Cited by 116Sarcoma Diagnosis and TreatmentCancer Risks and FactorsGrowth Hormone and Insulin-like Growth Factors

The DOI matches its Crossref record; 71 of the 74 references it cites were found in a registry or an index.

Height at diagnosis and birth-weight as risk factors for osteosarcoma

Open access

Mirabello, Lisa, Pfeiffer, Ruth, Murphy, Gwen, Daw, Najat C., Patiño-Garcia, Ana, Troisi, Rebecca J., Hoover, Robert N., Douglass, Chester, Schüz, Joachim, Craft, Alan W., Savage, Sharon A.·2011·Cancer Causes & Control

DOI 10.1007/s10552-011-9763-2PMC PMC3494416

Open this paper in CoChat — free account

Abstract

Objectives Osteosarcoma typically occurs during puberty. Studies of the association between height and/or birth-weight and osteosarcoma are conflicting. Therefore, we conducted a large pooled analysis of height and birth-weight in osteosarcoma.Methods Patient data from seven studies of height and three of birth-weight were obtained, resulting in 1,067 cases with height and 434 cases with birth-weight data. We compared cases to the 2000 US National Center for Health Statistics Growth Charts by simulating 1,000 age- and gender-matched controls per case. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between height or birth-weight and risk of osteosarcoma for each study were estimated using logistic regression. All of the case data were combined for an aggregate analysis.Results Compared to average birth-weight subjects (2,665-4,045 g), individuals with high birth-weight (≥ 4,046 g) had an increased osteosarcoma risk (OR 1.35, 95% CI 1.01-1.79). Taller than average (51st - 89th percentile) and very tall individuals (≥ 90th percentile) had an increased risk of osteosarcoma (OR 1.35, 95% CI 1.18-1.54 and OR 2.60, 95% CI 2.19-3.07, respectively; P (trend) < 0.0001).Conclusions This is the largest analysis of height at diagnosis and birth-weight in relation to osteosarcoma. It suggests that rapid bone growth during puberty and in utero contributes to OS etiology.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s10552-011-9763-2

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
CDC GROWTH CHARTS FOR THE UNITED STATES: METHODS AND DEVELOPMENT 2000
Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Strawn, L. G., Flegal, K. M., & Mei, Z. (2002) · Cited by 6,426
2000 CDC Growth Charts for the United States: methods and development.
Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Grummer‐Strawn, L. M., Flegal, K. M., Mei, Z., Wei, R. X., Curtin, L. R., Roche, A. F., & Johnson, C. L. (2002) · PubMed · Cited by 3,716
Cancer Epidemiology and Prevention
Schottenfeld, D. (2006) · doi:10.1093/acprof:oso/9780195149616.001.0001 · Cited by 3,376
Effect of Treatment of Gestational Diabetes Mellitus on Pregnancy Outcomes
Crowther, C. A., Hiller, J. E., Moss, J. R., McPhee, A. J., Jeffries, W. S., & Robinson, J. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042973 · Cited by 3,159
Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II.
Tanner, J. M., Whitehouse, R. H., & Takaishi, M. (1966) · Archives of Disease in Childhood · doi:10.1136/adc.41.220.613 · Cited by 2,549
Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the Surveillance, Epidemiology, and End Results Program
Mirabello, L., Troisi, R. J., & Savage, S. A. (2009) · Cancer · doi:10.1002/cncr.24121 · Cited by 2,199
Self-citation
Insulin-like growth factors and neoplasia
Pollak, M., Schernhammer, E. S., & Hankinson, S. E. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1387 · Cited by 1,477

Show all 74 references

Research works printed but not linked: 4

Unni KK (1996) Dahlin’s bone tumors: general aspects and data on 11,087 cases. In. 5 edn. Philadelphia: Lippincott-Raven, pp 143–183
Dorfman HA, Czerniak B (1997) Bone tumors. St. Louis, Mosby, pp 128–252
Hernández M, Castellet J, Narvaiza JL et al (1988) Curvas y tablas de crecimiento. Instituto de investigación sobre crecimiento y desarrollo. Orbegozo Editorial Garsi, Fundación F. Madrid
Ruddon RW (1987) Cancer biology. Oxford University Press, New York

