The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
The impact of diabetes on survival following breast cancer
Abstract
Purpose It has been suggested that type 2 diabetes may affect breast cancer prognosis, possibly due to increased diabetes-related comorbidity, or direct effects of insulin resistance and/or hyperinsulinemia. The purpose of this study was to examine the impact of diabetes on survival following breast cancer.Methods Using population-based health databases from Ontario, Canada, this retrospective cohort study compared deaths between women with breast cancer aged 55-79 years with diabetes and without diabetes. Women were followed for all cause mortality from breast cancer diagnosis until March 31st 2006.Results Of the 6,107 women with breast cancer, 1,011 had diabetes and 5,096 did not have diabetes. Women with diabetes were slightly older, were more likely to reside in a lower income neighborhood, and had greater comorbidity compared to women without diabetes. After a mean follow-up of 5.0 years and adjustment for age, prior mammograms and other covariates, mortality following breast cancer was significantly higher among women with versus without diabetes (hazard ratio, HR 1.39, 95% confidence interval, CI 1.22-1.59, P < 0.0001). The effect of diabetes on mortality was comparable to that seen in women with diabetes without breast cancer over a 7-year follow-up.Conclusion This study found that diabetes was associated with a close to 40% increase in mortality within the first 5 years following breast cancer, which was similar to that seen in women with diabetes without breast cancer. These findings suggest that early survival following breast cancer is reduced in women with diabetes, possibly due to diabetes-related causes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“in one study, 5-year mortality rates were significantly higher (hazard ratio 1.39) in patients diagnosed with both breast cancer and diabetes than in comparable breast cancer patients without diabetes (9).”
From Diabetes and Cancer (2010) · cites this paper as [9]
Citations
Cites
(1968) · American Association of Industrial Nurses Journal · doi:10.1177/216507996801601208 · Cited by 8,811
Evaluating medication effects outside of clinical trials: new-user designs
Ray, W. A. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg231 · Cited by 1,646
Hux, J. E., Ivis, F. J., Flintoft, V. F., & Bica, A. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.512 · Cited by 1,290
Efficacy of screening mammography. A meta-analysis
Kerlikowske, K. M. (1995) · JAMA · doi:10.1001/jama.273.2.149 · Cited by 1,136
Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women
Jee, S. H. (2005) · JAMA · doi:10.1001/jama.293.2.194 · Cited by 989
Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study
Goodwin, P. J., Ennis, M., Pritchard, K. I., Trudeau, M. E., Koo, J., Madarnas, Y., Hartwick, W., Hoffman, B., & Hood, N. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.1.42 · Cited by 978
Effect of Age and Comorbidity in Postmenopausal Breast Cancer Patients Aged 55 Years and Older
Yancik, R. (2001) · JAMA · doi:10.1001/jama.285.7.885 · Cited by 897
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2005) · Diabetes Care · doi:10.2337/diacare.28.suppl_1.s37 · Cited by 830
Diabetes Mellitus as a Predictor of Cancer Mortality in a Large Cohort of US Adults
Coughlin, S. S., Calle, E. E., Teras, L. R., Petrelli, J. M., & Thun, M. J. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh161 · Cited by 795
Development and Application of a Population-Oriented Measure of Ambulatory Care Case-Mix
Weiner, J. P., Starfield, B. H., Steinwachs, D. M., & Mumford, L. M. (1991) · Medical Care · doi:10.1097/00005650-199105000-00006 · Cited by 677
Cited by
Sorted by citations
Giovannucci, E., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · Diabetes Care · doi:10.2337/dc10-0666 · Cited by 2,366
“39) in patients diagnosed with both breast cancer and diabetes than in comparable breast cancer patients without diabetes (9).”
Diabetes and Cancer: A Consensus Report
Giovannucci, E. L., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20078 · Cited by 1,082
Vigneri, P., Frasca, F., Sciacca, L., Pandini, G., & Vigneri, R. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0087 · Cited by 1,009
Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer
Bodmer, M., Meier, C., Krähenbühl, S., Jick, S. S., & Meier, C. R. (2010) · Diabetes Care · doi:10.2337/dc09-1791 · Cited by 466
“Furthermore, diabetes was associated with markedly increased mortality in women with breast cancer (5).”
