Cited by 132Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

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Insights into Candida tropicalis nosocomial infections and virulence factors

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Negri, M., Silva, S., Henriques, M., Oliveira, R.·2012·European Journal of Clinical Microbiology & Infectious Diseases

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Abstract

Candida tropicalis is considered the first or the second non-Candida albicans Candida (NCAC) species most frequently isolated from candidosis, mainly in patients admitted in intensive care units (ICUs), especially with cancer, requiring prolonged catheterization, or receiving broad-spectrum antibiotics. The proportion of candiduria and candidemia caused by C. tropicalis varies widely with geographical area and patient group. Actually, in certain countries, C. tropicalis is more prevalent, even compared with C. albicans or other NCAC species. Although prophylactic treatments with fluconazole cause a decrease in the frequency of candidosis caused by C. tropicalis, it is increasingly showing a moderate level of fluconazole resistance. The propensity of C. tropicalis for dissemination and the high mortality associated with its infections might be strongly related to the potential of virulence factors exhibited by this species, such as adhesion to different host surfaces, biofilm formation, infection and dissemination, and enzymes secretion. Therefore, the aim of this review is to outline the present knowledge on all the above-mentioned C. tropicalis virulence traits.

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Authors: Negri, M., Silva, S., Henriques, M., & Oliveira, R.
Affiliations: Institute for Biotechnology and Bioengineering (PT)
Corresponding author: Henriques, M.
ORCID: Negri, M.
Silva, S.
Henriques, M.
Venue: European Journal of Clinical Microbiology & Infectious Diseases
Publisher: Springer Science and Business Media LLC
Published: 2011-10-30
Volume: 31
Issue: 7
Pages: 1399-1412
ISSN: 0934-9723 (ISSN-L)
1435-4373
DOI: 10.1007/s10096-011-1455-z
OpenAlex: W2105761493
Cited by: 132
References: 125
Citations by year: 2026: 3 · 2025: 8 · 2024: 7 · 2023: 24 · 2022: 5 · 2021: 14 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 11 · 2016: 15 · 2015: 5 · 2014: 8 · 2013: 8 · 2012: 3
FWCI: 4.06
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: Candida tropicalis, non-albicans Candida, nosocomial candidiasis, virulence factors, candidemia, candiduria, intensive care unit infections, fluconazole resistance, biofilm formation, adhesion, enzyme secretion, systemic candidiasis, antifungal prophylaxis
MeSH terms: Antifungal Agents, Candidiasis, Cross Infection, Humans, Fluconazole, Drug Resistance, Fungal, Virulence Factors, Candida tropicalis

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Insights into Candida tropicalis nosocomial infections and virulence factors

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