Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080 · see citing works

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · see citing works

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · see citing works

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,822 · see citing works

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/ng756 · Cited by 1,679 · see citing works

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

Pelegrı́n, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,428 · see citing works

Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion

Aguilar-Bryan, L., Nichols, C. G., Wechsler, S. W., Clement, J. P., Boyd, A. E., González, G., Herrera-Sosa, H., Nguy, K., Bryan, J., & Nelson, D. A. (1995) · Science · doi:10.1126/science.7716547 · Cited by 1,315 · see citing works

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Kanneganti, T., Özören, N., Body–Malapel, M., Amer, A. O., Park, J., Franchi, L., Whitfield, J. R., Barchet, W., Colonna, M., Vandenabeele, P., et al. (2006) · Nature · doi:10.1038/nature04517 · Cited by 1,149 · see citing works

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980 · see citing works

Altered Cytokine Production in Mice Lacking P2X7Receptors

Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924 · see citing works

The Nalp3 inflammasome is essential for the development of silicosis

Cassel, S. L., Eisenbarth, S. C., Iyer, S. S., Sadler, J. J., Colegio, O. R., Tephly, L. A., Carter, A. B., Rothman, P. B., Flavell, R. A., & Sutterwala, F. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803933105 · Cited by 907 · see citing works

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

Boyden, E. D., & Dietrich, W. F. (2006) · Nature Genetics · doi:10.1038/ng1724 · Cited by 860 · see citing works

Association and Stoichiometry of KATP Channel Subunits

Clement, J. P., Kunjilwar, K., Gonzalez, G., Schwanstecher, M., Panten, U., Aguilar-Bryan, L., & Bryan, J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80321-9 · Cited by 692 · see citing works

ATP-sensitive potassium channelopathies: focus on insulin secretion

Ashcroft, F. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25495 · Cited by 627 · see citing works

Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.

Miki, T., Nagashima, K., Tashiro, F., Kotake, K., Yoshitomi, H., Tamamoto, A., Gonoi, T., Iwanaga, T., Miyazaki, J., & Seino, S. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.18.10402 · Cited by 541 · see citing works

Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

Kanneganti, T., Lamkanfi, M., Kim, Y., Chen, G., Park, J., Franchi, L., Vandenabeele, P., & Núñez, G. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.008 · Cited by 526 · see citing works

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

Duncan, J. A., Bergstralh, D. T., Wang, Y., Willingham, S. B., Ye, Z., Zimmermann, A. G., & Ting, J. P.-Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611496104 · Cited by 503 · see citing works

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages

Yvan‐Charvet, L., Welch, C. L., Pagler, T. A., Ranalletta, M., Lamkanfi, M., Han, S., Ishibashi, M., Li, R., Wang, N., & Tall, A. R. (2008) · Circulation · doi:10.1161/circulationaha.108.793869 · Cited by 456 · see citing works

Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex

Locovei, S., Scemes, E., Qiu, F., Spray, D. C., & Dahl, G. (2007) · FEBS Letters · doi:10.1016/j.febslet.2006.12.056 · Cited by 434 · see citing works

Inflammasomes: guardians of cytosolic sanctity

Lamkanfi, M., & Dixit, V. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00730.x · Cited by 364 · see citing works

Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1

Miki, T., Suzuki, M., Shibasaki, T., Uemura, H., Sato, T., Yamaguchi, K., Koseki, H., Iwanaga, T., Nakaya, H., & Seino, S. (2002) · Nature Medicine · doi:10.1038/nm0502-466 · Cited by 347 · see citing works

Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1β Release through a Dye Uptake-independent Pathway

Pelegrı́n, P., & Surprenant, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610351200 · Cited by 301 · see citing works

Pharmacological Characterization of Pannexin-1 Currents Expressed in Mammalian Cells

Ma, W., Hui, H., Pelegrı́n, P., & Surprenant, A. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.146365 · Cited by 273 · see citing works

Interleukin-1β Secretion Is Impaired by Inhibitors of the Atp Binding Cassette Transporter, ABC1

Hamon, Y., Luciani, M., Becq, F., Verrier, B., Rubartelli, A., & Chimini, G. (1997) · Blood · doi:10.1182/blood.v90.8.2911 · Cited by 224 · see citing works

