Sweat testing to evaluate autonomic function

Illigens, Ben M. W.; Gibbons, Christopher H.

doi:10.1007/s10286-008-0506-8

Cited by 255Peripheral Nerve DisordersSympathectomy and Hyperhidrosis TreatmentsPeripheral Neuropathies and Disorders

Sweat testing to evaluate autonomic function

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Illigens, Ben M. W., Gibbons, Christopher H.·2009·Clinical Autonomic Research

DOI 10.1007/s10286-008-0506-8PMC PMC3046462

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Abstract

Sudomotor dysfunction is common in many subtypes of neuropathy but is one of the earliest detectable neurophysiologic abnormalities in distal small fiber neuropathy. Clinical assessments of sudomotor function include thermoregulatory sweat testing (TST), quantitative sudomotor axon reflex testing (QSART), silicone impressions, the sympathetic skin response (SSR), the acetylcholine sweat-spot test and quantitative direct and indirect axon reflex testing (QDIRT). These testing techniques, when used in combination, can detect and localize pre- and postganglionic lesions, can provide early diagnosis of sudomotor dysfunction and can monitor disease progression or disease recovery. In this article, we describe many of the common clinical tests available for evaluation of sudomotor function with focus on the testing methodology and limitations while providing concrete examples of test results.

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Sweat testing has historically been used in applications ranging from medical diagnosis of cystic fibrosis and autonomic neuropathy to assessment of fluid and electrolyte balance in endurance athletes.
“Sweat testing has historically been used in applications ranging from medical diagnosis of cystic fibrosis and autonomic neuropathy to assessment of fluid and electrolyte balance in endurance athletes (6–10).”
From Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat (2019) · cites this paper as [7]
The Summary says sudomotor testing can help confirm autonomic dysfunction and detect distal small-fiber neuropathy. Our copy does not describe sweat testing for cystic fibrosis or for assessing fluid and electrolyte balance in endurance athletes; it lists hydration status as a factor that can alter test results, not as an assessment target. No page numbers are available in our copy. (LLM, conf=0.87)
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A NEW PROGNOSTIC CLASSIFICATION OF RECTAL CANCER
Jass, J. R., Love, S., & Northover, J. M. A. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90552-6 · Cited by 701 · see citing works
Sympathetic skin response--a method of assessing unmyelinated axon dysfunction in peripheral neuropathies.
Shahani, B. T., HALPERIN, J. J., Boulu, P., & Cohen, J. (1984) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.47.5.536 · Cited by 602 · see citing works
Quantitative sudomotor axon reflex test in normal and neuropathic subjects
Low, P. A., Caskey, P. E., Tuck, R. R., Fealey, R. D., & Dyck, P. J. B. (1983) · Annals of Neurology · doi:10.1002/ana.410140513 · Cited by 491 · see citing works
Sympathetic skin response
Vetrugno, R., Liguori, R., Cortelli, P., & Montagna, P. (2003) · Clinical Autonomic Research · doi:10.1007/s10286-003-0107-5 · Cited by 475 · see citing works
Acta Neurologica Belgica
(2013) · Acta Neurologica Belgica · doi:10.1007/13760.2240-2993 · Cited by 462 · see citing works
Sympathetic reflex latencies and conduction velocities in normal man
Fagius, J., & Wallin, B. G. (1980) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(80)90098-2 · Cited by 366 · see citing works
Thermoregulatory Sweating Abnormalities in Diabetes Mellitus