BackgroundDiabetes Mellitus and Breast Cancer Outcomes: A Systematic Review and Meta-Analysis
Peairs, K. S., Barone, B. B., Snyder, C. F., Yeh, H., Stein, K. B., Derr, R. L., Brancati, F. L., & Wolff, A. C. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.3011 · Cited by 451
“We considered studies to be of higher quality and calculated separate random-effects pooled HRs if they were population based (n 4)(6,17-19) or used medical records or medication use for diabetes ascertainment (n 4)(17,18,20,21) and evaluated diabetes as the primary exposure variable (n 3).(6,18,19) We also calculated…”
BackgroundMethodMortality After Incident Cancer in People With and Without Type 2 Diabetes
Currie, C. J., Poole, C., Jenkins‐Jones, S., Gale, E. A., Johnson, J. A., & Morgan, C. L. (2012) · Diabetes Care · doi:10.2337/dc11-1313 · Cited by 398
“Certain types of cancers are more common in people with diabetes than in those without (1–3), and diabetes is also associated with reduced survival after cancer (4,5).”
BackgroundPatterson, R. E., Cadmus, L. A., Emond, J. A., & Pierce, J. P. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.01.004 · Cited by 246
Capparelli, C., Guido, C., Whitaker‐Menezes, D., Bonuccelli, G., Balliet, R. M., Pestell, T. G., Goldberg, A. F., Pestell, R. G., Howell, A., Sneddon, S., et al. (2012) · Cell Cycle · doi:10.4161/cc.20718 · Cited by 238
He, X., Esteva, F. J., Ensor, J., Hortobágyi, G. N., Lee, M., & Yeung, S. J. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr534 · Cited by 206
Currie, C. J., Poole, C. D., Evans, M., Peters, J. R., & Morgan, C. L. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3042 · Cited by 203
“Indeed, endogenous hyperinsulinemia has been linked to an increase in cancer incidence in people without diabetes (30), whereas epidemiological data have linked exogenous insulin therapy with an increased cancer incidence in people with T2DM (22).”
BackgroundClinically Defined Type 2 Diabetes Mellitus and Prognosis in Early-Stage Breast Cancer
Erickson, K. D., Patterson, R. E., Flatt, S. W., Natarajan, L., Parker, B. A., Heath, D. D., Laughlin, G. A., Saquib, N., Rock, C. L., & Pierce, J. P. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.29.3183 · Cited by 189
Secondary Effects of Antipsychotics: Women at Greater Risk Than Men
Seeman, M. V. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn023 · Cited by 184
“Lipscombe et al.(88) found that having diabetes was associated with an almost 40% increase in mortality within the first 5 years following breast cancer.”
BackgroundAssociation between diabetes mellitus and breast cancer risk: a meta-analysis of the literature.
Liao, S., Li, J., Wei, W., Wang, L., Zhang, Y., Li, J., Wang, C., & Sun, S. (2011) · PubMed · Cited by 164
Rizos, C. V., & Elisaf, M. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.02.038 · Cited by 155
Diabetes mellitus and prognosis in women with breast cancer
Zhao, X., & Ren, G.-S. (2016) · Medicine · doi:10.1097/md.0000000000005602 · Cited by 137
D’Esposito, V., Passaretti, F., Hammarstedt, A., Liguoro, D., Terracciano, D., Molea, G., Canta, L., Miele, C., Smith, U., Bèguinot, F., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2629-7 · Cited by 134
“Moreover, case–control and cohort studies showed that women with diabetes may have a 20% increased risk of breast cancer [19] and increased cancerrelated mortality rate [20].”
BackgroundGlucose Promotes Breast Cancer Aggression and Reduces Metformin Efficacy
Wahdan-Alaswad, R., Fan, Z., Edgerton, S. M., Liu, B., Deng, X.-S., Arnadottir, S. S., Richer, J. K., Anderson, S. M., & Thor, A. D. (2013) · Cell Cycle · doi:10.4161/cc.26641 · Cited by 125
“In contrast, physical activity, weight loss, and a lean body habitus are associated with a reduced breast cancer incidence and improved survival.(3,12-21) Mechanisms by which obesity and dysregulation of host metabolism may promote breast cancer are reportedly diverse, including upregulation of growth factors, inflamm…”
BackgroundIncidence of diabetes among postmenopausal breast cancer survivors
Lipscombe, L. L., Chan, W. W., Yun, L., Austin, P. C., Anderson, G. M., & Rochon, P. A. (2012) · Diabetologia · doi:10.1007/s00125-012-2793-9 · Cited by 124
“For instance, women with diabetes have an estimated 20% higher risk of postmenopausal breast cancer [1, 2] and up to a 50% increase in mortality after breast cancer diagnosis [3, 4].”
BackgroundImpact of Diabetes and Hyperglycemia on Survival in Advanced Breast Cancer Patients
Villarreal-Garza, C. M., Shaw-Dulin, R. J., Lara-Medina, F. U., Bacon, L., Rivera, D., Urzua, L., Águila, C., Ramírez-Morales, R., Santamaria, J., Bargalló, E., et al. (2012) · Experimental Diabetes Research · doi:10.1155/2012/732027 · Cited by 111
“[19], who reported a similar mortality in diabetic patients with and without breast cancer.”
