Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · see citing works

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535 · see citing works

Why Do Cancers Have High Aerobic Glycolysis?

Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784 · see citing works

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 1× · see citing works

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981 · see citing works

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905 · see citing works

On Respiratory Impairment in Cancer Cells

Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472 · see citing works

Regulation of angiogenesis by hypoxia: role of the HIF system

Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520 · see citing works

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267 · see citing works

Oxygen sensing by HIF hydroxylases

Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068 · see citing works

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

Semenza, G., Roth, P. H., Fang, H. M., & Wang, G. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31580-6 · Cited by 1,892 · see citing works

c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

Dang, C. V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.1 · Cited by 1,707 · see citing works

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Fantin, V. R., St-Pierre, J., & Leder, P. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.023 · Cited by 1,635 · see citing works

HIF‐1α is required for solid tumor formation and embryonic vascularization

Ryan, H. E., Lo, J., & Johnson, R. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3005 · Cited by 1,579 · see citing works

A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

Bonnet, S., Archer, S. L., Allalunis‐Turner, J., Haromy, A., Beaulieu, C., Thompson, R. B., Lee, C. T., Lopaschuk, G. D., Puttagunta, L., Bonnet, S. B., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.020 · Cited by 1,530 · see citing works

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

Wang, G. L., & Semenza, G. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4304 · Cited by 1,468 · see citing works

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386 · see citing works

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

Tian, H., McKnight, S. L., & Russell, D. W. (1997) · Genes & Development · doi:10.1101/gad.11.1.72 · Cited by 1,351 · see citing works

HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., & Pouysségur, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg392 · Cited by 1,348 · see citing works

Cancer's Molecular Sweet Tooth and the Warburg Effect

Kim, J., & Dang, C. V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1501 · Cited by 1,217 · see citing works

c-MYC: more than just a matter of life and death

Pelengaris, S., Khan, M., & Evan, G. I. (2002) · Nature reviews. Cancer · doi:10.1038/nrc904 · Cited by 1,172 · see citing works

MYC oncogenes and human neoplastic disease

Nesbit, C. E., Tersak, J. M., & Prochownik, E. V. (1999) · Oncogene · doi:10.1038/sj.onc.1202746 · Cited by 1,163 · see citing works

Transcriptional regulation and transformation by Myc proteins

Adhikary, S., & Eilers, M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1703 · Cited by 1,122 · see citing works

c-Myc transactivation of <i>LDH-A</i> : Implications for tumor metabolism and growth

Shim, H., Dolde, C., Lewis, B. C., Wu, C.-S., Dang, G., Jungmann, R. A., Dalla-Favera, R., & Dang, C. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6658 · Cited by 1,092 · see citing works

HIF-1 and tumor progression: pathophysiology and therapeutics

Semenza, G. L. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02317-1 · Cited by 1,060 · see citing works

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W., & Ratcliffe, P. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.18.5197 · Cited by 1,014 · see citing works

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

Gottlob, K., Majewski, N., Kennedy, S., Kandel, E., Robey, R. B., & Hay, N. (2001) · Genes &amp; Development · doi:10.1101/gad.889901 · Cited by 961 · see citing works

HIF-1, O2, and the 3 PHDs

Semenza, G. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00518-9 · Cited by 935 · see citing works

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885 · see citing works

Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc

Osthus, R. C., Shim, H., Kim, S., Li, Q., Reddy, R., Mukherjee, M., Xu, Y., Wonsey, D. R., Lee, L. A., & Dang, C. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000023200 · Cited by 876 · see citing works

HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growthPreprint

Covello, K. L., Kehler, J., Yu, H., Gordan, J. D., Arsham, A. M., Hu, C., Labosky, P. A., Simon, M. C., & Keith, B. (2006) · Genes & Development · doi:10.1101/gad.1399906 · Cited by 818 · see citing works

HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity

Gordan, J. D., Bertout, J. A., Hu, C.-J., Diehl, J. A., & Simon, M. C. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.006 · Cited by 781 · see citing works

Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

Min, J.-H., Yang, H., Ivan, M., Gertler, F., Kaelin, W. G., & Pavletich, N. P. (2002) · Science · doi:10.1126/science.1073440 · Cited by 765 · see citing works

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

Kondo, K., Klco, J., Nakamura, E., Lechpammer, M., & Kaelin, W. G. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00043-0 · Cited by 761 · see citing works

Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

Hon, W.-C., Wilson, M. I., Harlos, K., Claridge, T. D. W., Schofield, C. J., Pugh, C. W., Maxwell, P. H., Ratcliffe, P. J., Stuart, D. I., & Jones, E. Y. (2002) · Nature · doi:10.1038/nature00767 · Cited by 751 · see citing works

Mitochondrial Binding of Hexokinase II Inhibits Bax-induced Cytochrome c Release and Apoptosis

Pastorino, J. G., Shulga, N., & Hoek, J. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109950200 · Cited by 714 · see citing works

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

Danial, N. N., Gramm, C. F., Scorrano, L., Zhang, C.-Y., Krauss, S., Ranger, A. M., Robert Datta, S., Greenberg, M. E., Licklider, L. J., Lowell, B. B., et al. (2003) · Nature · doi:10.1038/nature01825 · Cited by 705 · see citing works

HIF-1α induces cell cycle arrest by functionally counteracting Myc

Koshiji, M., Kageyama, Y., Pete, E. A., Horikawa, I., Barrett, J. C., & Huang, L. E. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600196 · Cited by 652 · see citing works

HIF-1 as a target for drug development

Giaccia, A., Siim, B. G., & Johnson, R. S. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1199 · Cited by 631 · see citing works

Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis

Li, F., Wang, Y., Zeller, K. I., Potter, J. J., Wonsey, D. R., O’Donnell, K. A., Kim, J., Yustein, J. T., Lee, L. A., & Dang, C. V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6225-6234.2005 · Cited by 615 · see citing works

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1

Kelly, B. D., Hackett, S. F., Hirota, K., Oshima, Y., Cai, Z., Berg-Dixon, S., Rowan, A., Yan, Z., Campochiaro, P. A., & Semenza, G. L. (2003) · Circulation Research · doi:10.1161/01.res.0000102937.50486.1b · Cited by 611 · see citing works

Hypoxia-induced energy stress regulates mRNA translation and cell growth

Liu, L., Cash, T. P., Jones, R. G., Keith, B., Thompson, C. B., & Simon, M. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.010 · Cited by 607 · see citing works

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

Rathmell, J. C., Fox, C. J., Plas, D. R., Hammerman, P. S., Cinalli, R. M., & Thompson, C. B. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7315-7328.2003 · Cited by 572 · see citing works

Glucose metabolism and cancer

Shaw, R. J. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.10.005 · Cited by 543 · see citing works

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

Li, Z., Calcar, S. V., Qu, C., Cavenee, W. K., Zhang, M. Q., & Ren, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332764100 · Cited by 524 · see citing works

HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo

Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.004 · Cited by 523 · see citing works

Hypoxia-Inducible Factor 1α Is Essential for Cell Cycle Arrest during Hypoxia

Goda, N., Ryan, H. E., Khadivi, B., McNulty, W., Rickert, R. C., & Johnson, R. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.359-369.2003 · Cited by 520 · see citing works

Global mapping of c-Myc binding sites and target gene networks in human B cells

Zeller, K. I., Zhao, X., Lee, C. W. H., Chiu, K. P., Yao, F., Yustein, J. T., Ooi, H., Orlov, Y. L., Shahab, A., Yong, H. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604129103 · Cited by 518 · see citing works

c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progressionPreprint

Baudino, T. A., McKay, C., Pendeville, H., Nilsson, J. A., Maclean, K. H., White, E. L., Davis, A. C., Ihle, J. N., & Cleveland, J. L. (2002) · Genes & Development · doi:10.1101/gad.1024602 · Cited by 516 · see citing works

Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation

Holness, M. J., & Sugden, M. C. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311143 · Cited by 479 · see citing works

Hypoxia-inducible factors: central regulators of the tumor phenotype

Gordan, J. D., & Simon, M. C. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.006 · Cited by 450 · see citing works

Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.

Mateyak, M. K., Obaya, Á. J., Adachi, S., & Sedivy, J. M. (1997) · PubMed · Cited by 445 · see citing works

The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma

Maranchie, J. K., Vasselli, J. R., Riss, J., Bonifacino, J. S., Linehan, W. M., & Klausner, R. D. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00044-2 · Cited by 433 · see citing works

Hypoxia-Inducible Factor-1-Dependent Repression of <i>E-cadherin</i> in von Hippel-Lindau Tumor Suppressor–Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B

Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., Baek, J. H., & Semenza, G. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3719 · Cited by 415 · see citing works

Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression

Gardner, L. B., Li, Q., Park, M. S., Flanagan, W. M., Semenza, G. L., & Dang, C. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010189200 · Cited by 390 · see citing works