Fealey, R. D., Low, P. A., & Thomas, J. E. (1989) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65338-5 · Cited by 274 · see citing works
Testing the Autonomic Nervous System
Low, P. A. (2003) · Seminars in Neurology · doi:10.1055/s-2004-817725 · Cited by 241 · see citing works
Detection of small‐fiber neuropathy by sudomotor testing
Low, V. A., Sandroni, P., Fealey, R. D., & Low, P. A. (2006) · Muscle & Nerve · doi:10.1002/mus.20551 · Cited by 227 · see citing works
Clinical autonomic disorders : evaluation and management
Low, P. A. (1997) · Cited by 202 · see citing works
Polyvinyl siloxane impression materials: An update on clinical use
Mandikos, M. N. (1998) · Australian Dental Journal · doi:10.1111/j.1834-7819.1998.tb00204.x · Cited by 193 · see citing works
Peripheral autonomic surface potential
Knezevic, W., & Bajada, S. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90120-0 · Cited by 177 · see citing works
Clinical Autonomic Disorders: Evaluation and Management
Streeten, D. H. P. (1998) · Mayo Clinic Proceedings · doi:10.4065/73.11.1126-a · Cited by 169 · see citing works
Sympathetic skin response: normal results in different experimental conditions
Elie, B., & Guihéneuc, P. (1990) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(90)90020-k · Cited by 169 · see citing works
Hypothalamic mechanisms in thermoregulation.
Boulant, J. (1981) · PubMed · Cited by 166 · see citing works
Thermoregulation in spinal man
Guttmann, L., Silver, J., & Wyndham, C. H. (1958) · The Journal of Physiology · doi:10.1113/jphysiol.1958.sp006026 · Cited by 147 · see citing works
Regional and Individual Variations in the Function of the Human Eccrine Sweat Gland
Sato, K., & Dobson, R. L. (1970) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12259272 · Cited by 147 · see citing works
The sympathetic skin response: Normal values, elucidation of afferent components and application limits
Uncini, A., Pullman, S. L., Lovelace, R. E., & Gambi, D. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90254-7 · Cited by 145 · see citing works
Evaluation of sudomotor function
Low, P. A. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.01.023 · Cited by 143 · see citing works
Quantitation of the sweating deficiency in diabetes mellitus
Kennedy, W. R., Sakuta, M., Sutherland, D. E. R., & Goetz, F. C. (1984) · Annals of Neurology · doi:10.1002/ana.410150514 · Cited by 127 · see citing works
Autonomic surface potential analysis: Assessment of reproducibility and sensitivity
Hoeldtke, R. D., Davis, K. M., Hshieh, P., Gaspar, S. R., & Dworkin, G. E. (1992) · Muscle & Nerve · doi:10.1002/mus.880150810 · Cited by 93 · see citing works
THE PSYCHO-GALVANIC REFLEX: A PHARMACOLOGICAL STUDY OF THE PERIPHERAL MECHANISM
Lader, M., & Montagu, J. D. (1962) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.25.2.126 · Cited by 92 · see citing works
Combining skin conductance and forced choice in the detection of concealed information
Meijer, E. H., Smulders, F. T. Y., Johnston, J. E., & Merckelbach, H. L. G. J. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00543.x · Cited by 91 · see citing works
Under what conditions can human affective conditioning occur without contingency awareness? Test of the evaluative conditioning paradigm.
Dawson, M. E., Rissling, A. J., Schell, A. M., & Wilcox, R. R. (2007) · Emotion · doi:10.1037/1528-3542.7.4.755 · Cited by 87 · see citing works
Thermoregulation and Fever in Normal Persons and in Those With Spinal Cord Injuries
Schmidt, K. D., & CHAN, C. W. (1992) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)60394-2 · Cited by 87 · see citing works
RELATION OF ELECTRICAL PROPERTIES OF SKIN TO STRUCTURE AND PHYSIOLOGIC STATE
Edelberg, R. (1977) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12507771 · Cited by 85 · see citing works
QDIRT