Sorted by citations

Childhood and adolescent cancer statistics, 2014
Ward, E., Desantis, C. E., Robbins, A., Kohler, B., & Jemal, A. (2014) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21219 · Cited by 2,416
The Epidemiology of Sarcoma
Burningham, Z. R., Hashibe, M., Spector, L. G., & Schiffman, J. D. (2012) · Clinical Sarcoma Research · doi:10.1186/2045-3329-2-14 · Cited by 690
Osteosarcoma
Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660
Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy
Gianferante, D. M., Mirabello, L. J., & Savage, S. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.16 · Cited by 477
Self-citation
Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics
Simpson, S., Dunning, M., de Brot, S., Grau‐Roma, L., Mongan, N. P., & Rutland, C. S. (2017) · Acta veterinaria Scandinavica · doi:10.1186/s13028-017-0341-9 · Cited by 304
Osteosarcoma: A Surveillance, Epidemiology, and End Results program‐based analysis from 1975 to 2017
Cole, S., Gianferante, D. M., Zhu, B., & Mirabello, L. (2022) · Cancer · doi:10.1002/cncr.34163 · Cited by 277
Self-citation
Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma
Mirabello, L., Zhu, B., Koster, R., Karlins, E., Dean, M., Yeager, M., Gianferante, M., Spector, L. G., Morton, L. M., Karyadi, D., et al. (2020) · JAMA Oncology · doi:10.1001/jamaoncol.2020.0197 · Cited by 243
Self-citation
Epidemiology and Risk Factors of Osteosarcoma
Sadykova, L. R., Ntekim, A., Muyangwa-Semenova, M., Rutland, C. S., Jeyapalan, J. N., Blatt, N. L., & Rizvanov, A. A. (2020) · Cancer Investigation · doi:10.1080/07357907.2020.1768401 · Cited by 246
Birth weight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analyses
Belbasis, L., Savvidou, M. D., Kanu, C., Evangelou, E., & Tzoulaki, I. (2016) · BMC Medicine · doi:10.1186/s12916-016-0692-5 · Cited by 237
Genome-wide association study identifies two susceptibility loci for osteosarcoma
Savage, S. A., Mirabello, L. J., Wang, Z., Gastier, J. M., Gorlick, R. G., Khanna, C., Flanagan, A. M., Tirabosco, R., Andrulis, I. L., Wunder, J. S., et al. (2013) · Nature Genetics · doi:10.1038/ng.2645 · Cited by 200
Self-citation
Germline TP53 Variants and Susceptibility to Osteosarcoma
Mirabello, L., Yeager, M., Mai, P. L., Gastier-Foster, J. M., Gorlick, R., Khanna, C., Patiño-Garcia, A., Sierrasesúmaga, L., Lecanda, F., Andrulis, I. L., et al. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv101 · Cited by 155
Self-citation
Epidemiology and therapies for metastatic sarcoma
Reed, D. R., Amankwah, & Conley, A. P. (2013) · Clinical Epidemiology · doi:10.2147/clep.s28390 · Cited by 154
Bone cancer incidence by morphological subtype: a global assessment
Valery, P. C., Laversanne, M., & Bray, F. (2015) · Cancer Causes & Control · doi:10.1007/s10552-015-0607-3 · Cited by 154
Cancer risks in patients treated with growth hormone in childhood: the SAGhE European cohort study
Swerdlow, A. J., Cooke, R., Beckers, D., Borgström, B., Butler, G., Carel, J.-C., Cianfarani, S., Clayton, P., Coste, J., Deodati, A., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2046 · Cited by 153
“There was no evidence in our data that bone cancer risk was related to GH dose, but the significant bone cancer excess in both cancer and noncancer patients, and the anatomical and age distributions of bone cancer and association with height in the general population (28), argue that the relation needs reexamination i…”
Background
Sex ratio among childhood cancers by single year of age