Identification and Characterization of a Novel Class of Interleukin-1 Post-Translational Processing Inhibitors

Perregaux, D. G., McNiff, P. A., Laliberte, R. E., Hawryluk, N. A., Peurano, H., Stam, E. J., Eggler, J., Griffiths, R., Dombroski, M. A., & Gabel, C. A. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29317-4 · Cited by 218 · see citing works

ATP Treatment of Human Monocytes Promotes Caspase-1 Maturation and Externalization

Laliberte, R. E., Eggler, J. F., & Gabel, C. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.36944 · Cited by 138 · see citing works

The Nod-Like Receptor Family Member Naip5/Birc1e Restricts Legionella pneumophila Growth Independently of Caspase-1 Activation

Lamkanfi, M., Amer, A. O., Kanneganti, T., Muñoz-Planillo, R., Chen, G., Vandenabeele, P., Fortier, A. H., Gros, P., & Núñez, G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.8022 · Cited by 112 · see citing works

Sulfonylureas Differ in Effects on Ischemic Preconditioning—Is it Time to Retire Glyburide?

Riddle, M. C. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021971 · Cited by 92 · see citing works

Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia

Rosengren, S., Mueller, J. L., Anderson, J. P., Niehaus, B. L., Misaghi, A., Anderson, S., Boyle, D. L., & Hoffman, H. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.649 · Cited by 58 · see citing works

Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse

Schott, W. H., Haskell, B. D., Tse, H. M., Milton, M. J., Piganelli, J. D., Choisy, C., Reifsnyder, P. C., Chervonsky, A. V., & Leiter, E. H. (2004) · Diabetes · doi:10.2337/diabetes.53.1.99 · Cited by 56 · see citing works

Structural requirements of sulphonylureas and analogues for interaction with sulphonylurea receptor subtypes

Meyer, M. E., Chudziak, F., Schwanstecher, C., Schwanstecher, M., & Panten, U. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702763 · Cited by 47 · see citing works

Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress

Stoller, D. A., Kakkar, R. K., Smelley, M. P., Chalupský, K., Earley, J. U., Shi, N., Makielski, J. C., & McNally, E. M. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.07.058 · Cited by 45 · see citing works

ATP binding cassette transporter ABC1 is required for the release of interleukin‐1β by P2X₇‐stimulated and lipopolysaccharide‐primed mouse Schwann cells

Marty, V., Médina, C., Combe, C., Parnet, P., & Amédée, T. (2005) · Glia · doi:10.1002/glia.20138 · Cited by 41 · see citing works

Inflammasomes: mechanism of action, role in disease, and therapeutics

Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340 · see citing works

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works

Activation and regulation of the inflammasomes

Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884 · see citing works

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3806 · Cited by 2,849 · see citing works

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282 · see citing works

Inflammasomes in health and disease

Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230 · see citing works

Molecular and cellular mechanisms of liver fibrosis and its regression

Kisseleva, T., & Brenner, D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00372-7 · Cited by 2,024 · see citing works

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan, M. S. J., Olhava, E. J., Roush, W. R., Seidel, H. M., Glick, G. D., & Latz, E. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.97 · Cited by 1,885 · see citing works

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

Davis, B. K., Wen, H., & Ting, J. P.-Y. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101405 · Cited by 1,618 · see citing works

Understanding the mechanism of IL-1β secretion

Lopez-Castejon, G., & Brough, D. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.10.001 · Cited by 1,519 · see citing works

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology · doi:10.1038/ni.1935 · Cited by 1,330 · see citing works

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

Doitsh, G., Galloway, N. L. K., Geng, X., Yang, Z., Monroe, K. M., Zepeda, O., Hunt, P. W., Hatano, H., Sowinski, S., Muñoz-Arias, I., et al. (2013) · Nature · doi:10.1038/nature12940 · Cited by 1,181 · see citing works

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

Schroder, K., Zhou, R., & Tschopp, J. (2010) · Science · doi:10.1126/science.1184003 · Cited by 1,131 · see citing works

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

Zheng, D., Liwinski, T., & Elinav, E. (2020) · Cell Discovery · doi:10.1038/s41421-020-0167-x · Cited by 1,042 · see citing works

Caspases in Cell Death, Inflammation, and Pyroptosis

Kesavardhana, S., Malireddi, R. K. S., & Kanneganti, T. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-073119-095439 · Cited by 927 · see citing works

