Prevention of age-associated neurodegeneration and promotion of healthy brain ageing in female Wistar rats by long term use of bacosides
Abstract
Bacopa monnieri (L.), popularly known as Brahmi, is a revered Ayurvedic medicinal plant used as nerve tonic since time immemorial. The present study aims to investigate the neuroprotective effect of bacosides, the active saponins of Bacopa monnieri (L.) against age associated neurodegeneration and its impact over the prevention of Senile Dementia of Alzheimer's Type (SDAT). The optimum dose of bacosides with no adverse effect was selected by screening its dose dependant activity on ageing biomarker lipofuscin and SDAT biomarker neurotransmitter acetylcholine in the aged female Wistar rat brain. The selected therapeutic dose of bacosides (200 mg/kg) was orally administered for 3 months in middle aged and aged rats and further investigated for its protective action against age associated alterations in neurotransmission system, behavioral paradigms, hippocampal neuronal loss and oxidative stress markers. The results of the present study suggest that bacosides may act as a potential therapeutic intervention in forestalling the deleterious effects of ageing and preventing the age associated pathologies like SDAT.
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Administration of bacosides (200 mg/kg) for 3 months in middle-aged and aged rats exerted a protective effect against age associated alterations in the neurotransmission system, behavioral paradigms, hippocampal neuronal loss and oxidative stress markers.
“Administration of bacosides (200 mg/kg) for 3 months in middle-aged and aged rats exerted a protective effect against age associated alterations in the neurotransmission system, behavioral paradigms, hippocampal neuronal loss and oxidative stress markers [79].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [79]
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221 · see citing works
Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,383 · see citing works
Selenium: Biochemical Role as a Component of Glutathione Peroxidase
Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G., & Hoekstra, W. G. (1973) · Science · doi:10.1126/science.179.4073.588 · Cited by 7,815 · see citing works
Colorimetric assay of catalase
Sinha, A. K. (1972) · Analytical Biochemistry · doi:10.1016/0003-2697(72)90132-7 · Cited by 5,574 · see citing works
Global prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336 · see citing works
Carlberg, I., & Mannervik, B. (1985) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(85)13062-4 · Cited by 3,009 · see citing works
[38] Oxidative damage to proteins: Spectrophotometric method for carbonyl assay
Reznick, A. Z., & Packer, L. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33041-7 · Cited by 2,455 · see citing works
(1993) · Methods in plant biochemistry · doi:10.1016/b978-0-12-461020-0.50001-9 · Cited by 1,774 · see citing works
Active Ageing: A Policy Framework
Kalache, A., & Gatti, A. (2002) · The Aging Male · doi:10.1080/713604647 · Cited by 1,764 · see citing works
Jiang, Z. Y., Hunt, J. V., & Wolff, S. P. (1992) · Analytical Biochemistry · doi:10.1016/0003-2697(92)90122-n · Cited by 1,624 · see citing works
The Generation of Superoxide Radical during the Autoxidation of Hemoglobin
Misra, H. P., & Fridovich, I. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44679-6 · Cited by 1,173 · see citing works
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883 · see citing works
Age-Related Reductions in Human Recognition Memory Due to Impaired Encoding
Grady, C. L., McIntosh, A. R., Horwitz, B., Maisog, J. M., Ungerleider, L. G., Mentis, M. J., Pietrini, P., Schapiro, M. B., & Haxby, J. V. (1995) · Science · doi:10.1126/science.7618082 · Cited by 633 · see citing works
(1990) · Methods in plant biochemistry · doi:10.1016/b978-0-12-461013-2.50001-0 · Cited by 387 · see citing works
Acetylcholine, Aging, and Alzheimer's Disease
Muir, J. L. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00431-5 · Cited by 357 · see citing works
Fischer, W., Gage, F. H., & Björklund, A. (1989) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1989.tb00772.x · Cited by 334 · see citing works
Chronic Effects of Brahmi (Bacopa monnieri) on Human Memory
Roodenrys, S. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00419-5 · Cited by 310 · see citing works