The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

Giaccia, A. J., Simon, M. C., & Johnson, R. (2004) · Genes &amp; Development · doi:10.1101/gad.1243304 · Cited by 380 · see citing works

Glucose Catabolism in Cancer Cells

Mathupala, S. P., Rempel, A., & Pedersen, P. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108181200 · Cited by 374 · see citing works

Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays

Kim, J.-W., Zeller, K. I., Wang, Y., Jegga, A. G., Aronow, B. J., O'Donnell, K. A., & Dang, C. V. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5923-5936.2004 · Cited by 371 · see citing works

HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression

Koshiji, M., To, K. K.-W., Hammer, S., Kumamoto, K., Harris, A. L., Modrich, P., & Huang, L. E. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.015 · Cited by 346 · see citing works

Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor—Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B

Gordon, M. S. (2007) · Yearbook of Oncology · doi:10.1016/s1040-1741(08)70352-x · Cited by 346 · see citing works

Deconstructing Myc: Figure 1.Preprint

Eisenman, R. N. (2001) · Genes & Development · doi:10.1101/gad928101 · Cited by 319 · see citing works

The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation

Cole, M. D., & McMahon, S. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202748 · Cited by 314 · see citing works

Hypoxia signalling controls metabolic demand

Brahimi-Horn, M. C., Chiche, J., & Pouysségur, J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.003 · Cited by 298 · see citing works

Akt Inhibits Apoptosis Downstream of BID Cleavage via a Glucose-Dependent Mechanism Involving Mitochondrial Hexokinases

Majewski, N., Nogueira, V., Robey, R. B., & Hay, N. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.730-740.2004 · Cited by 289 · see citing works

Control of cell growth by c-Myc in the absence of cell division

Schuhmacher, M., Staege, M. S., Pajic, A., Polack, A., Weidle, U. H., Bornkamm, G. W., Eick, D., & Kohlhuber, F. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80507-7 · Cited by 288 · see citing works

Myc target genes

Grandori, C. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01025-6 · Cited by 285 · see citing works

Hexokinase II: The Integration of Energy Metabolism and Control of Apoptosis

Pastorino, J. G., & Hoek, J. B. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033457269 · Cited by 257 · see citing works

Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo

Kim, W. Y., Safran, M., Buckley, M. R., Ebert, B. L., Glickman, J., Bosenberg, M., Regan, M., & Kaelin, W. G. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601300 · Cited by 235 · see citing works

Cell cycle activation by c-myc in a Burkitt lymphoma model cell line

Pajic, A., Spitkovsky, D., Christoph, B., Kempkes, B., Schuhmacher, M., Staege, M. S., Brielmeier, M., Ellwart, J. W., Kohlhuber, F., Bornkamm, G. W., et al. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20000915)87:6 · Cited by 204 · see citing works

The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1βPreprint

Shchors, K., Shchors, E., Rostker, F., Lawlor, E. R., Swigart, L. B., & Evan, G. I. (2006) · Genes & Development · doi:10.1101/gad.1455706 · Cited by 200 · see citing works

Cancer's sweet tooth

Bui, T., & Thompson, C. B. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.05.012 · Cited by 195 · see citing works

Cancer therapeutics: Targeting the dark side of Myc

Ponzielli, R., Katz, S., Baršytė-Lovejoy, D., & Penn, L. Z. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.08.017 · Cited by 166 · see citing works

Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location.

Parry, D. M., & Pedersen, P. L. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44361-4 · Cited by 142 · see citing works

Mxi1 is induced by hypoxia in a HIF-1–dependent manner and protects cells from c-Myc-induced apoptosis

Corn, P. G., Ricci, M., Scata, K. A., Arsham, A. M., Simon, M. C., Dicker, D. T., & El‐Deiry, W. S. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.11.2299 · Cited by 128 · see citing works

Oxygen, genes, and development: An analysis of the role of hypoxic gene regulation during murine vascular development

Maltepe, E., & Simon, M. C. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050231 · Cited by 126 · see citing works

Targeted Replacement of Hypoxia-Inducible Factor-1α by a Hypoxia-Inducible Factor-2α Knock-in Allele Promotes Tumor Growth

Covello, K. L., Simon, M. C., & Keith, B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3246 · Cited by 121 · see citing works

c-Myc Interacts with Hypoxia to Induce Angiogenesis In vivo by a Vascular Endothelial Growth Factor-Dependent Mechanism

Knies, U. E., Fox, S. B., Poulsom, R., Evan, G. I., & Harris, A. L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3176 · Cited by 121 · see citing works

Hexokinase Binding to Mitochondria: A Basis for Proliferative Energy Metabolism

Golshani-Hebroni, S. G., & Bessman, S. P. (1997) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1022442629543 · Cited by 120 · see citing works

Traps to catch unwary oncogenes

Hueber, A., & Evan, G. I. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01520-0 · Cited by 114 · see citing works

Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc.

