Muscle mitochondrial metabolism and calcium signaling impairment in patients treated with statins
Abstract
The most common and problematic side effect of statins is myopathy. To date, the patho-physiological mechanisms of statin myotoxicity are still not clearly understood. In previous studies, we showed that acute application in vitro of simvastatin caused impairment of mitochondrial function and dysfunction of calcium homeostasis in human and rat healthy muscle samples. We thus evaluated in the present study, mitochondrial function and calcium signaling in muscles of patients treated with statins, who present or not muscle symptoms, by oxygraphy and recording of calcium sparks, respectively. Patients treated with statins showed impairment of mitochondrial respiration that involved mainly the complex I of the respiratory chain and altered frequency and amplitude of calcium sparks. The muscle problems observed in statin-treated patients appear thus to be related to impairment of mitochondrial function and muscle calcium homeostasis, confirming the results we previously reported in vitro.
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A prior study's groups were not matched for VO2max, which is problematic because exercise training strongly stimulates mitochondrial biogenesis and unmeasured mitochondrial content differences would affect respiration results.
“However, the study groups were not matched for maximal oxygen uptake (physical fitness), which is problematic because exercise training is the most powerful stimulus for mitochondrial biogenesis (18), and differences in mitochondrial content (which was not measured in the study [17]) would have had a major influence on the respiratory results.”
From Simvastatin Effects on Skeletal Muscle (2013) · cites this paper as [17]
A prior study of patients on different statins reported lower complex I OXPHOS capacity and no difference in complex II-linked OXPHOS capacity.
“Recently, the same group investigated mitochondrial function in patients treated with different statins (lipophilic and hydrophilic) and reported the same results: decreased complex I OXPHOS capacity in the patients and no differences in complex II-linked OXPHOS capacity (17).”
From Simvastatin Effects on Skeletal Muscle (2013) · cites this paper as [17]
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- Authors
- Sirvent, P., Fabre, O., Bordenave, S., Hillaire-Buys, D., Raynaud De Mauverger, E., Lacampagne, A., & Mercier, J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Sirvent, P.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 259
- Issue
- 2
- Pages
- 263-268
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2084828565
- Cited by
- 90
- References
- 43
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 15 · 2014: 6 · 2013: 10 · 2012: 7
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology and Applied Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- statin-induced myopathy, mitochondrial respiration, complex I dysfunction, calcium homeostasis, calcium sparks, simvastatin, statin adverse effects
- MeSH terms
- Adult, Biopsy, Creatine Kinase, Humans, L-Lactate Dehydrogenase, Male, Middle Aged, Mitochondria, Muscle, Exercise, Muscle, Skeletal, Statistics, Nonparametric, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Calcium Signaling
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