Separate mechanisms for short- and long-term memory
Izquierdo, I., Medina, J. H., Vianna, M. R. M. R., Izquierdo, L. A., & Barros, D. M. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00036-4 · Cited by 293 · see citing works
Cognitive enhancement and neuroprotective effects of Bacopa monnieri in alzheimer’s disease model
Uabundit, N., Wattanathorn, J., Mucimapura, S., & Ingkaninan, K. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.09.056 · Cited by 282 · see citing works
Abe, K., & Saito, H. (2000) · Phytotherapy Research · doi:10.1002/(sici)1099-1573(200005)14:3 · Cited by 271 · see citing works
A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba
Das, A., Shanker, G., Nath, C., Pal, R., Singh, S., & Singh, H. K. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00940-1 · Cited by 264 · see citing works
Spatial learning deficits in old rats: A model for memory decline in the aged
Gallagher, M., & Pelleymounter, M. A. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80112-x · Cited by 253 · see citing works
Navarro, A., Sánchez-del-Pino, M. J., Gómez, C., Peralta, J.-L., & Boveris, A. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00537.2001 · Cited by 237 · see citing works
Sairam, K., Dorababu, M., Goel, R. K., & Bhattacharya, S. K. (2002) · Phytomedicine · doi:10.1078/0944-7113-00116 · Cited by 231 · see citing works
Tappel, A. L., Fletcher, B. L., & Deamer, D. W. (1973) · Journal of Gerontology · doi:10.1093/geronj/28.4.415 · Cited by 224 · see citing works
The Generation of Superoxide Radical during the Autoxidation of Ferredoxins
Misra, H. P., & Fridovich, I. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45929-2 · Cited by 214 · see citing works
Free radical scavenging capacity and protective effect of Bacopa monniera L. on DNA damage
Russo, A., Izzo, A., Borrelli, F., Renis, M., & Vanella, A. (2003) · Phytotherapy Research · doi:10.1002/ptr.1061 · Cited by 205 · see citing works
Neuroprotective and Anti-ageing Effects of Curcumin in Aged Rat Brain Regions
Bala, K., Tripathy, B. C., & Sharma, D. (2006) · Biogerontology · doi:10.1007/s10522-006-6495-x · Cited by 176 · see citing works
Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats
Anbarasi, K., Vani, G., Balakrishna, K., & Devi, C. S. S. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.07.030 · Cited by 170 · see citing works
Effect of Bacopa monniera Linn. (Brāhmi) extract on avoidance responses in rat
Singh, H. K., & Dhawan, B. N. (1982) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(82)90044-7 · Cited by 162 · see citing works
Suh, J. H., Wang, H., Liu, R.-M., Liu, J., & Hagen, T. M. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.020 · Cited by 147 · see citing works
Complex maze learning in rodents as a model of age-related memory impairment
Ingram, D. K. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80101-5 · Cited by 138 · see citing works
Age and sex differences in human skeletal muscle: Role of reactive oxygen species
Pansarasa, O., Castagna, L., Colombi, B., Vecchiet, J., Felzani, G., & Marzatico, F. (2000) · Free Radical Research · doi:10.1080/10715760000301451 · Cited by 135 · see citing works
Nitric oxide-related toxicity in cultured astrocytes: effect of Bacopa monniera.
Russo, A., Borrelli, F., Campisi, A., Acquaviva, R., Raciti, G., & Vanella, A. (2003) · Life Science · doi:10.1016/s0024-3205(03)00476-4 · Cited by 125 · see citing works
Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain
Jyoti, A., Sethi, P., & Sharma, D. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.10.037 · Cited by 119 · see citing works
Individual differences in response to imipramine in the mouse tail suspension test
Vaugeois, J., Passera, G. X. E. R., Zuccaro, F., & Costentin, J. (1997) · Psychopharmacology · doi:10.1007/s002130050475 · Cited by 92 · see citing works
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
Blagosklonny, M. V. (2010) · Aging · doi:10.18632/aging.100149 · Cited by 87 · see citing works
Hu, W. T., Gray, N. W., & Brimijoin, S. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01855.x · Cited by 86 · see citing works
Hof, P. R., Bussière, T., Gold, G., Kövari, E., Giannakopoulos, P., Bouras, C., Perl, D. P., & Morrison, J. H. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.1.55 · Cited by 85 · see citing works
Pawar, R. S., Gopalakrishnan, C., & Bhutani, K. K. (2001) · Planta Medica · doi:10.1055/s-2001-18351 · Cited by 68 · see citing works
