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Height at diagnosis and birth-weight as risk factors for osteosarcoma
Open accessAbstract
Objectives Osteosarcoma typically occurs during puberty. Studies of the association between height and/or birth-weight and osteosarcoma are conflicting. Therefore, we conducted a large pooled analysis of height and birth-weight in osteosarcoma.Methods Patient data from seven studies of height and three of birth-weight were obtained, resulting in 1,067 cases with height and 434 cases with birth-weight data. We compared cases to the 2000 US National Center for Health Statistics Growth Charts by simulating 1,000 age- and gender-matched controls per case. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between height or birth-weight and risk of osteosarcoma for each study were estimated using logistic regression. All of the case data were combined for an aggregate analysis.Results Compared to average birth-weight subjects (2,665-4,045 g), individuals with high birth-weight (≥ 4,046 g) had an increased osteosarcoma risk (OR 1.35, 95% CI 1.01-1.79). Taller than average (51st - 89th percentile) and very tall individuals (≥ 90th percentile) had an increased risk of osteosarcoma (OR 1.35, 95% CI 1.18-1.54 and OR 2.60, 95% CI 2.19-3.07, respectively; P (trend) < 0.0001).Conclusions This is the largest analysis of height at diagnosis and birth-weight in relation to osteosarcoma. It suggests that rapid bone growth during puberty and in utero contributes to OS etiology.
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Metadata
- Authors
- Mirabello, L., Pfeiffer, R., Murphy, G., Daw, N. C., Patiño-Garcia, A., Troisi, R. J., Hoover, R. N., Douglass, C., Schüz, J., Craft, A. W., & Savage, S. A.
- Affiliations
- National Institutes of Health (US)
- St. Jude Children's Research Hospital (US)
- Harvard University (US)
- Johannes Gutenberg University Mainz (DE)
- Newcastle University (GB)
- Corresponding author
- Mirabello, Lisa
- ORCID
- Venue
- Cancer Causes & Control
- Published
- 2011-04-05
- Volume
- 22
- Issue
- 6
- Pages
- 899-908
- ISSN
- 0957-5243 (ISSN-L)
- 1573-7225
- PMC
- PMC3494416
- OpenAlex
- W2107929386
- Cited by
- 116
- References
- 74
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 9 · 2021: 10 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 11 · 2014: 5 · 2013: 7 · 2012: 6
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cancer Causes & Control (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (Z99 CA999999)
- National Cancer Institute (Y99 CA999999)
- Topics
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- osteosarcoma, birth weight, tall stature, puberty, cancer risk factors, pooled analysis
- MeSH terms
- Adolescent, Adult, Birth Weight, Body Height, Bone Neoplasms, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Risk Factors, Osteosarcoma, Case-Control Studies, Young Adult
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