Homocysteine-lowering interventions for preventing cardiovascular events

Measuring inconsistency in meta-analyses

Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works

GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables

Guyatt, G., Oxman, A. D., Akl, E. A., Kunz, R., Vist, G., Brozek, J., Norris, S., Falck-Ytter, Y., Glasziou, P., & deBeer, H. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.04.026 · Cited by 10,681 · see citing works

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663 · see citing works

GRADE guidelines: 3. Rating the quality of evidence

Balshem, H., Helfand, M., Schünemann, H. J., Oxman, A. D., Kunz, R., Brozek, J., Vist, G. E., Falck-Ytter, Y., Meerpohl, J., & Norris, S. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.015 · Cited by 8,285 · see citing works

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)

(1996) · The Lancet · doi:10.1016/s0140-6736(96)09457-3 · Cited by 6,503 · see citing works

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

SCANDINAVIANSIMVASTATINSURVIVAL (1994) · The Lancet · doi:10.1016/s0140-6736(94)90566-5 · Cited by 3,638 · see citing works

Disease control priorities in developing countries

(2006) · Choice Reviews Online · doi:10.5860/choice.44-0343 · Cited by 3,635 · see citing works

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

Boushey, C. J. (1995) · JAMA · doi:10.1001/jama.1995.03530130055028 · Cited by 3,604 · see citing works

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

Pedersen, T. R. (2004) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2004.08.027 · Cited by 3,098 · see citing works

GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias)

Guyatt, G. H., Oxman, A. D., Vist, G., Kunz, R., Brozek, J., Alonso-Coello, P., Montori, V., Akl, E. A., Djulbegovic, B., & Falck-Ytter, Y. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.017 · Cited by 2,798 · see citing works

GRADE guidelines 6. Rating the quality of evidence—imprecision

Guyatt, G. H., Oxman, A. D., Kunz, R., Brozek, J., Alonso-Coello, P., Rind, D., Devereaux, P. J., Montori, V. M., Freyschuss, B., Vist, G., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.01.012 · Cited by 2,693 · see citing works

GRADE guidelines: 7. Rating the quality of evidence—inconsistency

Guyatt, G. H., Oxman, A. D., Kunz, R., Woodcock, J., Brozek, J., Helfand, M., Alonso-Coello, P., Glasziou, P., Jaeschke, R., Akl, E. A., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.03.017 · Cited by 2,320 · see citing works

Homocysteine and Cardiovascular Disease

Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180 · see citing works

Homocysteine and Risk of Ischemic Heart Disease and Stroke: A Meta-analysis

Homocysteine Studies Collaboration (2002) · JAMA · doi:10.1001/jama.288.16.2015 · Cited by 2,059 · see citing works

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

Selhub, J. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03510220049033 · Cited by 1,972 · see citing works

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

Wald, D. S., Law, M., & Morris, J. K. (2002) · BMJ · doi:10.1136/bmj.325.7374.1202 · Cited by 1,945 · see citing works

GRADE guidelines: 2. Framing the question and deciding on important outcomes

Guyatt, G. H., Oxman, A. D., Kunz, R., Atkins, D., Brozek, J., Vist, G., Alderson, P., Glasziou, P., Falck-Ytter, Y., & Schünemann, H. J. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.09.012 · Cited by 1,911 · see citing works

Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis

Wetterslev, J., Thorlund, K., Brok, J., & Gluud, C. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.03.013 · Cited by 1,881 · see citing works

GRADE guidelines: 8. Rating the quality of evidence—indirectness

Guyatt, G. H., Oxman, A. D., Kunz, R., Woodcock, J., Brozek, J., Helfand, M., Alonso-Coello, P., Falck-Ytter, Y., Jaeschke, R., Vist, G., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.04.014 · Cited by 1,843 · see citing works

GRADE guidelines: 5. Rating the quality of evidence—publication bias

Guyatt, G. H., Oxman, A. D., Montori, V., Vist, G., Kunz, R., Brozek, J., Alonso-Coello, P., Djulbegovic, B., Atkins, D., Falck-Ytter, Y., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.01.011 · Cited by 1,819 · see citing works

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease

(2006) · New England Journal of Medicine · doi:10.1056/nejmoa060900 · Cited by 1,729 · see citing works

A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians

Stampfer, M. J. (1992) · JAMA · doi:10.1001/jama.1992.03490070059042 · Cited by 1,705 · see citing works

Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction

Bønaa, K. H., Njølstad, I., Ueland, P. M., Schirmer, H., Tverdal, A., Steigen, T., Wang, H., Nordrehaug, J. E., Arnesen, E., & Rasmussen, K. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055227 · Cited by 1,442 · see citing works

Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death: The Vitamin Intervention for Stroke Prevention (VISP) Randomized Controlled Trial

Toole, J. F., Malinow, M. R., Chambless, L. E., Spence, J. D., Pettigrew, L. C., Howard, V. J., Sides, E. G., Wang, C.-H., & Stampfer, M. (2004) · JAMA · doi:10.1001/jama.291.5.565 · Cited by 1,391 · see citing works

GRADE guidelines: 9. Rating up the quality of evidence

Guyatt, G. H., Oxman, A. D., Sultan, S., Glasziou, P., Akl, E. A., Alonso-Coello, P., Atkins, D., Kunz, R., Brozek, J., Montori, V., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.06.004 · Cited by 1,336 · see citing works

Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses

Brok, J. S., Thorlund, K., Gluud, C. N., & Wetterslev, J. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.10.007 · Cited by 1,116 · see citing works

Estimating required information size by quantifying diversity in random-effects model meta-analyses

Wetterslev, J., Thorlund, K., Brok, J. S., & Gluud, C. N. (2009) · BMC Medical Research Methodology · doi:10.1186/1471-2288-9-86 · Cited by 934 · see citing works

Apparently conclusive meta-analyses may be inconclusive—Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses

Brok, J. S., Thorlund, K., Wetterslev, J., & Gluud, C. N. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn188 · Cited by 918 · see citing works

Homocyst(e)ine and Cardiovascular Disease: A Critical Review of the Epidemiologic Evidence

Eikelboom, J. W., Lonn, E., Genest, J. J., Hankey, G. J., & Yusuf, S. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-5-199909070-00008 · Cited by 908 · see citing works

Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?

Thorlund, K., Devereaux, P. J., Wetterslev, J., Guyatt, G. H., Ioannidis, J. P. A., Thabane, L., Gluud, L. L., Als-Nielsen, B. E. T., & Gluud, C. N. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn179 · Cited by 835 · see citing works

Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions

Crider, K. S., Bailey, L. B., & Berry, R. J. (2011) · Nutrients · doi:10.3390/nu3030370 · Cited by 608 · see citing works

Efficacy of folic acid supplementation in stroke prevention: a meta-analysis

Wang, X., Qin, X., Demirtaş, H., Li, J., Mao, G., Huo, Y., Sun, N., Liu, L., & Xu, X. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60854-x · Cited by 589 · see citing works

Emerging Risk Factors for Atherosclerotic Vascular Disease

Hackam, D. G., & Anand, S. S. (2003) · JAMA · doi:10.1001/jama.290.7.932 · Cited by 548 · see citing works

Homocysteine lowering interventions for preventing cardiovascular events

Martí-Carvajal, A. J., Solà, I., Lathyris, D., & Salanti, G. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006612.pub2 · Cited by 520 · see citing works

Effect of Folic Acid and B Vitamins on Risk of Cardiovascular Events and Total Mortality Among Women at High Risk for Cardiovascular Disease

Albert, C. M., Cook, N. R., Gaziano, J. M., Zaharris, E., MacFadyen, J. G., Danielson, E., Buring, J. E., & Manson, J. E. (2008) · JAMA · doi:10.1001/jama.299.17.2027 · Cited by 509 · see citing works

Effects of Lowering Homocysteine Levels With B Vitamins on Cardiovascular Disease, Cancer, and Cause-Specific Mortality<subtitle>Meta-analysis of 8 Randomized Trials Involving 37 485 Individuals</subtitle><alt-title>Effects of Lowering Homocysteine Levels</alt-title>

(2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.348 · Cited by 498 · see citing works

Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial

Galan, P., Kesse-Guyot, E., Czernichow, S., Briancon, S., Blacher, J., Hercberg, S., & for the SU.FOL.OM3 Collaborative Group (2010) · BMJ · doi:10.1136/bmj.c6273 · Cited by 457 · see citing works

Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects

Blom, H. J., & Smulders, Y. M. (2010) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-010-9177-4 · Cited by 455 · see citing works

Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials

Homocysteine Lowering Trialists’ Collaboration (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.806 · Cited by 454 · see citing works

Effect of Homocysteine Lowering on Mortality and Vascular Disease in Advanced Chronic Kidney Disease and End-stage Renal Disease

