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Cited by 3Schizophrenia research and treatmentBipolar Disorder and TreatmentElectroconvulsive Therapy Studies

Adolescent female with withdrawal psychosis following abrupt termination of ziprasidone

Jacob, Maryann K., Ash, Peter, Craighead, W. Edward·2012·European Child & Adolescent Psychiatry
DOI 10.1007/s00787-012-0239-z
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Abstract

It is widely known that discontinuation reactions can occur after neuroleptics are stopped resulting in dyskinesia through its effect on the nigrostriatal pathway. Less discussed is the concept of "supersensitivity psychosis" which has been described as a rapid onset of psychosis after a neuroleptic medication has been withdrawn. Although the concept of supersensitivity psychosis has been described with the discontinuation of some neuroleptics, it has not been described with ziprasidone. Furthermore, the following case report is the first time that this phenomenon has been described in an adolescent patient who has discontinued ziprasidone. Reasons for supersensitivity psychosis are explored in addition to suggestions about precautions about prescribing neuroleptics in young people.

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Crossref · 10.1007/s00787-012-0239-z

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18 of 18 references verified0 citation errors · 0 not checkable

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  • People with no history of psychosis who develop psychotic symptoms on abrupt cessation of dopamine antagonists used in a non-psychiatric context provide support for the hypothesis that dopaminergic hypersensitivity contributes to early relapse into psychosis after antipsychotic cessation.

    “People with no history of psychosis who develop psychotic symptoms on abrupt cessation of dopamine antagonists used in a non-psychiatric context (eg, breast milk stimulation or treatment of nausea) provide support for this hypothesis (table 1).”

    From A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse (2021) · cites this paper as [45]

  • Eight case reports describe psychotic symptoms arising in 13 patients with no history of psychosis after the abrupt withdrawal of dopamine antagonists.

    “Eight case reports describe psychotic symptoms arising in 13 patients with no history of psychosis after the abrupt withdrawal of dopamine antagonists (table 1).”

    From A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse (2021) · cites this paper as [45]

  • This may account for the relative ease of reductions at higher doses of antipsychotic and the difficulties in tapering at lower doses.

    “this may account for the relative ease of reductions at higher doses of antipsychotic and the difficulties in tapering at lower doses.45,51,74”

    From A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse (2021) · cites this paper as [45]

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Related

Authors
Jacob, M. K., Ash, P., & Craighead, W. E.
Affiliations
  • Emory University (US)
  • Emory University Hospital (US)
Corresponding author
Jacob, Maryann K.
ORCID
Craighead, W. Edward
Venue
European Child & Adolescent Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2012-01-17
Volume
21
Issue
3
Pages
165-168
ISSN
  • 1018-8827 (ISSN-L)
  • 1435-165X
DOI
10.1007/s00787-012-0239-z
OpenAlex
W2038292438
Cited by
3
References
19
Citations by year
2021: 1 · 2014: 1 · 2013: 1
FWCI
0.46
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
ziprasidone, adolescent girls, atypical antipsychotics
MeSH terms
Depressive Disorder, Female, Hallucinations, Humans, Piperazines, Psychoses, Substance-Induced, Substance Withdrawal Syndrome, Thiazoles

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