BackgroundComorbidity and survival after early breast cancer. A review
Land, L. H., Dalton, S. O., Jørgensen, T. L., & Ewertz, M. (2011) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2011.03.001 · Cited by 108
Insulin Resistance: The Increased Risk of Cancers
Szablewski, L. (2024) · Current Oncology · doi:10.3390/curroncol31020075 · Cited by 123
“For example, patients with T2DM had more than 2-fold relative risks for endometrial, hepatic, and pancreatic cancers, and in the cases of bladder, breast, and colorectal cancers, diabetic patients had up to 1.5-fold higher risks of cancer disease [201,206–208].”
BackgroundInfluentialBreast cancer risk factors and their effects on survival: a Mendelian randomisation study
Escala-Garcia, M., Morra, A., Canisius, S., Chang-Claude, J. C., Kar, S., Zheng, W., Bojesen, S. E., Easton, D. F., Pharoah, P. D. P., & Schmidt, M. K. (2020) · BMC Medicine · doi:10.1186/s12916-020-01797-2 · Cited by 109
Kamineni, A., Anderson, M. L., White, E., Taplin, S. H., Porter, P. L., Ballard-Barbash, R. R., Malone, K. E., & Buist, D. S. M. (2012) · Cancer Causes & Control · doi:10.1007/s10552-012-0115-7 · Cited by 100
The impact of type 2 diabetes mellitus on cancer‐specific survival: A follow‐up study in sweden
Liu, X., Ji, J., Sundquist, K., Sundquist, J., & Hemminki, K. (2012) · Cancer · doi:10.1002/cncr.26420 · Cited by 97
“Only a few previous studies have investigated the impact of T2DM on the survival of cancer patients, and several epidemiologic studies have documented an increase in cancer mortality among individuals with T2DM, including cancers of the colon, breast, and pancreas and, in men, cancers of the liver and bladder.(10,20,2…”
Cause-specific mortality in diabetes: recent changes in trend mortality
Khalil, C. A., Roussel, R., Mohammedi, K., Danchin, N., & Marre, M. (2012) · European Journal of Preventive Cardiology · doi:10.1177/1741826711409324 · Cited by 98
“found that diabetes was associated with a close to 40% increase in mortality within the first 5 years following breast cancer.(41) The public health sciences department at the University of Edinburgh reported that breast cancer- and diabetes-related mortality was approximately twice as high as that of the general fema…”
BackgroundInsulin-Sensitizing Therapy Attenuates Type 2 Diabetes–Mediated Mammary Tumor Progression
Fierz, Y., Novosyadlyy, R., Vijayakumar, A., Yakar, S., & LeRoith, D. (2009) · Diabetes · doi:10.2337/db09-1291 · Cited by 92
The association between diabetes and breast cancer stage at diagnosis: a population-based study
Lipscombe, L. L., Fischer, H. D., Austin, P. C., Fu, L., Jaakkimainen, R. L., Ginsburg, O., Rochon, P. A., Narod, S. A., & Paszat, L. F. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3323-5 · Cited by 84
Klepin, H. D., Pitcher, B. N., Ballman, K. V., Kornblith, A. B., Hurria, A., Winer, E. P., Hudis, C. A., Cohen, H. J., Muss, H. B., & Kimmick, G. G. (2014) · Journal of Oncology Practice · doi:10.1200/jop.2014.001388 · Cited by 84
The Impact of Obesity on Breast Cancer: A Retrospective Review
Haakinson, D. J., Leeds, S. G., Dueck, A. C., Gray, R. J., Wasif, N., Stucky, C.-C., Northfelt, D., Apsey, H. A., & Pockaj, B. A. (2012) · Annals of Surgical Oncology · doi:10.1245/s10434-012-2320-8 · Cited by 82
Joung, K. H., Jeong, J., & Ku, B. J. (2015) · BioMed Research International · doi:10.1155/2015/920618 · Cited by 86
“Female diabetic patients were more likely to have increased risk of andmortality frombreast cancer [3, 116–118].”