Jamison, R. L., Hartigan, P. M., Kaufman, J. S., Goldfarb, D. S., Warren, S. R., Guarino, P., Gaziano, J. M., & for the RED-CABG Steering Committee and Investigators (2007) · JAMA · doi:10.1001/jama.298.10.1163 · Cited by 452 · see citing works

Homocysteine and stroke: evidence on a causal link from mendelian randomisation

Casas, J. P., Bautista, L. E., Smeeth, L. L., Sharma, P. K., & Hingorani, A. D. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17742-3 · Cited by 442 · see citing works

Cancer Incidence and Mortality After Treatment With Folic Acid and Vitamin B12

Ebbing, M. (2009) · JAMA · doi:10.1001/jama.2009.1622 · Cited by 428 · see citing works

Effect of Folic Acid Supplementation on Risk of Cardiovascular Diseases

Bazzano, L., Reynolds, K., Holder, K. N., & He, J. (2006) · JAMA · doi:10.1001/jama.296.22.2720 · Cited by 426 · see citing works

Mortality and Cardiovascular Events in Patients Treated With Homocysteine-Lowering B Vitamins After Coronary Angiography

Ebbing, M., Bleie, Ø., Ueland, P. M., Nordrehaug, J. E., Nilsen, D. W. T., Vollset, S. E., Refsum, H., Pedersen, E. R., & Nygard, O. K. (2008) · JAMA · doi:10.1001/jama.300.7.795 · Cited by 408 · see citing works

Homocysteine Level and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis

Humphrey, L. L., Fu, R. F., Rogers, K. R., Freeman, M., & Helfand, M. (2008) · Mayo Clinic Proceedings · doi:10.4065/83.11.1203 · Cited by 398 · see citing works

Effect of Homocysteine-Lowering Therapy With Folic Acid, Vitamin B12, and Vitamin B6on Clinical Outcome After Percutaneous Coronary Intervention

Schnyder, G., Roffi, M., Flammer, Y., Pin, R., & Hess, O. M. (2002) · JAMA · doi:10.1001/jama.288.8.973 · Cited by 378 · see citing works

Folate Therapy and In-Stent Restenosis after Coronary Stenting

Lange, H., Suryapranata, H., De Luca, G., Börner, C., Dille, J., Kallmayer, K., Pasalary, M. N., Scherer, E., & Dambrink, J.-H. E. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032845 · Cited by 336 · see citing works

Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials

Holmes, M. V., Newcombe, P. J., Hubacek, J. A., Sofat, R., Ricketts, S. L., Cooper, J. A., Breteler, M. M. B., Bautista, L. E., Sharma, P. K., Whittaker, J. C., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60872-6 · Cited by 331 · see citing works

Effects of Homocysteine-Lowering With Folic Acid Plus Vitamin B ₁₂ vs Placebo on Mortality and Major Morbidity in Myocardial Infarction Survivors: A Randomized Trial

(2010) · JAMA · doi:10.1001/jama.2010.840 · Cited by 327 · see citing works

Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50 000 individuals

Vollset, S. E., Clarke, R., Lewington, S., Ebbing, M., Halsey, J., Lonn, E., Armitage, J., Manson, J. E., Hankey, G. J., Spence, J. D., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62001-7 · Cited by 327 · see citing works

Mechanisms of homocysteine toxicity in humans

Perła‐Kaján, J., Twardowski, T., & Jakubowski, H. (2007) · Amino Acids · doi:10.1007/s00726-006-0432-9 · Cited by 314 · see citing works

The Treatment of Hyperhomocysteinemia

Maron, B. A., & Loscalzo, J. (2008) · Annual Review of Medicine · doi:10.1146/annurev.med.60.041807.123308 · Cited by 312 · see citing works

B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial

(2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70187-3 · Cited by 312 · see citing works

Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: An overview

Castro, R., Rivera, I. A., Blom, H. J., Jakobs, C., & de Almeida, I. T. (2006) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-006-0106-5 · Cited by 311 · see citing works

Grading quality of evidence and strength of recommendations in clinical practice guidelines Part 3 of 3. The GRADE approach to developing recommendations

Brożek, J., Akl, E. A., Compalati, E., Kreis, J., Terracciano, L., Fiocchi, A. G., Ueffing, E., Andrews, J., Alonso‐Coello, P., Meerpohl, J. J., et al. (2011) · Allergy · doi:10.1111/j.1398-9995.2010.02530.x · Cited by 300 · see citing works

The Impact of Prevention on Reducing the Burden of Cardiovascular Disease

Kahn, R., Robertson, R. M., Smith, R. A., & Eddy, D. M. (2008) · Circulation · doi:10.1161/circulationaha.108.190186 · Cited by 299 · see citing works

Homocysteine and cardiovascular disease: a review of the evidence

Wierzbicki, A. S. (2007) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2007.033 · Cited by 284 · see citing works

Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals

Mills (2010) · Clinical Epidemiology · doi:10.2147/clep.s9242 · Cited by 281 · see citing works

Vitamin B6 salvage enzymes: Mechanism, structure and regulation

di Salvo, M. L., Contestabile, R., & Safo, M. K. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.12.006 · Cited by 261 · see citing works

Homocysteine-Lowering Therapy and Stroke Risk, Severity, and Disability

Saposnik, G., Ray, J. G., Sheridan, P., McQueen, M., Lonn, E., & the HOPE 2 Investigators (2009) · Stroke · doi:10.1161/strokeaha.108.529503 · Cited by 260 · see citing works

Molecular basis of homocysteine toxicity in humans

Jakubowski, H. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3204-7 · Cited by 257 · see citing works

Homocysteine Thiolactone: Metabolic Origin and Protein Homocysteinylation in Humans

Jakubowski, H. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.377s · Cited by 255 · see citing works

Endothelial Dysfunction: The Link Between Homocysteine and Hydrogen Sulfide

Pushpakumar, S. B., Kundu, S., & Sen, U. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140706142335 · Cited by 255 · see citing works

Vitamin Intervention for Stroke Prevention Trial

Spence, J. D., Bang, H., Chambless, L. E., & Stampfer, M. J. (2005) · Stroke · doi:10.1161/01.str.0000185929.38534.f3 · Cited by 245 · see citing works

Prevention of chronic disease by means of diet and lifestyle changes.

Willett, W. C., Koplan, J. P., Nugent, R. A., Dusenbury, C. M., Puska, P., & Gaziano, T. A. (2006) · Cited by 242 · see citing works

Meta‐research: The art of getting it wrong

Ioannidis, J. P. A. (2010) · Research Synthesis Methods · doi:10.1002/jrsm.19 · Cited by 231 · see citing works

Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies

Ford, E. S., Smith, S. J., Stroup, D. F., STEINBERG, K. K., Mueller, P. W., & Thacker, S. B. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.1.59 · Cited by 231 · see citing works

Homocysteine and Its Disulfide Derivatives

Mudd, S. H., Finkelstein, J. D., Refsum, H., Ueland, P. M., Malinow, M. R., Lentz, S. R., Jacobsen, D. W., Brattström, L. E., Wilcken, B., Wilcken, D. E. L., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.7.1704 · Cited by 215 · see citing works

The Many Facets of Hyperhomocysteinemia: Studies from the Framingham Cohorts

Selhub, J. (2006) · Journal of Nutrition · doi:10.1093/jn/136.6.1726s · Cited by 212 · see citing works

Genetics of homocysteine metabolism and associated disorders

Pitt, S. B., Giugliani, R., & Félix, T. M. (2010) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2009007500021 · Cited by 208 · see citing works

Effect of Combined Folic Acid, Vitamin B 6 , and Vitamin B 12 on Cancer Risk in Women

Zhang, S. M., Cook, N. R., Albert, C. M., Gaziano, J. M., Buring, J. E., & Manson, J. E. (2008) · JAMA · doi:10.1001/jama.2008.555 · Cited by 195 · see citing works

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Emerging Biomarkers for Primary Prevention of Cardiovascular Disease

Myers, G. L., Christenson, R. H., Cushman, M., Ballantyne, C. M., Cooper, G. R., Pfeiffer, C. M., Grundy, S. M., Labarthe, D. R., Levy, D. A., Rifai, N., et al. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.115899 · Cited by 186 · see citing works

Homocysteine and lipids: S‐Adenosyl methionine as a key intermediate

Obeid, R., & Herrmann, W. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.03.038 · Cited by 180 · see citing works

Plasma homocysteine and coronary heart disease: systematic review of published epidemiological studies

Danesh, J., & Lewington, S. (1998) · Journal of Cardiovascular Risk · doi:10.1097/00043798-199808000-00004 · Cited by 179 · see citing works

