The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143 · see citing works

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074 · see citing works

Glutathione Metabolism and Its Implications for Health

Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842 · see citing works

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

Boushey, C. J. (1995) · JAMA · doi:10.1001/jama.1995.03530130055028 · Cited by 3,604 · see citing works

Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation

Czeizel, A. E., & Dudás, I. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212243272602 · Cited by 3,200 · see citing works

Epigenetic Reprogramming in Mammalian Development

Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078 · see citing works

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

Clarke, R., Daly, L., Robinson, K., Naughten, E. R., Cahalane, S. F., Fowler, B., & Graham, I. M. (1991) · New England Journal of Medicine · doi:10.1056/nejm199104253241701 · Cited by 2,160 · see citing works

Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease

Clarke, R., Smith, A. D., Jobst, K. A., Refsum, H., Sutton, L., & Ueland, P. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.11.1449 · Cited by 1,408 · see citing works

Homocysteine and vascular disease

Hankey, G. J., & Eikelboom, J. W. (1999) · The Lancet · doi:10.1016/s0140-6736(98)11058-9 · Cited by 1,070 · see citing works

Role of homocysteine in the development of cardiovascular disease

Ganguly, P. K., & Alam, S. F. (2015) · Nutrition Journal · doi:10.1186/1475-2891-14-6 · Cited by 1,030 · see citing works

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1611 · Cited by 955 · see citing works

Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

Mattson, M. P., & Shea, T. B. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00032-8 · Cited by 847 · see citing works

Neurotoxicity associated with dual actions of homocysteine at the N -methyl- d -aspartate receptor

Lipton, S. A., Kim, W.-K., Choi, Y., Kumar, S., D’Emilia, D. M., Posina, V. R., Arnelle, D. R., & Stamler, J. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5923 · Cited by 845 · see citing works

Neurologic Aspects of Cobalamin Deficiency

Healton, E. B., Savage, D. G., Brust, J. C. M., Garrett, T. J., & Lindenbaum, J. (1991) · Medicine · doi:10.1097/00005792-199107000-00001 · Cited by 770 · see citing works

Neopterin as a Marker for Immune System Activation

Murr, C., Widner, B., Wirleitner, B., & Fuchs, D. (2002) · Current Drug Metabolism · doi:10.2174/1389200024605082 · Cited by 737 · see citing works

Homocysteine and vascular disease

McCully, K. S. (1996) · Nature Medicine · doi:10.1038/nm0496-386 · Cited by 705 · see citing works

Homocysteine Impairs the Nitric Oxide Synthase Pathway

Stuehlinger, M., Tsao, P. S., Her, J. H., Kimoto, M., Balint, R. F., & Cooke, J. P. (2001) · Circulation · doi:10.1161/hc4601.098514 · Cited by 662 · see citing works

Folic Acid Deficiency and Homocysteine Impair DNA Repair in Hippocampal Neurons and Sensitize Them to Amyloid Toxicity in Experimental Models of Alzheimer's Disease

Kruman, I. I., Kumaravel, T. S., Lohani, A., Pedersen, W. A., Cutler, R. G., Kruman, Y., Haughey, N. J., Lee, J., Evans, M. K., & Mattson, M. P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01752.2002 · Cited by 643 · see citing works

Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy.

Ueland, P. M., & Refsum, H. (1989) · PubMed · Cited by 595 · see citing works

Neural tube defects and folate: case far from closed

Blom, H. J., Shaw, G. M., den Heijer, M., & Finnell, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1986 · Cited by 562 · see citing works

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

Nelson, A. R., Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.016 · Cited by 559 · see citing works

Homocysteine, B Vitamins, and Cognitive Impairment

Smith, A. D., & Refsum, H. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050947 · Cited by 526 · see citing works

Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia

Obeid, R., & Herrmann, W. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.088 · Cited by 490 · see citing works

S-adenosylmethionine synthesis: Molecular mechanisms and clinical implications

Mato, J. M., Álvarez, L., Ortiz, P., & Pajares, M. A. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00197-0 · Cited by 489 · see citing works

Vitamin B 12 and folate in relation to the development of Alzheimer’s disease

Wang, H., Wåhlin, Å., Basun, H., Fastbom, J., Winblad, B. G., & Fratiglioni, L. (2001) · Neurology · doi:10.1212/wnl.56.9.1188 · Cited by 469 · see citing works

B vitamins, homocysteine, and neurocognitive function in the elderly

Selhub, J., Bagley, L. C., Miller, J. W., & Rosenberg, I. H. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.614s · Cited by 462 · see citing works

Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects

Blom, H. J., & Smulders, Y. M. (2010) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-010-9177-4 · Cited by 455 · see citing works

Folate and neural tube defects

Pitkin, R. M. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.285s · Cited by 443 · see citing works

High Prevalence of Cobalamin Deficiency in Elderly Outpatients

Pennypacker, L. C., Allen, R. H., Kelly, J. P., Matthews, L. M., Grigsby, J., Kaye, K., Lindenbaum, J., & Stabler, S. P. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb03641.x · Cited by 422 · see citing works

S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production

Fuso, A., Seminara, L., Cavallaro, R. A., D’Anselmi, F., & Scarpa, S. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.09.007 · Cited by 408 · see citing works

Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria

Leclerc, D., Wilson, A., Dumas, R., Gafuik, C. J., Song, D., Watkins, D., Heng, H. H., Rommens, J. M., Scherer, S. W., Rosenblatt, D. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3059 · Cited by 391 · see citing works

Endothelial function and nitric oxide: clinical relevance

Vallance, P. J., & Chan, N. N. (2001) · Heart · doi:10.1136/heart.85.3.342 · Cited by 389 · see citing works

Folate, Vitamin B12, and Neuropsychiatric Disorders

Bottiglieri, T. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1996.tb03851.x · Cited by 356 · see citing works

Pathology and pathogenesis of vascular cognitive impairment—a critical update

Jellinger, K. A. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00017 · Cited by 353 · see citing works

