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Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects
Open accessAbstract
This overview addresses homocysteine and folate metabolism. Its functions and complexity are described, leading to explanations why disturbed homocysteine and folate metabolism is implicated in many different diseases, including congenital birth defects like congenital heart disease, cleft lip and palate, late pregnancy complications, different kinds of neurodegenerative and psychiatric diseases, osteoporosis and cancer. In addition, the inborn errors leading to hyperhomocysteinemia and homocystinuria are described. These extreme human hyperhomocysteinemia models provide knowledge about which part of the homocysteine and folate pathways are linked to which disease. For example, the very high risk for arterial and venous occlusive disease in patients with severe hyperhomocysteinemia irrespective of the location of the defect in remethylation or transsulphuration indicates that homocysteine itself or one of its “direct” derivatives is considered toxic for the cardiovascular system. Finally, common diseases associated with elevated homocysteine are discussed with the focus on cardiovascular disease and neural tube defects.
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Citations
Cites
Epigenetic Reprogramming in Mammalian Development
Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078
Neural tube defects and folate: case far from closed
Blom, H. J., Shaw, G. M., den Heijer, M., & Finnell, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1986 · Cited by 562
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Cited by
Homocysteine lowering interventions for preventing cardiovascular events
Martí-Carvajal, A. J., Solà, I., Lathyris, D., & Salanti, G. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006612.pub2 · Cited by 520
Targeting folate receptor alpha for cancer treatment
Cheung, A., Bax, H. J., Josephs, D. H., Ilieva, K. M., Pellizzari, G., Opzoomer, J., Bloomfield, J., Fittall, M., Grigoriadis, A., Figini, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9651 · Cited by 430
The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice
Moretti, R., & Caruso, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010231 · Cited by 248
Vascular aspects of multiple sclerosis
D'haeseleer, M., Cambron, M., Vanopdenbosch, L., & De Keyser, J. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70105-3 · Cited by 241
Li, F., He, X., Ye, D., Lin, Y., Yu, H., Yao, C., Huang, L., Zhang, J., Wang, F., Xu, S., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.017 · Cited by 244
Lee, H.-S. (2015) · Nutrients · doi:10.3390/nu7115467 · Cited by 236
Homocysteine-lowering interventions for preventing cardiovascular events
Martí-Carvajal, A. J., Solà, I., & Lathyris, D. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006612.pub4 · Cited by 113
Siervo, M., Shannon, O., Kandhari, N., Prabhakar, M., Fostier, W., Köchl, C., Rogathi, J., Temu, G., Stephan, B. C., Gray, W. K., et al. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxaa170 · Cited by 57
Min, D.-J., Vural, S., & Krushkal, J. (2019) · Cancer Genetics · doi:10.1016/j.cancergen.2019.05.005 · Cited by 23
Metadata
- Authors
- Blom, H. J., & Smulders, Y.
- Venue
- Journal of Inherited Metabolic Disease
- Publisher
- Wiley
- Published
- 2010-09-04
- Volume
- 34
- Issue
- 1
- Pages
- 75-81
- ISSN
- 0141-8955 (ISSN-L)
- 1573-2665
- OpenAlex
- W1978998408
- Cited by
- 454
- References
- 2
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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