Structural Modifications of HDL and Functional Consequences

Ferretti, G., Bacchetti, T., Nègre-Salvayre, A., Salvayre, R., Dousset, N., & Curatola, G. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.08.008 · Cited by 176 · see citing works

Diabetes: The Pandemic and Potential Solutions

Narayan, K. M. V., Zhang, P., Kanaya, A. M., Williams, D. E., Engelgau, M. M., Imperatore, G., & Ramachandran, A. (2006) · Europe PMC (PubMed Central) · Cited by 167 · see citing works

Homocysteine: Role and implications in atherosclerosis

Guthikonda, S., & Haynes, W. G. (2006) · Current Atherosclerosis Reports · doi:10.1007/s11883-006-0046-4 · Cited by 156 · see citing works

Homocysteine: Overview of Biochemistry, Molecular Biology, and Role in Disease Processes

Fowler, B. (2005) · Seminars in Vascular Medicine · doi:10.1055/s-2005-872394 · Cited by 155 · see citing works

Efficacy of Homocysteine-Lowering Therapy With Folic Acid in Stroke Prevention

Lee, M., Hong, K., Chang, S., & Saver, J. L. (2010) · Stroke · doi:10.1161/strokeaha.109.573410 · Cited by 154 · see citing works

Secondary prevention with folic acid: effects on clinical outcomes

Liem, A. H., Reynierse-Buitenwerf, G. H., Zwinderman, A. H., Jukema, J. W., & van Veldhuisen, D. J. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00485-6 · Cited by 152 · see citing works

High-Dose B Vitamin Supplementation and Progression of Subclinical Atherosclerosis

Hodis, H. N., Mack, W. J., Dustin, L. L., Mahrer, P. R., Azen, S. P., Detrano, R., Selhub, J., Alaupovic, P., Liu, C., Liu, C.-H., et al. (2008) · Stroke · doi:10.1161/strokeaha.108.526798 · Cited by 138 · see citing works

The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease.

Jakubowski, H. (2008) · PubMed · Cited by 129 · see citing works

Human Folate Bioavailability

Öhrvik, V., & Witthöft, C. M. (2011) · Nutrients · doi:10.3390/nu3040475 · Cited by 129 · see citing works

Public Health Significance of Elevated Homocysteine

Selhub, J. (2008) · Food and Nutrition Bulletin · doi:10.1177/15648265080292s116 · Cited by 127 · see citing works

Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms

Zhou, J., & Austin, R. C. (2009) · BioFactors · doi:10.1002/biof.17 · Cited by 124 · see citing works

Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality

Huang, T., Chen, Y., Yang, B., Yang, J., Wahlqvist, M. L., & Li, D. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2011.01.003 · Cited by 122 · see citing works

Dietary Folate and Vitamin B 6 and B 12 Intake in Relation to Mortality From Cardiovascular Diseases

Cui, R., Iso, H., Date, C., Kikuchi, S., & Tamakoshi, A. (2010) · Stroke · doi:10.1161/strokeaha.110.578906 · Cited by 121 · see citing works

Homocysteine and cardiovascular disease: biological mechanisms, observational epidemiology, and the need for randomized trials

Splaver, A., Lamas, G. A., & Hennekens, C. H. (2004) · American Heart Journal · doi:10.1016/j.ahj.2004.02.004 · Cited by 119 · see citing works

Cardiovascular disease

Gaziano, T. A., Reddy, S., Paccaud, F., Horton, S., & Chaturvedi, V. (2005) · IRIS · Cited by 116 · see citing works

Homocysteine metabolism and its relation to health and disease

Williams, K. T., & Schalinske, K. L. (2010) · BioFactors · doi:10.1002/biof.71 · Cited by 115 · see citing works

The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis

Jardine, M., Kang, A., Zoungas, S., Navaneethan, S. D., Ninomiya, T., Nigwekar, S. U., Gallagher, M., Cass, A., Strippoli, G. F., & Perkovic, V. (2012) · BMJ · doi:10.1136/bmj.e3533 · Cited by 112 · see citing works

Meta-Analysis of Folic Acid Supplementation Trials on Risk of Cardiovascular Disease and Risk Interaction With Baseline Homocysteine Levels

Miller, E. R., Juraschek, S., Pastor-Barriuso, R., Bazzano, L. A., Appel, L. J., & Guallar, E. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.03.064 · Cited by 112 · see citing works

Pyridoxal phosphate: Biosynthesis and catabolism

Mukherjee, T., Hanes, J. W., Tews, I., Ealick, S. E., & Begley, T. P. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.06.018 · Cited by 111 · see citing works

Efficacy of folic acid supplementation in cardiovascular disease prevention: An updated meta-analysis of randomized controlled trials

Yang, H.-T., Lee, M., Hong, K., Ovbiagele, B. I., & Saver, J. L. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.07.004 · Cited by 106 · see citing works

Study of the effectiveness of additional reductions in cholesterol and homocysteine (SEARCH): Characteristics of a randomized trial among 12 064 myocardial infarction survivors

SEARCH Study Collaborative Group (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.06.034 · Cited by 105 · see citing works

Biochemistry of homocysteine in health and diseases.

Ramakrishnan, S., Sulochana, K. N., Lakshmi, S. V. V., Selvi, R., & Angayarkanni, N. (2006) · PubMed · Cited by 99 · see citing works

Biochemistry of B12-Cofactors in Human Metabolism

Kräutler, B. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2199-9_17 · Cited by 99 · see citing works

Physiological and Molecular Aspects of Cobalamin Transport

Fedosov, S. N. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2199-9_18 · Cited by 97 · see citing works

Biomedical aspects of pyridoxal 5 -phosphate availability

Contestabile, R. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e428 · Cited by 97 · see citing works

Cardiovascular Disease Epidemiology

Epstein, F. H. (1996) · Circulation · doi:10.1161/01.cir.93.9.1755 · Cited by 94 · see citing works

Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease

Ji, Y., Tan, S., Xu, Y., Chandra, A., Shi, C., Song, B., Qin, J., & Gao, Y. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a823cc · Cited by 94 · see citing works

Hyperhomocysteinemia and arteriosclerosis: historical perspectives

McCully, K. S. (2005) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2005.172 · Cited by 92 · see citing works

Homocysteine-Lowering Treatment With Folic Acid, Cobalamin, and Pyridoxine Does Not Reduce Blood Markers of Inflammation, Endothelial Dysfunction, or Hypercoagulability in Patients With Previous Transient Ischemic Attack or Stroke

Dusitanond, P., Eikelboom, J. W., Hankey, G. J., Thom, J., Gilmore, G., Loh, K., Yi, Q., Klijn, C. J. M., Langton, P. D., BOCKXMEER, F. M. V., et al. (2004) · Stroke · doi:10.1161/01.str.0000150494.91762.70 · Cited by 91 · see citing works

Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis

Huo, Y., Qin, X., Wang, J., Sun, N., Zeng, Q., Xu, X., Liu, L., Xu, X., & Wang, X. (2012) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2012.02929.x · Cited by 88 · see citing works

Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women

Song, Y., Cook, N. R., Albert, C. M., Denburgh, M. V., & Manson, J. E. (2009) · Diabetes · doi:10.2337/db09-0087 · Cited by 87 · see citing works

Homocysteine-lowering interventions for preventing cardiovascular events

Martí-Carvajal, A. J., Solà, I., Lathyris, D., Karakitsiou, D.-E., & Simancas‐Racines, D. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006612.pub3 · Cited by 87 · see citing works

B Vitamins and Magnetic Resonance Imaging–Detected Ischemic Brain Lesions in Patients With Recent Transient Ischemic Attack or Stroke

Cavalieri, M., Schmidt, R., Chen, C., Mok, V., de Freitas, G. R., Song, S. J., Yi, Q., Ropele, S., Grazer, A., Homayoon, N., et al. (2012) · Stroke · doi:10.1161/strokeaha.112.665703 · Cited by 85 · see citing works

Effect of Folic Acid Supplementation on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

Zhou, Y.-H., Tang, J.-Y., Wu, M.-J., Lu, J., Wei, X., Qin, Y.-Y., Wang, C., Xu, J., & He, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025142 · Cited by 83 · see citing works

Uremic hyperhomocysteinemia: A randomized trial of folate treatment for the prevention of cardiovascular events

Vianna, A. C. A., Mocelin, A. J., Matsuo, T., Filho, D. D. M., Largura, Á., Delfino, V. D. A., Soares, A. E., & Matni, A. M. (2007) · Hemodialysis International · doi:10.1111/j.1542-4758.2007.00171.x · Cited by 80 · see citing works

Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis

Sudchada, P., Saokaew, S., Sridetch, S., Incampa, S., Jaiyen, S., & Khaithong, W. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.05.027 · Cited by 80 · see citing works

Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial

Liem, A. H., van Boven, A. J., Veeger, N. J. G. M., Withagen, A. J. A. M., de Medina, R. M. R., Tijssen, J. G. P., & van Veldhuisen, D. J. (2003) · International Journal of Cardiology · doi:10.1016/j.ijcard.2003.02.001 · Cited by 76 · see citing works

Methoxistasis: Integrating the Roles of Homocysteine and Folic Acid in Cardiovascular Pathobiology

Joseph, J., & Loscalzo, J. (2013) · Nutrients · doi:10.3390/nu5083235 · Cited by 74 · see citing works

Combined analyses and extended follow‐up of two randomized controlled homocysteine‐lowering B‐vitamin trials

Ebbing, M., Bønaa, K. H., Arnesen, E., Ueland, P. M., Nordrehaug, J. E., Rasmussen, K., Njølstad, I., Nilsen, D. W. T., Refsum, H., Tverdal, A., et al. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02259.x · Cited by 72 · see citing works

Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia

Clarke, R., Lewington, S., Sherliker, P., & Armitage, J. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328011aa71 · Cited by 71 · see citing works

Homocysteine and vitamin therapy in stroke prevention and treatment: a review.