Homocysteine and Alzheimer's disease

Morris, M. S. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00438-1 · Cited by 349 · see citing works

Guidelines for diagnosis and management of the cobalamin‐related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency

Huemer, M., Diodato, D., Schwahn, B., Schiff, M., Bandeira, A., Benoist, J., Burlina, A., Cerone, R., Couce, M. L., García‐Cazorla, À., et al. (2016) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-016-9991-4 · Cited by 326 · see citing works

Homocysteine and Alzheimer's disease

LeBoeuf, R. C. (2003) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(03)00032-4 · Cited by 321 · see citing works

The Treatment of Hyperhomocysteinemia

Maron, B. A., & Loscalzo, J. (2008) · Annual Review of Medicine · doi:10.1146/annurev.med.60.041807.123308 · Cited by 312 · see citing works

PP2A mRNA Expression Is Quantitatively Decreased in Alzheimer's Disease Hippocampus

Vogelsberg-Ragaglia, V., Schuck, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7630 · Cited by 281 · see citing works

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B

Wang, J.-Z., Gong, C.-X., Zaidi, T., Grundke-Iqbal, I., & Iqbal, K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4854 · Cited by 269 · see citing works

5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation

Castro, R., Rivera, I. A., Ravasco, P., Camilo, M., Jakobs, C., Blom, H. J., & de Almeida, I. T. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.017244 · Cited by 265 · see citing works

Endothelial Dysfunction: The Link Between Homocysteine and Hydrogen Sulfide

Pushpakumar, S. B., Kundu, S., & Sen, U. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140706142335 · Cited by 255 · see citing works

Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults

Kluijtmans, L. A. J., Young, I. S., Boreham, C. A., Murray, L., McMaster, D., McNulty, H., Strain, J. J., McPartlin, J. M., Scott, J. M., & Whitehead, A. S. (2003) · Blood · doi:10.1182/blood.v101.7.2483 · Cited by 244 · see citing works

Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine

Ho, P. I. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00070-6 · Cited by 242 · see citing works

Short-Term Folate, Vitamin B-12 or Vitamin B-6 Supplementation Slightly Affects Memory Performance But Not Mood in Women of Various Ages

Bryan, J., Calvaresi, E., & Hughes, D. (2002) · Journal of Nutrition · doi:10.1093/jn/132.6.1345 · Cited by 240 · see citing works

S -adenosylmethionine stabilizes cystathionine β-synthase and modulates redox capacity

Prudova, A., Bauman, Z. M., Braun, A., Vitvitsky, V., Lu, S. C.-L., & Banerjee, R. V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509531103 · Cited by 237 · see citing works

Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway

Surtees, R. A. H., Leonard, J., & Austin, S. (1991) · The Lancet · doi:10.1016/0140-6736(91)92373-a · Cited by 235 · see citing works

Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

Tolstykh, T., Lee, J., Vafai, S. B., & Stock, J. B. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5682 · Cited by 233 · see citing works

Redox regulation and reaction mechanism of human cystathionine-β-synthase: a PLP-dependent hemesensor protein

Banerjee, R. V., & Zou, C.-G. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.08.037 · Cited by 226 · see citing works

Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products

Kotb, M., Mudd, S. H., Mato, J. M., Geller, A. M., Kredich, N. M., CHOU, J. Y., & Cantoni, G. L. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01013-5 · Cited by 215 · see citing works

Elevated levels of homocysteine compromise blood-brain barrier integrity in mice

Kamath, A. F., Chauhan, A. K., Kisucka, J., Dole, V. S., Loscalzo, J., Handy, D. E., & Wagner, D. D. (2005) · Blood · doi:10.1182/blood-2005-06-2506 · Cited by 213 · see citing works

Betaine–Homocysteine Methyltransferase Expression in Porcine and Human Tissues and Chromosomal Localization of the Human Gene

Sunden, S. L. F., Renduchintala, M. S., Park, E. I., et al. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0246 · Cited by 205 · see citing works

Hyperhomocysteinemia and Neurologic Disorders: a Review

Ansari, R., Mahta, A., Mallack, E. J., & Luo, J. J. (2014) · Journal of Clinical Neurology · doi:10.3988/jcn.2014.10.4.281 · Cited by 205 · see citing works

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

Selkoe, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211352598 · Cited by 202 · see citing works

Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat

McKeever, M., Weir, D. G., Molloy, A. M., & Scott, J. M. (1991) · Clinical Science · doi:10.1042/cs0810551 · Cited by 202 · see citing works

Homocysteine and oxidative stress

Perna, A. F., Ingrosso, D., & Santo, N. G. D. (2003) · Amino Acids · doi:10.1007/s00726-003-0026-8 · Cited by 197 · see citing works

Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine

Finkelstein, J. D. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.341 · Cited by 196 · see citing works

Presenilin 1 gene silencing by S ‐adenosylmethionine: a treatment for Alzheimer disease?

Scarpa, S., Fuso, A., D’Anselmi, F., & Cavallaro, R. A. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00277-1 · Cited by 195 · see citing works

Elevated Plasma Homocysteine Was Associated With Hemorrhagic and Ischemic Stroke, but Methylenetetrahydrofolate Reductase Gene C677T Polymorphism Was a Risk Factor for Thrombotic Stroke

Li, Z., Sun, L. J., Zhang, H., et al. (2003) · Stroke · doi:10.1161/01.str.0000086753.00555.0d · Cited by 195 · see citing works

Downregulation of Protein Phosphatase 2A Carboxyl Methylation and Methyltransferase May Contribute to Alzheimer Disease Pathogenesis

Sontag, E., Hladik, C. L., Montgomery, L. G., Luangpirom, A., Mudrak, I., Ogris, E., & White, C. L. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.10.1080 · Cited by 191 · see citing works

Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization

Garrow, T. A., Brenner, A., Whitehead, V. M., Chen, X. N., Duncan, R., Korenberg, J. R., & Shane, B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50286-1 · Cited by 179 · see citing works

Selective Phosphorylation of Adult Tau Isoforms in Mature Hippocampal Neurons Exposed to Fibrillar Aβ

