Differential diagnosis of Parkinson's disease and atypical parkinsonian disorders by magnetic resonance imaging
Abstract
Magnetic resonance imaging (MRI) is not usually considered helpful for establishing the diagnosis of Parkinson's disease, but it is much more important to support the clinical diagnosis in atypical parkinsonian disorders. In multiple system atrophy with predominant parkinsonian features (MSA-P), MRI demonstrates putaminal abnormalities due to loss of neurons and gliosis and accumulation of iron in the posterior lateral part of the nucleus. When cerebellar features are present (MSA-C), pontine and cerebellar atrophy is seen with signal abnormalities that correspond to the distribution of the degenerative changes. In progressive supranuclear palsy, the main abnormality is atrophy of the midbrain. Mild-to-moderate cerebral atrophy may be present, but more-marked asymmetrical atrophy in the posterior frontal and parietal regions contralateral to the side of the clinical manifestations is characteristic of corticobasal degeneration.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The study of morphological and iron concentration changes in the midbrain and cerebellum might help to distinguish Parkinson's disease from other disorders with similar symptoms, such as multiple system atrophy and progressive supranuclear palsy.
“Furthermore, the study of morphological and iron concentration changes in the midbrain and cerebellum might help to distinguish Parkinson’s disease from other disorders with similar symptoms, such as multiple system atrophy and progressive supranuclear palsy.146,147”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [146]
Cites
Differentiation of atypical parkinsonian syndromes with routine MRI
Schrag, A. E., Good, C. D., Miszkiel, K., Morris, H. R., Mathias, C. J., Lees, A. J., & Quinn, N. P. (2000) · Neurology · doi:10.1212/wnl.54.3.697 · Cited by 412 · see citing works
Clinical usefulness of magnetic resonance imaging in multiple system atrophy
Schrag, A. E., Kingsley, D. P. E., Phatouros, C. C., Mathias, C. J., Lees, A. J., Daniel, S. E., & Quinn, N. P. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.1.65 · Cited by 274 · see citing works
Olivopontocerebellar atrophy: MR diagnosis and relationship to multisystem atrophy.
Savoiardo, M., Strada, L., Girotti, F., et al. (1990) · Radiology · doi:10.1148/radiology.174.3.2305051 · Cited by 205 · see citing works
Self-citationSoliveri, P., Monza, D., Paridi, D., Radice, D., Grisoli, M., Testa, D., Savoiardo, M., & Girotti, F. (1999) · Neurology · doi:10.1212/wnl.53.3.502 · Cited by 185 · see citing works
Self-citationMagnetic resonance imaging in progressive supranuclear palsy and other parkinsonian disorders
Savoiardo, M., Girotti, F., Strada, L., et al. (1994) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6641-3_8 · Cited by 123 · see citing works
Self-citationStructural changes of the substantia nigra in Parkinson's disease as revealed by MR imaging.
Hutchinson, M., & Raff, U. (2000) · PubMed · Cited by 116 · see citing works
Righini, A., Antonini, A., Ferrarini, M., Notaris, R. D., Canesi, M., Triulzi, F. M., & Pezzoli, G. (2002) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-200203000-00018 · Cited by 56 · see citing works
MRI in corticobasal degeneration
Grisoli, M., Fetoni, V., Savoiardo, M., et al. (1995) · European Journal of Neurology · doi:10.1111/j.1468-1331.1995.tb00172.x · Cited by 48 · see citing works
Self-citationMagnetic resonance imaging in CBD, related atypical parkinsonian disorders, and dementias.
Savoiardo, M., Grisoli, M., & Girotti, F. (2000) · PubMed · Cited by 32 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works
Messina, D., Cerasa, A., Condino, F., Arabia, G., Novellino, F., Nicoletti, G., Salsone, M., Morelli, M., Lanza, P. L., & Quattrone, A. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.12.010 · Cited by 163 · see citing works
- Authors
- Savoiardo, M.
- Affiliations
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Corresponding author
- Savoiardo, M.
- Venue
- Neurological Sciences
- Published
- 2003-05-01
- Volume
- 24
- Issue
- 0
- Pages
- s35-s37
- ISSN
- 1590-1874 (ISSN-L)
- 1590-3478
- OpenAlex
- W2002684697
- Cited by
- 97
- References
- 9
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 7 · 2012: 7
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- Parkinson's disease, atypical parkinsonism, differential diagnosis, multiple system atrophy, MSA-P, MSA-C, progressive supranuclear palsy, corticobasal degeneration, gliosis, midbrain atrophy, cerebellar atrophy, pontine atrophy, brain atrophy, MRI findings
- MeSH terms
- Atrophy, Brain Diseases, Diagnosis, Differential, Humans, Magnetic Resonance Imaging, Parkinson Disease, Supranuclear Palsy, Progressive, Multiple System Atrophy, Neurodegenerative Diseases, Parkinsonian Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