Williams, L. A., Richardson, M. R., Marcotte, E. L., Poynter, J. N., & Spector, L. G. (2019) · Pediatric Blood & Cancer · doi:10.1002/pbc.27620 · Cited by 114
A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma
Mirabello, L. J., Koster, R., Moriarity, B. S., Spector, L. G., Meltzer, P. S., Gary, J. M., Machiela, M. J., Pankratz, N., Panagiotou, O. A., Largaespada, D. A., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0125 · Cited by 101
Self-citation
IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma
Kuijjer, M. L., Peterse, E. F. P., van den Akker, B. E., Bruijn, I. H. B., Serra, M., Meza‐Zepeda, L. A., Myklebost, O., Hassan, A. B., Hogendoorn, P. C. W., & Cleton-Jansen, A. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-245 · Cited by 95
Risk Factors for Development of Canine and Human Osteosarcoma: A Comparative Review
Makielski, K. M., Mills, L. J., Sarver, A. L., Henson, M. S., Spector, L. G., Naik, S., & Modiano, J. F. (2019) · Veterinary Sciences · doi:10.3390/vetsci6020048 · Cited by 94
Osteosarcoma in patients below 25�years of age: An observational study of incidence, metastasis, treatment and outcomes
Nie, Z., & Peng, H. (2018) · Oncology Letters · doi:10.3892/ol.2018.9453 · Cited by 84
Canine and murine models of osteosarcoma
Beck, J. A., Ren, L., Huang, S., Berger, E. P., Bardales, K., Mannheimer, J., Mazcko, C. N., & LeBlanc, A. K. (2022) · Veterinary Pathology · doi:10.1177/03009858221083038 · Cited by 84
Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63
Liu, L., Xu, Y., & Reiter, R. J. (2013) · Bone · doi:10.1016/j.bone.2013.02.021 · Cited by 76
A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma
the National Osteosarcoma Etiology Study Group, Mirabello, L. J., Yu, K. F., Berndt, S. I., Burdett, L. A., Wang, Z., Chowdhury, S., Teshome, K., Uzoka, A., Hutchinson, A. A., et al. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-209 · Cited by 74
Self-citation
Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations?
Sarver, A. L., Makielski, K. M., DePauw, T. A., Schulte, A. J., & Modiano, J. F. (2022) · Aging and Cancer · doi:10.1002/aac2.12046 · Cited by 73
Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways
Pang, H., Wu, T., Peng, Z., Tan, Q., Peng, X., Zhan, Z., Song, L., & Wei, B. (2022) · Journal of bone oncology · doi:10.1016/j.jbo.2022.100415 · Cited by 65
Of dogs and men: Comparative biology as a tool for the discovery of novel biomarkers and drug development targets in osteosarcoma
Rankin, K. S., Starkey, M., Lunec, J., Gerrand, C., Murphy, S., & Biswas, S. (2011) · Pediatric Blood & Cancer · doi:10.1002/pbc.23341 · Cited by 62
The Oncolytic Adenovirus VCN-01 as Therapeutic Approach Against Pediatric Osteosarcoma
Martínez-Vélez, N., Xipell, E., Vera, B., de la Rocha, A. A., Zalacaín, M., Marrodán, L., González-Huarriz, M., Toledo, G., Cascalló, M., Alemany, R., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1899 · Cited by 57
Osteogenic Sarcoma: A 21st Century Review
Osasan, S. A., Zhang, M.-Y., Shen, F., Paul, P., Persad, S., & Sergi, C. M. (2016) · Anticancer Research · doi:10.21873/anticanres.10982 · Cited by 55
Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop
Hingorani, P., Janeway, K. A., Crompton, B. D., Kadoch, C., Mackall, C. L., Khan, J. I., Shern, J. F., Schiffman, J. D., Mirabello, L. J., Savage, S. A., et al. (2016) · Cancer Genetics · doi:10.1016/j.cancergen.2016.03.004 · Cited by 51
Self-citation
Understanding the Osteosarcoma Pathobiology: A Comparative Oncology Approach