Ferreira, A., Lu, Q., Orecchio, L., & Kosik, K. S. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0615 · Cited by 178 · see citing works

Time Dependency of Cognitive Recovery with Cobalamin Replacement: Report or a Pilot Study

Martin, D. C., Francis, J., Protetch, J., & Huff, F. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb01939.x · Cited by 174 · see citing works

Homocysteine to Hydrogen Sulfide or Hypertension

Sen, U., Mishra, P. K., Tyagi, N., & Tyagi, S. C. (2010) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-010-9079-y · Cited by 171 · see citing works

Homocysteine as a Predictor of Early Neurological Deterioration in Acute Ischemic Stroke

Kwon, H., Lee, Y. S., Bae, H., et al. (2014) · Stroke · doi:10.1161/strokeaha.113.004099 · Cited by 170 · see citing works

Acquired and inherited disorders of cobalamin and folate in children

Whitehead, V. M. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06133.x · Cited by 168 · see citing works

Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series)

Loscalzo, J., & Handy, D. E. (2014) · Pulmonary Circulation · doi:10.1086/675979 · Cited by 164 · see citing works

ACTIVATION OF METHIONINE FOR TRANSMETHYLATION

Mudd, S. H., & Cantoni, G. L. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77322-0 · Cited by 163 · see citing works

Homocysteine induces the expression of C-reactive protein via NMDAr-ROS-MAPK-NF-κB signal pathway in rat vascular smooth muscle cells

Pang, X., Liu, J., Zhao, J., Mao, J., Zhang, X., Feng, L., Han, C., Li, M., Wang, S., & Wu, D. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.06.021 · Cited by 163 · see citing works

Association of homocysteine with plasma amyloid β protein in aging and neurodegenerative disease

Irizarry, M., Gurol, M., Raju, S., Diaz-Arrastia, R., Locascio, J., Tennis, M., Hyman, B., Growdon, J., Greenberg, S., & Bottiglieri, T. (2005) · Neurology · doi:10.1212/01.wnl.0000183063.99107.5c · Cited by 157 · see citing works

The history of folic acid

Hoffbrand, A. V., & Weir, D. G. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.02822.x · Cited by 151 · see citing works

Homocysteine and Redox Signaling

Zou, C.-G., & Banerjee, R. V. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.547 · Cited by 148 · see citing works

Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.

Hum, D. W., Bell, A. W., Rozen, R. R., & MacKenzie, R. E. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37540-9 · Cited by 144 · see citing works

Oligodendrocytes utilize a matrix metalloproteinase, MMP-9, to extend processes along an astrocyte extracellular matrix

Uhm, J. H., Dooley, N. P., Oh, L. Y. S., & Yong, V. W. (1998) · Glia · doi:10.1002/(sici)1098-1136(199801)22:1 · Cited by 144 · see citing works

Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine

Nilsson, K. H., Gustafson, L., & Hultberg, B. L. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.388 · Cited by 141 · see citing works

Hyperhomocysteinemia: Impact on Neurodegenerative Diseases

Sharma, M., Tiwari, M., & Tiwari, R. K. (2015) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12424 · Cited by 137 · see citing works

Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID)

Hainsworth, A. H., Yeo, N., Weekman, E. M., & Wilcock, D. M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.015 · Cited by 136 · see citing works

Hypothesis: Hyperhomocysteinemia is an indicator of oxidant stress

Hoffman, M. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.09.009 · Cited by 135 · see citing works

Role of group I metabotropic glutamate receptors and NMDA receptors in homocysteine-evoked acute neurodegeneration of cultured cerebellar granule neurones

Ziemińska, E., Stafiej, A., & Łazarewicz, J. W. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(03)00038-x · Cited by 134 · see citing works

Folic acid, methylation and neural tube closure in humans

Blom, H. J. (2009) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20581 · Cited by 134 · see citing works

Nigral endothelial dysfunction, homocysteine, and Parkinson's disease

Müller, T. H., Weme, B., Fowler, B., & Kuhn, W. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01660-8 · Cited by 132 · see citing works

Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease

Vafai, S. B., & Stock, J. B. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02702-3 · Cited by 129 · see citing works

Cystathionine β-synthase is enriched in the brains of Down’s patients

Ichinohe, A., Kanaumi, T., Takashima, S., Enokido, Y., Nagai, Y., & Kimura, H. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.118 · Cited by 128 · see citing works

Hyperhomocysteinemia as a Risk Factor for Vascular Contributions to Cognitive Impairment and Dementia

Price, B. R., Wilcock, D. M., & Weekman, E. M. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00350 · Cited by 128 · see citing works

Endoplasmic Reticulum Stress-inducible Protein, Herp, Enhances Presenilin-mediated Generation of Amyloid β-Protein

Sai, X., Kawamura, Y., Kokame, K., Yamaguchi, H., Shiraishi, H., Suzuki, R., Suzuki, T., Kawaichi, M., Miyata, T., Kitamura, T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112372200 · Cited by 126 · see citing works

Elevated Total Homocysteine Levels in Acute Ischemic Stroke Are Associated With Long-Term Mortality

Shi, Z., Guan, Y., Huo, Y. R., et al. (2015) · Stroke · doi:10.1161/strokeaha.115.009136 · Cited by 124 · see citing works

Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter

Li, J., Li, Q., Du, H., Wang, Y., You, S., Wang, F., Xu, X., Cheng, J. G., Cao, Y., Liu, C., et al. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160612560 · Cited by 123 · see citing works

Increase of total homocysteine concentration in cerebrospinal fluid in patients with Alzheimer's disease and Parkinson's disease

Isobe, C., Murata, T., Sato, C., et al. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.02.014 · Cited by 122 · see citing works

Conversion from cognitive health to mild cognitive impairment and Alzheimer's disease: Prediction by plasma amyloid beta 42, medial temporal lobe atrophy and homocysteine

