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Cited by 14Genetic and phenotypic traits in livestockAnimal Genetics and ReproductionGenetics and Physical Performance

Associations Between BLG, CSN3, DGAT1, GH, PIT1, and PRL Gene Polymorphisms and Milk Production Traits in Holstein Dairy Cows: A Meta-Analysis

Ozdemir, Memis, Motmain, Zekrullah, Ekinci, Kubra, Saygılı, Esranur·2025·Biochemical Genetics
DOI 10.1007/s10528-024-10706-8
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Abstract

The current meta-analysis was employed to combine the results of multiple studies into a single estimate related to B-LG, CSN3, DGAT1, PRL, GH, and PIT1 gene polymorphisms and their effects on milk production traits. The purpose of this meta-analysis was to investigate associations between B-LG, CSN3, DGAT1, GH, PIT1, and PRLgene polymorphisms with milk production traits in Holstein dairy cows. An extensive search was done from 2002 to 2022 year. Statistical analyses were performed by using Stata 11.2 software. Genetic models viz codominant (AA vs. AB, AA vs. BB, and AB vs. BB), dominant (AA + AB vs. BB), recessive (AA vs. AB + BB), and completely over-dominant (AA + BB vs. AB) were applied. The results of meta-analysis of association between B-LG genotypes with milk yield where found a significant (P < 0.05) and with fat and protein contents (P < 0.01). In CSN3 polymorphisms of A/A and A/B genotypes had a significant effect on fat yield (P < 0.05) and protein content (P < 0.01). DGAT1 polymorphisms had a significant effect on milk yield, fat yield, protein yield (P < 0.05), with fat and protein contents showed high effect (P < 0.01). No significant association was detected between GH and milk traits (P > 0.05). PIT1 genotype polymorphisms had a significant effect on milk yield (P < 0.05) and protein content (P < 0.01). PRL genotype polymorphisms were significantly associated with milk yield (P < 0.05), fat content and protein yield (P < 0.01). The B-LG, DGAT1,CSN3 and PRL gene polymorphisms could be utilized as good markers to improve milk production traits in the Holstein cattle breed.

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  • Lactation-related genes including DGAT1, SCD1, ABCG2, GHR, and PR are strongly associated with milk yield and milk composition.

    “Genomic studies have revealed that lactation-related genes, including DGAT1, SCD1, ABCG2, GHR, and PR, are strongly associated with milk yield and milk composition [148].”

    From The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution (2026) · cites this paper as [148]

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Authors
Ozdemir, M., Motmain, Z., Ekinci, K., & Saygılı, E.
Affiliations
Atatürk University (TR)
Corresponding author
Motmain, Zekrullah
ORCID
Venue
Biochemical Genetics
Publisher
Springer Science and Business Media LLC
Published
2024-03-04
Volume
63
Issue
1
Pages
1-21
ISSN
  • 0006-2928 (ISSN-L)
  • 1573-4927
DOI
10.1007/s10528-024-10706-8
OpenAlex
W4392369044
Cited by
14
References
32
Citations by year
2026: 6 · 2025: 5 · 2024: 3
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biochemical Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Ataturk University - AVESIS (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Keywords
beta-lactoglobulin gene, CSN3, DGAT1, growth hormone gene, PTTG1, prolactin gene, genetic polymorphism, milk production traits, milk yield, milk fat content, milk protein content, Holstein cows, genetic markers
MeSH terms
Animals, Caseins, Cattle, Female, Genotype, Lactation, Milk, Polymorphism, Genetic, Prolactin, Growth Hormone, Polymorphism, Single Nucleotide, Transcription Factor Pit-1, Diacylglycerol O-Acyltransferase

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