The Influence of Hormonal Contraception on Mood and Sexual Interest among Adolescents
Open accessAbstract
Mood and sexual interest changes are commonly cited reasons for discontinuing hormonal contraceptives. Data, however, are inconsistent and limited to adult users. We examined associations of hormonal contraceptive use with mood and sexual interest among adolescents. We recruited 14-17-year-old women from primary care clinics and followed them longitudinally for up to 41 months. Participants completed face-to-face interviews quarterly and two 12-week periods of daily diary collection per year. On daily diaries, participants recorded positive mood, negative mood, and sexual interest. We classified 12-week diary periods as "stable OCP use," "non-use," "initiated use," "stopped use," and "DMPA use" based on self-report of oral contraceptive pill (OCP) use and depot medroxyprogesterone acetate (DMPA) use from medical charts. Diary periods were the unit of analysis. Participants could contribute more than one diary period. We analyzed data using linear models with a random intercept and slope across weeks in a diary period, an effect for contraceptive group, and an adjustment for age at the start of a diary period. Mean weekly positive mood was higher in diary periods characterized by stable OCP use, compared to other groups. Mean weekly negative mood was lower in diary periods characterized by stable OCP use and higher in periods characterized by DMPA use. Periods characterized by stable OCP use additionally showed less mood variation than other groups. Changes in mood among adolescent hormonal contraceptive users differed from those anticipated for adult users. Attention to adolescent-specific changes in mood and sexual interest may improve contraceptive adherence.
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A review of early studies is consistent with the intuition that OC users, especially users of monophasic pills, show less affective variability than NC women, and recent research is generally consistent.
“A review of early studies is consistent with the intuition that OC users, especially users of monophasic pills, show less affective variability than NC women44, and recent research is generally consistent35,42,45,46.”
From Little evidence for sex or ovarian hormone influences on affective variability (2021) · cites this paper as [46]
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- Authors
- Ott, M. A., Shew, M. L., Ofner, S., Tu, W., & Fortenberry, J. D.
- Affiliations
- Indiana University Indianapolis (US)
- Corresponding author
- Ott, Mary A.
- Venue
- Archives of Sexual Behavior
- Published
- 2008-02-21
- Volume
- 37
- Issue
- 4
- Pages
- 605-613
- ISSN
- 0004-0002 (ISSN-L)
- 1573-2800
- PMC
- PMC3020653
- OpenAlex
- W1996774277
- Semantic Scholar
- 26adada26bc691400994f36984abc01d5bd6f17a
- Cited by
- 63
- References
- 35
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 6 · 2018: 1 · 2017: 2 · 2016: 8 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Sexual Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD049444)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Health Professions › General Health Professions › Adolescent Sexual and Reproductive Health
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- hormonal contraception, adolescents, mood, sexual interest, oral contraceptives, depot medroxyprogesterone acetate, contraceptive discontinuation, contraceptive adherence, mood variability
- MeSH terms
- Adolescent, Affect, Arousal, Contraceptive Agents, Female, Contraceptives, Oral, Hormonal, Delayed-Action Preparations, Female, Humans, Libido, Longitudinal Studies, Sexual Behavior, Cohort Studies, Linear Models, Medroxyprogesterone Acetate
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