Blasko, I., Jellinger, K. A., Kemmler, G., Krampla, W. W., Jungwirth, S., Wichart, I., Tragl, K. H., & Fischer, P. A. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.002 · Cited by 121 · see citing works

The central nervous system in animal models of hyperhomocysteinemia

Troen, A. M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.06.025 · Cited by 120 · see citing works

Vitamin B12 and folate status in acute geropsychiatric inpatients: Affective and cognitive characteristics of a vitamin nondeficient population

Bell, I. R., Edman, J. S., Marby, D. W., Satlin, A., Dreier, T., Liptzin, B., & Cole, J. O. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90642-f · Cited by 115 · see citing works

DNA methylation in mammalian development and disease

Dean, W., Lucifero, D., & Santos, F. (2005) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20037 · Cited by 113 · see citing works

The uptake of cysteine in cultured primary astrocytes and neurons

Shanker, G., Allen, J. W., Mutkus, L. A., & Aschner, M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02342-3 · Cited by 112 · see citing works

Hyperhomocysteinemia as a risk factor for the neuronal system disorders.

Petráš, M., Tatarková, Z., Kovalská, M., Mokrá, D., Dobrota, D., Lehotský, J., & Drgova, A. (2014) · PubMed · Cited by 111 · see citing works

Inhibition of Na+,K+-ATPase Activity in Hippocampus of Rats Subjected to Acute Administration of Homocysteine Is Prevented by Vitamins E and C Treatment

Wyse, Â. T. D. S., Zugno, A. I., Streck, E. L., et al. (2002) · Neurochemical Research · doi:10.1023/a:1021647329937 · Cited by 108 · see citing works

Guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health

EFSA Panel on Dietetic Products, N. A. A. (. (2011) · EFSA Journal · doi:10.2903/j.efsa.2011.2474 · Cited by 106 · see citing works

Homocysteine and neural tube defects.

Mills, J. L., Scott, J., Kirke, P. N., et al. (1996) · Journal of NutriLife · doi:10.1093/jn/126.suppl_3.756s · Cited by 105 · see citing works

Integrity of the methylation cycle is essential for mammalian neural tube closure

Dunlevy, L. P. E., Burren, K. A., Mills, K., et al. (2006) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20286 · Cited by 104 · see citing works

Methylation Deficiency Causes Vitamin B12‐Associated Neuropathy in the Pig

Weir, D. G., Keating, S., Molloy, A. M., et al. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb01184.x · Cited by 104 · see citing works

l-Homocysteine Sulfinic Acid and Other Acidic Homocysteine Derivatives Are Potent and Selective Metabotropic Glutamate Receptor Agonists

Shi, Q., Savage, J. E., Hufeisen, S. J., Rauser, L., Grajkowska, E., Ernsberger, P. R., Wroblewski, J. T., Nadeau, J. H., & Roth, B. L. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.047092 · Cited by 102 · see citing works

Role of homocysteine in age-related vascular and non-vascular diseases

Parnetti, L., Bottiglieri, T., & Lowenthal, D. (1997) · Aging Clinical and Experimental Research · doi:10.1007/bf03341827 · Cited by 101 · see citing works

l-Homocysteate is a potent neurotoxin on cultured cortical neurons

Kim, J. P., Koh, J., & Choi, D. W. (1987) · Brain Research · doi:10.1016/0006-8993(87)91531-9 · Cited by 96 · see citing works

Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study

Faux, N. G., Ellis, K. A., Porter, L., Fowler, C. J., Laws, S. M., Martins, R. N., Pertile, K. K., Rembach, A., Rowe, C. C., Rumble, R. L., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110752 · Cited by 95 · see citing works

The Effect of Vitamin B 12 Deficiency on Older Veterans and Its Relationship to Health

Bernard, M., Nakonezny, P. A., & Kashner, T. M. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb04534.x · Cited by 93 · see citing works

Soluble Oligomers of Amyloid-β Cause Changes in Redox State, DNA Methylation, and Gene Transcription by Inhibiting EAAT3 Mediated Cysteine Uptake

Hodgson, N., Trivedi, M. S., Muratore, C., Li, S., & Deth, R. C. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130101 · Cited by 92 · see citing works

The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation

Krishna, S. M., Dear, A. E., Craig, J. M., Norman, P. E., & Golledge, J. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.02.019 · Cited by 91 · see citing works

Melatonin improves learning and memory performances impaired by hyperhomocysteinemia in rats

Baydaş, G., Özer, M., Yaşar, A., et al. (2005) · Brain Research · doi:10.1016/j.brainres.2005.04.011 · Cited by 90 · see citing works

Melatonin Relieves the Neural Oxidative Burden that Contributes to Dementias

Reiter, R. J., Tan, D. X., & Pappolla, M. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.012 · Cited by 89 · see citing works

Homocysteine, Ischemic Stroke, and Coronary Heart Disease in Hypertensive Patients

Han, L., Wu, Q., Wang, C., Hao, Y., Zhao, J., Zhang, L., Fan, R., Liu, Y., Li, R., Chen, Z., et al. (2015) · Stroke · doi:10.1161/strokeaha.115.009111 · Cited by 88 · see citing works

Structure of Protein Phosphatase Methyltransferase 1 (PPM1), a Leucine Carboxyl Methyltransferase Involved in the Regulation of Protein Phosphatase 2A Activity

Leulliot, N., Quevillon‐Chéruel, S., Sorel, I., de la Sierra-Gallay, I. L., Collinet, B., Graille, M., Blondeau, K., Bettache, N., Anne Poupon, B., Janin, J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311484200 · Cited by 86 · see citing works

Folate status, vascular disease and cognition in elderly Canadians

Ebly, E. M., Schaefer, J. P., Campbell, N. R. C., et al. (1998) · Age and Ageing · doi:10.1093/ageing/27.4.485 · Cited by 86 · see citing works

Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect

Al-Gazali, L. I., Padmanabhan, R., Melnyk, S., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1509 · Cited by 86 · see citing works

Further evidence on the effects of vitamin B12 and folate levels on episodic memory functioning: a population-based study of healthy very old adults