Gibbons, C. H., Illigens, B. M. W., Centi, J., & Freeman, R. L. (2008) · Neurology · doi:10.1212/01.wnl.0000314646.49565.c0 · Cited by 67 · see citing works
Self-citation
Comparison of directly stimulated with axon‐reflex–mediated sudomotor responses in human subjects and in patients with diabetes
Kihara, M., Opfer‐Gehrking, T. L., & Low, P. A. (1993) · Muscle & Nerve · doi:10.1002/mus.880160612 · Cited by 62 · see citing works
Chronic idiopathic anhidrosis
Low, P. A., Fealey, R. D., Sheps, S. G., Su, W. P. D., Trautmann, J. C., & Kuntz, N. L. (1985) · Annals of Neurology · doi:10.1002/ana.410180312 · Cited by 58 · see citing works
ACETYLCHOLINE SWEATSPOT TEST FOR AUTONOMIC DENERVATION
Ryder, R. E. J., Johnson, K., Owens, D. R., Marshall, R., Ryder, A., & Tm, H. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92120-4 · Cited by 56 · see citing works
Sympathetic skin responses (SSRs) in monofocal brain lesions: topographical aspects of central sympathetic pathways
Linden, D., & Berlit, P. (1995) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1995.tb07023.x · Cited by 55 · see citing works
The sweating deficiency in diabetes mellitus
Kennedy, W. R., Sakuta, M., Sutherland, D. E. R., & Goetz, F. C. (1984) · Neurology · doi:10.1212/wnl.34.6.758 · Cited by 54 · see citing works
Sympathetic skin response differentiates hereditary sensory autonomic neuropathies III and IV
Hilz, M. J., Stemper, B., & Axelrod, F. B. (1999) · Neurology · doi:10.1212/wnl.52.8.1652 · Cited by 50 · see citing works
New silicones for the evaluation of sudomotor function with the impression mold technique
Vilches, J., & Navarro, X. (2002) · Clinical Autonomic Research · doi:10.1007/s102860200006 · Cited by 49 · see citing works
Splanchnic preganglionic neurons in man
Low, P. A., Okazaki, H., & Dyck, P. J. B. (1977) · Acta Neuropathologica · doi:10.1007/bf00688573 · Cited by 47 · see citing works
Chemically and electrically induced sweating and flare reaction
Namer, B., Bickel, A., Krämer, H., Birklein, F., & Schmelz, M. (2004) · Autonomic Neuroscience · doi:10.1016/j.autneu.2004.06.007 · Cited by 43 · see citing works
Differential impairment of the sudomotor and nociceptor axon‐reflex in diabetic peripheral neuropathy
Berghoff, M., Kilo, S., Hilz, M. J., & Freeman, R. L. (2006) · Muscle & Nerve · doi:10.1002/mus.20497 · Cited by 31 · see citing works
The evaluation of small fiber function—autonomic and quantitative sensory testing
Gibbons, C. H., & Freeman, R. L. (2004) · Neurologic Clinics · doi:10.1016/j.ncl.2004.03.002 · Cited by 29 · see citing works
Self-citation
Quantitative sweat testing using acetylcholine for direct and axon reflex mediated stimulation with silicone mold recording; controls versus neuropathic diabetics
Stewart, J. D., Nguyen, D. M., & Abrahamowicz, M. (1994) · Muscle & Nerve · doi:10.1002/mus.880171205 · Cited by 28 · see citing works
Splanchnic preganglionic neurons in man: II. Morphometry of myelinated fibers of T7 ventral spinal root
Low, P. A., & Dyck, P. J. (1977) · Acta Neuropathologica · doi:10.1007/bf00691957 · Cited by 25 · see citing works
III. Morphometry of Myelinated Fibers of Rami Communicantes
Low, P. A., & Dyck, P. J. B. (1978) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197811000-00002 · Cited by 21 · see citing works
Sympathetic skin response versus maximum motor and sensory conduction velocity to detect subclinical neuropathy in non-insulin-dependent diabetics.
Caccia, M. R., Dezuanni, E., SALVAGGIO, A., Osio, M., Bevilacqua, M. T., Norbiato, G., & Mangoni, A. (1991) · PubMed · Cited by 13 · see citing works
Peripheral autonomic surface potential: a quantitative technique for recording autonomic neural function in man.
Knezevic, W., & Bajada, S. (1985) · PubMed · Cited by 11 · see citing works

