Associations between serotonin transporter polymorphisms and cognitive processing applying the Emo 1-back task
Abstract
Down regulation of serotonin transporter (5-HTT) expression has been associated with brain function and major depression. The aim of this study was to explore the allelic variation (short and long) of the 5-HTTLPR polymorphism in attention bias associated with top-down processing of emotion. One hundred sixty-two healthy participants underwent genotyping (5-HTTLPR), background interviews, psychological screening, and a computerised test session (The Emo 1-back task). Carriers of the short 5-HTTLPR alleles in the serotonin transporter gene (SLC6A4) demonstrated less accuracy in The Emo 1-back task when presented with successive images of sad or fearful faces, but not for happy or neutral emotional faces. The study suggests an association between 5-HTTLPR variation in the serotonin transporter gene and altered emotion processing.
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Similar attention bias effects have been shown in healthy subjects at genetic risk.
“In our own research group we have shown similar effects in healthy subjects at genetic risk [18].”
Cites
Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. D. (2000) · Cognitive Psychology · doi:10.1006/cogp.1999.0734 · Cited by 15,798 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
Attentional bias in emotional disorders
MacLeod, C., Mathews, A., & Tata, P. (1986) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.95.1.15 · Cited by 3,152 · see citing works
Attentional bias in emotional disorders.
MacLeod, C., Mathews, A., & Tata, P. R. (1986) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.95.1.15 · Cited by 2,553 · see citing works
International Standard Classification of Education, ISCED 1997
Scientific (2003) · Springer eBooks · doi:10.1007/978-1-4419-9186-7_10 · Cited by 2,510 · see citing works
Diagnostic Interview for Genetic Studies
Nürnberger, J. I. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950110009002 · Cited by 2,066 · see citing works
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · cited 2× · see citing works
“The association between 5-HTTLPR variability and cognition seems to be linked to 470 COGNITION AND EMOTION, 2013, 27 (3) subcomponents that are part of the interplay between emotion perception and cognitive control of emotion, which is involved in emotion regulation (Price & Drevets, 2010).”
Hu, X., Lipsky, R. H., Zhu, G., Akhtar, L. A., Taubman, J., Greenberg, B. D., Xu, K., Arnold, P. D., Richter, M. A., Kennedy, J. L., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/503850 · Cited by 1,124 · see citing works
Attentional biases for negative interpersonal stimuli in clinical depression
Gotlib, I. H., Krasnoperova, E., Yue, D. N., & Joormann, J. (2004) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.113.1.121 · Cited by 911 · see citing works
The Journal of Abnormal Psychology
(1906) · Journal of Mental Science · doi:10.1192/bjp.52.218.580 · Cited by 877 · see citing works
Social supports and serotonin transporter gene moderate depression in maltreated children
Kaufman, J., Yang, B., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D. S., Krystal, J. H., & Gelernter, J. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404376101 · Cited by 801 · see citing works
The Karolinska Directed Emotional Faces: A validation study
Goeleven, E., De Raedt, R., Leyman, L., & Verschuere, B. (2008) · Cognition & Emotion · doi:10.1080/02699930701626582 · Cited by 793 · see citing works
Serotonin Transporter (5-HTTLPR) Genotype and Amygdala Activation: A Meta-Analysis
Munafò, M. R., Brown, S. M., & Hariri, A. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.08.016 · Cited by 789 · see citing works
Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., Vollstädt‐Klein, S., Grüsser, S. M., Flor, H., Schumann, G., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1366 · Cited by 700 · see citing works
Kendler, K. S., Kuhn, J. W., Vittum, J., Prescott, C. A., & Riley, B. P. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.529 · Cited by 669 · see citing works
Selective attention to emotional faces following recovery from depression
Joormann, J., & Gotlib, I. H. (2007) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.116.1.80 · Cited by 591 · see citing works
Wendland, J. R., Martin, B. J., Kruse, M. R., Lesch, K., & Murphy, D. L. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001789 · Cited by 561 · see citing works
Gelernter, J. E., Kranzler, H. R., & Cubells, J. F. (1997) · Human Genetics · doi:10.1007/s004390050624 · Cited by 435 · see citing works
Taylor, S. E., Way, B. M., Welch, W. T., Hilmert, C. J., Lehman, B. J., & Eisenberger, N. I. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.019 · Cited by 432 · see citing works
Rumination and attention in major depression