Hassing, L. B., Wåhlin, Å., Winblad, B. G., & Bäckman, L. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00234-0 · Cited by 82 · see citing works

Homocysteine and Its Relationship to Stroke Subtypes in a UK Black Population

Khan, U., Crossley, C., Kalra, L., Rudd, A. G., Wolfe, C. D. A., Collinson, P. O., & Markus, H. S. (2008) · Stroke · doi:10.1161/strokeaha.107.513416 · Cited by 82 · see citing works

Plasma homocysteine levels in Parkinson's disease: role of antiparkinsonian medications

Zoccolella, S., Lamberti, P., Armenise, E., Mari, M. D., Lamberti, S. V., Mastronardi, R., Fraddosio, A., Iliceto, G., & Livrea, P. (2004) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2004.07.008 · Cited by 81 · see citing works

Homocysteine Inhibits Arterial Endothelial Cell Growth Through Transcriptional Downregulation of Fibroblast Growth Factor-2 Involving G Protein and DNA Methylation

Chang, P., Lu, S., Lee, C., Chen, Y.-J., Dugan, T. A., Huang, W.-H., Chang, S., Liao, W. S. ‐., Chen, C., & Lee, Y. (2008) · Circulation Research · doi:10.1161/circresaha.108.171082 · Cited by 81 · see citing works

Toxic Effects of Mildly Elevated Homocysteine Concentrations in Neuronal-Like Cells

Currò, M., Gugliandolo, A., Gangemi, C. M. A., et al. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1338-7 · Cited by 80 · see citing works

Age-Related Changes in Cobalamin (Vitamin B12) Handling

Nilsson‐Ehle, H. (1998) · Drugs & Aging · doi:10.2165/00002512-199812040-00003 · Cited by 79 · see citing works

Plasma Folate, Vitamin B12, and Total Homocysteine and Homozygosity for the C677T Mutation of the 5,10-Methylene Tetrahydrofolate Reductase Gene in Patients with Alzheimer’s Dementia

Postiglione, A., Milan, G., Ruocco, A., Gallotta, G., Guiotto, G., & Minno, G. D. (2001) · Gerontology · doi:10.1159/000052822 · Cited by 79 · see citing works

Inhibitory effects of melatonin on neural lipid peroxidation induced by intracerebroventricularly administered homocysteine

Baydaş, G., Kutlu, S., Nazıroğlu, M., et al. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02939.x · Cited by 79 · see citing works

Dementia and subnormal levels of vitamin B12: Effects of replacement therapy on dementia

Teunisse, S., Bollen, A. E., van Gool, W. A., & Walstra, G. J. M. (1996) · Journal of Neurology · doi:10.1007/bf00886874 · Cited by 76 · see citing works

Vitamins B12, B6 and folate as determinants of homocysteine concentration in the healthy population

Pietrzik, K. F., & Brönstrup, A. (1998) · European Journal of Pediatrics · doi:10.1007/pl00014298 · Cited by 76 · see citing works

Lipid Peroxidation‐Mediated Inflammation Promotes Cell Apoptosis through Activation of NF‐ κ B Pathway in Rheumatoid Arthritis Synovial Cells

Yin, G., Wang, Y., Cen, X.-M., Yang, M., Liang, Y., & Xie, Q. (2015) · Mediators of Inflammation · doi:10.1155/2015/460310 · Cited by 75 · see citing works

Pretreatment with Vitamins E and C Prevent the Impairment of Memory Caused by Homocysteine Administration in Rats

dos Reis, E. A., Zugno, A. I., Franzon, R. C., Tagliari, B., Matté, C., Lamers, M. L., Netto, C. A., & Wyse, Â. T. D. S. (2002) · Metabolic Brain Disease · doi:10.1023/a:1019982223034 · Cited by 73 · see citing works

Why Is Homocysteine Toxic for the Nervous and Immune Systems?

Болдырев, А. А., Bryushkova, E. A., Mashkina, A. P., & Vladychenskaya, E. A. (2013) · Current Aging Science · doi:10.2174/18746098112059990007 · Cited by 72 · see citing works

Long-term homocysteine exposure induces alterations in spatial learning, hippocampal signalling and synaptic plasticity

Algaidi, S. A., Christie, L. A., Jenkinson, A. M., Whalley, L. J., Riedel, G., & Platt, B. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.003 · Cited by 71 · see citing works

Three years survival in patients with a clinical diagnosis of dementia with Lewy bodies

Walker, Z., Allen, R. L., Shergill, S. S., Mullan, E., & Katona, C. (2000) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(200003)15:3 · Cited by 71 · see citing works

Homocysteic acid induces intraneuronal accumulation of neurotoxic Aβ42: Implications for the pathogenesis of Alzheimer's disease

Hasegawa, T., Ukai, W., Jo, D., Xu, X. Z. S., Mattson, M. P., Nakagawa, M., Araki, W., Saito, T., & Yamada, T. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20514 · Cited by 70 · see citing works

Synaptosomal plasma membrane transport of excitatory sulphur amino acid transmitter candidates: Kinetic characterisation and analysis of carrier specificity

Grieve, A., Butcher, S. P., & Griffiths, R. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490320108 · Cited by 70 · see citing works

Homocysteine Activates B Cells via Regulating PKM2-Dependent Metabolic Reprogramming

Deng, J., Lü, S., Liu, H., Liu, B., Jiang, C., Xu, Q., Feng, J., & Wang, X. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600613 · Cited by 70 · see citing works

Relationship Between Homocysteine and Thrombotic Disease

Selhub, J., & D’Angelo, A. (1998) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199808000-00008 · Cited by 69 · see citing works

Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus

Robert, K., Pagès, C., Ledru, A., Delabar, J. M., Caboche, J., & Janel, N. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.034 · Cited by 64 · see citing works

Conversion from mild cognitive impairment to dementia: Influence of folic acid and vitamin B12 use in the vita cohort

Blasko, I., Hinterberger, M., Kemmler, G., Jungwirth, S., Krampla, W. W., Leitha, T., Tragl, K. H., & Fischer, P. A. (2012) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0051-y · Cited by 63 · see citing works

Asymmetric Dimethylarginine Reference Intervals Determined with Liquid Chromatography–Tandem Mass Spectrometry: Results from the Framingham Offspring Cohort

Schwedhelm, E., Xanthakis, V., Maas, R., SULLIVAN, L. M., Schulze, F., Riederer, U., Benndorf, R. A., Böger, R. H., & Vasan, R. S. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.124263 · Cited by 62 · see citing works

Vitamin B12 and folate depletion in cognition: a review.

