The DOI matches its Crossref record; 124 of the 125 references it cites were found in a registry or an index.
Insights into Candida tropicalis nosocomial infections and virulence factors
Open accessAbstract
Candida tropicalis is considered the first or the second non-Candida albicans Candida (NCAC) species most frequently isolated from candidosis, mainly in patients admitted in intensive care units (ICUs), especially with cancer, requiring prolonged catheterization, or receiving broad-spectrum antibiotics. The proportion of candiduria and candidemia caused by C. tropicalis varies widely with geographical area and patient group. Actually, in certain countries, C. tropicalis is more prevalent, even compared with C. albicans or other NCAC species. Although prophylactic treatments with fluconazole cause a decrease in the frequency of candidosis caused by C. tropicalis, it is increasingly showing a moderate level of fluconazole resistance. The propensity of C. tropicalis for dissemination and the high mortality associated with its infections might be strongly related to the potential of virulence factors exhibited by this species, such as adhesion to different host surfaces, biofilm formation, infection and dissemination, and enzymes secretion. Therefore, the aim of this review is to outline the present knowledge on all the above-mentioned C. tropicalis virulence traits.
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“In addition to the high antifungal drugs resistance and inability to form hyphae or secret hydrolases, C. glabrata retain many virulence factors”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [39]
In the citing paper
“C. glabrata retain many virulence factors that contribute to its extreme aggressiveness and result in a low therapeutic response and serious recurrent candidiasis”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [39]
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1 retracted
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Metadata
- Authors
- Negri, M., Silva, S., Henriques, M., & Oliveira, R.
- Affiliations
- Institute for Biotechnology and Bioengineering (PT)
- Corresponding author
- Henriques, M.
- Venue
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2011-10-30
- Volume
- 31
- Issue
- 7
- Pages
- 1399-1412
- ISSN
- 0934-9723 (ISSN-L)
- 1435-4373
- OpenAlex
- W2105761493
- Cited by
- 132
- References
- 125
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 24 · 2022: 5 · 2021: 14 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 11 · 2016: 15 · 2015: 5 · 2014: 8 · 2013: 8 · 2012: 3
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Candida tropicalis, non-albicans Candida, nosocomial candidiasis, virulence factors, candidemia, candiduria, intensive care unit infections, fluconazole resistance, biofilm formation, adhesion, enzyme secretion, systemic candidiasis, antifungal prophylaxis
- MeSH terms
- Antifungal Agents, Candidiasis, Cross Infection, Humans, Fluconazole, Drug Resistance, Fungal, Virulence Factors, Candida tropicalis
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