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Magnetic Nanoparticle Targeted Hyperthermia of Cutaneous Staphylococcus aureus Infection
Open accessAbstract
The incidence of wound infections that do not adequately respond to standard-of-care antimicrobial treatment has been increasing. To address this challenge, a novel antimicrobial magnetic thermotherapy platform has been developed in which a high-amplitude, high-frequency, alternating magnetic field is used to rapidly heat magnetic nanoparticles that are bound to Staphylococcus aureus (S. aureus). The antimicrobial efficacy of this platform was evaluated in the treatment of both an in vitro culture model of S. aureus biofilm and a mouse model of cutaneous S. aureus infection. We demonstrated that an antibody-targeted magnetic nanoparticle bound to S. aureus was effective at thermally inactivating S. aureus and achieving accelerated wound healing without causing tissue injury.
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“Local injection of anti-protein A-functionalized nanoparticles was observed to be nearly twice as effective at killing S. aureus in murine cutaneous infection models compared with the control 57 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [57]
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“Binding of the antibody-functionalized nanoparticles to cultures of S. aureus was quantified by flow cytometry and demonstrated a 2.5-fold increase in binding compared with the IgG-coated nanoparticles.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [57]
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Cites
Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
Donlan, R. M., & Costerton, J. W. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.167-193.2002 · Cited by 6,644
Applications of magnetic nanoparticles in biomedicine
Pankhurst, Q. A., Connolly, J., Jones, S. K., & Dobson, J. (2003) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/36/13/201 · Cited by 5,974
Liu, C., Bayer, A. S., Cosgrove, S. E., Daum, R. S., Fridkin, S. K., Gorwitz, R. J., Kaplan, S. L., Karchmer, A. W., Levine, D. P., Murray, B. E., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq146 · Cited by 4,260
Understanding biofilm resistance to antibacterial agents
Davies, D. G. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1008 · Cited by 2,786
Applications of Magnetic Nanoparticles in Biomedicine
Bárcena, C., Sra, A. K., & Gao, J. (2009) · Springer eBooks · doi:10.1007/978-0-387-85600-1_20 · Cited by 2,571
Bacterial Biofilms: An Emerging Link to Disease Pathogenesis
Parsek, M. R., & Singh, P. K. (2003) · Annual Review of Microbiology · doi:10.1146/annurev.micro.57.030502.090720 · Cited by 1,597
Exchange-coupled magnetic nanoparticles for efficient heat induction
Lee, J., Jang, J.-T., Choi, J., Moon, S. H., Noh, S.-H., Kim, J.-W., Kim, J., Kim, I., Park, K. I., & Cheon, J. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.95 · Cited by 1,365
Immune evasion by staphylococci
Foster, T. J. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1289 · Cited by 1,214
Edwards, R., & Harding, K. G. (2004) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200404000-00004 · Cited by 1,099
Why chronic wounds will not heal: a novel hypothesis
Bjarnsholt, T., Kirketerp‐Møller, K., Jensen, P. Ø., Madsen, K. G., Phipps, R. K., Krogfelt, K. A., Høiby, N., & Givskov, M. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00283.x · Cited by 886
Maier-Hauff, K., Rothe, R., Scholz, R., Gneveckow, U., Wust, P., Thiesen, B., Feussner, A., von Deimling, A., Waldöfner, N., Felix, R., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9195-0 · Cited by 772
Faust, N., Varas, F., Kelly, L. M., Heck, S., & Graf, T. (2000) · Blood · doi:10.1182/blood.v96.2.719 · Cited by 751
Biodistribution, Clearance, and Biocompatibility of Iron Oxide Magnetic Nanoparticles in Rats
Jain, T. K., Reddy, M. K., Morales, M. A., Leslie‐Pelecky, D. L., & Labhasetwar, V. D. (2008) · Molecular Pharmaceutics · doi:10.1021/mp7001285 · Cited by 709
Fonder, M. A., Lazarus, G. S., Cowan, D. A., Aronson-Cook, B., Kohli, A. R., & Mamelak, A. J. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.08.048 · Cited by 689
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice
Cho, J. S., Pietras, E. M., Garcia, N. C., Ramos, R. I., Farzam, D. M., Monroe, H. R., Magorien, J. E., Blauvelt, A., Kolls, J. K., Cheung, A. L., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40891 · Cited by 658
Nanomaterials for targeted detection and photothermal killing of bacteria
Ray, P. C., Khan, S. A., Singh, A. K., Senapati, D., & Fan, Z. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15340h · Cited by 483
Dowd, S. E., Wolcott, R. D., Sun, Y., McKeehan, T., Smith, E., & Rhoads, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003326 · Cited by 481