BackgroundAssociation between tamoxifen treatment and diabetes
Lipscombe, L. L., Fischer, H. D., Yun, L., Gruneir, A., Austin, P. C., Paszat, L. F., Anderson, G., & Rochon, P. A. (2011) · Cancer · doi:10.1002/cncr.26559 · Cited by 80
Wu, A. H., Kurian, A. W., Kwan, M. L., John, E. M., Lu, Y., Keegan, T. H. M., Gomez, S. L., Cheng, I. C., Shariff‐Marco, S., Caan, B. J., et al. (2014) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-1140 · Cited by 83
Insulin and cancer: a tangled web
Leitner, B. P., Siebel, S., Akingbesote, N. D., Zhang, X., & Perry, R. J. (2022) · Biochemical Journal · doi:10.1042/bcj20210134 · Cited by 79
Stendell-Hollis, N. R., Thomson, C. A., Thompson, P. A., Bea, J. W., CUSSLER, E. C., & Hakim, I. A. (2010) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2010.01078.x · Cited by 76
“Obesity, and its related co-morbidities, results in a poorer prognosis for both pre- and postmenopausal breast cancer survivors (Coates et al., 1999; Pasanisi et al., 2006; Lipscombe et al., 2008).”
Chowdhury, T. A. (2010) · QJM · doi:10.1093/qjmed/hcq149 · Cited by 76
“39 compared to non diabetic women with breast cancer.(17) Similar results are seen in colorectal cancer; with a 32% increased all cause mortality.”
ResultCleveland, R. J., North, K. E., Stevens, J., Teitelbaum, S. L., Neugut, A. I., & Gammon, M. D. (2012) · Cancer Causes & Control · doi:10.1007/s10552-012-9989-7 · Cited by 74
“Some studies have found increased associations with breast cancer death [12, 28, 29]; however, other studies have not found this association [30].”
Diabetes After Hormone Therapy in Breast Cancer Survivors: A Case-Cohort Study
Hamood, R., Hamood, H., Merhasin, I., & Keinan‐Boker, L. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.3524 · Cited by 74
Comorbidities and breast cancer survival: a report from the Shanghai Breast Cancer Survival Study
Nechuta, S., Lu, W., Zheng, Y., Cai, H., Bao, P., Gu, K., Zheng, W., & Shu, X. O. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2521-2 · Cited by 70
Impact of Acquired Comorbidities on All-Cause Mortality Rates Among Older Breast Cancer Survivors
Ahern, T. P., Lash, T. L., Thwin, S. S., & Silliman, R. A. (2008) · Medical Care · doi:10.1097/mlr.0b013e318180913c · Cited by 68
“6) was consistent with the findings from an earlier study that examined the association between baseline Charlson index and all-cause mortality while controlling for age, primary treatment type, tumor stage, histologic grade, and hormone receptor status,(8) as well as a second study that examined only the impact of di…”
BackgroundResultDiabetes and prognosis in a breast cancer cohort
Schrauder, M. G., Fasching, P. A., Häberle, L., Lux, M. P., Rauh, C., Hein, A., Bayer, C. M., Heusinger, K., Hartmann, A., Strehl, J. D., et al. (2010) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-010-0960-2 · Cited by 67
“It has been suggested, that early survival following BC is reduced due to DM-related causes (Lipscombe et al. 2008).”
BackgroundDiabetes and Overall Survival among Breast Cancer Patients in the U.S. Military Health System
Shao, S., Gill, A. A., Zahm, S. H., Jatoi, I., Shriver, C. D., McGlynn, K. A., & Zhu, K. (2017) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-17-0439 · Cited by 65
The biological and pharmacological connections between diabetes and various types of cancer
Wang, X., & Ding, S. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153641 · Cited by 60
Vallianou, N. G., Evangelopoulos, A. A., & Kazazis, C. E. (2013) · The Review of Diabetic Studies · doi:10.1900/rds.2013.10.228 · Cited by 59
“Diabetes is also associated with reduced survival after cancer [5-8].”
BackgroundPre-existing diabetes and breast cancer prognosis among elderly women
Luo, J., HENDRYX, M. S., Virnig, B. A., Wen, S., Chlebowski, R. T., Chen, C., Rohan, T. E., Tinker, L. F., Wactawski‐Wende, J., Lessin, L. S., et al. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.249 · Cited by 58
“…evidence suggests that people with diabetes have a significantly higher risk of breast cancer incidence (Larsson et al, 2007; Liao et al, 2011; Boyle et al, 2012) than their nondiabetic counterparts (Lipscombe et al, 2008; Schrauder et al, 2010; Erickson et al, 2011; Kaplan et al, 2012).”