The inflammasome: an integrated view

Gross, O., Thomas, C. J., Guarda, G., & Tschopp, J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01046.x · Cited by 778 · see citing works

NLRP3 and pyroptosis blockers for treating inflammatory diseases

Coll, R. C., Schroder, K., & Pelegrı́n, P. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.04.003 · Cited by 767 · see citing works

Inflammasomes in neuroinflammatory and neurodegenerative diseases

Voet, S., Srinivasan, S., Lamkanfi, M., & van Loo, G. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201810248 · Cited by 761 · see citing works

Mechanism of NLRP3 inflammasome activation

Sutterwala, F. S., Haasken, S., & Cassel, S. L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12458 · Cited by 736 · see citing works

Pharmacological Inhibitors of the NLRP3 Inflammasome

Zahid, A., Li, B., Kombe, A. J. K., Jin, T., & Tao, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02538 · Cited by 671 · see citing works

The NLRP3 inflammasome in acute myocardial infarction

Toldo, S. A., & Abbate, A. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.161 · Cited by 673 · see citing works

Diverging inflammasome signals in tumorigenesis and potential targeting

Karki, R., & Kanneganti, T. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0123-y · Cited by 641 · see citing works

Hyperferritinemia and inflammation

Kernan, K. F., & Carcillo, J. A. (2017) · International Immunology · doi:10.1093/intimm/dxx031 · Cited by 638 · see citing works

Inflammasomes in the CNS

Walsh, J. G., Muruve, D. A., & Power, C. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3638 · Cited by 637 · see citing works

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

Juliana, C. A., Fernandes‐Alnemri, T., Wu, J., Datta, P., Solórzano, L., Yu, J., Meng, R., Quong, A. A., Latz, E., Scott, C. P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.082305 · Cited by 617 · see citing works

Inflammasome activation and function in liver disease

Szabó, G., & Petrasek, J. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.94 · Cited by 600 · see citing works

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases

Blevins, H. M., Xu, Y., Biby, S., & Zhang, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.879021 · Cited by 587 · see citing works

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

Iwata, M., Ota, K. T., & Duman, R. S. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.12.008 · Cited by 580 · see citing works

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

Huang, Y., Jiang, H., Chen, Y., Wang, X., Yang, Y., Tao, J., Deng, X., Liang, G., Zhang, H., Jiang, W., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708689 · Cited by 521 · see citing works

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

Vince, J. E., Wong, W. W.-L., Gentle, I., Lawlor, K. E., Allam, R., O'Reilly, L., Mason, K., Gross, O., Ma, S., Guarda, G., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.012 · Cited by 491 · see citing works

Reactive oxygen species at the crossroads of inflammasome and inflammation

Harijith, A. K., Ebenezer, D. L., & Natarajan, V. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00352 · Cited by 474 · see citing works

The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease

Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., et al. (2016) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2016.09.023 · Cited by 472 · see citing works

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

Lamkanfi, M., Sarkar, A., Walle, L. V., Vitari, A. C., Amer, A. O., Wewers, M. D., Tracey, K. J., Kanneganti, T., & Dixit, V. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000803 · Cited by 468 · see citing works

NLRP3 inflammasome in neurological diseases, from functions to therapies

Song, L., Pei, L., Yao, S., Wu, Y., & Shang, Y. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00063 · Cited by 467 · see citing works

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

Wen, H., Ting, J. P. ‐., & O'Neill, L. A. J. (2012) · Nature Immunology · doi:10.1038/ni.2228 · Cited by 455 · see citing works

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

Wang, S., Yuan, Y., Chen, N., & Wang, H. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.019 · Cited by 447 · see citing works

Emerging inflammasome effector mechanisms

Lamkanfi, M. (2011) · Nature reviews. Immunology · doi:10.1038/nri2936 · Cited by 435 · see citing works

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

Hirota, S. A., Ng, J., Lueng, A., Khajah, M. A., Parhar, K. K. S., Li, Y., Lam, V. L., Potentier, M. S., Ng, K., Bawa, M., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21478 · Cited by 434 · see citing works

Adipose tissue macrophages: going off track during obesity

Boutens, L., & Stienstra, R. (2016) · Diabetologia · doi:10.1007/s00125-016-3904-9 · Cited by 430 · see citing works