The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma
Jordan, A., Scholz, R., Maier-Hauff, K., van Landeghem, F. K. H., Waldoefner, N., Teichgraeber, U., Pinkernelle, J., Bruhn, H., Neumann, F., Thiesen, B., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-9059-z · Cited by 459
Miller, L. S., O’Connell, R. M., Gutiérrez, M. Á., Pietras, E. M., Shahangian, A., Gross, C. E., Thirumala, A., Cheung, A. L., Cheng, G., & Modlin, R. L. (2006) · Immunity · doi:10.1016/j.immuni.2005.11.011 · Cited by 353
Looking for Chinks in the Armor of Bacterial Biofilms
Monroe, D. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050307 · Cited by 342
Kim, M. H., Liu, W., Borjesson, D. L., CURRY, F. E., Miller, L. S., Cheung, A. L., Liu, F., Isseroff, R. R., & Simon, S. I. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701223 · Cited by 283
Self-citationLimits of localized heating by electromagnetically excited nanoparticles
Keblinski, P., Cahill, D. G., Bodapati, A., Sullivan, C. R., & Taton, T. A. (2006) · Journal of Applied Physics · doi:10.1063/1.2335783 · Cited by 281
Staphylococcal innate immune evasion
Rooijakkers, S. H. M., van Kessel, K. P. M., & van Strijp, J. A. G. (2005) · Trends in Microbiology · doi:10.1016/j.tim.2005.10.002 · Cited by 267
Antibiotic susceptibility assay for Staphylococcus aureus in biofilms developed in vitro
Amorena, B., Gracia, E., Monzón, M., Leiva, J., Oteiza, C., Pérez, M. M., Alabart, J. L., & Hernández-Yago, J. (1999) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/44.1.43 · Cited by 247
Bernthal, N. M., Stavrakis, A. I., Billi, F., Cho, J. S., Kremen, T. J., Simon, S. I., Cheung, A. L., Finerman, G. A. M., Lieberman, J. R., Adams, J. S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012580 · Cited by 216
Self-citationDynamics in the mixed microbial concoursePreprint
Wintermute, E. H., & Silver, P. A. (2010) · Genes & Development · doi:10.1101/gad.1985210 · Cited by 196
In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent
Zolfaghari, P., Packer, S., Singer, M., Nair, S. P., Bennett, J. H., Street, C. N., & Wilson, M. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-27 · Cited by 195
Ivkov, R., DeNardo, S. J., Daum, W., Foreman, A. R., Goldstein, R. C., Nemkov, V. S., & DeNardo, G. L. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1004-0016 · Cited by 187
Photodynamic therapy for Staphylococcus aureus infected burn wounds in mice
Lambrechts, S. A. G., Demidova, T. N., Aalders, M. C. G., Hasan, T. G., & Hamblin, M. R. (2005) · Photochemical & Photobiological Sciences · doi:10.1039/b502125a · Cited by 182
Progress Toward a Staphylococcus aureus Vaccine
Daum, R. S., & Spellberg, B. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cir828 · Cited by 165
The importance of a multifaceted approach to characterizing the microbial flora of chronic wounds
Han, A., Zenilman, J. M., Melendez, J. H., Shirtliff, M. E., Agostinho, A. M., James, G. A., Stewart, P. S., Mongodin, E. F., Rao, D., Rickard, A. H., et al. (2011) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2011.00720.x · Cited by 163
Poto, A. D., Sbarra, M. S., Provenza, G., Visai, L., & Speziale, P. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.038 · Cited by 162
Staphylococcus aureus among insulin-injecting diabetic patients. An increased carrier rate
Tuazon, C. U. (1975) · JAMA · doi:10.1001/jama.231.12.1272 · Cited by 147
Bordelon, D. E., Cornejo, C., Grüttner, C., Westphal, F., DeWeese, T. L., & Ivkov, R. (2011) · Journal of Applied Physics · doi:10.1063/1.3597820 · Cited by 142
Carboxylic acid-stabilised iron oxide nanoparticles for use in magnetic hyperthermia
Thomas, L. A., Dekker, L., Kallumadil, M., Southern, P., Wilson, M., Nair, S. P., Pankhurst, Q. A., & Parkin, I. P. (2009) · Journal of Materials Chemistry · doi:10.1039/b908187a · Cited by 139
Ultrasonic enhancement of antibiotic action on gram-negative bacteria
Pitt, W. G., McBride, M. O., Lunceford, J. K., Roper, R. J., & Sagers, R. D. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.11.2577 · Cited by 135
Kim, M. H., Granick, J. L., Kwok, C., Walker, N. J., Borjesson, D. L., CURRY, F. E., Miller, L. S., & Simon, S. I. (2011) · Blood · doi:10.1182/blood-2010-07-296970 · Cited by 120
Self-citationA Radio Frequency Electric Current Enhances Antibiotic Efficacy against Bacterial Biofilms
Caubet, R., Pedarros-Caubet, F., Chu, M., Freye, E., Rodrigues, M. D. B., Moreau, J. M., & Ellison, W. J. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.12.4662-4664.2004 · Cited by 112
Ensing, G. T., Roeder, B. L., Nelson, J. L., Horn, J. R., der Mei, H. C., Busscher, H. J., & Pitt, W. G. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02643.x · Cited by 79
Bacterial avoidance of phagocytosis
Celli, J., & Finlay, B. B. (2002) · Trends in Microbiology · doi:10.1016/s0966-842x(02)02343-0 · Cited by 77
