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Cited by 201Neurotransmitter Receptor Influence on BehaviorGenetic Associations and EpidemiologyStress Responses and Cortisol

Effects of Environmental Stress and Gender on Associations among Symptoms of Depression and the Serotonin Transporter Gene Linked Polymorphic Region (5-HTTLPR)

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Brummett, Beverly H., Boyle, Stephen H., Siegler, Ilene C., Kuhn, Cynthia M., Ashley-Koch, Allison, Jonassaint, Charles R., Züchner, Stephan, Collins, Ann +1 more·2008·Behavior Genetics
DOI 10.1007/s10519-007-9172-1PMC PMC2777886
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Abstract

The short (s) variant of the serotonin transporter (5-HTT) gene linked functional polymorphic region (5-HTTLPR) is associated with depression. Stressful life events, gender, and race have been shown to moderate this association. We examined the relationship between 5-HTTLPR genotype and symptoms of depression in two samples. Study 1 = 288 participants from a study of caregiver stress; and Study 2 = 142 participants from a study examining psychosocial stressors, genetics, and health. Main effects of 5-HTTLPR on symptoms of depression were examined, along with moderation by stress (caregiving status or low childhood socioeconomic status (SES), gender, and race. The 5-HTTLPR x stress group x gender interaction was significant in both samples (P < 0.003, and P < 0.008, respectively). For females, the s allele, combined with caregiving stress (Study 1) or low childhood SES (Study 2), was associated with higher depression scores as compared to participants in the non-stressor group and those with the long (l) allele; whereas, in males, the l allele, combined with a stressor, was associated with higher depression scores as compared to those in the non-stressor group and those with the s allele. Findings from two independent samples suggest that the association of 5-HTTLPR with depression varies according to gender and stressful life events.

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  • ELA effects are modified by genetics, child sex and/or gender, exposure features (e.g., timing, nature, and intensity), and the presence of other risks or protective factors.

    “Some observed modifiers of ELA effects include genetics [25, 87–89], child sex and/or gender [19, 90, 91], exposure features (e.g., timing, nature, and intensity) [21, 25], and the presence of other risks or protective factors [36].”

    From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [91]

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Authors
Brummett, B. H., Boyle, S. H., Siegler, I. C., Kuhn, C. M., Ashley-Koch, A., Jonassaint, C. R., Züchner, S., Collins, A., & Williams, R. B.
Affiliations
  • Duke University (US)
  • Duke Medical Center (US)
Corresponding author
Brummett, Beverly H.
ORCID
Venue
Behavior Genetics
Publisher
Springer Science and Business Media LLC
Published
2007-10-23
Volume
38
Issue
1
Pages
34-43
ISSN
  • 0001-8244 (ISSN-L)
  • 1573-3297
DOI
10.1007/s10519-007-9172-1
PMC
PMC2777886
OpenAlex
W2097280669
Cited by
201
References
6
Citations by year
2026: 4 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 4 · 2018: 11 · 2017: 7 · 2016: 13 · 2015: 11 · 2014: 16 · 2013: 22 · 2012: 20
FWCI
6.10
Type
journal article
Language
en
Update notices
correction (2020-12-21)
Open access
Licence
Locations
  • Behavior Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01 AG19605, R01AG019605)
  • National Heart, Lung, and Blood Institute (P01HL036587)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
5-HTTLPR, serotonin transporter gene, depressive symptoms, gene-environment interaction, gender differences, caregiving stress, childhood socioeconomic status, life events, race, genetic susceptibility to depression
MeSH terms
Depression, DNA, Educational Status, Environment, Female, Genotype, Humans, Life Change Events, Male, Polymorphism, Genetic, Sex Characteristics, Stress, Psychological, Caregivers, Black People, White People, Serotonin Plasma Membrane Transport Proteins

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