The NLRP3 inflammasome: Mechanism of action, role in disease and therapies

Wang, L., & Hauenstein, A. V. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100889 · Cited by 426 · see citing works

The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases

Toldo, S. A., & Abbate, A. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00946-3 · Cited by 426 · see citing works

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

Gurung, P., Lukens, J. R., & Kanneganti, T.-D. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.11.008 · Cited by 393 · see citing works

The Acute Respiratory Distress Syndrome: From Mechanism to Translation

Han, S., & Mallampalli, R. K. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402513 · Cited by 391 · see citing works

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

Iwata, M., Ota, K. T., Li, X.-Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.026 · Cited by 387 · see citing works

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

Lupfer, C., Thomas, P. G., Anand, P. K., Vogel, P., Milasta, S., Martinez, J., Huang, G., Green, M., Kundu, M., Chi, H., et al. (2013) · Nature Immunology · doi:10.1038/ni.2563 · Cited by 384 · see citing works

Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

Doyle, S., Ozaki, E., & Campbell, M. (2015) · Journal of Inflammation Research · doi:10.2147/jir.s51250 · Cited by 382 · see citing works

Insulin and Insulin Resistance in Alzheimer’s Disease

Sędzikowska, A., & Szablewski, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189987 · Cited by 404 · see citing works

Inflammasomes and Cancer

Karki, R., Man, S. M., & Kanneganti, T. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0269 · Cited by 378 · see citing works

Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury

Toldo, S. A., Mauro, A. G., Cutter, Z., & Abbate, A. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00158.2018 · Cited by 373 · see citing works

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5

Baker, P. J., Boucher, D., Bierschenk, D., Tebartz, C., Whitney, P. G., D’Silva, D. B., Tanzer, M. C., Monteleone, M. M., Robertson, A. A. B., Cooper, M. A., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545655 · Cited by 370 · see citing works

Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets

Walle, L. V., & Lamkanfi, M. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00822-2 · Cited by 376 · see citing works

Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania

Lima-Junior, D. S., Costa, D. L., Carregaro, V., Cunha, L. D., Silva, A. L. N., Mineo, T. W. P., Gutierrez, F. R. S., Bellio, M., Bortoluci, K. R., Flavell, R. A., et al. (2013) · Nature Medicine · doi:10.1038/nm.3221 · Cited by 358 · see citing works

Pathogenesis of acute stroke and the role of inflammasomes

Fann, D. Y., Lee, S.-Y., Manzanero, S., Chunduri, P., Sobey, C. G., & Arumugam, T. V. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.09.004 · Cited by 334 · see citing works

Targeting the NLRP3 inflammasome in cardiovascular diseases

Toldo, S. A., Mezzaroma, E., Buckley, L. F., Potere, N., Nisio, M. D., Biondi‐Zoccai, G., Tassell, B. W. V., & Abbate, A. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108053 · Cited by 340 · see citing works

Cell death pathways: intricate connections and disease implications

Kist, M., & Vucic, D. (2021) · The EMBO Journal · doi:10.15252/embj.2020106700 · Cited by 328 · see citing works

Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice

Mirza, R. E., Fang, M. M., Weinheimer-Haus, E. M., Ennis, W. J., & Koh, T. J. (2014) · Diabetes · doi:10.2337/db13-0927 · Cited by 319 · see citing works

Macrophage functions in lean and obese adipose tissue

Thomas, D. D., & Apovian, C. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.04.005 · Cited by 318 · see citing works

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

Vaccari, J. P. D. R., Dietrich, W. D., & Keane, R. W. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.227 · Cited by 315 · see citing works

NLRP3 Inflammasome and Inflammatory Diseases

Wang, Z., Zhang, S., Xiao, Y., Zhang, W., Wu, S., Qin, T., Yue, Y., Qian, W., & Li, L. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4063562 · Cited by 315 · see citing works

Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes

Pandeya, A., & Kanneganti, T. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.10.001 · Cited by 314 · see citing works

The role of inflammasomes in kidney disease

Komada, T., & Muruve, D. A. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0158-z · Cited by 311 · see citing works

Diabetes is an inflammatory disease: evidence from traditional Chinese medicines

Xie, W., & Du, L. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01336.x · Cited by 305 · see citing works

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

Perera, A. P., Fernando, R., Shinde, T., Gundamaraju, R., Southam, B., Sohal, S. S., Robertson, A. A. B., Schroder, K., Kunde, D., & Eri, R. D. (2018) · Scientific Reports · doi:10.1038/s41598-018-26775-w · Cited by 300 · see citing works

Mitochondria: Sovereign of inflammation?