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Research works printed but not linked: 2

[9]Fealey RD Low PA Thomas JE Thermoregulatory sweating abnormalities in diabetes mellitus Mayo Clinic proceedings 1989 64 617 628 2747292
[11]Gibbons CH Illigens BM Centi J Freeman R QDIRT: quantitative direct and indirect test of sudomotor function Neurology 2008 70 2299 2304 18541883 PMC3046813

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Metzler‐Wilson, K., Sammons, D. L., Ossim, M. A., Metzger, N. R., Jurovcik, A. J., Krause, B. A., & Wilson, T. E. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.076547 · Cited by 35 · see citing works
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Luk, A. O. Y., Fu, W.-C., Li, X., Ozaki, R., Chung, H. H. Y., Wong, R. Y. M., So, W., Chow, F. C. C., & Chan, J. C. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134981 · Cited by 33 · see citing works
Structural and functional assessment of skin nerve fibres in small‐fibre pathology
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Campanati, A., Giuliodori, K., Martina, E., Giuliano, A., Ganzetti, G., & Offidani, A. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1074-1 · Cited by 26 · see citing works
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Brock, C., Brock, B., Pedersen, A. G., Drewes, A. M., Jessen, N., & Farmer, A. D. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i16.321 · Cited by 23 · see citing works
Assessment of cutaneous axon-reflex responses to evaluate functional integrity of autonomic small nerve fibers
Hijazi, M. M., Buchmann, S. J., Sedghi, A., Illigens, B. M. W., Reichmann, H., Schackert, G., & Siepmann, T. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04293-w · Cited by 23 · see citing works
Self-citation
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Yu, Q., Wu, J., Xiao, W., Zhao, C., Zhang, W., Chen, Y., Liu, Y., Liu, H., Zhou, J., Ding, L., et al. (2025) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2024.102389 · Cited by 21 · see citing works
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Osilla, E. V., Marsidi, J. L., & Sharma, S. (2019) · StatPearls · Cited by 21 · see citing works
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Lefaucheur, J. P. (2014) · Revue Neurologique · doi:10.1016/j.neurol.2014.10.008 · Cited by 20 · see citing works
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Maarek, A., Rao, G. H. R., & Gandhi, P. G. (2015) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s75857 · Cited by 22 · see citing works
Pilomotor function is impaired in patients with Parkinson's disease: A study of the adrenergic axon-reflex response and autonomic functions
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Self-citation
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Inukonda, S. M., Parambil, A. M., & Panda, S. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.147066 · Cited by 17 · see citing works
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Kornum, D. S., Bertoli, D., Kufaishi, H., Wegeberg, A., Okdahl, T., Mark, E. B., Høyer, K. L., Frøkjær, J. B., Brock, B., Krogh, K., et al. (2024) · Diabetologia · doi:10.1007/s00125-024-06129-0 · Cited by 17 · see citing works
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Cameron, A. E. P. (2016) · Thoracic surgery clinics/Thorac. surg. clin. · doi:10.1016/j.thorsurg.2016.06.004 · Cited by 17 · see citing works
Self-powered sensors for biomarker detection
Li, J., Xu, L., Zou, Y., & Li, Z. (2023) · Sensors & Diagnostics · doi:10.1039/d3sd00050h · Cited by 15 · see citing works
Age‐ and sex‐related differences in sudomotor function evaluated by the quantitative sudomotor axon reflex test ( QSART ) in healthy humans
Lee, J. B., Lee, I.-H., Shin, Y. O., Min, Y. K., & Yang, H. M. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12234 · Cited by 16 · see citing works
Abnormal modulation of electrodermal activity by thermoalgesic stimuli in patients with primary palmar hyperhidrosis
Schestatsky, P., Callejas, M. A., & Valls‐Solé, J. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.203687 · Cited by 16 · see citing works
Sex-Related Differences in Sudomotor Function in Healthy Early Twenties Focused on Activated Sweat Gland Density
Park, T.-H., Lee, J., Lee, H.-J., & Yun, B. (2020) · The Chinese Journal of Physiology · doi:10.4103/cjp.cjp_46_19 · Cited by 15 · see citing works
Regional Gastrointestinal Transit and Contractility Patterns Vary in Postural Orthostatic Tachycardia Syndrome (POTS)
Zhou, W., Zikos, T. A., Clarke, J. O., Nguyen, L. A. B., Triadafilopoulos, G., & Neshatian, L. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06808-z · Cited by 15 · see citing works
NGLY1 deficiency: a prospective natural history study
Tong-Starksen, S., Ventola, P. E., Frater, C. H., Klotz, J. M., Phillips, J. M., Muppidi, S., Dwight, S. S., Mueller, W. F., Beahm, B. J., Wilsey, M., et al. (2023) · Human Molecular Genetics · doi:10.1093/hmg/ddad106 · Cited by 15 · see citing works
Electrically induced quantitative sudomotor axon reflex test in human volunteers
Sommer, P., Kluschina, O., Schley, M. T., Namer, B., Schmelz, M., & Rukwied, R. (2010) · Autonomic Neuroscience · doi:10.1016/j.autneu.2010.09.004 · Cited by 15 · see citing works
Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson’s Disease (CAPTURE PD): Protocol for a Multicenter Study
Siepmann, T. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00212 · Cited by 15 · see citing works
Thermoregulation in neuropathies
Fealey, R. D. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64074-1.00048-3 · Cited by 15 · see citing works
Abnormal sweating patterns associated with itching, burning and tingling of the skin indicate possible underlying small-fibre neuropathy
Flores, S. J., Davis, M. D. P., Pittelkow, M. R., Sandroni, P., Weaver, A. L., & Fealey, R. D. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13576 · Cited by 14 · see citing works
Sweat output measurement of the post-ganglion sudomotor response by Q-Sweat Test: a normative database of Chinese individuals
Chen, S.-F., Chang, Y., Lu, C., Huang, C., Tsai, N.-W., Chang, C., Huang, C., Chuang, Y., & Chang, W. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-62 · Cited by 14 · see citing works
From Sudoscan to bedside: theory, modalities, and application of electrochemical skin conductance in medical diagnostics
Vittrant, B., Ayoub, H., & Brunswick, P. (2024) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2024.1454095 · Cited by 16 · see citing works
A device to measure secretion of individual sweat glands for diagnosis of peripheral neuropathy
Loavenbruck, A. J., Hodges, J. S., Provitera, V., Nolano, M., Wendelschafer‐Crabb, G., & Kennedy, W. R. (2017) · Journal of the Peripheral Nervous System · doi:10.1111/jns.12212 · Cited by 13 · see citing works

