Cited by 541Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsPain Management and Treatment

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Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome

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Meeus, Mira, Nijs, Jo·2007·Clinical Rheumatology

DOI 10.1007/s10067-006-0433-9PMC PMC1820749

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Abstract

In addition to the debilitating fatigue, the majority of patients with chronic fatigue syndrome (CFS) experience chronic widespread pain. These pain complaints show the greatest overlap between CFS and fibromyalgia (FM). Although the literature provides evidence for central sensitization as cause for the musculoskeletal pain in FM, in CFS this evidence is currently lacking, despite the observed similarities in both diseases. The knowledge concerning the physiological mechanism of central sensitization, the pathophysiology and the pain processing in FM, and the knowledge on the pathophysiology of CFS lead to the hypothesis that central sensitization is also responsible for the sustaining pain complaints in CFS. This hypothesis is based on the hyperalgesia and allodynia reported in CFS, on the elevated concentrations of nitric oxide presented in the blood of CFS patients, on the typical personality styles seen in CFS and on the brain abnormalities shown on brain images. To examine the present hypothesis more research is required. Further investigations could use similar protocols to those already used in studies on pain in FM like, for example, studies on temporal summation, spatial summation, the role of psychosocial aspects in chronic pain, etc.

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Authors: Meeus, M., & Nijs, J.
Affiliations: Vrije Universiteit Brussel (BE)
Corresponding author: Nijs, Jo
ORCID: Meeus, Mira
Nijs, Jo
Venue: Clinical Rheumatology
Publisher: Springer Science and Business Media LLC
Published: 2006-11-18
Volume: 26
Issue: 4
Pages: 465-473
ISSN: 0770-3198 (ISSN-L)
1434-9949
DOI: 10.1007/s10067-006-0433-9
PMC: PMC1820749
OpenAlex: W1992707234
Cited by: 541
References: 102
Citations by year: 2026: 21 · 2025: 22 · 2024: 18 · 2023: 25 · 2022: 29 · 2021: 43 · 2020: 43 · 2019: 33 · 2018: 27 · 2017: 33 · 2016: 17 · 2015: 36 · 2014: 34 · 2013: 35 · 2012: 30
FWCI: 1.66
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/2.0 (tdm)
creativecommons.org/licenses/by-nc/2.0 (vor)
Locations: Clinical Rheumatology (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: central sensitization, chronic widespread pain, fibromyalgia, chronic fatigue syndrome, hyperalgesia, allodynia, nitric oxide, personality, brain abnormalities, pain processing, biopsychosocial model, temporal summation, spatial summation
MeSH terms: Fibromyalgia, Humans, Hyperalgesia, Nervous System Physiological Phenomena, Pain, Perception, Fatigue Syndrome, Chronic, Referred Pain

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Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome

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