Changes in Cell Membranes during Aging
Grinna, L. S. (2009) · Gerontology · doi:10.1159/000212222 · Cited by 66 · see citing works
Changes In Endogenous Monoamines In Aged Rats
Lee, J., Chang, C., Liu, I., Chi, T., Yu, H., & Cheng, J.-T. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03439.x · Cited by 60 · see citing works
Carnitine - a known compound, a novel function in neural cells
Nałęcz, K. A., & Nałȩcz, M. J. (1996) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-1996-1165 · Cited by 60 · see citing works
Aging and the biophysical properties of cell membranes
Cohen, B. M., & Zubenko, G. S. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90079-7 · Cited by 59 · see citing works
Fellman, J. H. (1969) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1969.tb05932.x · Cited by 47 · see citing works
Dietary restriction reduces fluorescent age pigment accumulation in mice
Enesco, H. E., & Kruk, P. A. (1981) · Experimental Gerontology · doi:10.1016/0531-5565(81)90056-5 · Cited by 41 · see citing works
Dave, U. P., Chauvan, V., & Dalvi, J. (1993) · The Indian Journal of Pediatrics · doi:10.1007/bf02751207 · Cited by 36 · see citing works
Age-Related Changes of Cholinergic Markers in the Rat Brain
Yufu, F., Egashira, T., & Yamanaka, Y. (1994) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.66.247 · Cited by 35 · see citing works
Lakshmana, M. K., Rao, Dhingra, Ravikumar, R., Govindaiah, Sudha, Meti, B. L., & Raju (1998) · Neurochemical Research · doi:10.1023/a:1020799700885 · Cited by 24 · see citing works
Women and Alzheimer’s Disease1
Lerner, A. J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5725 · Cited by 23 · see citing works
A microprocessor-based animal monitoring system
Nakatsu, K., & Owen, J. A. (1980) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(80)90066-2 · Cited by 13 · see citing works
Lerner, A. J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.6.1830 · Cited by 12 · see citing works
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Neuropharmacological Review of the Nootropic Herb <i>Bacopa monnieri</i>
Aguiar, S., & Borowski, T. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1431 · Cited by 295 · see citing works
Valotto Neto, L. J., Reverete de Araujo, M., Moretti Junior, R. C., Mendes Machado, N., Joshi, R. K., dos Santos Buglio, D., Barbalho Lamas, C., Direito, R., Fornari Laurindo, L., Tanaka, M., et al. (2024) · Antioxidants · doi:10.3390/antiox13040393 · Cited by 146 · see citing works
Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020) · Brain Sciences · doi:10.3390/brainsci10120964 · Cited by 108 · see citing works
“Administration of bacosides (200 mg/kg) for 3 months in middle-aged and aged rats exerted a protective effect against age associated alterations in the neurotransmission system, behavioral paradigms, hippocampal neuronal loss and oxidative stress markers [79].”
BackgroundSushma, Sahu, M. R., Murugan, N. A., & Mondal, A. C. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300245 · Cited by 17 · see citing works
- Authors
- Rastogi, M., Ojha, R. P., Prabu, P. C., Devi, B. P., Agrawal, A., & Dubey, G. P.
- Affiliations
- SASTRA University (IN)
- Banaras Hindu University (IN)
- Central Council for Research in Ayurvedic Science (IN)
- Corresponding author
- Dubey, G. P.
- Venue
- Biogerontology
- Published
- 2011-12-06
- Volume
- 13
- Issue
- 2
- Pages
- 183-195
- ISSN
- 1389-5729 (ISSN-L)
- 1573-6768
- OpenAlex
- W1977452409
- Cited by
- 71
- References
- 55
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 4 · 2012: 2
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biogerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- SASTRA University
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- bacosides, Bacopa monnieri, age-related neurodegeneration, senile dementia of Alzheimer's type, neuroprotection, lipofuscin, acetylcholine, hippocampal neuronal loss, oxidative stress, female rats, saponins, Ayurvedic medicinal plants
- MeSH terms
- Acetylcholine, Acetylcholinesterase, Administration, Oral, Age Factors, Aging, Animals, Behavior, Animal, Brain, Cognition, Dose-Response Relationship, Drug, Female, Lipofuscin, Memory, Motor Activity, Neurons, Saponins, Biogenic Monoamines, Biomarkers, Cell Death, Rats, Wistar, Oxidative Stress, Neuroprotective Agents, Neurodegenerative Diseases, Bacopa, Rats, GPI-Linked Proteins
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