Varshney, J., Scott, M. C., Largaespada, D. A., & Subramanian, S. (2016) · Veterinary Sciences · doi:10.3390/vetsci3010003 · Cited by 51
New Approaches to Understand Cognitive Changes Associated With Chemotherapy for Non-Central Nervous System Tumors
Nelson, W. L., & Suls, J. M. (2013) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2012.11.005 · Cited by 50
Endochondral ossification and the evolution of limb proportions
Rolian, C. (2020) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.373 · Cited by 49
Childhood acute lymphoblastic leukaemia and birthweight: Insights from a pooled analysis of case–control data from Germany, the United Kingdom and the United States
Roman, E., Lightfoot, T. J., Smith, A. G., Forman, M. R., Linet, M. S., Robison, L. L., Simpson, J., Kaatsch, P., Grell, K., Frederiksen, K., et al. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.11.017 · Cited by 39
Self-citation
Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery
Simpson, S., Rizvanov, A. A., Jeyapalan, J. N., de Brot, S., & Rutland, C. S. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.965391 · Cited by 38
Towards cancer-aware life-history modelling
Kokko, H., & Hochberg, M. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0234 · Cited by 33
Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers
Aoki, K., Ideta, H., Komatsu, Y., Tanaka, A., Kito, M., Okamoto, M., Takahashi, J. A., Suzuki, S., & Saito, N. (2024) · Bioengineering · doi:10.3390/bioengineering11020180 · Cited by 31
High Birth Weight Increases the Risk for Bone Tumor: A Systematic Review and Meta-Analysis
Chen, S., Yang, L., Pu, F., Lin, H., Wang, B., Liu, J., & Shao, Z. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120911178 · Cited by 31
Oncolytic adenoviruses as a therapeutic approach for osteosarcoma: A new hope
García-Moure, M., Martínez-Vélez, N., Patiño‐García, A., & Alonso, M. M. (2016) · Journal of bone oncology · doi:10.1016/j.jbo.2016.12.001 · Cited by 30
Genetic determinants of childhood and adult height associated with osteosarcoma risk
Zhang, C., Morimoto, L. M., de Smith, A. J., Hansen, H. M., Gonzalez‐Maya, J., Endicott, A. A., Smirnov, I. V., Metayer, C., Wei, Q., Eward, W. C., et al. (2018) · Cancer · doi:10.1002/cncr.31645 · Cited by 29
Immunohistochemical Validation of Spontaneously Arising Canine Osteosarcoma as a Model for Human Osteosarcoma
Al-Khan, A. A., Gunn, H. J., Day, M. J., Tayebi, M., Ryan, S. D., Kuntz, C. A., Saad, E., Richardson, S. J., & Danks, J. A. (2017) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2017.07.005 · Cited by 28
Perinatal factors associated with clinical presentation of osteosarcoma in children and adolescents
Endicott, A. A., Morimoto, L. M., Kline, C., Wiemels, J. L., Metayer, C., & Walsh, K. M. (2016) · Pediatric Blood & Cancer · doi:10.1002/pbc.26349 · Cited by 27
Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children's Oncology Group (COG) study.
Musselman, J. R. B., Bergemann, T. L., Ross, J. A., Sklar, C. A., Silverstein, K. A. T., Langer, E. K., Savage, S. A., Nagarajan, R., Krailo, M., Malkin, D. M., et al. (2012) · PubMed Central · Cited by 27
Self-citation
Nutritional status of children and young adults with Ewing sarcoma or osteosarcoma at diagnosis and during multimodality therapy
Tenardi, R. D., Frühwald, M. C., Jürgens, H., Hertroijs, D. F. L., & Bauer, J. (2011) · Pediatric Blood & Cancer · doi:10.1002/pbc.24001 · Cited by 27
