Impairment of Energy-Dependent Processes in the Muscle Tissue as a Pathogenetic Mechanism of Statin-Induced Myopathy
Abstract
Administration of simvastatin was followed by a decrease in activities of superoxide dismutase and cytochrome oxidase in rat mitochondria, which attested to dysfunction of the respiratory chain. The decrease in total ATPase and Ca 2+-ATPase activities in muscle tissue homogenates reflected impaired transport of active cations essential for muscle contraction. We conclude that abnormal relationships in the system of energy synthetic and energy-dependent processes in myocytes serve as the molecular basis for the formation of statin-induced degenerative changes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Decreased CoQ10 levels disturb mitochondrial electron transport, resulting in limited ATP synthase activity and impaired energy metabolism and mitochondrial dysfunction.
“Decreased CoQ10 levels are considered to disturb the mitochondrial electron transport, resulting in a limited adenosine triphosphate (ATP) synthase activity and thus leading to an impaired energy metabolism and mitochondrial dysfunction.(16,18,19)”
From Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysis (2025) · cites this paper as [18]
Reduction of circulating or intramuscular CoQ10 after statin treatment decreased the phosphorylation potential of adenosine diphosphate and the activity of mitochondrial complex I and IV, contributing to mitochondrial dysfunction.
“The studies performed by Liu et al revealed that the reduction of circulating/intramuscular CoQ10 after statin treatment decreased the phosphorylation potential of adenosine diphosphate and the activity of mitochondrial complex I and IV, which contributes to mitochondrial dysfunction.31, 32, 33, 34”
From Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials (2018) · cites this paper as [33]
Cites
Effect of Statins on Skeletal Muscle
Parker, B. A., & Thompson, P. D. (2012) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31826c169e · Cited by 122 · see citing works
Muscle mitochondrial metabolism and calcium signaling impairment in patients treated with statins
Sirvent, P., Fabre, O., Bordenave, S., Hillaire-Buys, D., Raynaud De Mauverger, E., Lacampagne, A., & Mercier, J. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.01.008 · Cited by 90 · see citing works
Muscular effects of statins in the elderly female: a review
Schneider, E. B., Bhardwaj, & Selvarajah, S. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s29686 · Cited by 89 · see citing works
Muraki, A., Miyashita, K., Mitsuishi, M., Tamaki, M., Tanaka, K., & Itoh, H. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01362.2011 · Cited by 80 · see citing works
Lankin, V. Z., Tikhaze, A. K., Kukharchuk, V. V., Георгиевна, К. Г., Pisarenko, O. I., Каминный, А. И., Шумаев, К. Б., & Belenkov, Y. N. (2003) · Springer eBooks · doi:10.1007/978-1-4419-9236-9_17 · Cited by 47 · see citing works
Lankin, V. Z., Tikhaze, A. K., Kukharchuk, V. V., Георгиевна, К. Г., Pisarenko, O. I., Каминный, А. И., Шумаев, К. Б., & Belenkov, Y. N. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024742907379 · Cited by 38 · see citing works
Kumar, A., Vashist, A., Kumar, P., et al. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70930-1 · Cited by 36 · see citing works
A randomized trial of coenzyme Q10 in patients with statin myopathy: Rationale and study design
Parker, B. A., Gregory, S. M., Lorson, L., Polk, D. M., White, C. M., & Thompson, P. D. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.02.002 · Cited by 33 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Qu, H., Guo, M., Chai, H., Wang, W., Gao, Z., & Shi, D. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009835 · Cited by 178 · see citing works
Derosa, G., D'Angelo, A., & Maffioli, P. (2019) · Drug Design, Development and Therapy · doi:10.2147/dddt.s223153 · Cited by 44 · see citing works
Kovacic, S., Habicht, S. D., & Eckert, G. P. (2025) · Journal of Nutritional Science · doi:10.1017/jns.2025.10043 · Cited by 4 · see citing works
“(16,18,19) Mitochondrial dysfunction in muscle cells can lead to altered biochemical parameters such as a higher lactate to pyruvate ratio (L/P ratio), but also to development of myopathic symptoms.”
- Authors
- Mikashinovich, Z. I., Belousova, E. S., & Sarkisyan, O. G.
- Affiliations
- Rostov State Medical University (RU)
- Venue
- Bulletin of Experimental Biology and Medicine
- Published
- 2017-02
- Volume
- 162
- Issue
- 4
- Pages
- 433-435
- ISSN
- 0007-4888 (ISSN-L)
- 1573-8221
- OpenAlex
- W2590735958
- Cited by
- 16
- References
- 8
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 3
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bulletin of Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Keywords
- statin-induced myopathy, simvastatin, mitochondrial dysfunction, electron transport chain, superoxide dismutase, cytochrome c oxidase, ATPase, Ca2+-ATPase, muscle contraction, energy metabolism
- MeSH terms
- Animals, Anticholesteremic Agents, Electron Transport Complex IV, Electron Transport, Male, Mitochondria, Muscle Contraction, Muscular Diseases, Oxidative Phosphorylation, Superoxide Dismutase, Muscle, Skeletal, Simvastatin, Animals, Outbred Strains, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