Donaldson, C., Lam, D., & Mathews, A. (2007) · Behaviour Research and Therapy · doi:10.1016/j.brat.2007.07.002 · Cited by 337 · see citing works
(2010) · Frontiers in neuroscience · doi:10.1201/crcfroneusci · Cited by 322 · see citing works
Sjöberg, R. L., Nilsson, K. W., Nordquist, N., Öhrvik, J., Leppert, J., Lindström, L., & Oreland, L. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005936 · Cited by 251 · see citing works
SEX STEROID CONTROL OF MOOD, MENTAL STATE AND MEMORY
Fink, G., SUMNER, B. E. H., McQueen, J. K., Wilson, H., & Rosie, R. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02151.x · Cited by 236 · see citing works
Looking on the bright side: biased attention and the human serotonin transporter gene
Fox, E., Ridgewell, A., & Ashwin, C. (2009) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2008.1788 · Cited by 220 · see citing works
Brummett, B. H., Boyle, S. H., Siegler, I. C., Kuhn, C. M., Ashley-Koch, A., Jonassaint, C. R., Züchner, S., Collins, A., & Williams, R. B. (2008) · Behavior Genetics · doi:10.1007/s10519-007-9172-1 · Cited by 201 · see citing works
Beevers, C. G., Wells, T. T., Ellis, A. J., & McGeary, J. E. (2009) · Journal of Abnormal Psychology · doi:10.1037/a0016198 · Cited by 179 · see citing works
Association of the5-HTTLPRgenotype and unipolar depression: a meta-analysis
Clarke, H. F., Flint, J., Attwood, A. S., & Munafo, M. R. (2010) · Psychological Medicine · doi:10.1017/s0033291710000516 · Cited by 177 · see citing works
Neumeister, A., Hu, X.-Z., Luckenbaugh, D. A., Schwarz, M., Nugent, A. C., Bonne, O., Herscovitch, P., Goldman, D., Drevets, W. C., & Charney, D. S. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.9.978 · Cited by 161 · see citing works
Howarth, H., Bolton, J., & Bell, G. (2022) · CRC Press eBooks · doi:10.1201/9781003193616-14 · Cited by 138 · see citing works
Vanderhasselt, M., & Raedt, R. D. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.03.009 · Cited by 100 · see citing works
Lazáry, J., Lazáry, Á., Gonda, X., Benkő, A., Molnár, E., Juhász, G., & Bagdy, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.030 · Cited by 99 · see citing works
Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance
Martin, J., Cleak, J., Willis‐Owen, S. A. G., Jonathan Flint, C., & Shifman, S. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001952 · Cited by 82 · see citing works
Beevers, C. G., Marti, C. N., Lee, H., Stote, D. L., Ferrell, R. E., Hariri, A. R., & Telch, M. J. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0022125 · Cited by 73 · see citing works
Prefrontal morphology, 5‐HTTLPR polymorphism and biased attention for emotional stimuli
Beevers, C. G., Pacheco, J., Clasen, P. C., McGeary, J. E., & Schnyer, D. M. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00550.x · Cited by 42 · see citing works
Jonassen, R., Endestad, T., Neumeister, A., Haug, K. B. F., Berg, J. P., & Landrø, N. I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030564 · Cited by 19 · see citing works
Self-citationRepetition Blindness for Faces Reflects Identity Coding but Not Emotion Coding
Buttle, H. (2010) · Perceptual and Motor Skills · doi:10.2466/pms.110.1.245-256 · Cited by 5 · see citing works
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Serotonin transporter polymorphisms (5-HTTLPR) in emotion processing
Jonassen, R., & Landrø, N. I. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.02.003 · Cited by 67 · see citing works
Self-citationØstergaard, T., Lundgren, T., Zettle, R., Jonassen, R., Harmer, C. J., Stiles, T. C., Landrø, N. I., & Haaland, V. Ø. (2018) · Trials · doi:10.1186/s13063-018-2515-9 · Cited by 10 · see citing works
“In our own research group we have shown similar effects in healthy subjects at genetic risk [18].”
Self-citation
- Authors
- Jonassen, R., Foss Haug, K. B., Endestad, T., Bentsen, H., Grimholt, R. M., & Landrø, N. I.
- Affiliations
- University of Oslo (NO)
- Diakonhjemmet Hospital (NO)
- Oslo University Hospital (NO)
- Corresponding author
- Jonassen, Rune
- Venue
- Cognition & Emotion
- Publisher
- Informa UK Limited
- Published
- 2013-04
- Volume
- 27
- Issue
- 3
- Pages
- 465-473
- ISSN
- 0269-9931 (ISSN-L)
- 1464-0600
- OpenAlex
- W2168651951
- Cited by
- 8
- References
- 37
- Citations by year
- 2018: 1 · 2017: 1 · 2016: 2 · 2014: 4
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cognition & Emotion (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- serotonin transporter, 5-HTTLPR polymorphism, attentional bias, emotional processing, top-down processing, facial emotion recognition, genetic association, major depressive disorder
- MeSH terms
- Adult, Alleles, Cognition, Emotions, Facial Expression, Female, Humans, Male, Middle Aged, Psychomotor Performance, Sex Characteristics, Polymorphism, Single Nucleotide, Serotonin Plasma Membrane Transport Proteins
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