Mazure, N. M., Chauvet, C., Bois-Joyeux, B., Bernard, M.-A., Nacer-Chérif, H., & Danan, J.-L. (2002) · PubMed · Cited by 90 · see citing works

Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis

Ashrafian, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68228-7 · Cited by 79 · see citing works

Dynamic Balancing of the Dual Nature of HIF-1alpha for Cell Survival

Koshiji, M., & Huang, L. E. (2004) · Cell Cycle · doi:10.4161/cc.3.7.989 · Cited by 55 · see citing works

Genomic Binding and Transcriptional Regulation by the Drosophila Myc and Mnt Transcription FactorsPreprint

Orian, A., Grewal, S., Knoepfler, P. S., Edgar, B. A., Parkhurst, S. M., & Eisenman, R. N. (2005) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2005.70.019 · Cited by 43 · see citing works

Genetic Instability: The Dark Side of THE Hypoxic Response

To, K. K. W., Koshiji, M., Hammer, S., & Huang, E. L. (2005) · Cell Cycle · doi:10.4161/cc.4.7.1839 · Cited by 31 · see citing works

A New Look at Rho GTPases in the Cell Cycle: Their Role in Kinetochore-Microtubule Attachment

Narumiya, S., Oceguera-Yañez, F., & Yasuda, S. (2004) · Cell Cycle · doi:10.4161/cc.3.7.990 · Cited by 26 · see citing works

Regulation of cancer cell metabolism

Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744 · see citing works

Otto Warburg's contributions to current concepts of cancer metabolism

Koppenol, W. H., Bounds, P. L., & Dang, C. V. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3038 · Cited by 3,427 · see citing works

MYC on the Path to Cancer

Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390 · see citing works

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · see citing works

Tumor cell metabolism: cancer's Achilles' heel

Kroemer, G., & Pouyssegur, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.005 · Cited by 2,337 · see citing works

Hypoxia, HIF1 and glucose metabolism in the solid tumour

Denko, N. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2468 · Cited by 1,707 · see citing works

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693 · see citing works

Cancer metabolism: a therapeutic perspective

Martinez-Outschoorn, U. E., Peiris-Pagés, M., Pestell, R. G., Sotgia, F., & Lisanti, M. P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.60 · Cited by 1,505 · see citing works

HIF-1: upstream and downstream of cancer metabolism

Semenza, G. L. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.10.009 · Cited by 1,381 · see citing works

Targeting cancer metabolism in the era of precision oncology

Stine, Z. E., Schug, Z. T., Salvino, J. M., & Dang, C. V. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00339-6 · Cited by 1,189 · see citing works

ERK signalling: A master regulator of cell behaviour, life and fate

Lavoie, H., Gagnon, J., & Therrien, M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0255-7 · Cited by 1,185 · see citing works

Targeting lactate metabolism for cancer therapeutics

Doherty, J. R., & Cleveland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69741 · Cited by 1,173 · see citing works

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Hay, N. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.77 · Cited by 1,124 · see citing works

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

Le, A., Lane, A. N., Hamaker, M., Bose, S., Gouw, A., Barbi, J., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Zhang, H., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.009 · Cited by 1,095 · see citing works

Links between metabolism and cancerPreprint

Dang, C. V. (2012) · Genes & Development · doi:10.1101/gad.189365.112 · Cited by 991 · see citing works

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

Dang, C. V., Le, A., & Gao, P. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0889 · Cited by 934 · see citing works

c-Myc and Cancer Metabolism

Miller, D. M., Thomas, S. D., Islam, A., Muench, D. E., & Sedoris, K. C. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0977 · Cited by 844 · see citing works

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 772 · see citing works

Hypoxia and cancer

Brahimi-Horn, M. C., Chiche, J., & Pouysségur, J. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0281-3 · Cited by 765 · see citing works