Moretti, R., Torre, P., Antonello, R. M., Cattaruzza, T., Cazzato, G., & Bava, A. (2004) · PubMed · Cited by 60 · see citing works

The status of plasma homocysteine and related B-vitamins in healthy young vegetarians and nonvegetarians

Huang, Y., Chang, S.-J., Chiu, Y.-T., Chang, H.-H., & Cheng, C. (2003) · European Journal of Nutrition · doi:10.1007/s00394-003-0387-5 · Cited by 60 · see citing works

The influence of serum vitamin B12 and folate status on cognitive functioning in very old age

Wahlin, T. R., Wåhlin, Å., Winblad, B. G., & Bäckman, L. (2001) · Biological Psychology · doi:10.1016/s0301-0511(01)00079-5 · Cited by 60 · see citing works

Homocysteine in Microvascular Endothelial Cell Barrier Permeability

Tyagi, S. C., Lominadze, D. G., & Roberts, A. M. (2005) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:43:1:037 · Cited by 60 · see citing works

Inhibition of transmethylation disturbs neurulation in chick embryos

Afman, L. A., Blom, H. J., Drittij-Reijnders, M.-J., Brouns, M. R., & van Straaten, H. W. M. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2005.06.002 · Cited by 60 · see citing works

Folate Deficiency Alters Melatonin Secretion in Rats

Fournier, I., Ploye, F., Brun, J., Claustrat, B., & Cottet-Émard, J. M. (2002) · Journal of Nutrition · doi:10.1093/jn/132.9.2781 · Cited by 60 · see citing works

Spatial and Temporal Expression of the Cystathionine β-Synthase Gene During Early Human Development

Quéré, I., Paul, V., Rouillac, C., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9079 · Cited by 58 · see citing works

Methylenetetrahydrofolate reductase C677T genotype and PD

de Lau, L. M. L., Koudstaal, P. J., van Meurs, J. B. J., Uitterlinden, A. G., Albert Hofman, D., & Breteler, M. M. B. (2005) · Annals of Neurology · doi:10.1002/ana.20509 · Cited by 58 · see citing works

Release of endogenous amino acids, including homocysteic acid and cysteine sulphinic acid, from rat hippocampal slices evoked by electrical stimulation of Schaffer collateral-commissural fibres

Klančnik, J. M., Cuénod, M., Gähwiler, B. H., et al. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90226-r · Cited by 56 · see citing works

Effects of the disruption of transmethylation in the central nervous system: an animal model

Scott, J. M., Molloy, A. M., Kennedy, D. G., Kennedy, S., Weir, D. G., & Scott, J. M. (1994) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1994.tb05406.x · Cited by 55 · see citing works

Homocysteine‐lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease

Bleie, Ø., Semb, A. G., Grundt, H., Nordrehaug, J. E., Vollset, S. E., Ueland, P. M., Nilsen, D. W. T., Bakken, A. M., Refsum, H., & Nygard, O. K. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01810.x · Cited by 55 · see citing works

Serum Folate Levels and Subsequent Adverse Cerebrovascular Outcomes in Elderly Persons

Maxwell, C. J., Hogan, D. B., & Ebly, E. M. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000057701 · Cited by 53 · see citing works

Homocysteine and Pulsatility Index of Cerebral Arteries

Lim, M.-H., Cho, Y. I., & Jeong, S. (2009) · Stroke · doi:10.1161/strokeaha.109.558403 · Cited by 52 · see citing works

Cerebrospinal Fluid and Plasma Total Homocysteine and Related Metabolites in Children with Cystathionine β-Synthase Deficiency: The Effect of Treatment

Surtees, R., Leung, D. Y. M., Bowron, A., et al. (1997) · Pediatric Research · doi:10.1203/00006450-199711000-00004 · Cited by 51 · see citing works

Cognitive and Behavioral Correlates of Low Vitamin B12 Levels in Elderly Patients With Progressive Dementia

Whyte, E. M., Mulsant, B. H., Butters, M. A., Qayyum, M., Towers, A. L., Sweet, R. A., Klunk, W. E., Wisniewski, S. R., & DeKosky, S. T. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200205000-00012 · Cited by 50 · see citing works

Changes in cystathionine gamma-lyase in various regions of rat brain during development.

Awata, S., Nakayama, K., Suzuki, I., et al. (1995) · PubMed · Cited by 50 · see citing works

Elevated plasma homocysteine in acute stroke was not associated with severity and outcome: stronger association with small artery disease

Perini, F., Galloni, E., Bolgan, I., et al. (2005) · Neurological Sciences · doi:10.1007/s10072-005-0505-7 · Cited by 49 · see citing works

Acute phase homocysteine related to severity and outcome of atherothrombotic stroke

Wu, X., Ding, J., Ge, A., et al. (2013) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2013.01.015 · Cited by 45 · see citing works

Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines

Antoniades, C. A., Tousoulis, D., Marinou, K., Vasiliadou, C., Tentolouris, C., Bouras, G., Pitsavos, C. E., & Stefanadis, C. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.4.781 · Cited by 45 · see citing works

The effect of local application of homocysteine on neuronal activity in the central nervous system of the rat

Wuerthele, S. E., Yasuda, R. P., Freed, W. J., et al. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90712-3 · Cited by 44 · see citing works

Serial measurements of plasma homocysteine levels in early and late phases of ischemic stroke

Haapaniemi, E., Helenius, J., Soinne, L., et al. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01518.x · Cited by 44 · see citing works

Toxicity of substrate‐bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine

Mok, S. S., Turner, B. J., Beyreuther, K. T., Masters, C. L., Barrow, C. J., & Small, D. H. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02976.x · Cited by 43 · see citing works

Five year changes in mental health and associations with vitamin B12/folate status of elderly Europeans.

