The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Anaplerotic molecules: Current and future
Abstract
Summary: This review presents the concepts of anaplerosis and cataplerosis in relation to the regulation of citric acid cycle operation. Anaplerosis is the re‐filling of the catalytic intermediates of the cycle that carry acetyl‐CoA as it is oxidized. The main anaplerotic substrates are pyruvate, glutamine/glutamate and precursors of propionyl‐CoA (odd‐chain fatty acids, specific amino acids, C 5‐ketone bodies). Cataplerosis balances anaplerosis by removing excess intermediates from the citric acid cycle. The properties of the main anaplerotic substrates are reviewed from the point of view of potential clinical applications to the treatment of some inherited and acquired conditions.
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Cites
Regulation of hepatic fatty acid oxidation and ketone body production
McGarry, J. D., & Foster, D. W. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.002143 · Cited by 1,460 · cited 1×
“This is because the oxidation of heptanoate, a mediumchain fatty acid, in liver mitochondria is not regulated by the carnitine palmitoyltransferase system, the activity of which is inhibited by dietary carbohydrates (McGarry and Foster 1980).”
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Cited by
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 865
Metabolic adaptation in hypoxia and cancer
Paredes, F., Williams, H. C., & San Martin, A. (2021) · Cancer Letters · doi:10.1016/j.canlet.2020.12.020 · Cited by 259
Cunnane, S. C., Courchesne‐Loyer, A., St‐Pierre, V., Vandenberghe, C., Pierotti, T., Fortier, M., Croteau, E., & Castellano, C. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12999 · Cited by 250
Hasan, N. M., Longacre, M. J., Stoker, S. W., Boonsaen, T., Jitrapakdee, S., Kendrick, M. A., Wallace, J. C., & MacDonald, M. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804170200 · Cited by 88
Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof
McDonald, T., Puchowicz, M., & Borges, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00274 · Cited by 77
Metadata
- Authors
- Brunengraber, H., & Roe, C. R.
- Venue
- Journal of Inherited Metabolic Disease
- Publisher
- Wiley
- Published
- 2005-12-27
- Volume
- 29
- Issue
- 2-3
- Pages
- 327-331
- ISSN
- 0141-8955 (ISSN-L)
- 1573-2665
- OpenAlex
- W2060762124
- Cited by
- 202
- References
- 1
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brunengraber, H., & Roe, C. R. (2006). Anaplerotic molecules: Current and future. Journal of Inherited Metabolic Disease. https://doi.org/10.1007/s10545-006-0320-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