Authors: Illigens, B. M. W., & Gibbons, C. H.
Affiliations: Beth Israel Deaconess Medical Center (US)
ORCID: Gibbons, Christopher H.
Venue: Clinical Autonomic Research
Publisher: Springer Science and Business Media LLC
Published: 2008-11-06
Volume: 19
Issue: 2
Pages: 79-87
ISSN: 0959-9851 (ISSN-L)
1619-1560
DOI: 10.1007/s10286-008-0506-8
PMC: PMC3046462
OpenAlex: W2155748720
Cited by: 255
References: 43
Citations by year: 2026: 10 · 2025: 15 · 2024: 20 · 2023: 31 · 2022: 18 · 2021: 20 · 2020: 16 · 2019: 16 · 2018: 11 · 2017: 18 · 2016: 18 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 9
FWCI: 0.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Clinical Autonomic Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (K23NS050209)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
Health Sciences › Medicine › Physiology › Sympathectomy and Hyperhidrosis Treatments
Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords: sweat test, sudomotor dysfunction, autonomic function, thermoregulatory sweat test, sympathetic skin response, small fiber neuropathy, disease progression monitoring
MeSH terms: Acetylcholine, Diagnostic Techniques, Neurological, Humans, Peripheral Nervous System Diseases, Reflex, Sweat, Sweating

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