Antidepressant-Induced Sexual Dysfunction
Abstract
OBJECTIVE: To review the evidence regarding antidepressant-induced sexual dysfunction and address implications for treatment strategy and health plan coverage policies for antidepressant medications. DATA SOURCES: Primary articles were identified by a MEDLINE and HealthSTAR search to identify English-language studies published between January 1986 and July 2000. Search terms included sexual dysfunction or sexual function and antidepressants, fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, venlafaxine, nefazodone, bupropion, and mirtazapine. A cross-check of references cited in 10 published reviews yielded additional in-scope articles. STUDY SELECTION AND DATA EXTRACTION: Approximately 200 articles were identified, including 8 randomized controlled trials and numerous open-label studies, case series, and case reports. Of the randomized controlled trials, only 5 were designed to evaluate the incidence of sexual dysfunction associated with antidepressant treatment. Three additional randomized controlled trials included a structured assessment of sexual dysfunction within an efficacy trial. Data extraction excluded case reports, letters, and other limited study designs. A panel survey augmented published reports. DATA SYNTHESIS: Sexual dysfunction is a relatively common adverse effect of many of the antidepressants in common use today. Rates of sexual dysfunction observed in clinical practice may be higher than those reported in the product information for several agents. Selective serotonin-reuptake inhibitors (SSRIs) appear to be the class of antidepressants most likely to cause sexual dysfunction. Published studies suggest that between 30% and 60% of SSRI-treated patients may experience some form of treatment-induced sexual dysfunction. Bupropion and nefazodone appear to be much less likely to cause sexual dysfunction (≤10% of patients). Mirtazapine also appears to be associated with a low rate of sexual adverse effects. Panel results largely reflect the consensus of the literature. CONCLUSIONS: Sexual dysfunction is a common adverse effect of antidepressant treatment. Physicians should monitor their patients for antidepressant-induced sexual adverse effects, as these may affect compliance with therapy and ultimate treatment success. In addition to the consequences for patient health and well-being, managed-care organizations should be concerned with sexually related adverse effects of antidepressants, insofar as additional healthcare resources may be required to treat depressed patients in whom these adverse effects arise.
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Published studies suggest that between 30% and 60% of SSRI-treated patients may experience some form of treatment-induced sexual dysfunction.
“Published studies suggest that between 30% and 60% of SSRI-treated patients may experience some form of treatment-induced sexual dysfunction (553,554).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [554]
Some side-effects such as increased agitation and sexual dysfunction can be especially distressing for people with social anxiety disorder.
“Some side-effects such as increased agitation18 and sexual dysfunction20 can be especially distressing for people with social anxiety disorder”
From Psychological and pharmacological interventions for social anxiety disorder in adults: a systematic review and network meta-analysis (2014) · cites this paper as [20]
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“Dose-dependent inhibiting effects of the SSRI paroxetine Paroxetine (and most other SSRIs (Gregorian et al. , 2002, Montejo-Gonzalez et al., 1997, Waldinger et al., 1998b)) have strong inhibitory effects on sexual behavior of humans, both in healthy individuals (Waldinger et al. , 2007) and in…”
- Authors
- Gregorian, R. S., Golden, K. A., Bahce, A., Goodman, C., Kwong, W. J., & Khan, Z. M.
- Affiliations
- Lewin Group (United States) (US)
- Icahn School of Medicine at Mount Sinai (US)
- GlaxoSmithKline (United States) (US)
- GlaxoSmithKline (United Kingdom) (GB)
- Corresponding author
- Goodman, Clifford
- ORCID
- Goodman, Clifford
- Venue
- Annals of Pharmacotherapy
- Publisher
- SAGE Publications
- Published
- 2002-10
- Volume
- 36
- Issue
- 10
- Pages
- 1577-1589
- ISSN
- 0012-6578 (ISSN-L)
- 1060-0280
- 1542-6270
- OpenAlex
- W2171466849
- Cited by
- 320
- References
- 71
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 11 · 2023: 9 · 2022: 18 · 2021: 4 · 2020: 9 · 2019: 10 · 2018: 15 · 2017: 6 · 2016: 12 · 2015: 13 · 2014: 17 · 2013: 22 · 2012: 22
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- antidepressant-induced sexual dysfunction, selective serotonin reuptake inhibitors, adverse drug reactions, fluoxetine, sertraline, paroxetine, bupropion, nefazodone, mirtazapine, depression treatment, medication adherence
- MeSH terms
- Antidepressive Agents, Clinical Trials as Topic, Depressive Disorder, Female, Humans, Libido, Male, Selective Serotonin Reuptake Inhibitors, Sexual Dysfunctions, Psychological
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