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Establishment of 2-mercaptoethanol-dependent differentiated insulin- secreting cell lines

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Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin

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A plate reader method for the measurement of NAD, NADP, glutathione, and ascorbate in tissue extracts: Application to redox profiling during Arabidopsis rosette development

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Feasibility of a Mitochondrial Pyruvate Malate Shuttle in Pancreatic Islets

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Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

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Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion

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A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase Regulates Glucose-stimulated Insulin Secretion

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Anaplerotic molecules: Current and future

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A Role for ATP-Citrate Lyase, Malic Enzyme, and Pyruvate/Citrate Cycling in Glucose-induced Insulin Secretion

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Cytosolic and Mitochondrial Malic Enzyme Isoforms Differentially Control Insulin Secretion

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Anaplerotic roles of pyruvate carboxylase in mammalian tissues

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Compensatory Responses to Pyruvate Carboxylase Suppression in Islet β-Cells

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Evidence for the malate aspartate shuttle in pancreatic islets

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Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid.

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13C NMR Isotopomer Analysis of Anaplerotic Pathways in INS-1 Cells

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Mitochondrial Metabolism Sets the Maximal Limit of Fuel-stimulated Insulin Secretion in a Model Pancreatic Beta Cell

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Critical Role for Cataplerosis via Citrate in Glucose-Regulated Insulin Release

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Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells

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Quantifying the Carboxylation of Pyruvate in Pancreatic Islets

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Estimates of Glycolysis, Pyruvate (De)Carboxylation, Pentose Phosphate Pathway, and Methyl Succinate Metabolism in Incapacitated Pancreatic Islets

MacDonald, M. J. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1413 · Cited by 84 · see citing works

Normalization by Insulin Treatment of Low Mitochondrial Glycerol Phosphate Dehydrogenase and Pyruvate Carboxylase in Pancreatic Islets of the GK Rat

MacDonald, M. J., Efendić, S., & Östenson, C. (1996) · Diabetes · doi:10.2337/diab.45.7.886 · Cited by 82 · see citing works

Feasibility of Pathways for Transfer of Acyl Groups from Mitochondria to the Cytosol to Form Short Chain Acyl-CoAs in the Pancreatic Beta Cell

MacDonald, M. J., Smith, A. D., Hasan, N. M., Sabat, G., & Fahien, L. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702732200 · Cited by 75 · see citing works

Comparison of the effects of leucines, non-metabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenase

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Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis.

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Lack of Glyconeogenesis in Pancreatic Islets: Expression of Gluconeogenic Enzyme Genes in Islets

MacDonald, M., McKenzie, D., Walker, T. M., & Kaysen, J. H. (1992) · Hormone and Metabolic Research · doi:10.1055/s-2007-1003284 · Cited by 68 · see citing works

Reverse flux through cardiac NADP+-isocitrate dehydrogenase under normoxia and ischemia

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Low Mitochondrial Glycerol Phosphate Dehydrogenase and Pyruvate Carboxylase in Pancreatic Islets of Zucker Diabetic Fatty Rats

MacDonald, M. J., Tang, J., & Polonsky, K. S. (1996) · Diabetes · doi:10.2337/diab.45.11.1626 · Cited by 63 · see citing works

Pyruvate dehydrogenase and pyruvate carboxylase. Sites of pretranslational regulation by glucose of glucose-induced insulin release in pancreatic islets.

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Peroxisome proliferator-activated receptor gamma as a novel target in cancer therapy: binding and activation by an aromatic fatty acid with clinical antitumor activity.

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Regulation of Rat Pyruvate Carboxylase Gene Expression by Alternate Promoters during Development, in Genetically Obese Rats and in Insulin-secreting Cells

Jitrapakdee, S., Gong, Q., MacDonald, M. J., & Wallace, J. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34422 · Cited by 56 · see citing works

Glucose enters mitochondrial metabolism via both carboxylation and decarboxylation of pyruvate in pancreatic islets

MacDonald, M. J. (1993) · Metabolism · doi:10.1016/0026-0495(93)90118-8 · Cited by 52 · see citing works

The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells

MacDonald, M. J., Dobrzyń, A., Ntambi, J. M., & Stoker, S. W. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.11.017 · Cited by 48 · see citing works

Acetoacetate and β-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion

MacDonald, M. J., Longacre, M. J., Stoker, S. W., Brown, L. J., Hasan, N. M., & Kendrick, M. A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00368.2007 · Cited by 48 · see citing works

Glucose regulation of acetyl-CoA carboxylase in hepatoma and islet cells.

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Metabolism of the Insulin Secretagogue Methyl Succinate by Pancreatic Islets

MacDonald, M. J. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1028 · Cited by 44 · see citing works

Do Pancreatic Islets Contain Significant Amounts of Phosphoenolpyruvate Carboxykinase or Ferroactivator Activity?