BackgroundPan, B., Ren, H., He, Y., Lv, X., Ma, Y., Li, J., Huang, L. T., Yu, B., Kong, J., Niu, C., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0817 · Cited by 57
“org Clin Cancer Res; 18(5) March 1, 2012 1247”
BackgroundInfluentialZelenko, Z., & Gallagher, E. J. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.008 · Cited by 57
Dutkowska, A., & Antczak, A. J. (2016) · Advances in respiratory medicine · doi:10.5603/piap.2016.0022 · Cited by 62
Pan, B., Ren, H., Ma, Y., Liu, D., Yu, B., Liang, J., Pan, L., Li, J., Yang, L., Lv, X., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.26341 · Cited by 56
“Another observation showed that breast cancer patients with T2DM tend to present a more advanced stage of neoplasm(8) and have an increased risk of breast cancer mortality in comparison with nondiabetic counterparts.(9,10) However, the underlying mechanisms are poorly understood at present.”
BackgroundRetractedBronsveld, H. K., ter Braak, B., Karlstad, Ø., Vestergaard, P., Starup‐Linde, J., Bazelier, M. T., Bruin, M. L. D., de Boer, A., Siezen, C. L. E., van de Water, B., et al. (2015) · Breast Cancer Research · doi:10.1186/s13058-015-0611-2 · Cited by 54
“But studies that investigated the association between breast cancer-specific mortality and diabetes have inconsistent results [45, 78, 80, 81].”
Pandey, V., Chaube, B., & Bhat, M. K. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23210 · Cited by 54
“A large pool of data as an evidence for direct and indirect relevance of diabetes on the occurrence, progression, and pathogenesis of breast cancer has been accumulated [Wolf et al., 2006; Larsson et al., 2007; Lipscombe et al., 2008].”
BackgroundChoi, H. J., Kim, J. H., Lim, S., Kim, G., Yun, H. J., & Choi, H. S. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13274 · Cited by 53
“Furthermore, diabetes is associated with markedly increased mortality in women with breast cancer (Lipscombe et al., 2008).”
BackgroundType 2 diabetes, insulin treatment and prognosis of breast cancer
Mu, L., Zhu, N., Zhang, J., Fang, X., Li, D., & Wang, X. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2823 · Cited by 50
“[13] also found that the increased overall mortality in breast cancer patients with diabetes was similar to that in diabetic women without breast cancer.”
ResultMetformin Targets Glucose Metabolism in Triple Negative Breast Cancer
Wahdan-Alaswad, R. S., Edgerton, S. M., Salem, H. S., & Thor, A. D. (2018) · Journal of Oncology Translational Research · doi:10.4172/2476-2261.1000129 · Cited by 50
“These chronic diseases are also independently associated with a worse prognosis and higher diseaseassociated mortality for these women [11,12].”
BackgroundDiabetes, diabetes treatment and breast cancer prognosis
Luo, J., Virnig, B. A., HENDRYX, M. S., Wen, S., Chelebowski, R., Chen, C., Rohan, T. E., Tinker, L. F., Wactawski‐Wende, J., Lessin, L. S., et al. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3146-9 · Cited by 49
“There is also convincing evidence that overall mortality following breast cancer is significantly higher in diabetic women with breast cancer than their non-diabetic counterparts [12, 18, 22, 34].”
BackgroundInfluence of diabetes mellitus on mortality in breast cancer patients
Zhou, Y., Zhang, X., Gu, C., & Xia, J. (2014) · ANZ Journal of Surgery · doi:10.1111/ans.12877 · Cited by 47
The Impact of Diabetes Mellitus on Prognosis of Early Breast Cancer in Asia
Chen, T. W., Shao, Y., Shau, W., Lin, Z., Lu, Y., Chen, H., Kuo, R. N.-C., Cheng, A., & Lai, M. (2012) · The Oncologist · doi:10.1634/theoncologist.2011-0412 · Cited by 43
“DM is associated with other comorbidities, such as metabolic disorder, cardiovascular disease, and renal disease [7, 14, 15], and thus, the prognostic influence of DM is affected when other comorbidities are present [9, 14, 16].”
BackgroundGlucose metabolism disorders in cancer patients in a Chinese population
Ya-shi, Z., Feng, L., Tang, S., Li, W.-G., Xu, M., Liu, T., Zhou, Y.-F., Ma, Y., Zhang, Y., & Pu, X.-M. (2009) · Medical Oncology · doi:10.1007/s12032-009-9189-9 · Cited by 39
“Presently, plenty of studies investigating the relationships between malignancy and DM have been reported, but most of them were focused on pancreatic cancer [33, 41, 42], breast cancer [10, 39, 43–45], prostatic carcinoma [38, 46– 50], or colorectal cancer [36, 37, 51, 52], whereas the evidence of changed glucose met…”
BackgroundObesity and Angiolymphatic Invasion in Primary Breast Cancer
Gillespie, E. F., Sorbero, M. E. S., Hanauer, D. A., Sabel, M. S., Herrmann, E., Weiser, L. J., Jagielski, C. H., & Griggs, J. J. (2009) · Annals of Surgical Oncology · doi:10.1245/s10434-009-0797-6 · Cited by 39
Wang, Y., Gao, D., Chen, Y., Hu, G., Liu, H., & Jiang, Y. (2016) · RSC Advances · doi:10.1039/c6ra12131d · Cited by 38
Zelenko, Z., Gallagher, E. J., Tobin‐Hess, A., Belardi, V., Rostoker, R., Blank, J., Dina, Y., & LeRoith, D. (2016) · Oncogene · doi:10.1038/onc.2016.305 · Cited by 38
“Of these factors, hyperinsulinemia has emerged to be a key player and has been associated with decreased breast cancer survival and recurrence free survival (6, 7).”