Manolescu, B. N., Oprea, E., FARCASANU, I. C., Berteanu, M., & Cercasov, C. (2010) · Acta Biochimica Polonica · doi:10.18388/abp.2010_2432 · Cited by 71 · see citing works

Cobalamin Deficiency

Herrmann, W., & Obeid, R. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2199-9_16 · Cited by 71 · see citing works

The controversial role of B-vitamins in cardiovascular risk: An update

Ntaios, G., Savopoulos, C. G., Grekas, D. M., & Hatzitolios, A. I. (2009) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2009.07.002 · Cited by 69 · see citing works

The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis

Potter, K., Hankey, G. J., GREEN, D. J., Eikelboom, J. W., Jamrozik, K. D., & Arnolda, L. (2008) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-8-24 · Cited by 68 · see citing works

Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia

Zappacosta, B., Mastroiacovo, P., Persichilli, S., Pounis, G., Ruggeri, S., Minucci, A., Carnovale, E., Andria, G., Ricci, R., Scala, I., et al. (2013) · Nutrients · doi:10.3390/nu5051531 · Cited by 64 · see citing works

Secondary prevention with folic acid: results of the Goes extension study: Figure 1

Liem, A. H., Reynierse-Buitenwerf, G. H., Zwinderman, A. H., Jukema, J. W., & van Veldhuisen, D. J. (2005) · Heart · doi:10.1136/hrt.2004.035030 · Cited by 64 · see citing works

A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy

Tighe, P., Ward, M., McNulty, H., Finnegan, O., Dunne, A., Strain, J., Molloy, A. M., Duffy, M. E., Pentieva, K. D., & Scott, J. M. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29427 · Cited by 59 · see citing works

Molecular targeting by homocysteine: a mechanism for vascular pathogenesis

Jacobsen, D. W., Cătănescu, O., DiBello, P. M., & Barbato, J. C. (2005) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2005.188 · Cited by 57 · see citing works

Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: The Heart Outcomes Prevention Evaluation (HOPE)-2 trial

Lonn, E. (2006) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(06)70238-0 · Cited by 57 · see citing works

Effect of homocysteine interventions on the risk of cardiocerebrovascular events: a meta-analysis of randomised controlled trials

Mei, W., Rong, Y., Jinming, L., Li, Y., & Hu, Z. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02207.x · Cited by 56 · see citing works

Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India

Deshmukh, U., Joglekar, C. V., Lubree, H., Ramdas, L. V., Bhat, D., Naik, S. S., Hardikar, P. S., RAUT, D. A., Konde, T. B., Wills, A. K., et al. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.15 · Cited by 53 · see citing works

Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels

Sofi, F., Marcucci, R., Bolli, P., Giambene, B., Sodi, A., Fedi, S., Menchini, U., Gensini, G. F., Abbate, R., & Prisco, D. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.09.009 · Cited by 51 · see citing works

Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women

Rautiainen, S., Åkesson, A., Levitan, E. B., Morgenstern, R., Mittleman, M. A., & Wolk, A. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29371 · Cited by 50 · see citing works

Homocysteine-lowering vitamins do not lower plasmaS-adenosylhomocysteine in older people with elevated homocysteine concentrations

Green, T., Skeaff, C. M., McMahon, J. A., Venn, B. J., Williams, S., Devlin, A. M., & Innis, S. M. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114509993552 · Cited by 49 · see citing works

Effect of Homocysteine-Lowering B Vitamin Treatment on Angiographic Progression of Coronary Artery Disease: A Western Norway B Vitamin Intervention Trial (WENBIT) Substudy

Løland, K. H., Bleie, Ø., Blix, A. J., Strand, E., Ueland, P. M., Refsum, H., Ebbing, M., Nordrehaug, J. E., & Nygard, O. K. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.01.019 · Cited by 48 · see citing works

Folate and vitamin B-12 biomarkers in NHANES: history of their measurement and use

Yetley, E. A. D., & Johnson, C. L. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.013300 · Cited by 48 · see citing works

Background and rationale of the SU.FOL.OM3 study: double-blind randomized placebo-controlled secondary prevention trial to test the impact of supplementation with folate, vitamin B6 and B12 and/or omega-3 fatty acids on the prevention of recurrent ischemic events in subjects with atherosclerosis in the coronary or cerebral arteries.

Galan, P., de Bree, A., Mennen, L. I., de Courcy, G. P., Preziozi, P., Bertrais, S., Castetbon, K., & Herçberg, S. (2003) · PubMed · Cited by 48 · see citing works

Genetic Aspects of Folate Metabolism

Molloy, A. M. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2199-9_7 · Cited by 47 · see citing works

The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: A randomized, placebo-controlled trial

Ntaios, G., Savopoulos, C. G., Karamitsos, D. T., Economou, I., Destanis, E., Chryssogonidis, I., Pidonia, I., Zebekakis, P. E., Polatides, C., Sion, M. L., et al. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.01.023 · Cited by 47 · see citing works

Folate and risk of coronary heart disease: A meta-analysis of prospective studies

Wang, Z.-M., Zhou, B., Nie, Z., Gao, W. Q., Wang, Y.-C., Zhao, H., Zhu, J., Yan, J., Yang, Z., & Wang, L.-S. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.04.011 · Cited by 45 · see citing works

Homocysteine-lowering therapy does not lead to reduction in cardiovascular outcomes in chronic kidney disease patients: a meta-analysis of randomised, controlled trials

Pan, Y., Guo, L., Cai, L. L., Zhu, X. J., Shu, J. L., Liu, X. L., & Jin, H. M. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511007033 · Cited by 42 · see citing works

Cardiovascular effects of B-vitamins and/or N-3 fatty acids: The Su.Fol.Om3 trial

Blacher, J., Czernichow, S., Paillard, F., Ducimetière, P., Herçberg, S., & Galan, P. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.01.060 · Cited by 42 · see citing works

Vitamin B6 and Cardiovascular Disease

Friso, S., Lotto, V., Corrocher, R., & Choi, S. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2199-9_14 · Cited by 41 · see citing works

The SU.FOL.OM3 Study: a secondary prevention trial testing the impact of supplementation with folate and B-vitamins and/or Omega-3 PUFA on fatal and non fatal cardiovascular events, design, methods and participants characteristics

Galan, P., Briançon, S., Blacher, J., Czernichow, S., & Herçberg, S. (2008) · Trials · doi:10.1186/1745-6215-9-35 · Cited by 41 · see citing works

Untitled work

Andreeva (2012) · doi:10.1001/archinternmed.2011.1450 · Cited by 40 · see citing works

Effect of 3 y of folic acid supplementation on the progression of carotid intima-media thickness and carotid arterial stiffness in older adults

Durga, J., Bots, M. L., Schouten, E. G., Grobbee, D. E., Kok, F. J., & Verhoef, P. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.006429 · Cited by 39 · see citing works

VITATOPS, the VITAmins TO Prevent Stroke Trial: Rationale and Design of a Randomised Trial of B-Vitamin Therapy in Patients with Recent Transient Ischaemic Attack or Stroke (NCT00097669) (ISRCTN74743444)

The VITATOPS Trial Study Group (2007) · International Journal of Stroke · doi:10.1111/j.1747-4949.2007.00111.x · Cited by 39 · see citing works

The growing burden of risk from high blood pressure, cholesterol, and bodyweight.