MacDonald, M. J., & Chang, C.-M. (1985) · Diabetes · doi:10.2337/diab.34.3.246 · Cited by 44 · see citing works

The export of metabolites from mitochondria and anaplerosis in insulin secretion

MacDonald, M. J. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00443-9 · Cited by 40 · see citing works

Synergistic Potent Insulin Release by Combinations of Weak Secretagogues in Pancreatic Islets and INS-1 Cells

MacDonald, M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606652200 · Cited by 40 · see citing works

Studies with leucine, β-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion

MacDonald, M. J., Hasan, N., & Longacre, M. M. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.03.017 · Cited by 38 · see citing works

Elimination of KATP Channels in Mouse Islets Results in Elevated [U-13C]Glucose Metabolism, Glutaminolysis, and Pyruvate Cycling but a Decreased γ-Aminobutyric Acid Shunt

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Vulnerability of multidrug-resistant tumor cells to the aromatic fatty acids phenylacetate and phenylbutyrate.

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Metabolomic and Mass Isotopomer Analysis of Liver Gluconeogenesis and Citric Acid Cycle

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Survey of normal appearing mouse strain which lacks enzyme and NAD+-linked glycerol phosphate dehydrogenase: Normal pancreatic beta cell function, but abnormal metabolite pattern in skeltal muscle

MacDonald, M. J., & Marshall, L. K. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1010821821921 · Cited by 28 · see citing works

Methods of enzymatic analysis, Vol. VII

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Insights into the role of anaplerosis in insulin secretion: a 13C NMR study

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Flavin Content of Intracellular Compartments of Pancreatic Islets Compared with Acinar Tissue and Liver

MacDonald, M. J. (1981) · Endocrinology · doi:10.1210/endo-108-5-1899 · Cited by 20 · see citing works

Stimulation of insulin release by glyceraldehyde may not be similar to glucose

MacDonald, M. J., Chaplen, F. W. R., Triplett, C. K., Gong, Q., & Drought, H. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.01.019 · Cited by 18 · see citing works

Involvement of specific proteins (Sp1/Sp3) and nuclear factor Y in basal transcription of the distal promoter of the rat pyruvate carboxylase gene in β-cells

Sunyakumthorn, P., Boonsaen, T., Boonsaeng, V., Wallace, J. C., & Jitrapakdee, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.108 · Cited by 17 · see citing works

Anaplerosis from glucose, α-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria

MacDonald, M. J., Stoker, S. W., & Hasan, N. M. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9757-x · Cited by 11 · see citing works

Functional mapping of disease susceptibility loci using cell biology

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Phosphoenol pyruvate carboxykinase in mouse pancreatic islets ATP-induced changes in sensitivity to Mn2+ activation

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Production and export of metabolites from liver and heart mitochondria and anaplerosis

MacDonald, M. J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000012856.31929.91 · Cited by 7 · see citing works

Glutamine addiction: a new therapeutic target in cancer

Wise, D. R., & Thompson, C. B. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.003 · Cited by 1,770 · see citing works

The role of mitochondria in the pathogenesis of type 2 diabetes

Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551 · see citing works

Metabolic Signaling in Fuel-Induced Insulin Secretion

Prentki, M., Matschinsky, F. M., & Madiraju, S. R. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.018 · Cited by 548 · see citing works

Structure and function of biotin-dependent carboxylases

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Regulation of insulin secretion: role of mitochondrial signalling

Jitrapakdee, S., Wutthisathapornchai, A., Wallace, J. C., & MacDonald, M. J. (2010) · Diabetologia · doi:10.1007/s00125-010-1685-0 · Cited by 293 · see citing works

Mitochondrial function and redox state in mammalian embryos

Dumollard, R., Carroll, J., Duchen, M. R., Campbell, K., & Swann, K. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.12.013 · Cited by 270 · see citing works

Mitochondrial pyruvate transport: a historical perspective and future research directions

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Nutrient regulation of insulin secretion and action

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Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis

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Wnt/Snail Signaling Regulates Cytochrome c Oxidase and Glucose Metabolism

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The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells

Prochownik, E. V., & Wang, H. (2021) · Cells · doi:10.3390/cells10040762 · Cited by 145 · see citing works

Pyruvate carboxylase and cancer progression

Kiesel, V. A., Sheeley, M. P., Coleman, M. F., Kulkoyluoglu‐Cotul, E., Donkin, S. S., Hursting, S. D., Wendt, M. K., & Teegarden, D. (2021) · Cancer & Metabolism · doi:10.1186/s40170-021-00256-7 · Cited by 123 · see citing works

Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells

Jermendy, Á., Toschi, E., Aye, T., Koh, A., Aguayo‐Mazzucato, C., Sharma, A., Weir, G. C., Sgroi, D. C., & Bonner‐Weir, S. (2011) · Diabetologia · doi:10.1007/s00125-010-2036-x · Cited by 118 · see citing works

Differences between Human and Rodent Pancreatic Islets

MacDonald, M. J., Longacre, M. J., Stoker, S. W., Kendrick, M. A., Thonpho, A., Brown, L. J., Hasan, N. M., Jitrapakdee, S., Fukao, T., Hanson, M. S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.241182 · Cited by 100 · see citing works

Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion

Patterson, J. N., Cousteils, K., Lou, J. W., Manning Fox, J. E., MacDonald, P. E., & Joseph, J. W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.521666 · Cited by 98 · see citing works

Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection

Lao-On, U., Attwood, P. V., & Jitrapakdee, S. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1622-0 · Cited by 85 · see citing works

Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells

Phannasil, P., Ansari, I. H., Azzouny, M. E., Longacre, M. J., Rattanapornsompong, K., Burant, C., MacDonald, M. J., & Jitrapakdee, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.021 · Cited by 65 · see citing works

The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion

Fahien, L. A., & MacDonald, M. J. (2011) · Diabetes · doi:10.2337/db10-1150 · Cited by 61 · see citing works

Discovery of a Genetic Metabolic Cause for Mauriac Syndrome in Type 1 Diabetes

MacDonald, M. J., Hasan, N. M., Ansari, I. H., Longacre, M. J., Kendrick, M. A., & Stoker, S. W. (2016) · Diabetes · doi:10.2337/db16-0099 · Cited by 60 · see citing works

Characterization of Phospholipids in Insulin Secretory Granules and Mitochondria in Pancreatic Beta Cells and Their Changes with Glucose Stimulation

MacDonald, M. J., Ade, L., Ntambi, J. M., Ansari, I. H., & Stoker, S. W. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.628420 · Cited by 59 · see citing works

The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells

Huypens, P., Pillai, R., Sheinin, T., Schaefer, S., Huang, M., Odegaard, M. L., Ronnebaum, S. M., Wettig, S. D., & Joseph, J. W. (2010) · Diabetologia · doi:10.1007/s00125-010-1923-5 · Cited by 59 · see citing works

The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?

Sugden, M. C., & Holness, M. J. (2011) · Islets · doi:10.4161/isl.3.6.17806 · Cited by 58 · see citing works

Mitochondria mediated cell death in diabetes

Szabadkai, G., & Duchen, M. R. (2009) · APOPTOSIS · doi:10.1007/s10495-009-0363-5 · Cited by 52 · see citing works

Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion

Ansari, I. H., Longacre, M. J., Stoker, S. W., Kendrick, M. A., O’Neill, L. M., Zitur, L. J., Fernandez, L. A., Ntambi, J. M., & MacDonald, M. J. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.02.001 · Cited by 52 · see citing works

Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development

Sayed, T. S., Maayah, Z. H., Zeidan, H. A., Agouni, A., & Korashy, H. M. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00397-7 · Cited by 54 · see citing works

Interaction between the Biotin Carboxyl Carrier Domain and the Biotin Carboxylase Domain in Pyruvate Carboxylase from Rhizobium etli

Lietzan, A. D., Menefee, A. L., Zeczycki, T. N., Kumar, S., Attwood, P. V., Wallace, J. C., Cleland, W. W., & Maurice, M. S. (2011) · Biochemistry · doi:10.1021/bi201277j · Cited by 49 · see citing works

A Role for Cytosolic Isocitrate Dehydrogenase as a Negative Regulator of Glucose Signaling for Insulin Secretion in Pancreatic ß-Cells

Guay, C., Joly, E. C., Pépin, É., Barbeau, A., Hentsch, L., Pineda, M., Madiraju, S. R. M., Brunengraber, H., & Prentki, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077097 · Cited by 48 · see citing works

Assessment of the Metabolic Pathways Associated With Glucose-Stimulated Biphasic Insulin Secretion

Huang, M., & Joseph, J. W. (2014) · Endocrinology · doi:10.1210/en.2013-1805 · Cited by 48 · see citing works

Metabolic Regulation of Insulin Secretion

Keane, K. N., & Newsholme, P. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800174-5.00001-6 · Cited by 48 · see citing works

Inhibitors of Pyruvate Carboxylase~!2009-12-01~!2010-02-01~!2010-04-15~!

Zeczycki, T. N., Maurice, M. S., & Attwood, P. V. (2010) · The Open Enzyme Inhibition Journal · doi:10.2174/1874940201003010008 · Cited by 48 · see citing works

Liver X Receptor Agonists Augment Human Islet Function through Activation of Anaplerotic Pathways and Glycerolipid/Free Fatty Acid Cycling

Ogihara, T., Chuang, J.-C., Vestermark, G. L., Garmey, J. C., Ketchum, R. J., Huang, X., Brayman, K. L., Thorner, M. O., Repa, J. J., Mirmira, R. G., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064659 · Cited by 47 · see citing works

An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

McCommis, K. S., Hodges, W. T., Bricker, D. K., Wisidagama, D. R., Compan, V., Remedi, M. S., Thummel, C. S., & Finck, B. N. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.016 · Cited by 44 · see citing works

Adaptation and failure of pancreatic β cells in murine models with different degrees of metabolic syndrome

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