Molecular Characterisation of Canine Osteosarcoma in High Risk Breeds
Simpson, S., Dunning, M., de Brot, S., Alibhai, A. A., Bailey, C., Woodcock, C. L., Mestas, M., Akhtar, S., Jeyapalan, J. N., Lothion‐Roy, J. H., et al. (2020) · Cancers · doi:10.3390/cancers12092405 · Cited by 26
GRM4 gene polymorphism is associated with susceptibility and prognosis of osteosarcoma in a Chinese Han population
Jiang, C., Chen, H., Shao, L., & Dong, Y. (2014) · Medical Oncology · doi:10.1007/s12032-014-0050-4 · Cited by 24
Silencing of Long Non-Coding RNA LINC00607 Prevents Tumor Proliferation of Osteosarcoma by Acting as a Sponge of miR-607 to Downregulate E2F6
Zheng, Y., Chen, Z., Zhou, Z., Xu, X., & Yang, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.584452 · Cited by 23
Identification of Key Genes and miRNAs in Osteosarcoma Patients with Chemoresistance by Bioinformatics Analysis
Xie, B., Li, Y., Zhao, R., Xu, Y., Wu, Y., Wang, J., Xia, D., Han, W., & Chen, D. (2018) · BioMed Research International · doi:10.1155/2018/4761064 · Cited by 22
Loading and Releasing Behavior of Selenium and Doxorubicin Hydrochloride in Hydroxyapatite with Different Morphologies
Gao, J., Huang, J., Shi, R., Wei, J., Lei, X., Dou, Y., Li, Y., Zuo, Y., & Li, J. (2021) · ACS Omega · doi:10.1021/acsomega.1c00092 · Cited by 23
Cesarean Section Is Associated with an Increased Risk of Acute Lymphoblastic Leukemia and Hepatoblastoma in Children from Minnesota
Williams, L. A., Richardson, M. R., Spector, L. G., & Marcotte, E. L. (2021) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-1406 · Cited by 21
Systematic meta-analysis of genetic variants associated with osteosarcoma susceptibility
Wang, X., & Liu, Z. (2018) · Medicine · doi:10.1097/md.0000000000012525 · Cited by 20
A Bayesian Gene-Based Genome-Wide Association Study Analysis of Osteosarcoma Trio Data Using a Hierarchically Structured Prior
Yang, Y. A., Basu, S., Mirabello, L. J., Spector, L. G., & Zhang, L. (2018) · Cancer Informatics · doi:10.1177/1176935118775103 · Cited by 19
Self-citation
Classical osteosarcoma in children and adolescents
Рогожин, Д. В., Булычева, И. В., Коновалов, Д. М., Гаврилович, Т. А., Roshchin, V. Y., Эктова, А. П., Богородицкий, Ю. С., Strykov, V. A., Казакова, А. Н., Olshanskaya, Y. V., et al. (2015) · Russian Journal of Archive of Pathology · doi:10.17116/patol201577568-74 · Cited by 19
MicroRNA-150 upregulation reduces osteosarcoma cell invasion and metastasis by downregulating Ezrin
Zhan, C., Li, C., Zhang, H., Tang, H., Ji, F., Qiao, S., Xu, W., & Wang, Z. (2016) · Oncology Letters · doi:10.3892/ol.2016.5046 · Cited by 19
Retracted
Epidemiology of bone and soft-tissue sarcomas
Beckingsale, T. B., & Shaw, C. (2017) · Orthopaedics and Trauma · doi:10.1016/j.mporth.2017.03.005 · Cited by 19
Fibroblastic Subtype has a Favourable Prognosis in Appendicular Osteosarcoma of Dogs
Al-Khan, A. A., Nimmo, J. S., Day, M. J., Tayebi, M., Ryan, S. D., Kuntz, C. A., Simcock, J. O., Tarzi, R., Saad, E., Richardson, S. J., et al. (2020) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2020.02.011 · Cited by 18
Sex differences in expression of immune elements emerge in children, young adults and mice with osteosarcoma.
Mills, L. J., Spector, L. G., Largaespada, D. A., & Williams, L. A. (2021) · Biology of Sex Differences · doi:10.1186/s13293-020-00347-y · Cited by 17
Singe nucleotide polymorphisms in osteosarcoma: Pathogenic effect and prognostic significance
