The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
The impact of diabetes on survival following breast cancer
Abstract
Purpose It has been suggested that type 2 diabetes may affect breast cancer prognosis, possibly due to increased diabetes-related comorbidity, or direct effects of insulin resistance and/or hyperinsulinemia. The purpose of this study was to examine the impact of diabetes on survival following breast cancer.Methods Using population-based health databases from Ontario, Canada, this retrospective cohort study compared deaths between women with breast cancer aged 55-79 years with diabetes and without diabetes. Women were followed for all cause mortality from breast cancer diagnosis until March 31st 2006.Results Of the 6,107 women with breast cancer, 1,011 had diabetes and 5,096 did not have diabetes. Women with diabetes were slightly older, were more likely to reside in a lower income neighborhood, and had greater comorbidity compared to women without diabetes. After a mean follow-up of 5.0 years and adjustment for age, prior mammograms and other covariates, mortality following breast cancer was significantly higher among women with versus without diabetes (hazard ratio, HR 1.39, 95% confidence interval, CI 1.22-1.59, P < 0.0001). The effect of diabetes on mortality was comparable to that seen in women with diabetes without breast cancer over a 7-year follow-up.Conclusion This study found that diabetes was associated with a close to 40% increase in mortality within the first 5 years following breast cancer, which was similar to that seen in women with diabetes without breast cancer. These findings suggest that early survival following breast cancer is reduced in women with diabetes, possibly due to diabetes-related causes.
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“in one study, 5-year mortality rates were significantly higher (hazard ratio 1.39) in patients diagnosed with both breast cancer and diabetes than in comparable breast cancer patients without diabetes (9).”
From Diabetes and Cancer (2010) · cites this paper as [9]
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Cites
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Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study
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Effect of Age and Comorbidity in Postmenopausal Breast Cancer Patients Aged 55 Years and Older
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Diagnosis and Classification of Diabetes Mellitus
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Diabetes Mellitus as a Predictor of Cancer Mortality in a Large Cohort of US Adults
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Giovannucci, E., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · Diabetes Care · doi:10.2337/dc10-0666 · Cited by 2,366
“39) in patients diagnosed with both breast cancer and diabetes than in comparable breast cancer patients without diabetes (9).”
Diabetes and Cancer: A Consensus Report
Giovannucci, E. L., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20078 · Cited by 1,082
Vigneri, P., Frasca, F., Sciacca, L., Pandini, G., & Vigneri, R. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0087 · Cited by 1,009
Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer
Bodmer, M., Meier, C., Krähenbühl, S., Jick, S. S., & Meier, C. R. (2010) · Diabetes Care · doi:10.2337/dc09-1791 · Cited by 466
“Furthermore, diabetes was associated with markedly increased mortality in women with breast cancer (5).”
BackgroundDiabetes Mellitus and Breast Cancer Outcomes: A Systematic Review and Meta-Analysis
Peairs, K. S., Barone, B. B., Snyder, C. F., Yeh, H., Stein, K. B., Derr, R. L., Brancati, F. L., & Wolff, A. C. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.3011 · Cited by 451
“We considered studies to be of higher quality and calculated separate random-effects pooled HRs if they were population based (n 4)(6,17-19) or used medical records or medication use for diabetes ascertainment (n 4)(17,18,20,21) and evaluated diabetes as the primary exposure variable (n 3).(6,18,19) We also calculated…”
BackgroundMethod
Metadata
- Authors
- Lipscombe, L. L., Goodwin, P. J., Zinman, B., McLaughlin, J. R., & Hux, J. E.
- Affiliations
- Institute for Clinical Evaluative Sciences (CA)
- Mount Sinai Hospital (CA)
- University of Toronto (CA)
- Sunnybrook Health Science Centre (CA)
- Corresponding author
- Lipscombe, Lorraine L.
- Venue
- Breast Cancer Research and Treatment
- Published
- 2007-07-21
- Volume
- 109
- Issue
- 2
- Pages
- 389-395
- ISSN
- 0167-6806 (ISSN-L)
- 1573-7217
- OpenAlex
- W2025598781
- Cited by
- 176
- References
- 26
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 10 · 2021: 4 · 2020: 18 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 15 · 2015: 13 · 2014: 15 · 2013: 11 · 2012: 14
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Breast Cancer Research and Treatment (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- type 2 diabetes, breast cancer, survival, mortality, comorbidities, insulin resistance, hyperinsulinemia, prognosis, women
- MeSH terms
- Aged, Breast Neoplasms, Diabetes Mellitus, Type 2, Female, Humans, Middle Aged, Diabetes Complications, Kaplan-Meier Estimate
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