Tschopp, J. (2011) · European Journal of Immunology · doi:10.1002/eji.201141436 · Cited by 292 · see citing works

Focus on the Role of NLRP3 Inflammasome in Diseases

Fusco, R., Siracusa, R., Genovese, T., Cuzzocrea, S., & Paola, R. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124223 · Cited by 292 · see citing works

Programming inflammatory cell death for therapy

Christgen, S. L., Tweedell, R. E., & Kanneganti, T. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108010 · Cited by 290 · see citing works

p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1

He, Y., She, H., Zhang, T., Xu, H., Cheng, L., Yepes, M., Zhao, Y., & Mao, Z. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201701049 · Cited by 291 · see citing works

Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications

Zeng, C., Wang, R., & Tan, H. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.33568 · Cited by 285 · see citing works

The role of type 2 diabetes in neurodegeneration

Verdile, G., Fuller, S. J., & Martins, R. N. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.008 · Cited by 276 · see citing works

Innate Immune Recognition in Infectious and Noninfectious Diseases of the Lung

Opitz, B., van Laak, V., Eitel, J., & Suttorp, N. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200909-1427so · Cited by 274 · see citing works

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

He, Y., Varadarajan, S., Muñoz-Planillo, R., Burberry, A., Nakamura, Y., & Núñez, G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.515080 · Cited by 272 · see citing works

The Inflammasome Puts Obesity in the Danger Zone

Stienstra, R., Tack, C. J., Kanneganti, T., Joosten, L. A. B., & Netea, M. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.011 · Cited by 272 · see citing works

A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse

Marchetti, C., Chojnacki, J. E., Toldo, S. A., Mezzaroma, E., Tranchida, N., Rose, S. W., Federici, M., Tassell, B. W. V., Zhang, S., & Abbate, A. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000053 · Cited by 268 · see citing works

Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome

Ng, J., Hirota, S. A., Groß, O., Li, Y., Ulke‐Lemée, A., Potentier, M. S., Schenck, L. P., Vilaysane, A., Seamone, M. E., Feng, H., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.005 · Cited by 261 · see citing works

Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications

Pollack, R. M., Donath, M. Y., LeRoith, D., & Leibowitz, G. (2016) · Diabetes Care · doi:10.2337/dcs15-3015 · Cited by 261 · see citing works

Staphylococcus aureus α-Hemolysin Mediates Virulence in a Murine Model of Severe Pneumonia Through Activation of the NLRP3 Inflammasome

Kébaïer, C., Chamberland, R. R., Allen, I. C., Gao, X., Broglie, P. M., Hall, J. D., Jania, C. M., Doerschuk, C. M., Tilley, S. L., & Duncan, J. A. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir846 · Cited by 261 · see citing works

The role of pattern recognition receptors in intestinal inflammation

Fukata, M., & Arditi, M. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.13 · Cited by 255 · see citing works

Reperfusion Injury in Patients With Acute Myocardial Infarction

Welt, F. G. P., Batchelor, W., Spears, J. R., Penna, C. R. R., Pagliaro, P., Ibáñez, B., Drakos, S. G., Dangas, G., & Kapur, N. K. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.02.056 · Cited by 262 · see citing works

The NLRP3 Inflammasome in Alzheimer’s Disease

Tan, M., Yu, J., Jiang, T., Zhu, X., & Tan, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8475-x · Cited by 249 · see citing works

Targeting the Microglial NLRP3 Inflammasome and Its Role in Parkinson's Disease

Haque, M. E., Akther, M., Jakaria, M., Kim, I., Azam, S., & Choi, D. (2019) · Movement Disorders · doi:10.1002/mds.27874 · Cited by 248 · see citing works

NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

Daley, D., Mani, V. R., Mohan, N., Akkad, N., Pandian, G. S. D. B., Savadkar, S., Lee, K. B., Torres-Hernandez, A., Aykut, B., Diskin, B., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20161707 · Cited by 244 · see citing works