Eussen, S. J. P. M., Ferry, M., Hininger‐Favier, I., et al. (2002) · PubMed · Cited by 43 · see citing works

Folate and ApoE DNA Methylation Induced by Homocysteine in Human Monocytes

Jiang, Y., Sun, T., Hui-ping, Z., Jian-Tuan, X., Jun, C., Li, G., & Shu-Ren, W. (2007) · DNA and Cell Biology · doi:10.1089/dna.2007.0619 · Cited by 42 · see citing works

Brain energy metabolism is compromised by the metabolites accumulating in homocystinuria

STRECK, E. L., Delwing, D., Tagliari, B., Matté, C., Wannmacher, C. M. D., Wajner, M., & Wyse, Â. T. D. S. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(02)00230-9 · Cited by 42 · see citing works

Excitatory amino acid receptors, excitotoxicity, and the human nervous system.

Shaw, P. J. (1993) · PubMed · Cited by 42 · see citing works

Changes in predictors and status of homocysteine in young male adults after a dietary intervention with vegetables, fruits and bread

Stea, T. H., Mansoor, M. A., Wandel, M., Uglem, S., & Frølich, W. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0714-y · Cited by 41 · see citing works

Homocysteine attenuates endothelial haem oxygenase‐1 induction by nitric oxide (NO) and hypoxia

Sawle, P., Foresti, R., Green, C. J., & Motterlini, R. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03117-9 · Cited by 41 · see citing works

Early Increase of Plasma Homocysteine in Sepsis Patients with Poor Outcome

Ploder, M., Kurz, K., Spittler, A., et al. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00008 · Cited by 39 · see citing works

Plasma homocysteine level and functional outcome of patients with ischemic stroke

Mizrahi, E. H., Fleissig, Y., Arad, M., et al. (2005) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2004.01.031 · Cited by 39 · see citing works

Effect of hyperhomocysteinemia on cardiovascular risk factors and initiation of atherosclerosis in Wistar rats

Sharma, M., Kumar, S., Tiwari, M., et al. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.07.022 · Cited by 39 · see citing works

l-Homocysteic acid mediates synaptic excitation at NMDA receptors in the hippocampus

Ito, S., Provini, L., & Cherubini, E. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90083-6 · Cited by 38 · see citing works

Plasma Homocysteine and Risk of Mild Cognitive Impairment

Reitz, C., Tang, M.-X., Miller, J., Green, R., & Luchsinger, J. A. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000182421 · Cited by 38 · see citing works

Elevated Homocysteine Levels Contribute to Larger Hematoma Volume in Patients with Intracerebral Hemorrhage

Zhou, F., chen, B., Chen, C., et al. (2015) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2014.11.005 · Cited by 38 · see citing works

Folate in CSF and age

Bottiglieri, T. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.4.562a · Cited by 37 · see citing works

Cognitive recovery with vitamin B 12 therapy

Meadows, M., Kaplan, R. F., & Bromfield, E. B. (1994) · Neurology · doi:10.1212/wnl.44.9.1764 · Cited by 37 · see citing works

Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders

Bottiglieri, T. (1997) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.6.4.417 · Cited by 36 · see citing works

Effect of S-adenosyl-l-methionine on rat brain oxidative stress damage in a combined model of permanent focal ischemia and global ischemia-reperfusion

Villalobos, M. A., Cruz, J. P. D. L., Cuerda, M. A., et al. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02873-0 · Cited by 36 · see citing works

Impairment of phosphatase 2A contributes to the prolonged MAP kinase phosphorylation in Alzheimer's disease fibroblasts

Zhao, W., Feng, C., & Alkon, D. L. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00124-4 · Cited by 36 · see citing works

S-adenosyl-L-methionine prevents ischemic neuronal death

Matsui, Y., Kubo, Y., & Iwata, N. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90521-8 · Cited by 34 · see citing works

Supplementation of folic acid and vitamin B12 reduces plasma levels of asymmetric dimethylarginine in patients with acute ischemic stroke

Xia, X., Li, X., Wang, L., et al. (2014) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2013.11.043 · Cited by 30 · see citing works

Therapeutic potential of folic acid supplementation for cardiovascular disease prevention through homocysteine lowering and blockade in rheumatoid arthritis patients

Essouma, M., & Noubiap, J. J. (2015) · Biomarker Research · doi:10.1186/s40364-015-0049-9 · Cited by 29 · see citing works

(±)-β-Parachlorophenylglutamate selectively enhances the depolarizing response to l-homocysteic acid in neocortical neurons of the rat: evidence for a specific uptake system

Zeise, M. L., Knöpfel, T., & Zieglgänsberger, W. (1988) · Brain Research · doi:10.1016/0006-8993(88)91636-8 · Cited by 29 · see citing works

Hyperhomocyst(e)inemia Is a Risk Factor of Secondary Vascular Events in Stroke Patients

del Ser, T., Barba, R., Herranz, A. S., et al. (2001) · Cerebrovascular Diseases · doi:10.1159/000047687 · Cited by 28 · see citing works

Association of Hyperhomocysteinemia with Stroke Recurrence after Initial Stroke

Kumral, E., Durmaz, G. S., Aktert, D., et al. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2016.05.008 · Cited by 28 · see citing works

Genetic and environmental factors for hyperhomocysteinaemia and its clinical implications in Parkinson's disease.