Kennedy, J., Blair, I., McDowell, D. A., & Bolton, D. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02697.x · Cited by 77
van der Borden, A. J., Maathuis, P. G. M., Engels, E., Rakhorst, G., van der Mei, H. C., Busscher, H. J., & Sharma, P. K. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.01.001 · Cited by 77
The safety and efficacy of ferumoxytol therapy in anemic chronic kidney disease patients
Spinowitz, B., Schwenk, M. H., Jacobs, P. M., Bolton, W. K., Kaplan, M. R., Charytan, C., & Galler, M. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00598.x · Cited by 74
Cho, J. S., Zussman, J., Donegan, N. P., Ramos, R. I., Garcia, N. C., Uslan, D. Z., Iwakura, Y., Simon, S. I., Cheung, A. L., Modlin, R. L., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.417 · Cited by 72
Self-citationNASAL CARRIAGE OF STAPHYLOCOCCUS AUREUS IN DIABETES MELLITUS
Smith, J. A., O'Connor, J. J., & Willis, A. T. (1966) · The Lancet · doi:10.1016/s0140-6736(66)90367-9 · Cited by 64
Luciani, N., Wilhelm, C., & Gazeau, F. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.062 · Cited by 60
Hassani, M., Cebrián, G., Mañas, P., Condón, S., & Pagán, R. (2006) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2006.02014.x · Cited by 45
Kennedy, C. A., & O’Gara, J. P. (2004) · Journal of Medical Microbiology · doi:10.1099/jmm.0.45764-0 · Cited by 44
Giladi, M., Porat, Y., Blatt, A., Shmueli, E., Wasserman, Y., Kirson, E. D., & Palti, Y. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01841-09 · Cited by 41
Cebrián, G., Raso, J., Condón, S., & Mañas, P. (2011) · Food Control · doi:10.1016/j.foodcont.2011.10.048 · Cited by 34
Local Arterial Infusion of Superparamagnetic Iron Oxide Particles in Hepatocellular Carcinoma
Dudeck, O., Bogusiewicz, K., Pinkernelle, J., Gaffke, G., Pech, M., Wieners, G., Bruhn, H., Jordan, A., & Ricke, J. (2006) · Investigative Radiology · doi:10.1097/01.rli.0000209601.15533.5a · Cited by 25
Antibiotic resistance and topical treatment.
(1978) · BMJ · doi:10.1136/bmj.2.6138.649 · Cited by 15
Dana, B., & Gannot, I. (2012) · Journal of Atomic Molecular and Optical Physics · doi:10.1155/2012/135708 · Cited by 5
Electromagnetism, nanotechnologies and biology: New challenges and opportunities
Bucci, O. M. (2010) · URSI International Symposium on Electromagnetic Theory · doi:10.1109/ursi-emts.2010.5637237 · Cited by 1
Research works printed but not linked: 1
- American Diabetes Association. Consensus development conference on diabetic foot wound care: 7–8, April 1999, Boston, Massachusetts. Diabetes Care 22(1354):1360, 1999.
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Antimicrobial Metal Nanomaterials: From Passive to Stimuli‐Activated Applications
Cheeseman, S., Christofferson, A. J., Kariuki, R., Cozzolino, D., Daeneke, T., Crawford, R. J., Truong, V. K., Chapman, J., & Elbourne, A. J. (2020) · Advanced Science · doi:10.1002/advs.201902913 · Cited by 346
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Yang, Y., He, P., Wang, Y., Bai, H., Wang, S., Xu, J., & Zhang, X. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201708971 · Cited by 311
Ramasamy, M., & Lee, J. (2016) · BioMed Research International · doi:10.1155/2016/1851242 · Cited by 285
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Metadata
- Authors
- Kim, M.-H., Yamayoshi, I., Mathew, S., Lin, H., Nayfach, J., & Simon, S. I.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Simon, Scott I.
- Venue
- Annals of Biomedical Engineering
- Published
- 2012-11-13
- Volume
- 41
- Issue
- 3
- Pages
- 598-609
- ISSN
- 0090-6964 (ISSN-L)
- 1573-9686
- PMC
- PMC3740557
- OpenAlex
- W2093770231
- Cited by
- 135
- References
- 53
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 11 · 2023: 11 · 2022: 12 · 2021: 10 · 2020: 18 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 16 · 2015: 10 · 2014: 3 · 2013: 3
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Annals of Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- University of California, Davis
- National Cancer Institute (P30CA093373)
- National Institute of Allergy and Infectious Diseases (AI47294, R01AI047294)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Keywords
- magnetic nanoparticles, magnetic hyperthermia, Staphylococcus aureus, skin infections, biofilm, antibody-targeted nanoparticles, antimicrobial therapy, wound healing, alternating magnetic field, mouse model
- MeSH terms
- Animals, Antibodies, Bacterial, Biomedical Engineering, Female, Hyperthermia, Induced, Mice, Inbred C57BL, Mice, Transgenic, Staphylococcal Protein A, Staphylococcal Skin Infections, Staphylococcus aureus, Wound Infection, Biofilms, Mice, Magnetic Field Therapy, Antibodies, Immobilized, Magnetite Nanoparticles
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