Rodgers, A., Lawes, C. M. M., Gaziano, T. A., & Vos, T. (2006) · Cited by 39 · see citing works

Effect of Long-Term Homocysteine Reduction with B Vitamins on Arterial Wall Inflammation Assessed by Fluorodeoxyglucose Positron Emission Tomography: A Randomised Double-Blind, Placebo-Controlled Trial

Potter, K., Lenzo, N. P., Eikelboom, J. W., Arnolda, L., Etherton‐Beer, C., & Hankey, G. J. (2009) · Cerebrovascular Diseases · doi:10.1159/000199463 · Cited by 37 · see citing works

Enhanced Cellular Adenosine Uptake Limits Adenosine Receptor Stimulation in Patients With Hyperhomocysteinemia

Riksen, N. P., Rongen, G. A. P. J. M., Boers, G. H. J., Blom, H. J., van den Broek, P. H. H., & Smits, P. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000150651.85907.69 · Cited by 37 · see citing works

Association between homocysteine, vitamin B6 concentrations and inflammation

Gori, A. M., Sofi, F., Marcucci, R., Giusti, B., Gensini, G. F., & Abbate, R. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.347 · Cited by 33 · see citing works

Hyperhomocysteinemia is an independent risk factor in young patients with coronary artery disease in southern China

Wu, Y., Huang, Y., Hu, Y., Zhong, J., He, Z., Li, W., Yang, Y., Xu, D., & Wu, S. (2013) · Herz · doi:10.1007/s00059-013-3761-y · Cited by 31 · see citing works

Dose-dependent effects of folic acid on plasma homocysteine in a randomized trial conducted among 723 individuals with coronary heart disease

Neal, B. C., MacMahon, S. W., Ohkubo, T., Tonkin, A. M., & Wilcken, D. E. L. (2002) · European Heart Journal · doi:10.1053/euhj.2002.3161 · Cited by 31 · see citing works

Folic Acid-Based Intervention in Non-ST Elevation Acute Coronary Syndromes

Imasa, M. S. B., Gomez, N. T., & Nevado, J. B. (2009) · Asian Cardiovascular and Thoracic Annals · doi:10.1177/0218492309102494 · Cited by 30 · see citing works

Mechanisms in homocysteine-induced vascular disease

Wang, H., Tan, H., & Yang, F. (2005) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2005.05.029 · Cited by 30 · see citing works

The Role of Vitamin B in Stroke Prevention

Saposnik, G. (2011) · Stroke · doi:10.1161/strokeaha.110.608356 · Cited by 28 · see citing works

Technical Aspects of Food Fortification

Wirakartakusumah, M. A., & Hariyadi, P. (1998) · Food and Nutrition Bulletin · doi:10.1177/156482659801900203 · Cited by 28 · see citing works

Homocysteine in the prevention of ischemic heart disease, stroke and venous thromboembolism: therapeutic target or just another distraction?

Lonn, E. (2007) · Current Opinion in Internal Medicine · doi:10.1097/moh.0b013e3282c48bd8 · Cited by 27 · see citing works

Impact of Homocysteine-Lowering Vitamin Therapy on Long-Term Outcome of Patients With Coronary Artery Disease

Mager, A., Orvin, K., Koren‐Morag, N., Lev, I. E., Assali, A. R., Kornowski, R., Shohat, M., Battler, A., & Hasdai, D. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.05.011 · Cited by 25 · see citing works

Effect of B-vitamins and n-3 PUFA supplementation for 5 years on blood pressure in patients with CVD

de Edelenyi, F. S., Vergnaud, A., Ahluwalia, N., Julia, C., Herçberg, S., Blacher, J., & Galan, P. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511003692 · Cited by 25 · see citing works

Effect of Folate Supplementation on Serum Homocysteine and Plasma Total Antioxidant Capacity in Hypercholesterolemic Adults under Lovastatin Treatment: A Double-blind Randomized Controlled Clinical Trial

Shidfar, F., Homayounfar, R., Fereshtehnejad, S., & Kalani, A. (2009) · Archives of Medical Research · doi:10.1016/j.arcmed.2009.06.004 · Cited by 24 · see citing works

Effect of B-vitamin Supplementation on Stroke: a Meta-Analysis of Randomized Controlled Trials

Zhang, C., Chi, F.-L., Xie, T., & Zhou, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081577 · Cited by 23 · see citing works

Treatment With B Vitamins and Incidence of Cancer in Patients With Previous Stroke or Transient Ischemic Attack

Hankey, G. J., Eikelboom, J. W., Yi, Q., Lees, K. R., Chen, C., Xavier, D., Navarro, J. C., Ranawaka, U. K., Uddin, W., Ricci, S., et al. (2012) · Stroke · doi:10.1161/strokeaha.111.641613 · Cited by 23 · see citing works

Homocysteine

Maron, B. A., & Loscalzo, J. (2006) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2006.06.008 · Cited by 23 · see citing works

Coronary blood flow in patients with stable coronary artery disease treated long term with folic acid and vitamin B12

Bleie, Ø., Strand, E., Ueland, P. M., Vollset, S. E., Refsum, H., Igland, J., Nordrehaug, J. E., & Nygard, O. K. (2011) · Coronary Artery Disease · doi:10.1097/mca.0b013e328344fff4 · Cited by 19 · see citing works

Homocysteine, vitamin B12 and folate levels in Iranian patients with ischemic stroke

Moghaddasi, M., Mamarabadi, M., Mirzadeh, S., Freydoonnejad, A. A., & Razjouyan, H. (2010) · Neurological Research · doi:10.1179/016164110x12644252260475 · Cited by 14 · see citing works

Homocysteine targeting of plasma proteins in hemodialysis patients

Jacobsen, D. W. (2006) · Kidney International · doi:10.1038/sj.ki.5000235 · Cited by 13 · see citing works

Control of baseline cardiovascular risk factors in the SU-FOL-OM3 study cohort: does the localization of the arterial event matter?

Vesin, C., Galan, P., Gautier, B., Czernichow, S., Herçberg, S., & Blacher, J. (2010) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3283383f47 · Cited by 12 · see citing works

Cerebrovascular diseases

Burroni, L., Grassetto, G., & Rubello, D. (2011) · Nuclear Medicine Communications · doi:10.1097/mnm.0b013e3283449330 · Cited by 12 · see citing works

Complementary Effects of Multivitamin and Omega-3 Fatty Acid Supplementation on Indices of Cardiovascular Health in Individuals with Elevated Homocysteine

Earnest, C. P., Kupper, S., Thompson, M., Guo, W., & Church, S. (2012) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000093 · Cited by 10 · see citing works

Homocysteine as a new risk factor for cardiovascular events in heart failure

Kardeşoğlu, E., Uz, Ö., Işılak, Z., & Cebeci, B. S. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.10.005 · Cited by 10 · see citing works

Priorities in Health

Jamison, D. T. T. (2006) · World Bank, Washington, DC eBooks · doi:10.1596/978-0-8213-6260-0 · Cited by 10 · see citing works

Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality

Zhou, C., Wu, J., & Fang, S. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.01.001 · Cited by 9 · see citing works

The effects of high-dose folic acid on blood pressure of hypertensive adults with hyperhomocysteinemia: A randomized double- blind placebo controlled clinical trial (Tehran Homocysteine Survey)

Sharifi, F., Fakhrzadeh, H., Mirarefin, M., Pourebrahim, R., Masoomeh, N., Hossein, F. M., Ghotbi, S., Ghaderpanahi, M., & Larijani, B. A. (2010) · Journal of Diabetes & Metabolic Disorders · Cited by 7 · see citing works

Meta‐Analysis

Hedges, L. V. (2005) · Encyclopedia of Statistical Sciences · doi:10.1002/0471667196.ess3051.pub2 · Cited by 7 · see citing works

Reply to Fang SK – Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality

Huang, T., & Li, D. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.01.002 · Cited by 4 · see citing works

Steps to control the burden of cardiovascular disease in the Indian Subcontinent.

