Sweat testing to evaluate autonomic function

Illigens, Ben M. W.; Gibbons, Christopher H.

doi:10.1007/s10286-008-0506-8

Cited by 255Peripheral Nerve DisordersSympathectomy and Hyperhidrosis TreatmentsPeripheral Neuropathies and Disorders

Sweat testing to evaluate autonomic function

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Illigens, Ben M. W., Gibbons, Christopher H.·2009·Clinical Autonomic Research

DOI 10.1007/s10286-008-0506-8PMC PMC3046462

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Abstract

Sudomotor dysfunction is common in many subtypes of neuropathy but is one of the earliest detectable neurophysiologic abnormalities in distal small fiber neuropathy. Clinical assessments of sudomotor function include thermoregulatory sweat testing (TST), quantitative sudomotor axon reflex testing (QSART), silicone impressions, the sympathetic skin response (SSR), the acetylcholine sweat-spot test and quantitative direct and indirect axon reflex testing (QDIRT). These testing techniques, when used in combination, can detect and localize pre- and postganglionic lesions, can provide early diagnosis of sudomotor dysfunction and can monitor disease progression or disease recovery. In this article, we describe many of the common clinical tests available for evaluation of sudomotor function with focus on the testing methodology and limitations while providing concrete examples of test results.

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Sweat testing has historically been used in applications ranging from medical diagnosis of cystic fibrosis and autonomic neuropathy to assessment of fluid and electrolyte balance in endurance athletes.
“Sweat testing has historically been used in applications ranging from medical diagnosis of cystic fibrosis and autonomic neuropathy to assessment of fluid and electrolyte balance in endurance athletes (6–10).”
From Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat (2019) · cites this paper as [7]
The Summary says sudomotor testing can help confirm autonomic dysfunction and detect distal small-fiber neuropathy. Our copy does not describe sweat testing for cystic fibrosis or for assessing fluid and electrolyte balance in endurance athletes; it lists hydration status as a factor that can alter test results, not as an assessment target. No page numbers are available in our copy. (LLM, conf=0.87)
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Research works printed but not linked: 2

[9]Fealey RD Low PA Thomas JE Thermoregulatory sweating abnormalities in diabetes mellitus Mayo Clinic proceedings 1989 64 617 628 2747292
[11]Gibbons CH Illigens BM Centi J Freeman R QDIRT: quantitative direct and indirect test of sudomotor function Neurology 2008 70 2299 2304 18541883 PMC3046813

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Authors: Illigens, B. M. W., & Gibbons, C. H.
Affiliations: Beth Israel Deaconess Medical Center (US)
ORCID: Gibbons, Christopher H.
Venue: Clinical Autonomic Research
Publisher: Springer Science and Business Media LLC
Published: 2008-11-06
Volume: 19
Issue: 2
Pages: 79-87
ISSN: 0959-9851 (ISSN-L)
1619-1560
DOI: 10.1007/s10286-008-0506-8
PMC: PMC3046462
OpenAlex: W2155748720
Cited by: 255
References: 43
Citations by year: 2026: 10 · 2025: 15 · 2024: 20 · 2023: 31 · 2022: 18 · 2021: 20 · 2020: 16 · 2019: 16 · 2018: 11 · 2017: 18 · 2016: 18 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 9
FWCI: 0.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Clinical Autonomic Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (K23NS050209)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
Health Sciences › Medicine › Physiology › Sympathectomy and Hyperhidrosis Treatments
Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords: sweat test, sudomotor dysfunction, autonomic function, thermoregulatory sweat test, sympathetic skin response, small fiber neuropathy, disease progression monitoring
MeSH terms: Acetylcholine, Diagnostic Techniques, Neurological, Humans, Peripheral Nervous System Diseases, Reflex, Sweat, Sweating

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