The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The impact of diabetes on the pathogenesis of sepsis
Open accessAbstract
Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is influenced by the presence of diabetes, fuelling the ongoing debate on the benefit of tight glucose regulation in patients with sepsis. The main reason for which diabetes predisposes to infection appears to be abnormalities of the host response, particularly in neutrophil chemotaxis, adhesion and intracellular killing, defects that have been attributed to the effect of hyperglycaemia. There is also evidence for defects in humoral immunity, and this may play a larger role than previously recognised. We review the literature on the immune response in diabetes and its potential contribution to the pathogenesis of sepsis. In addition, the effect of diabetes treatment on the immune response is discussed, with specific reference to insulin, metformin, sulphonylureas and thiazolidinediones.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Intensive versus Conventional Glucose Control in Critically Ill Patients
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810625 · Cited by 5,119
Intensive insulin therapy in the medical ICU
Van den Berghe, G., Wilmer, A., Hermans, G., Meersseman, W., Wouters, P. J., Milants, I., Van Wijngaerden, E., Bobbaers, H., & Bouillon, R. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052521 · Cited by 3,639
Overadjustment bias and unnecessary adjustment in epidemiologic studies.
Schisterman, E. F., Cole, S. R., & Platt, R. W. (2009) · Epidemiology · doi:10.1097/ede.0b013e3181a819a1 · Cited by 2,096 · cited 1×
“or spurious results [40].”
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
Lamkanfi, M., Mueller, J. L., Vitari, A. C., Misaghi, S., Fedorova, A., Deshayes, K., Lee, W. P., Hoffman, H. M., & Dixit, V. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903124 · Cited by 820
Cited by
Gregg, E. W., Cheng, Y. J., Srinivasan, M., Lin, J., Geiss, L. S., Albright, A. L., & Imperatore, G. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30314-3 · Cited by 480
Stojadinovic, O., Yin, N., Lehmann, J., Pastar, I., Kirsner, R. S., & Tomic-Canic, M. (2013) · Immunologic Research · doi:10.1007/s12026-013-8474-z · Cited by 88
Gut microbiota and sepsis and sepsis-related death: a Mendelian randomization investigation
Shang, W., Zhang, S., Qian, H., Huang, S., Li, H., Liu, J., & Chen, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1266230 · Cited by 23
Metadata
- Authors
- Koh, G. C. K. W., Peacock, S. J., van der Poll, T., & Wiersinga, W. J.
- Venue
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2011-07-30
- Volume
- 31
- Issue
- 4
- Pages
- 379-388
- ISSN
- 0934-9723 (ISSN-L)
- 1435-4373
- OpenAlex
- W1975235822
- Cited by
- 225
- References
- 5
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Koh, G. C. K. W., Peacock, S. J., van der Poll, T., & Wiersinga, W. J. (2012). The impact of diabetes on the pathogenesis of sepsis. European Journal of Clinical Microbiology & Infectious Diseases. https://doi.org/10.1007/s10096-011-1337-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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