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Cited by 39Magnesium in Health and DiseaseAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

Magnesium Deficiency Enhances Hydrogen Peroxide Production and Oxidative Damage in Chick Embryo Hepatocyte In Vitro

Yang, Ying, Wu, Zhenlong, Chen, Yue, Qiao, Jian, Gao, Mingyu, Yuan, Jianmin, Nie, Wei, Guo, Yuming·2006·Biometals
DOI 10.1007/s10534-005-6898-1
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Abstract

Magnesium deficiency and oxidative stress have been identified as correlative factors in many diseases. The origin of free radicals correlated with oxidative damage resulting from Mg-deficiency is unclear at the cellular level. To investigate whether hydrogen peroxide (H2O2) is associated in the oxidative stress induced by Mg-deficiency, the effect of Mg2+ deficiency (0, 0.4, 0.7 mM) on the metabolism of H2O2 was investigated in cultured chick embryo hepatocytes. After being cultured in the media with various concentrations of Mg2+ for 1, 2, 4, 6 and 10 days, parameters of H2O2 production, catalase activity, lipid peroxidation, intracellular total Mg and cell viability were analyzed. Results demonstrated that long-term incubation of chick embryo hepatocyte in extracellular Mg2+-deprivative and Mg2+-deficient (0.4 mM) states significantly enhanced the production of H2O2 (approximately twofold, respectively) and lipid peroxidation in the cell cultures, while decreasing the cell viability. Additionally, the reversing action of Mg2+ re-added to 1.0 mM and the partial reversing action of dimethylthiourea suggested that (i) [Mg2+]e deficiency induced the increase of H2O2 production, (ii) [Mg2+]e deficiency decreased catalase activity in chick embryo hepatocyte in vitro, subsequently causing oxidative stress and cell peroxidative damage.

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  • The structural and functional roles of zinc, selenium, magnesium, copper, and manganese are crucial for antioxidant defence.

    “Concerning the latter, the structural and functional roles of a few minerals such as zinc (Zn), selenium (Se), magnesium (Mg) copper (Cu) and manganese (Mn) is crucial (Table 5) [409,410,411,412,413,414,415,416,417,418,419,420].”

    From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [418]

  • In magnesium-deficient embryo-hepatocytes, production of hydrogen peroxide and oxidative damage are enhanced.

    “Further, an enhanced production of hydrogenase peroxide and oxidative damage were measured in Mg-deficient embryo-hepatocytes [418].”

    From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [418]

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Authors
Yang, Y., Wu, Z., Chen, Y., Qiao, J., Gao, M., Yuan, J., Nie, W., & Guo, Y.
Affiliations
  • China Agricultural University (CN)
  • National Natural Science Foundation of China (CN)
Corresponding author
Guo, Yuming
ORCID
Venue
Biometals
Publisher
Springer Science and Business Media LLC
Published
2006-02
Volume
19
Issue
1
Pages
71-81
ISSN
  • 0966-0844 (ISSN-L)
  • 1572-8773
DOI
10.1007/s10534-005-6898-1
OpenAlex
W1996898252
Cited by
39
References
40
Citations by year
2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 5
FWCI
9.92
Type
book chapter
Language
en
Open access
closed
Licence
Locations
  • BioMetals (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Chinese Academy of Sciences
  • Chinese Academy of Agricultural Sciences
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
hypomagnesemia, hydrogen peroxide production, oxidative stress, lipid peroxidation, catalase activity, chick embryo hepatocytes, dimethylthiourea, cell viability, extracellular magnesium
MeSH terms
Animals, Cell Survival, Cells, Cultured, Chick Embryo, Hydrogen Peroxide, Magnesium, Magnesium Deficiency, Time Factors, Oxidative Stress, Hepatocytes, In Vitro Techniques

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