BackgroundWei, M., Duan, P., Wang, Z., Ding, M., & Tu, P. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7420 · Cited by 37
“In addition, accumulating data suggest that diabetes and its complications can adversely affect cancer therapy (8) and increase mortality (9), thus affecting the outcome of breast cancer patients (10,11).”
BackgroundInsulin priming effect on estradiol-induced breast cancer metabolism and growth
Wairagu, P. M., Phan, A. N. H., Kim, M., Han, J., Kim, H.-W., Choi, J.-W., Kim, K. W., Cha, S., Park, K. H., & Jeong, Y. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1016660 · Cited by 40
“Insulin resistance arising from chronic hyperinsulinemia results in Type II diabetes, a metabolic disorder known as a poor prognostic marker for breast cancer and for being associated with an approximately 40% increase in mortality in the first 5 y with breast cancer diagnosis.(5) Shanik et al.”
BackgroundResultDurrani, I. A., Bhatti, A., & John, P. C. L. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02040-5 · Cited by 46
“For instance, studies tracking death in breast cancer patients reported an increasing trend for women with diabetes, and also supported a stronger independent link with prognosis as compared to breast cancer risk [51], which can be explained by higher insulin levels, late diagnosis, less aggressive treatment plan or d…”
BackgroundPre-diagnosis blood glucose and prognosis in women with breast cancer
Monzavi‐Karbassi, B., Gentry, R. W., Kaur, V., Siegel, E. R., Jousheghany, F., Medarametla, S., Fuhrman, B. J., Safar, A. M., Hutchins, L. F., & Kieber‐Emmons, T. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0147-7 · Cited by 36
“However, the contribution of other factors including the delay in diagnosis, lower use of effective adjuvant therapies, diabetes-prescribed drug use, and diabetes-related comorbidities on observed association between diabetes and breast cancer is not clearly addressed [9–20].”
BackgroundManagement of diabetes in patients with cancer
Jacob, P., & Chowdhury, T. A. (2014) · QJM · doi:10.1093/qjmed/hcu218 · Cited by 35
Anticancer Effect of Metformin in Herceptin-Conjugated Liposome for Breast Cancer
Lee, J., Shin, D. H., & Kim, J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics12010011 · Cited by 35
Shau, W., Shao, Y., Yeh, Y., Lin, Z., Kuo, R. N.-C., Hsu, C., Hsu, C., Cheng, A., & Lai, M. (2012) · The Oncologist · doi:10.1634/theoncologist.2012-0065 · Cited by 34
Javed, S. R., Skolariki, A., Zameer, M. Z., & Lord, S. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02833-1 · Cited by 38
The Role for Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes
LeRoith, D., Scheinman, E. J., & Bitton-Worms, K. (2011) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10043 · Cited by 33
Risk of esophagus cancer in diabetes mellitus: a population-based case-control study in Taiwan
Cheng, K. F., Chen, Y., Lai, S., Tsai, P., & Sung, F. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-177 · Cited by 31
“Discussion Studies investigating the relationship between malignancy and DM have revealed conflicting results on the association between DM and esophagus cancer, and other cancers [8,23-39].”
BackgroundResultIGF-1 and risk of additional breast cancer in the WHEL study
Al‐Delaimy, W. K., Flatt, S. W., Natarajan, L., Laughlin, G. A., Rock, C. L., Gold, E. B., Caan, B. J., Parker, B. A., & Pierce, J. P. (2011) · Endocrine Related Cancer · doi:10.1530/erc-10-0121 · Cited by 31
“2002), and in other studies, women with breast cancer and diabetes had a 40% increase in mortality within 5 years following diagnosis compared to women with breast cancer without diabetes (Lipscombe et al. 2008); and breast cancer survivors with HbA1cR7.”