Neutrophil-derived IL-1β Is Sufficient for Abscess Formation in Immunity against Staphylococcus aureus in Mice

Cho, J. S., Guo, Y., Ramos, R. I., Hebroni, F., Plaisier, S. B., Xuan, C., Granick, J. L., Matsushima, H., Takashima, A., Iwakura, Y., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1003047 · Cited by 233 · see citing works

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

Cullen, S. P., Kearney, C. J., Clancy, D. M., & Martin, S. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.003 · Cited by 234 · see citing works

The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease

Hanslik, K. L., & Ulland, T. K. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.570711 · Cited by 236 · see citing works

Necroinflammation in Kidney Disease

Mulay, S. R., Linkermann, A., & Anders, H. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015040405 · Cited by 231 · see citing works

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS

Walsh, J. G., Reinke, S. N., Mamik, M. K., McKenzie, B., Maingat, F. G., Branton, W. G., Broadhurst, D., & Power, C. (2014) · Retrovirology · doi:10.1186/1742-4690-11-35 · Cited by 228 · see citing works

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

Haneklaus, M., O'Neill, L. A. J., & Coll, R. C. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.12.004 · Cited by 230 · see citing works

Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma

Carbone, M., & Yang, H. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2259 · Cited by 229 · see citing works

The impact of diabetes on the pathogenesis of sepsis

Koh, G. C. K. W., Peacock, S. J., van der Poll, T., & Wiersinga, W. J. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-011-1337-4 · Cited by 226 · see citing works

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice

Pourcet, B., Zecchin, M., Ferri, L., Beauchamp, J., Sitaula, S., Billon, C., Delhaye, S., Vanhoutte, J., Mayeuf-Louchart, A., Thorel, Q., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.12.019 · Cited by 226 · see citing works

Therapeutic modulation of inflammasome pathways

Chauhan, D., Walle, L. V., & Lamkanfi, M. (2020) · Immunological Reviews · doi:10.1111/imr.12908 · Cited by 217 · see citing works

The Role of NLRP3 Inflammasome in Alzheimer’s Disease and Potential Therapeutic Targets

Liang, T., Zhang, Y., Wu, S., Chen, Q., & Wang, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.845185 · Cited by 220 · see citing works

Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications

Sharma, A., Tate, M., Mathew, G., Vince, J. E., Ritchie, R. H., & de Haan, J. B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00114 · Cited by 216 · see citing works

Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?

McElwain, C. J., Tuboly, E., McCarthy, F. P., & McCarthy, C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00655 · Cited by 224 · see citing works

The NLR family of innate immune and cell death sensors

Sundaram, B., Tweedell, R. E., Kumar, S. P., & Kanneganti, T. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.012 · Cited by 213 · see citing works

Critical role for NLRP3 in necrotic death triggered by <i>Mycobacterium tuberculosis</i>

Wong, K., & Jacobs Jr, W. R. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01625.x · Cited by 209 · see citing works

A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

Kuwar, R., Rolfe, A., Di, L., Xu, H., Liu, H., Jiang, Y., Zhang, S., & Sun, D. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1471-y · Cited by 208 · see citing works

NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials

Sun, B., Wang, X., Ji, Z., Li, R., & Xia, T. (2012) · Small · doi:10.1002/smll.201201962 · Cited by 206 · see citing works

Development of NLRP3 Inflammasome Inhibitors

Blevins, H. (2022) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/wk7f-1g56

Cryopyrin: A Specific Activator of the Inflammasome

(2006) · Science s STKE · doi:10.1126/stke.3262006tw93

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

Jiang, H., He, H., Chen, Y., Huang, W., Cheng, J., Ye, J., Wang, A., Tao, J., Wang, C., Liu, Q., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171419 · Cited by 771 · see citing works

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and

Inflammasomes, A., Coll, R. C., & O’neill, L. A. J. (2011)

A natural product inhibitor of the NLRP3 inflammasome derived from Glycyrrhiza uralensis for the treatment of inflammatory diseases

Yang, G., Lee, H., Han, S., An, T.-J., Jang, J.-K., & Lee, J. Y. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.198.supp.138.3 · Cited by 3 · see citing works