Math, M. V., & Balasubramaniam, P. (2007) · PubMed · Cited by 4 · see citing works

Stroke

Hankey, G. J. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30962-x · Cited by 1,248 · see citing works

B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review

Kennedy, D. (2016) · Nutrients · doi:10.3390/nu8020068 · Cited by 1,055 · see citing works

Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017

Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works

Excluding non-English publications from evidence-syntheses did not change conclusions: a meta-epidemiological study

Nussbaumer-Streit, B., Klerings, I., Dobrescu, A. I., Persad, E., Stevens, A., Garritty, C., Kamel, C., Affengruber, L., King, V. J., & Gartlehner, G. (2020) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2019.10.011 · Cited by 440 · see citing works

The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art

Esse, R., Barroso, M., de Almeida, I. T., & Castro, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040867 · Cited by 337 · see citing works

Cardiovascular comorbidity in rheumatic diseases

Nurmohamed, M. T., Heslinga, M., & Kitas, G. D. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.112 · Cited by 331 · see citing works

Biomarkers in Diabetic Retinopathy

Jenkins, A. J., Joglekar, M. V., Hardikar, A. A., KEECH, A. C., O'Neal, D. N., & Januszewski, A. S. (2015) · The Review of Diabetic Studies · doi:10.1900/rds.2015.12.159 · Cited by 317 · see citing works

Homocysteine-lowering interventions for preventing cardiovascular events

Martí-Carvajal, A. J., Solà, I., Lathyris, D., & Dayer, M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006612.pub5 · Cited by 284 · see citing works

Caffeine and cardiovascular health

Turnbull, D., Rodricks, J. V., Mariano, G. F., & Chowdhury, F. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.07.025 · Cited by 216 · see citing works

Role of folic acid in nitric oxide bioavailability and vascular endothelial function

Stanhewicz, A. E., & Kenney, W. L. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw053 · Cited by 156 · see citing works

Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis

Yuan, D., Chu, J., Lin, H., Zhu, G., Qian, J., Yu, Y., Yao, T., Ping, F., Chen, F., & Liu, X. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1109445 · Cited by 152 · see citing works

Mechanisms of homocysteine-induced damage to the endothelial, medial and adventitial layers of the arterial wall

Balint, B., Kosgei, V. J., Guéant, J., & Guéant‐Rodriguez, R. (2020) · Biochimie · doi:10.1016/j.biochi.2020.02.012 · Cited by 135 · see citing works

B vitamins in stroke prevention: time to reconsider

Spence, J. D., Yi, Q., & Hankey, G. J. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30180-1 · Cited by 130 · see citing works

Abdominal aortic calcification: A reappraisal of epidemiological and pathophysiological data

Szulc, P. (2015) · Bone · doi:10.1016/j.bone.2015.12.004 · Cited by 118 · see citing works

Homocysteine and disease: Causal associations or epiphenomenons?

Hannibal, L., & Blom, H. J. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.11.003 · Cited by 99 · see citing works

MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence‐Based Literature

Levin, B., & Varga, E. (2016) · Journal of Genetic Counseling · doi:10.1007/s10897-016-9956-7 · Cited by 90 · see citing works

Atherosclerosis in Systemic Lupus Erythematosus

Stojan, G., & Petri, M. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31829dd857 · Cited by 85 · see citing works

H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes

Nandi, S. S., & Mishra, P. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-03776-9 · Cited by 75 · see citing works

Abbreviated literature searches were viable alternatives to comprehensive searches: a meta-epidemiological study

Nussbaumer-Streit, B., Klerings, I., Wagner, G., Heise, T. L., Dobrescu, A. I., Armijo-Olivo, S., Stratil, J. M., Persad, E., Lhachimi, S. K., Van Noord, M. G., et al. (2018) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2018.05.022 · Cited by 72 · see citing works

Vitamin B12 as a Treatment for Pain

Buesing, S. (2019) · Pain Physician · doi:10.36076/ppj/2019.22.e45 · Cited by 68 · see citing works

Diet and primary prevention of stroke: Systematic review and dietary recommendations by the ad hoc Working Group of the Italian Society of Human Nutrition

Iacoviello, L., Bonaccio, M., Cairella, G., Catani, M. V., Costanzo, S., D’Elia, L., Giacco, R., Rendina, D., Sabino, P., Savini, I., et al. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2017.12.010 · Cited by 59 · see citing works

Pathophysiological Mechanisms and Potential Therapeutic Targets in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)

Locatelli, M., Padovani, A., & Pezzini, A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00321 · Cited by 64 · see citing works

Implication of homocysteine in diabetes and impact of folate and vitamin B12 in diabetic population

Mursleen, M. T., & Riaz, S. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.12.023 · Cited by 56 · see citing works

Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis

Ashtary‐Larky, D., Bagheri, R., Ghanavati, M., Asbaghi, O., Tinsley, G. M., Mombaini, D., Kooti, W., Kashkooli, S., & Wong, A. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1902938 · Cited by 55 · see citing works

Folic Acid in Stroke Prevention in Countries without Mandatory Folic Acid Food Fortification: A Meta-Analysis of Randomized Controlled Trials

Hsu, C., Chiu, S., Hong, K., Saver, J. L., Wu, Y., Lee, J.-D., Lee, M., & Ovbiagele, B. (2018) · Journal of Stroke · doi:10.5853/jos.2017.01522 · Cited by 55 · see citing works

DNA methylation patterns associated with oxidative stress in an ageing population

Hedman, Å. K., Zilmer, M., Sundström, J., Lind, L., & Ingelsson, E. (2016) · BMC Medical Genomics · doi:10.1186/s12920-016-0235-0 · Cited by 50 · see citing works

Effects of Four-Week Supplementation with a Multi-Vitamin/Mineral Preparation on Mood and Blood Biomarkers in Young Adults: A Randomised, Double-Blind, Placebo-Controlled Trial

White, D., Cox, K., Peters, R., Pipingas, A., & Scholey, A. (2015) · Nutrients · doi:10.3390/nu7115451 · Cited by 48 · see citing works

The Revised D‐A‐CH‐Reference Values for the Intake of Vitamin B12: Prevention of Deficiency and Beyond

Ströhle, A., Richter, M., González‐Gross, M., Neuhäuser‐Berthold, M., Wagner, K., Leschik‐Bonnet, E., Egert, S., & for the German Nutrition Society (DGE) (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801178 · Cited by 46 · see citing works

Phosphatidylethanolamine N-methyltransferase: from Functions to Diseases

Li, J., Xin, Y., Li, J., Chen, H., & Li, H. (2022) · Aging and Disease · doi:10.14336/ad.2022.1025 · Cited by 44 · see citing works

Folate and cancer: a tale of Dr. Jekyll and Mr. Hyde?

Kim, Y. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx076 · Cited by 43 · see citing works

Is there a causal role for homocysteine concentration in blood pressure? A Mendelian randomization study

Borges, M., Hartwig, F., Oliveira, I., & Horta, B. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.116038 · Cited by 40 · see citing works

Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine γ lyase S‐sulfhydration in ApoE‐knockout atherosclerotic mice

Fan, J., Zheng, F., Li, S., Cui, C., Jiang, S., Zhang, J., Cai, J., Cui, Q., Yang, J., Tang, X., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14719 · Cited by 41 · see citing works

Effect of Combined Treatment With Folic Acid, Vitamin B 6 , and Vitamin B 12 on Plasma Biomarkers of Inflammation and Endothelial Dysfunction in Women

Christen, W. G., Cook, N. R., Denburgh, M. V., Zaharris, E., Albert, C. M., & Manson, J. E. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.008517 · Cited by 39 · see citing works

The Role of Vitamin Supplementation in the Prevention of Cardiovascular Disease Events

Desai, C., Huang, J. J., Lokhandwala, A. M., Fernandez, A., Riaz, I. B., & Alpert, J. S. (2014) · Clinical Cardiology · doi:10.1002/clc.22299 · Cited by 37 · see citing works

Acetyl-L-carnitine for patients with hepatic encephalopathy

Martí-Carvajal, A. J., Gluud, C. N., Arévalo-Rodríguez, I., & Martí-Amarista, C. E. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011451.pub2 · Cited by 35 · see citing works

CADASIL: Treatment and Management Options

Bersano, A., Bedini, G., Oskam, J. A., Mariotti, C., Taroni, F., Baratta, S., & Parati, E. A. (2017) · Current Treatment Options in Neurology · doi:10.1007/s11940-017-0468-z · Cited by 38 · see citing works

Hydrogen sulphide reduces hyperhomocysteinaemia‐induced endothelial ER stress by sulfhydrating protein disulphide isomerase to attenuate atherosclerosis

Jiang, S., Xu, W., Chen, Z., Cui, C., Fan, X., Cai, J., Gong, Y., & Geng, B. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16423 · Cited by 35 · see citing works

Exploring the impact of community-based interventions on healthy older adults' physical health, psychological wellbeing, and social connections: A systematic review.