Białecka, M., Robowski, P., Honczarenko, K., et al. (2009) · PubMed · Cited by 26 · see citing works

The Relationship between Associative Learning, Transfer Generalization, and Homocysteine Levels in Mild Cognitive Impairment

Moustafa, A. A., Hewedi, D. H., Eissa, A. M., Myers, C. E., & Sadek, H. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046496 · Cited by 26 · see citing works

Reversible Dementia and Neuropathy Associated with Folate Deficiency 16 Years After Partial Gastrectomy

Enk, C. D., Hougaard, K., & Hippe, E. (1981) · Scandinavian Journal of Haematology · doi:10.1111/j.1600-0609.1981.tb01366.x · Cited by 26 · see citing works

Measurement of 8-Iso-Prostaglandin F2α in Biological Fluids as a Measure of Lipid Peroxidation

Tacconelli, S., Capone, M. L., & Patrignani, P. (2010) · Methods in molecular biology · doi:10.1007/978-1-59745-364-6_14 · Cited by 23 · see citing works

Recurrent cerebral venous thrombosis associated with heterozygote methylenetetrahydrofolate reductase C 677 T mutation and sickle cell trait without homocysteinemia: An autopsy case report and review of literature

Ali, Z., Troncoso, J. C., & Fowler, D. R. (2014) · Forensic Science International · doi:10.1016/j.forsciint.2014.07.007 · Cited by 23 · see citing works

Hyperhomocysteinemia is Associated with Aortic Atheroma Progression in Stroke/TIA Patients

Sen, S., Reddy, P. L., Grewal, R. P., Busby, M. G., Chang, P. P., & Hinderliter, A. L. (2010) · Frontiers in Neurology · doi:10.3389/fneur.2010.00131 · Cited by 22 · see citing works

Homocysteinemia and early outcome of acute ischemic stroke in elderly patients

Forti, P., Maioli, F., Arnone, G., Coveri, M., Pirazzoli, G. L., Zoli, M., & Procaccianti, G. (2016) · Brain and Behavior · doi:10.1002/brb3.460 · Cited by 21 · see citing works

Management and prevention of stroke associated with elevated homocysteine

Kelly, P. J., & Furie, K. L. (2002) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-002-0016-2 · Cited by 20 · see citing works

Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: A Meta-Analysis

Luo, H., Liu, B., Hu, J. Y., et al. (2014) · Cerebrovascular Diseases · doi:10.1159/000360753 · Cited by 20 · see citing works

Elevated Plasma Homocysteine Level Is Not Primarily Related to Alzheimers Disease

Nilsson, K. H., Gustafson, L., & Hultberg, B. L. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000342612 · Cited by 19 · see citing works

Lifestyle, Homocysteine, and the Metabolic Syndrome

Kulkarni, K. D., & Richard, B. C. (2003) · Metabolic Syndrome and Related Disorders · doi:10.1089/154041903322294461 · Cited by 17 · see citing works

Observations on the fate of cystathionine in rat brain

Griffiths, R., & Tudball, N. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90257-5 · Cited by 14 · see citing works

Vitamin B-12 status and neurologic function in older people: a cross-sectional analysis of baseline trial data from the Older People and Enhanced Neurological Function (OPEN) study,

Miles, L. M., Allen, E., Mills, K. R., Clarke, R., Uauy, R. D., & Dangour, A. D. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.137927 · Cited by 12 · see citing works

Is isolated vitamin B12 deficiency a sufficient causative factor of dementia?

Moretti, R., Torre, P., Antonello, R. M., & Cazzato, G. (2001) · European Journal of Neurology · doi:10.1046/j.1468-1331.2001.00163.x · Cited by 11 · see citing works

Homocysteine in Neurology: From Endothelium to Neurodegeneration

Moretti, R., Ben, M. D., Gazzin, S., & Tiribelli, C. (2017) · Current Nutrition & Food Science · doi:10.2174/1573401313666170213155338 · Cited by 11 · see citing works

[Effects of entacapone on plasma homocysteine in Parkinson's disease patients on levodopa].

Zhao, P., Yang, J., Liu, W., et al. (2013) · PubMed · Cited by 8 · see citing works

Testing for homocysteine in clinical practice

Nichols, J. (2017) · Nutrition and Health · doi:10.1177/0260106016686094 · Cited by 7 · see citing works

Folic acid as ultimate in disease prevention:Beware of vitamin B12 deficiency

Malnick, S. D. H., & Goland, S. (2004) · BMJ · doi:10.1136/bmj.328.7442.769 · Cited by 5 · see citing works

Vitamin B12 defect: what does it mean to cognition?

Moretti, R., Torre, P., Antonello, R. M., Cazzato, G., & Bava, A. (2001) · European Journal of Neurology · doi:10.1046/j.1468-1331.2001.00294.x · Cited by 3 · see citing works

Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence

Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541 · see citing works

Nutrition and longevity—From mechanisms to uncertainties

Ekmekcioglu, C. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1676698 · Cited by 87 · see citing works

Abstract 278: Enhanced Cystathionine ß-Synthase Nitration in Diet-Induced Hyperhomocysteinemic Rats Accelerates the Progression of Hyperhomocysteinemia

Wang, W., Zhang, H., Liu, W., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.34.suppl_1.278

Hyperhomocysteinemia in patients operated for lower extremity ischaemia below the age of 50—effect of smoking and extent of disease

Bergmark, C., Mansoor, M. A., Swedenborg, J., Fairé, U. D., Svardal, A. M., & Ueland, P. M. (1993) · European Journal of Vascular Surgery · doi:10.1016/s0950-821x(05)80255-5 · Cited by 76 · see citing works

Interrelations Between Plasma Homocysteine and Intracellular S-Adenosylhomocysteine

Fu, W., Dudman, N. P. B., Perry, M. A., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2587 · Cited by 50 · see citing works

Abstract 278: Enhanced Cystathionine ß-Synthase Nitration in Diet-Induced Hyperhomocysteinemic Rats Accelerates the Progression of Hyperhomocysteinemia

WenWang, HuiZhang, WeiLiu, et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology

Methionine loading test is necessary for detection of hyperhomocysteinemia

van der Griend, R., Haas, F. J. L. M., Durán, M., et al. (1998) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(98)90027-0 · Cited by 80 · see citing works