IRF4 addiction in multiple myeloma

Shaffer, A. L., Emre, N. C. T., Lamy, L., Ngo, V. N., Wright, G., Xiao, W., Powell, J., Dave, S., Yu, X., Zhao, H., et al. (2008) · Nature · doi:10.1038/nature07064 · Cited by 730 · see citing works

Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

Feng, J., Li, J., Wu, L., Yu, Q., Ji, J., Wu, J., Dai, W., & Guo, C. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01629-4 · Cited by 698 · see citing works

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

Zheng, X., Boyer, L., Jin, M., Mertens, J., Kim, Y., Ma, L., Ma, L., Hamm, M., Gage, F. H., & Hunter, T. (2016) · eLife · doi:10.7554/elife.13374 · Cited by 671 · see citing works

Causes and Consequences of Increased Glucose Metabolism of Cancers

Gillies, R. J., Robey, I., & Gatenby, R. A. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.047258 · Cited by 617 · see citing works

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

Abdel-Wahab, A. F., Mahmoud, W., & Al-Harizy, R. M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104511 · Cited by 589 · see citing works

Metabolic reprogramming in clear cell renal cell carcinoma

Wettersten, H. I., Aboud, O. A., Lara, P. N., & Weiss, R. H. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.59 · Cited by 573 · see citing works

RAF-MEK-ERK pathway in cancer evolution and treatment

Ullah, R., Yin, Q., Snell, A. H., & Wan, L. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.010 · Cited by 553 · see citing works

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

Mole, D. R., Blancher, C., Copley, R. R., Pollard, P. J., Gleadle, J. M., Ragoussis, J., & Ratcliffe, P. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901790200 · Cited by 552 · see citing works

Regulation and function of the mammalian tricarboxylic acid cycle

Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535 · see citing works

Altered metabolism in cancer: insights into energy pathways and therapeutic targets

Tufail, M., Jiang, C.-H., & Li, N. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02119-3 · Cited by 534 · see citing works

MYC: Connecting selective transcriptional control to global RNA production

Kress, T. R., Sabò, A., & Amati, B. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3984 · Cited by 521 · see citing works

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

Roberts, D. J., & Miyamoto, S. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.173 · Cited by 507 · see citing works

HIF-1 and HIF-2 Transcription Factors - Similar but Not Identical

Loboda, A., Jozkowicz, A., & Dulak, J. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0067-2 · Cited by 477 · see citing works

Roles of p53, MYC and HIF-1 in regulating glycolysis–the seventh hallmark of cancer

Yeung, S. J., Pan, J., & Lee, M.-H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8224-x · Cited by 514 · see citing works

Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis

Kim, Y.-N., Koo, K. H., Sung, J. Y., Yun, U.-J., & Kim, H. (2012) · International Journal of Cell Biology · doi:10.1155/2012/306879 · Cited by 461 · see citing works

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

Pate, K. T., Stringari, C., Sprowl‐Tanio, S., Wang, K., TeSlaa, T., Hoverter, N. P., McQuade, M. M., Garner, C., Digman, M. A., Teitell, M. A., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201488598 · Cited by 459 · see citing works

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Ye, J., Fan, J., Venneti, S., Wan, Y.-W., Pawel, B. R., Zhang, J., Finley, L. W. S., Lu, C., Lindsten, T., Cross, J. R., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0250 · Cited by 452 · see citing works

Tumor glycolysis, an essential sweet tooth of tumor cells

Paul, S., Ghosh, S., & Kumar, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.09.007 · Cited by 449 · see citing works

Energy metabolism in health and diseases

Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 438 · see citing works

CircRNAs in cancer metabolism: a review

Yu, T., Wang, Y., Fan, Y., Fang, N., Wang, T., Xu, T., & Shu, Y. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0776-8 · Cited by 425 · see citing works

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

Porporato, P. E., Dhup, S., Dadhich, R. K., Copetti, T., & Sonveaux, P. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00049 · Cited by 424 · see citing works

Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth,Angiogenesis and Metastasis

Dhup, S., Dadhich, R. K., Porporato, P. E., & Sonveaux, P. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799504902 · Cited by 419 · see citing works

Regulation of cancer cell metabolism: Oncogenic MYC in the driver’s seat

Dong, Y., Tu, R., Liu, H., & Qing, G. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00235-2 · Cited by 405 · see citing works

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Daemen, A., Peterson, D., Sahu, N., McCord, R., Du, X., Liu, B., Kowanetz, K., Hong, R., Moffat, J., Gao, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501605112 · Cited by 398 · see citing works