Elhag, S., Niechcial, M. A., Potter, L. M., & Gow, A. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102784 · Cited by 31 · see citing works

Coronary Artery Disease

Cagle, S., & Cooperstein, N. (2018) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2017.10.001 · Cited by 28 · see citing works

Vitamin D3 prevents cardiovascular diseases by lowering serum total homocysteine concentrations in overweight reproductive women: A randomized, placebo-controlled clinical trial

Al-Bayyari, N. S., Al-Zeidaneen, S. A., Hailat, R., & Hamadneh, J. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.07.012 · Cited by 28 · see citing works

A combination of omega-3 fatty acids, folic acid and B-group vitamins is superior at lowering homocysteine than omega-3 alone: A meta-analysis

Dawson, S. L., Bowe, S. J., & Crowe, T. C. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.03.010 · Cited by 27 · see citing works

Practical Management of Cardiovascular Comorbidities in Rheumatoid Arthritis

Gualtierotti, R., Ughi, N., Marfia, G., & Ingegnoli, F. (2017) · Rheumatology and Therapy · doi:10.1007/s40744-017-0068-0 · Cited by 27 · see citing works

A Japanese cross-sectional multicentre study of biomarkers associated with cardiovascular disease in smokers and non-smokers

Lüdicke, F., Magnette, J., Baker, G. S., & Weitkunat, R. (2015) · Biomarkers · doi:10.3109/1354750x.2015.1096303 · Cited by 25 · see citing works

Hyperhomocysteinemia is an independent predictor of long-term clinical outcomes in Chinese octogenarians with acute coronary syndrome

Fu, Z., Hao, X., Guo, J., Chen, L., Yang, X., Shen, M., Dong, W., Chen, Y., & Qian, G. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s91652 · Cited by 24 · see citing works

Yeast based spreads improve anxiety and stress

Mikkelsen, K., Hallam, K. T., Stojanovska, L., & Apostolopoulos, V. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.11.034 · Cited by 23 · see citing works

Sulfur Amino Acids and Skeletal Muscle

Papet, I., Rémond, D., Dardevet, D. P., Mosoni, L., Polakof, S., Peyron, M., & Savary‐Auzeloux, I. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-810422-4.00020-8 · Cited by 25 · see citing works

Sulfur Amino Acids Metabolism From Protein Synthesis to Glutathione

Courtney‐Martin, G., & Pencharz, P. B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802167-5.00019-0 · Cited by 24 · see citing works

Nutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort

Wargny, M., Croyal, M., Ragot, S., Gand, E., Jacobi, D., Trochu, J.-N., Prieur, X., Le May, C., Goronflot, T., Cariou, B., et al. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01505-9 · Cited by 21 · see citing works

Homocysteine and the Risk of Cardiovascular Events and All-Cause Death in Elderly Population: A Community-Based Prospective Cohort Study

Zhang, Z., Gu, X., Fang, X., Tang, Z., Guan, S., Liu, H., Wu, X., Wang, C., & Zhao, Y. (2020) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s239496 · Cited by 22 · see citing works

Folate and vitamin B12concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study

Iglesia, I., Huybrechts, I., González‐Gross, M., Mouratidou, T., Santabárbara, J., Chajès, V., González‐Gil, E. M., Park, J. Y., Bel‐Serrat, S., Cuenca‐García, M., et al. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114516004414 · Cited by 22 · see citing works

The Effect of Serum 25-Hydroxyvitamin D on Elevated Homocysteine Concentrations in Participants of a Preventive Health Program

Pham, T., Ekwaru, J. P., Mastroeni, S. S. D. B. S., Mastroeni, M. F., Loehr, S., & Veugelers, P. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161368 · Cited by 21 · see citing works

Decreasing serum homocysteine and hypocholesterolemic effects of bovine lactoferrin in male rat fed with high-cholesterol diet

Nozari, S., Maroufi, N. F., Nouri, M., Oskouei, M. P., Shiralizade, J., Yekani, F., Mamipour, M., & Faridvand, Y. (2018) · Journal of Cardiovascular and Thoracic Research · doi:10.15171/jcvtr.2018.35 · Cited by 18 · see citing works

Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats

Cui, S., Li, W., Lv, X., Wang, P., Huang, G., & Gao, Y. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0158 · Cited by 18 · see citing works

Serum folate levels and fatality among diabetic adults: A 15-y follow-up study of a national cohort

Afriyie-Gyawu, E., Ifebi, E., Ampofo‐Yeboah, A., Kyte, B. B., Shrestha, S., & Zhang, J. (2015) · Nutrition · doi:10.1016/j.nut.2015.10.021 · Cited by 17 · see citing works

Elevated serum homocysteine level as an independent risk factor for erectile dysfunction: a prospective pilot case-control study

Zhang, Z., Xu, Z., Dai, Y., & Chen, Y. (2016) · Andrologia · doi:10.1111/and.12684 · Cited by 17 · see citing works

The impact of MTHFR 677C → T risk knowledge on changes in folate intake: findings from the Food4Me study

O’Donovan, C. B., Walsh, M. C., Forster, H., Woolhead, C., Celis-Morales, C. A., Fallaize, R., Macready, A. L., Marsaux, C. F. M., Navas‐Carretero, S., San-Cristóbal, R., et al. (2016) · Genes & Nutrition · doi:10.1186/s12263-016-0539-x · Cited by 15 · see citing works

MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome

Li, M., Wang, H., Zhang, N.-R., Xuan, L., Shi, X., Zhou, T., Chen, B., Zhang, J., & Li, H. (2017) · Medicine · doi:10.1097/md.0000000000009044 · Cited by 16 · see citing works

Markers of inflammation and cardiovascular disease in recently diagnosed celiac disease patients

Tetzlaff, W., Meroño, T., Menafra, M., Martín, M., Botta, E., Matoso, M. D., Sorroche, P. B., Paula, J. A. D., Boero, L. E., & Brites, F. D. (2017) · World Journal of Cardiology · doi:10.4330/wjc.v9.i5.448 · Cited by 16 · see citing works

Anaemia and iron deficiency in chronic heart failure patients

Ватутин, Н. Т., Тарадин, Г. Г., Kanisheva, I. V., & Venzheha, V. V. (2019) · Kardiologiia · doi:10.18087/cardio.2638 · Cited by 15 · see citing works

Serum homocysteine is not independently associated with an atherogenic lipid profile: The Very Large Database of Lipids (VLDL-21) study

Lupton, J. R., Quispe, R., Kulkarni, K. R., Martin, S. S., & Jones, S. R. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.03.031 · Cited by 15 · see citing works

No evidence for thrombophilia in patients with retinal venous occlusion: a systematic GRADE ‐based review

Kirkegaard, K., Heegaard, S., & Hvas, A. (2016) · Acta Ophthalmologica · doi:10.1111/aos.13214 · Cited by 14 · see citing works

Comparative Analysis of Compatibility Influence on Invigorating Blood Circulation for Combined Use of Panax Notoginseng Saponins and Aspirin Using Metabolomics Approach

Sun, Z., Wu, H., Wu, Y., Wang, C., Wang, Y., Hu, S., & Du, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.544002 · Cited by 14 · see citing works

Comprehensive transcriptomics and metabolomics analyses reveal that hyperhomocysteinemia is a high risk factor for coronary artery disease in a chinese obese population aged 40–65: a prospective cross-sectional study

Zhang, C., Xu, R.-Q., Wang, X., Sun, L., Mo, P., Cai, R.-J., Lin, X., Luo, C.-F., Ou, W., Lu, L., et al. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01942-0 · Cited by 13 · see citing works

B-vitamins and metabolic syndrome in Mesoamerican children and their adult parents

Santos, C. V., Ramírez‐Zea, M., Villamor, E., & for the Nine Mesoamerican Countries Metabolic Syndrome (NiMeCoMeS) Study Group (2020) · Public Health Nutrition · doi:10.1017/s1368980020003936 · Cited by 13 · see citing works

Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus

Wang, Y.-S., Ye, J., Yang, X. M., Zhang, G., Cao, Y., Zhang, R., Dai, W., & Zhang, Q. (2018) · Archives of Medical Science · doi:10.5114/aoms.2018.79565 · Cited by 14 · see citing works

Antiphosphospholipid syndrome presenting with amaurosis fugax and cotton wool spots

Tran, K. D., Read, S. P., Patel, N. A., Flynn, H. W., & Schatz, N. J. (2017) · American Journal of Ophthalmology Case Reports · doi:10.1016/j.ajoc.2017.07.005 · Cited by 11 · see citing works

Pterostilbene antagonizes homocysteine-induced oxidative stress, apoptosis and lipid deposition in vascular endothelial cells

Jiang, Q., Wang, L., Si, X., Bian, Y., Zhang, W., Cui, H., Gui, H., Zhang, Y., Li, B., & Tan, D. (2023) · Food Science and Human Wellness · doi:10.1016/j.fshw.2023.02.029 · Cited by 10 · see citing works

A case report of branch retinal artery occlusion in a teenager due to hyperhomocysteinaemia; the interplay of genetic and nutritional defects

Shute, C. (2018) · BMC Ophthalmology · doi:10.1186/s12886-018-0859-2 · Cited by 10 · see citing works

Homocysteine is associated with the progression of non-culprit coronary lesions in elderly acute coronary syndrome patients after percutaneous coronary intervention.