ResultInfluentialGriffiths, R. I., Danese, M. D., Gleeson, M. L., & Valderas, J. M. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-613 · Cited by 30
“Recently, Peairs and colleagues [2] conducted a systematic review and meta-analysis in which they combined results from 6 studies [6-8,12-14], and found diabetes was associated with a 49% increased risk of death due to all causes.”
BackgroundNicholas, D., Andrieu, G. P., Strissel, K. J., Nikolajczyk, B. S., & Denis, G. V. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2320-0 · Cited by 30
“Epidemiological studies have associated increased risk and mortality in breast cancer with T2D [74–81].”
The female breast and diabetes
Gouveri, E., Παπάνας, Ν., & Maltezos, E. S. (2011) · The Breast · doi:10.1016/j.breast.2011.02.019 · Cited by 28
O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activity
Das, S., Bailey, S. K., Metge, B. J., Hanna, A., Hinshaw, D. C., Mota, M., Forero, A., Chatham, J. C., Samant, R. S., & Shevde, L. A. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0122-8 · Cited by 28
Challenges in the management of people with diabetes and cancer
Chowdhury, T. A., & Jacob, P. (2019) · Diabetic Medicine · doi:10.1111/dme.13919 · Cited by 27
Lee, K. N., Torres, M. A., Troeschel, A. N., He, J., Gogineni, K., & McCullough, L. E. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232581 · Cited by 27
A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes‐Associated Breast Cancer
Hao, Q., Huang, Z., Li, Q., Liu, D., Wang, P., Wang, K., Li, J., Cao, W., Deng, W., Wu, K., et al. (2022) · Advanced Science · doi:10.1002/advs.202102303 · Cited by 27
Ali, N. M., Besar, R., & Aziz, N. A. A. (2022) · Symmetry · doi:10.3390/sym14101955 · Cited by 31
Metformin and survival in diabetic patients with breast cancer
El-Benhawy, S. A., & Elsheredy, H. (2014) · Journal of the Egyptian Public Health Association · doi:10.1097/01.epx.0000456620.00173.c0 · Cited by 25
Use of Insulin and Mortality from Breast Cancer among Taiwanese Women with Diabetes
Tseng, C.-H. (2015) · Journal of Diabetes Research · doi:10.1155/2015/678756 · Cited by 23
“Because there were only 5 cases of breast cancer mortality in patients with type 1 diabetes mellitus (Table 1 and Figure 1) and the results did not markedly change when only patients with type 2 diabetes mellitus were analyzed in secondary analyses (data not shown), it is believed that the results…”
ResultMcCune, K. R., Bhat‐Nakshatri, P., Thorat, M. A., Nephew, K. P., Badve, S., & Nakshatri, H. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1530 · Cited by 23
“Hyperinsulinemia is an independent risk factor for breast cancer, and the presence of diabetes in breast cancer patients is linked to a 40% increase in mortality within the first 5 years after diagnosis (25, 46).”
BackgroundHuang, X., He, D., Ming, J., He, Y., Zhou, C., Ren, H., He, X., Wang, C., Jin, J., Liang, J., et al. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3696-0 · Cited by 23
The Role of Insulin Resistance in Cancer
Subedi, B. K., Bhimineni, C., Modi, S., Jahanshahi, A., Quiza, K., & Bitetto, D. (2025) · Current Oncology · doi:10.3390/curroncol32090477 · Cited by 26
“• Altered IGF-Axis Signaling: Hyperinsulinemia suppresses the hepatic production of IGF-binding proteins (IGFBP-1 and IGFBP-2), which may increase the bioavailability of IGF-1 [20,21].”
Sun, X., Zhang, Q., Kadier, K., Hu, P., Liu, X., Liu, J., Yan, Y., Sun, C., Yau, V., Lowe, S., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1059303 · Cited by 22
“In addition, a growing body of data suggests that diabetes and its complications adversely affect cancer treatment (14) and increase mortality (15), thereby affecting the prognosis of breast cancer patients (16, 17).”
BackgroundLifestyle Interventions for Cardiovascular Risk Reduction in Women with Breast Cancer
Knobf, M. T., & Coviello, J. S. (2012) · Current Cardiology Reviews · doi:10.2174/157340311799960627 · Cited by 23
“Pre-existing diabetes in breast cancer survivors has been associated with increased treatment toxicity and reduced survival [26-28].”