Cancer cell metabolism: implications for therapeutic targets

Jang, M., Kim, S. S., & Lee, J. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.85 · Cited by 398 · see citing works

Lactate in the Tumor Microenvironment: An Essential Molecule in Cancer Progression and Treatment

Pérez‐Tomás, R., & Pérez-Guillén, I. (2020) · Cancers · doi:10.3390/cancers12113244 · Cited by 395 · see citing works

Emerging roles of PKM2 in cell metabolism and cancer progression

Luo, W., & Semenza, G. L. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.06.010 · Cited by 380 · see citing works

FGF-dependent metabolic control of vascular development

Yu, P., Wilhelm, K., Dubrac, A., Tung, J. K., Alves, T. C., Fang, J. S., Xie, Y., Zhu, J., Chen, Z., Smet, F. D., et al. (2017) · Nature · doi:10.1038/nature22322 · Cited by 366 · see citing works

Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets

Bi, J., Chowdhry, S., Wu, S., Zhang, W., Masui, K., & Mischel, P. S. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0226-5 · Cited by 348 · see citing works

Regulation of Metabolism by Hypoxia-Inducible Factor 1

Semenza, G. L. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010678 · Cited by 342 · see citing works

Metabolic Codependencies in the Tumor Microenvironment

Dey, P., Kimmelman, A. C., & DePinho, R. A. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1211 · Cited by 342 · see citing works

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

Hitosugi, T., Fan, J., Chung, T., Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R. D., Roesel, J. L., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.10.015 · Cited by 329 · see citing works

Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy

Marengo, B., Nitti, M., Furfaro, A. L., Colla, R., Ciucis, C. D., Marinari, U. M., Pronzato, M. A., Traverso, N., & Domenicotti, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6235641 · Cited by 319 · see citing works

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

Fan, J., Shan, C., Kang, H.-B., Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S., Chen, H., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.026 · Cited by 305 · see citing works

Regulation of cell proliferation by hypoxia-inducible factors

Hubbi, M. E., & Semenza, G. L. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00279.2015 · Cited by 298 · see citing works

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

Godet, I., Shin, Y. J., Ju, J. A., Ye, I. C., Wang, G., & Gilkes, D. M. (2019) · Nature Communications · doi:10.1038/s41467-019-12412-1 · Cited by 274 · see citing works

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

Altman, B. J., Hsieh, A. L., Sengupta, A., Krishnanaiah, S. Y., Stine, Z. E., Walton, Z. E., Gouw, A. M., Venkataraman, A., Li, B., Goraksha-Hicks, P., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.003 · Cited by 273 · see citing works

Mitochondria in cancer: Not just innocent bystanders

Frezza, C., & Gottlieb, E. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.11.008 · Cited by 267 · see citing works

Regulation of gene expression by hypoxia

Kenneth, N. S., & Rocha, S. (2008) · Biochemical Journal · doi:10.1042/bj20081055 · Cited by 264 · see citing works

TGF-β signaling in the tumor metabolic microenvironment and targeted therapies

Shi, X., Yang, J., Deng, S., Xu, H., Wu, D., Zeng, Q., Wang, S., Hu, T., Wu, F., & Zhou, H. (2022) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-022-01349-6 · Cited by 262 · see citing works

Mitophagy in Cancer: A Tale of Adaptation

Vara‐Pérez, M., Felipe‐Abrio, B., & Agostinis, P. (2019) · Cells · doi:10.3390/cells8050493 · Cited by 256 · see citing works

Metabolic reprogramming in the tumor microenvironment of liver cancer

Lin, J., Rao, D., Zhang, M., & Gao, Q. (2024) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-024-01527-8 · Cited by 251 · see citing works

Drug resistance in pancreatic cancer: Impact of altered energy metabolism

Grasso, C., Jansen, G., & Giovannetti, E. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.03.026 · Cited by 250 · see citing works

Emerging roles of Myc in stem cell biology and novel tumor therapies

Yoshida, G. J. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0835-y · Cited by 244 · see citing works

CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis

Fang, Y., Shen, Z., Zhan, Y., Feng, X., Chen, K., Li, Y., Deng, H., Pan, S., Wu, D., & Ding, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-11662-3 · Cited by 242 · see citing works

Metabolic rearrangements in primary liver cancers: cause and consequences

Satriano, L., Lewińska, M., Rodrigues, P. M., Bañales, J. M., & Andersen, J. B. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0217-8 · Cited by 241 · see citing works

Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC

Blandino, G., Valerio, M., Cioce, M., Mori, F., Casadei, L., Pulito, C., Sacconi, A., Biagioni, F., Cortese, G., Galanti, S., et al. (2012) · Nature Communications · doi:10.1038/ncomms1859 · Cited by 240 · see citing works

Revisited Metabolic Control and Reprogramming Cancers by Means of the Warburg Effect in Tumor Cells

Abekura, F., Kim, H.-D., Chang, Y., & Kim, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710037 · Cited by 240 · see citing works

Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells

Delgado, T., Carroll, P. A., Punjabi, A. S., Margineantu, D. H., Hockenbery, D. M., & Lagunoff, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004882107 · Cited by 238 · see citing works

Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers

Lecarpentier, Y., Schussler, O., Hébert, J., & Vallée, A. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01248 · Cited by 236 · see citing works

The Warburg effect is genetically determined in inherited pheochromocytomas

Favier, J., Brière, J.-J., Burnichon, N., Rivière, J., Vescovo, L., Benit, P., Giscos-Douriez, I., De Reyniès, A., Bertherat, J., Badoual, C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007094 · Cited by 232 · see citing works

Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis

Feng, J., Dai, W., Mao, Y., Wu, L., Li, J., Chen, K., Yu, Q., Kong, R., Li, S., Zhang, J., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-1528-x · Cited by 232 · see citing works

Is Cancer a Metabolic Disease?

Coller, H. A. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.07.035 · Cited by 230 · see citing works

Metabolic transformation in cancer

Tennant, D. A., Durán, R. V., Boulahbel, H., & Gottlieb, E. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp070 · Cited by 226 · see citing works

Unlocking the Potential of HK2 in Cancer Metabolism and Therapeutics

Garcia, S. N., Guedes, R. C., & Marques, M. M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867326666181213092652 · Cited by 227 · see citing works

Cancer Cell MetabolismPreprint

Cairns, R. A., Harris, I. S., McCracken, S. A., & Mak, T. W. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.012856 · Cited by 223 · see citing works

Control of glutamine metabolism by the tumor suppressor Rb

Reynolds, M. R., Lane, A. N., Robertson, B., Kemp, S., Liu, Y., Hill, B. G., Dean, D. C., & Clem, B. F. (2014) · Oncogene · doi:10.1038/onc.2012.635 · Cited by 216 · see citing works

Glucose Oxidation Modulates Anoikis and Tumor Metastasis

Kamarajugadda, S., Stemboroski, L. N., Cai, Q., Simpson, N. E., Nayak, S., Tan, M., & Lu, J. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06248-11 · Cited by 216 · see citing works

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

Cai, J., Yi, M., Tan, Y., Li, X., Li, G., Zeng, Z., Xiong, W., & Xiang, B. (2021) · Journal of Experimental &amp; Clinical Cancer Research · doi:10.1186/s13046-021-01995-7 · Cited by 215 · see citing works

Hypoxia-inducible factors and their roles in energy metabolism

Goda, N., & Kanai, M. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1069-y · Cited by 213 · see citing works

How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?

Lincet, H., & Icard, P. (2014) · Oncogene · doi:10.1038/onc.2014.320 · Cited by 207 · see citing works

Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer

Świerczyński, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i9.2279 · Cited by 201 · see citing works

Mechanisms of adaptive angiogenesis to tissue hypoxia

Fong, G. (2008) · Angiogenesis · doi:10.1007/s10456-008-9107-3 · Cited by 201 · see citing works

The emerging role of lactate in tumor microenvironment and its clinical relevance

Chen, S., Xu, Y., Zhuo, W., & Zhang, L. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216837 · Cited by 200 · see citing works

The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues

Goetzman, E. S., & Prochownik, E. V. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00129 · Cited by 199 · see citing works

Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy

Xiao, L., Hu, Z., Dong, X., Tan, Z. W., Li, W., Tang, M., Chen, L., Yang, L., Tao, Y., Jiang, Y., et al. (2014) · Oncogene · doi:10.1038/onc.2014.32 · Cited by 197 · see citing works

Kaempferol Inhibits Angiogenesis and VEGF Expression Through Both HIF Dependent and Independent Pathways in Human Ovarian Cancer Cells

Luo, H., Rankin, G. O., Liu, L.-Z., Daddysman, M. K., Jiang, B., & Chen, Y. (2009) · Nutrition and Cancer · doi:10.1080/01635580802666281 · Cited by 195 · see citing works

Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo

Young, C. D., Lewis, A. S., Rudolph, M. C., Ruehle, M. D., Jackman, M. R., Yun, U. J., Ilkun, O. L., Pereira, R. O., Abel, E. D., & Anderson, S. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023205 · Cited by 194 · see citing works

Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

Kung-Chun Chiu, D., Pui-Wah Tse, A., Law, C.-T., Ming-Jing Xu, I., Lee, D., Chen, M., Kit-Ho Lai, R., Wai-Hin Yuen, V., Wing-Sum Cheu, J., Wai-Hung Ho, D., et al. (2019) · Cell Death &amp; Disease · doi:10.1038/s41419-019-2155-3 · Cited by 192 · see citing works

Metabolism and proliferation share common regulatory pathways in cancer cells

Fritz, V., & Lluis Fajas, A. (2010) · Oncogene · doi:10.1038/onc.2010.182 · Cited by 188 · see citing works

Metastasis and AKT activation

Sheng, S., Qiao, M., & Pardee, A. B. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21616 · Cited by 184 · see citing works

Role of long non-coding RNAs in glucose metabolism in cancer

Fan, C., Tang, Y., Wang, J., Xiong, F., Guo, C. J., Wang, Y., Zhang, S., Gong, Z., Wei, F., Yang, L., et al. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0699-3 · Cited by 182 · see citing works

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1

Ma, X., Li, C., Sun, L., Huang, D., Li, T., He, X., Wu, G., Yang, Z., Zhong, X., Song, L., et al. (2014) · Nature Communications · doi:10.1038/ncomms6212 · Cited by 180 · see citing works

Metabolic Regulation of Apoptosis in Cancer

Matsuura, K., Canfield, K., Feng, W. W., & Kurokawa, M. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.06.006 · Cited by 177 · see citing works

Impact of MYC in regulation of tumor cell metabolism

Wahlström, T., & Arsenian‐Henriksson, M. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.07.004 · Cited by 176 · see citing works

Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment

Lin, X., Xiao, Z., Chen, T., Liang, S. H., & Guo, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00317 · Cited by 176 · see citing works

Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition

Nikiforov, M. A., Riblett, M., Tang, W. H. W., Grachtchouk, V., Zhuang, D., Fernández, Y., Verhaegen, M. E., Varambally, S., Chinnaiyan, A. M., Jakubowiak, A. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708380104 · Cited by 174 · see citing works

Microbial carcinogenesis: Lactic acid bacteria in gastric cancer

Vinasco, K., Mitchell, H. M., Kaakoush, N. O., & Castaño‐Rodríguez, N. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.07.004 · Cited by 173 · see citing works

The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma

Goenka, A., Tiek, D., Song, X., Huang, T., Hu, B., & Cheng, S.-Y. (2021) · Cells · doi:10.3390/cells10030484 · Cited by 169 · see citing works

Long non-coding RNA FGF13-AS1 inhibits glycolysis and stemness properties of breast cancer cells through FGF13-AS1/IGF2BPs/Myc feedback loop

Ma, F., Liu, X., Zhou, S., Li, W., Liu, C., Chadwick, M., & Qian, C. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.02.008 · Cited by 168 · see citing works

Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy

Anwar, S., Shamsi, A., Mohammad, T., Islam, A., & Hassan, M. I. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188568 · Cited by 165 · see citing works

The Interplay Between MYC and HIF in the Warburg Effect

Dang, C. V. (2008) · Ernst Schering Research Foundation workshop/Ernst Schering Foundation Symposium proceedings · doi:10.1007/2789_2008_088 · Cited by 131 · see citing works

Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells

Doe, M. R., Ascano, J. M., Kaur, M., & Cole, M. D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2371 · Cited by 142 · see citing works

Molecular Crosstalk Between MYC and HIF in Cancer

Li, Y., Sun, X., Qian, D. Z., & Dai, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590576 · Cited by 90 · see citing works

A therapeutic role for targeting c-Myc/Hif-1- dependent signaling pathways

Podar, K., & Anderson, K. C. (2010) · Cell Cycle · doi:10.4161/cc.9.9.11358 · Cited by 82 · see citing works

MYC overrides HIF-1α to regulate proliferating primary cell metabolism in hypoxia

Copeland, C. A., Olenchock, B. A., Ziehr, D. R., McGarrity, S., Leahy, K., Young, J. D., Loscalzo, J., & Oldham, W. M. (2023) · eLife · doi:10.7554/elife.82597 · Cited by 12 · see citing works