Han, T.-W., Zhou, S., Li, J., Tian, F., Mu, Y., Jing, J., Han, Y., & Chen, Y. (2016) · PubMed Central · doi:10.11909/j.issn.1671-5411.2016.04.010 · Cited by 9 · see citing works

Mendelian randomisation study of the associations of vitamin B12 and folate genetic risk scores with blood pressure and fasting serum lipid levels in three Danish population-based studies

Husemoen, L. L. N., Skaaby, T., Thuesen, B. H., Grarup, N., Sandholt, C. H., Hansen, T. F., Pedersen, O. B., & Linneberg, A. R. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.5 · Cited by 9 · see citing works

MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemia

Qin, H., Hu, L., Wang, W., Yu, Z., Chen, Y., Zhao, Y., Liao, Y., Zhang, W., & Yang, R. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112330 · Cited by 8 · see citing works

Isolated Homocysteinemia Leading to Thromboembolism in Young Male with Normal Vitamin B12 and Folate Levels

Sadiq, W., & Subhan, M. (2017) · Cureus · doi:10.7759/cureus.1978 · Cited by 8 · see citing works

Folic acid supplementation reduces plasma homocysteine in postmenopausal women

Almassinokiani, F., Kashanian, M., Akbari, P., Mossayebi, E., & Sadeghian, E. (2016) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443615.2015.1091811 · Cited by 9 · see citing works

Homocysteine Levels and Arterial Stiffness in the General Population

Wakabayashi, I. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.ed043 · Cited by 8 · see citing works

2-(3-Hydroxy-5-phosphonooxymethyl-2-methyl-4-pyridyl)-1,3-thiazolidine-4-carboxylic Acid, Novel Metabolite of Pyridoxal 5′-Phosphate and Cysteine Is Present in Human Plasma—Chromatographic Investigations

Piechocka, J., Wrońska, M., Głowacka, I. E., & Głowacki, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103548 · Cited by 7 · see citing works

Prognostic Value of Elevated Homocysteine Levels in Korean Patients with Coronary Artery Disease: A Propensity Score Matched Analysis

Kwon, S. W., Kim, J., Suh, Y. J., Lee, D. H., Yoon, Y. W., Lee, B. K., Jung, Y.-H., Choi, E., Hong, B., Rim, S., et al. (2016) · Korean Circulation Journal · doi:10.4070/kcj.2016.46.2.154 · Cited by 7 · see citing works

Hyperhomocysteinemia: How Does it Affect the Development of Cardiovascular Disease?

Cardoso, I. L. (2018) · International Archives of Cardiovascular Diseases · doi:10.23937/iacvd-2017/1710008 · Cited by 6 · see citing works

Association of Hyperhomocysteinemia with Increased Coronary Microcirculatory Resistance and Poor Short‐Term Prognosis of Patients with Acute Myocardial Infarction after Elective Percutaneous Coronary Intervention

Peng, Y., Huang, M.-Y., Xue, Y., Pan, J., & Cong, L. (2020) · BioMed Research International · doi:10.1155/2020/1710452 · Cited by 6 · see citing works

Vitamins for Cardiovascular Diseases

Sultan, S., Murarka, S., Jahangir, A., Mookadam, F., Tajik, A. J., & Jahangir, A. (2017) · Cardiology in Review · doi:10.1097/crd.0000000000000150 · Cited by 6 · see citing works

Hypercoagulable States

Sun, Y.-M., & Kroll, M. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-47870-0.00062-3 · Cited by 5 · see citing works

Novel biomarkers identifying hypertrophic cardiomyopathy and its obstructive variant based on targeted amino acid metabolomics

Guo, L., Wang, B., Zhang, F., Gao, C., Hu, G., Zhou, M., Wang, R., Zhao, H., Yan, W., Zhang, L., et al. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002279 · Cited by 5 · see citing works

Fitting homocysteine to disease models, as well as adjusting the models to the disease

Luft, F. C. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1293-z · Cited by 3 · see citing works

Antagonistic effects of endostatin-vascular endothelial growth inhibitor chimeric recombinant adenovirus on homocysteine-induced vascular endothelial cells injury in vitro and in vivo

Cui, Z.-T., Liu, J., & Yao, J.-M. (2016) · Medicine · doi:10.1097/md.0000000000005197 · Cited by 3 · see citing works

The andrologist's contribution to a better life for ageing men: part 2

Comhaire, F. H., & Mahmoud, A. M. (2015) · Andrologia · doi:10.1111/and.12489 · Cited by 3 · see citing works

DNA methylation in heart failure

Anene-Nzelu, C. G., Stenzig, J., & Foo, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822258-4.00016-x · Cited by 2 · see citing works

The relationship between homocysteine and cardiopulmonary exercise testing in patients with acute coronary syndrome after percutaneous coronary intervention

Luo, J.-T., Zeng, C.-M., Zhao, Y.-M., & Zeng, Z. (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02976-0 · Cited by 2 · see citing works

FUNCTIONAL FOOD IN PREVENTION OF CARDIOVASCULAR DISEASES AND OBESITY

Papierska, K., & Ignatowicz, E. (2019) · Acta Poloniae Pharmaceutica - Drug Research · doi:10.32383/appdr/111353 · Cited by 2 · see citing works

Urinary metabolomics analysis based on LC-MS for the diagnosis and monitoring of acute coronary syndrome

Liu, J., Wang, A., Feng, Q., Liu, X., Guo, Z., Sun, H., Zhao, M., Li, T., Xue, F., Wang, H., et al. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1547476 · Cited by 1 · see citing works

Supplemental N-acetylcysteine and other measures that boost intracellular glutathione can downregulate interleukin-1β signalling: a potential strategy for preventing cardiovascular events?

DiNicolantonio, J. J., O’Keefe, J. H., & McCarty, M. F. (2017) · Open Heart · doi:10.1136/openhrt-2017-000599 · Cited by 1 · see citing works

Blut und blutbildende Organe

Herlan, K., Horn, H., Streitlein-Böhme, I., & Vetter, G. (2018) · Elsevier eBooks · doi:10.1016/b978-3-437-21521-6.00003-4 · Cited by 1 · see citing works

Effects of folic acid supplementation on homocysteine level as primary prevention of heart disease: a systematic review

Mahmood, M. I., Rosli, N. M., Shukor, M. F. A., Nawi, A. M., Ahmad, N., & Shah, S. A. (2015) · Journal of Public Health · doi:10.1007/s10389-015-0691-6

Hyperlipidämien im Kindes- und Jugendalter

Prell, C., & Koletzko, B. V. (2016) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-016-0142-7

Hyperhomocystéinémie et thromboses artérielles

Galanaud, J. ‐., Quéré, I., & Wahl, D. G. (2016) · Elsevier eBooks · doi:10.1016/b978-2-294-74970-4.00073-7

DNA Methylation in Heart Failure

Stenzig, J., & Foo, R. (2016) · Cardiac and vascular biology · doi:10.1007/978-3-319-41457-7_4

Padrões alimentares, nutrientes do metabolismo do folato e homocisteína e três desfechos em saúde

Teixeira, J. A. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.6.2018.tde-09112018-105631

Homocisteína, vitaminas do complexo B e perfil de ácidos graxos em crianças e adolescentes

Ued, F. D. V. (2019) · doi:10.11606/t.17.2019.tde-26072019-170058

Vitamine und Mineralstoffpräparate

Seifert, R. (2021) · Springer eBooks · doi:10.1007/978-3-662-63825-5_44

Vitamine und Mineralstoffpräparate

Mengel, K., & Dollen, K. N.-V. (2018) · Springer eBooks · doi:10.1007/978-3-662-57386-0_46

Vitamine und Mineralstoffpräparate

Dollen, K. N.-V. (2020) · Springer eBooks · doi:10.1007/978-3-662-62168-4_43

Unidentifiable Thrombophilia

Mantha, S. H., & Soff, G. A. (2016) · Springer eBooks · doi:10.1007/978-3-032-13858-3_35

Effect of homocysteine interventions on the risk of cardiocerebrovascular events: a meta-analysis of randomised controlled trials

Mei, W., Rong, Y., Jinming, L., Li, Y., & Hu, Z. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02207.x · Cited by 56 · see citing works

Homocysteine and vascular disease: review of published results of the homocysteine‐lowering trials

Clarke, R., Halsey, J., Bennett, D., & Lewington, S. (2011) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-010-9235-y · Cited by 104 · see citing works

Is there randomized controlled trial evidence to support the use of homocysteine-lowering interventions for preventing cardiovascular events in adults at risk of, or with existing cardiovascular disease?

(2014) · Cochrane Clinical Answers · doi:10.1002/cca.352

Can homocysteine-lowering interventions help prevent cardiovascular events?

Driscoll, A. L. (2016) · Cochrane Clinical Answers · doi:10.1002/cca.1131

CHAPTER 45. Homocysteine and Vascular Disease: A Review of the Published Results of 11 Trials involving 52 260 Individuals

Clarke, R., & Armitage, J. (2012) · Food and nutritional components in focus · doi:10.1039/9781849734714-00754