BackgroundTreatment and outcomes in diabetic breast cancer patients
Gold, H. T., Makarem, N., Nicholson, J., & Parekh, N. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-2833-x · Cited by 24
Ma, F.-J., Liu, Z.-B., Qu, L., Wu, J., Shao, Z.-M., Liu, G., & Hao, S. (2014) · OncoTargets and Therapy · doi:10.2147/ott.s71095 · Cited by 21
Hosio, M., Urpilainen, E., Hautakoski, A., Marttila, M., Arffman, M., Sund, R., Ahtikoski, A. M., Puistola, U., Karihtala, P., Jukkola‐Vuorinen, A., et al. (2020) · Acta Oncologica · doi:10.1080/0284186x.2020.1769858 · Cited by 20
Li, J., Wen, W., Liu, Z., Chen, C., Cheng, J., Yiping, G., Changhua, W., De-hua, Y., & Shengrong, S. (2015) · Tumor Biology · doi:10.1007/s13277-015-3380-8 · Cited by 19
“However, patients’ age and the tendency for obesity were both considered to be risk factors for diabetes [7].”
BackgroundTherapeutic effects of metformin in breast cancer: involvement of the immune system?
Schott, S., Bierhaus, A., Schütz, F., Beckhove, P., Schneeweiß, A., Sohn, C., & Domschke, C. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1062-y · Cited by 19
“Starting with a delayed and progressed initial presentation, interference with overlapping comorbidities often aVecting the choice of treatment and eventually a markedly increased mortality [ 6 , 7]. In this context, more recently, the discussion was heated in particular due to new insights into antidiabetics actions…”
BackgroundKhajah, M. A., Khushaish, S., & Luqmani, Y. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0272449 · Cited by 17
Kinesiophobia among Breast Cancer Survivors One Year after Hospital Treatment
Malchrowicz-Mośko, E. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192114565 · Cited by 19
Lawrence, W. R., Hosler, A. S., Gates, M. A., Leinung, M. C., Zhang, X., Schymura, M. J., & Boscoe, F. P. (2020) · Cancer Epidemiology · doi:10.1016/j.canep.2020.101710 · Cited by 19
Relationship between level of HbA1C and breast cancer
Jousheghany, F., Phelps, J. A., Crook, T. A., & Hakkak, R. (2016) · BBA Clinical · doi:10.1016/j.bbacli.2016.04.005 · Cited by 17
“Diabetes and cancer are two major public health issues worldwide and many studies have shown that diabetes is related to increased cancer mortality [8,17,18].”
BackgroundYang, H., Wu, C.-Y., Powell, J. D., & Lu, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114030 · Cited by 17
Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models
de Sousa-e-Silva, É. P., Conde, D. M., Costa‐Paiva, L., Martínez, E. Z., & Pinto-Neto, A. M. (2014) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1590/s0100-720320140050.0002 · Cited by 16
Vigen, C. L. P., Kwan, M. L., John, E. M., Gomez, S. L., Keegan, T. H. M., Lu, Y., Shariff‐Marco, S., Monroe, K. R., Kurian, A. W., Cheng, I. C., et al. (2016) · Cancer Causes & Control · doi:10.1007/s10552-016-0715-8 · Cited by 16
Ji, G., Jin, L., Wang, R., Bai, Y., Yao, Z.-X., Lu, L., Huang, J.-B., Liu, S., Li, H., Wang, Z., et al. (2013) · Medical Oncology · doi:10.1007/s12032-013-0687-4 · Cited by 16
“Up to 16 % of the elderly breast cancer patients additionally suffer from diabetes [4], and it was suggested that greater diabetes screening and prevention strategies among breast cancer survivors may be warranted [5].”
BackgroundTalley, C. H., & Williams, K. P. (2015) · Nursing Clinics of North America · doi:10.1016/j.cnur.2015.05.008 · Cited by 16
Metadata
- Authors
- Lipscombe, L. L., Goodwin, P. J., Zinman, B., McLaughlin, J. R., & Hux, J. E.
- Affiliations
- Institute for Clinical Evaluative Sciences (CA)
- Mount Sinai Hospital (CA)
- University of Toronto (CA)
- Sunnybrook Health Science Centre (CA)
- Corresponding author
- Lipscombe, Lorraine L.
- Venue
- Breast Cancer Research and Treatment
- Published
- 2007-07-21
- Volume
- 109
- Issue
- 2
- Pages
- 389-395
- ISSN
- 0167-6806 (ISSN-L)
- 1573-7217
- OpenAlex
- W2025598781
- Cited by
- 176
- References
- 26
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 10 · 2021: 4 · 2020: 18 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 15 · 2015: 13 · 2014: 15 · 2013: 11 · 2012: 14
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Breast Cancer Research and Treatment (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- type 2 diabetes, breast cancer, survival, mortality, comorbidities, insulin resistance, hyperinsulinemia, prognosis, women
- MeSH terms
- Aged, Breast Neoplasms, Diabetes Mellitus, Type 2, Female, Humans, Middle Aged, Diabetes Complications, Kaplan-Meier Estimate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
