The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Magnetic Nanoparticle Targeted Hyperthermia of Cutaneous Staphylococcus aureus Infection
Open accessAbstract
The incidence of wound infections that do not adequately respond to standard-of-care antimicrobial treatment has been increasing. To address this challenge, a novel antimicrobial magnetic thermotherapy platform has been developed in which a high-amplitude, high-frequency, alternating magnetic field is used to rapidly heat magnetic nanoparticles that are bound to Staphylococcus aureus (S. aureus). The antimicrobial efficacy of this platform was evaluated in the treatment of both an in vitro culture model of S. aureus biofilm and a mouse model of cutaneous S. aureus infection. We demonstrated that an antibody-targeted magnetic nanoparticle bound to S. aureus was effective at thermally inactivating S. aureus and achieving accelerated wound healing without causing tissue injury.
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“Local injection of anti-protein A-functionalized nanoparticles was observed to be nearly twice as effective at killing S. aureus in murine cutaneous infection models compared with the control 57 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [57]
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“Binding of the antibody-functionalized nanoparticles to cultures of S. aureus was quantified by flow cytometry and demonstrated a 2.5-fold increase in binding compared with the IgG-coated nanoparticles.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [57]
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Metadata
- Authors
- Kim, M.-H., Yamayoshi, I., Mathew, S., Lin, H., Nayfach, J., & Simon, S. I.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Simon, Scott I.
- Venue
- Annals of Biomedical Engineering
- Published
- 2012-11-13
- Volume
- 41
- Issue
- 3
- Pages
- 598-609
- ISSN
- 0090-6964 (ISSN-L)
- 1573-9686
- PMC
- PMC3740557
- OpenAlex
- W2093770231
- Cited by
- 135
- References
- 53
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 11 · 2023: 11 · 2022: 12 · 2021: 10 · 2020: 18 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 16 · 2015: 10 · 2014: 3 · 2013: 3
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Annals of Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- University of California, Davis
- National Cancer Institute (P30CA093373)
- National Institute of Allergy and Infectious Diseases (AI47294, R01AI047294)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Keywords
- magnetic nanoparticles, magnetic hyperthermia, Staphylococcus aureus, skin infections, biofilm, antibody-targeted nanoparticles, antimicrobial therapy, wound healing, alternating magnetic field, mouse model
- MeSH terms
- Animals, Antibodies, Bacterial, Biomedical Engineering, Female, Hyperthermia, Induced, Mice, Inbred C57BL, Mice, Transgenic, Staphylococcal Protein A, Staphylococcal Skin Infections, Staphylococcus aureus, Wound Infection, Biofilms, Mice, Magnetic Field Therapy, Antibodies, Immobilized, Magnetite Nanoparticles
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