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Cited by 143Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.

Mechanism of Candida pathogenesis: revisiting the vital drivers

Mba, Ifeanyi Elibe, Nweze, Emeka Innocent·2020·European Journal of Clinical Microbiology & Infectious Diseases
DOI 10.1007/s10096-020-03912-w
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Abstract

Candida is the most implicated fungal pathogen in the clinical setting. Several factors play important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits, morphological and phenotypic switching, biofilm formation, tissue damaging extracellular hydrolytic enzymes, metabolic flexibility, genome plasticity, adaptation to environmental pH fluctuation, robust nutrient acquisition system, adherence and invasions (mediated by adhesins and invasins), heat shock proteins (HSPs), cytolytic proteins, escape from phagocytosis, evasion from host immune system, synergistic coaggregation with resident microbiota, resistance to antifungal agents, and the ability to efficiently respond to multiple stresses are some of the major pathogenic determinants of Candida species. The existence of multiple connections, in addition to the interactions and associations among all of these factors, are distinctive features that play important roles in the establishment of Candida infections. This review describes all the underlying factors and mechanisms involved in Candida pathogenesis by evaluating pathogenic determinants of Candida species. It reinforces the already available pool of data on the pathogenesis of Candida species by providing a clear and simplified understanding of the most important factors implicated in the pathogenesis of Candida species. The Candida pathogenesis network, an illustration linking all the major determinants of Candida pathogenesis, is also presented. Taken together, they will further improve our current understanding of how these factors modulate virulence and consequent infection(s). Development of new antifungal drugs and better therapeutic approaches to candidiasis can be achieved in the near future with continuing progress in the understanding of the mechanisms of Candida pathogenesis.

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Crossref · 10.1007/s10096-020-03912-w

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Research works printed but not linked: 8

  1. Correia A, Sampaio P, Vilanova M, Pais C (2015) Candida albicans: clinical relevance, pathogenesis, and host immunity. In: Sing SK (ed) Human emerging and re-emerging infections: viral and parasitic infections, vol 1. John Wiley and Sons, New Jersey, pp 926–952
  2. Kadosh D (2017) Morphogenesis in C. albicans. In: Prasad R (ed) Candida albicans: Cell Mol Biol. Springer, Cham
  3. Brown A, Haynes K, Gow N, Quinn J (2012) Stress responses in Candida, 2nd edn. ASM Press, Washington, D.C., pp 225–242
  4. Liu S, Liu W (2015) Components of the canclium-calcinerium signaling pathways in fungal cells and their potential as antifungal targets. Eukaryot Cell 14:4
  5. Shapiro RS, Uppuluri P, Zaas AK, Collins C, Senn H, Perfect JR et al (2009) Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis and drug resistance. PLoS ONE 7:e44734 · DOI · Paper page
  6. Sathiya T, Malar AS, Morthy K, Punitha T, Vinodhini R, Saranya AS (2015) Candida albicans and non albicans species: a study of biofilm production and putative virulence properties. JOHRP 4:164–175
  7. Jasim ST, Flayyih MT, Hassan A (2016) Isolation and identification of Candida spp. from different clinical specimens and study the virulence factors. World J Pharm Pharm Sci 3:121–137
  8. Bandana K, Jashandeep K, Jagdeep K (2018) Phospholipase in bacterial virulence and pathogenesis. Adv Biotechnol Microbiol 10:555798

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Metadata

Authors
Mba, I. E., & Nweze, E. I.
Affiliations
University of Nigeria (NG)
Corresponding author
Nweze, Emeka Innocent
ORCID
Venue
European Journal of Clinical Microbiology & Infectious Diseases
Publisher
Springer Science and Business Media LLC
Published
2020-05-06
Volume
39
Issue
10
Pages
1797-1819
ISSN
  • 0934-9723 (ISSN-L)
  • 1435-4373
DOI
10.1007/s10096-020-03912-w
OpenAlex
W3021920646
Semantic Scholar
9a873a14a817c1928242b4ff3aa7bdb3341fc8f7
Cited by
143
References
230
Citations by year
2026: 13 · 2025: 35 · 2024: 26 · 2023: 29 · 2022: 19 · 2021: 16 · 2020: 4
FWCI
0.80
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords
Candida, fungal pathogenesis, virulence factors, candidiasis, morphological switching, biofilm formation, extracellular hydrolytic enzymes, metabolic flexibility, genome plasticity, pH adaptation, nutrient acquisition, adhesins, invasin, heat shock proteins, cytolytic proteins, phagocytosis evasion, immune evasion, antifungal resistance, stress response
MeSH terms
Antifungal Agents, Candida, Candidiasis, Humans, Drug Resistance, Fungal, Virulence Factors

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