiatry - up-to-date review 2011.
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Self-citationConvergent dysregulation of frontal cortical cognitive and reward systems in eating disorders
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Catechol-O-methyltransferase: potential relationship to idiopathic hypertension
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Self-citationAberrant Brain Activation During a Response Inhibition Task in Adolescent Eating Disorder Subtypes
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ADHD-like behavior in a patient with hypothalamic hamartoma
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Obesity in Men With Childhood ADHD: A 33-Year Controlled, Prospective, Follow-up Study
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Links between psychopathological symptoms and disordered eating behaviors in overweight/obese youths
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Dansky (1997) · doi:10.1002/(sici)1098-108x(199704)21:3
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- [111]Mantione K Kream RM Stefano GB Variations in critical morphine biosynthesis genes and their potential to influence human health Neuro Endocrinol Lett 2010 31 1 11 18 20150871
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ADHD and lifestyle habits in Czech adults, a national sample
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Prof. PhDr. et PhDr. Radek Ptáček, PhD. (26. prosince 1975 – září 2024)
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- Authors
- Ptacek, R., Stefano, G., Weissenberger, S., Akotia, D., Raboch, J., Papezova, H., Stepankova, T., Goetz, M., & Domkarova, L.
- Affiliations
- Charles University (CZ)
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2016-03
- Volume
- 12
- Pages
- 571
- ISSN
- 1176-6328 (ISSN-L)
- 1178-2021
- PMC
- PMC4780667
- OpenAlex
- W2292652034
- Cited by
- 60
- References
- 117
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 3 · 2023: 8 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 4
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- attention deficit hyperactivity disorder, disordered eating, eating disorders, bulimia nervosa, anorexia nervosa, binge eating, comorbidities, impulsivity, sex differences, dopaminergic signaling, nutritional deficiency, inattention, hyperactivity/impulsivity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-09.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-09.
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