Asnafi, A. A., Behzad, M. M., Ghanavat, M., Shahjahani, M., & Saki, N. (2018) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2018.12.002 · Cited by 17
Short hairpin RNA (shRNA) of type 2 interleukin-1 receptor (IL1R2) inhibits the proliferation of human osteosarcoma U-2 OS cells
Liu, X., Min, L., Duan, H., Shi, R., Zhang, W., Song, H., & Tu, C. (2014) · Medical Oncology · doi:10.1007/s12032-014-0364-2 · Cited by 17
Retracted: Inhibition of microRNA‐940 suppresses the migration and invasion of human osteosarcoma cells through the secreted frizzled‐related protein 1–mediated Wnt/β‐catenin signaling pathway
Lin, Z., Zhang, W., Jiang, S., Wei, W., & Li, X. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27580 · Cited by 16
Retracted
International patterns and trends of childhood and adolescent cancer, 1978-2012
Zhao, Y., Sun, P., Xiao, J., Jin, L., Ma, N., Li, Z., Feng, G., Huang, H., Deziel, N. C., Ma, X., et al. (2022) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2022.02.001 · Cited by 16
Single Image based Infant Body Height and Weight Estimation
Shu, H., Ren, L., Pan, L., Huang, D., Lu, H., & Wang, W. (2023) · IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW) · doi:10.1109/cvprw59228.2023.00644 · Cited by 16
Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology
McNally, R., Blakey, K., Parslow, R. C., James, P. W., Gómez‐Pozo, B., Stiller, C. A., Vincent, T. J., Norman, P. D., McKinney, P. A., Murphy, M. F. G., et al. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-270 · Cited by 15
Self-citation
Parathyroid hormone receptor 1 (PTHR1) is a prognostic indicator in canine osteosarcoma
Al-Khan, A. A., Nimmo, J. S., Tayebi, M., Ryan, S. D., Simcock, J. O., Tarzi, R., Kuntz, C. A., Saad, E., Day, M. J., Richardson, S. J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-58524-3 · Cited by 15
Unraveling the chaotic genomic landscape of primary and metastatic canine appendicular osteosarcoma with current sequencing technologies and bioinformatic approaches
Chu, S., Skidmore, Z. L., Kunisaki, J., Walker, J., Griffith, M., Griffith, O. L., & Bryan, J. N. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246443 · Cited by 17
LIM Kinases in Osteosarcoma Development
Brion, R., Regnier, L., Mullard, M., Amiaud, J., Rédiní, F., & Verrecchia, F. (2021) · Cells · doi:10.3390/cells10123542 · Cited by 14
Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis
Zhao, D., Zhu, J., Wang, W., Dong, F., Zhang, Q., Fan, H., Zhang, J., & Wang, Y.-M. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/837543 · Cited by 14
Retracted
Nanocarriers in Veterinary Medicine: A Challenge for Improving Osteosarcoma Conventional Treatments
Sapino, S., Chindamo, G., Chirio, D., Morel, S., Peira, E., Vercelli, C., & Gallarate, M. (2022) · Nanomaterials · doi:10.3390/nano12244501 · Cited by 13
A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma
Diessner, B. J., Marko, T. A., Scott, R. M., Eckert, A. L., Stuebner, K., Hohenhaus, A. E., Selting, K. A., Largaespada, D. A., Modiano, J. F., & Spector, L. G. (2019) · Cancer Medicine · doi:10.1002/cam4.2177 · Cited by 13
Age-specific bone tumour incidence rates are governed by stem cell exhaustion influencing the supply and demand of progenitor cells
Richardson, R. B. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.06.001 · Cited by 13
Characteristics of canine oral tumors: Insights into prevalence, types, and lesion distribution
Satthathum, C., Srisampane, S., Jariyarangsrirattana, P., Anusorn, P., Sattasathuchana, P., & Thengchaisri, N. (2023) · Journal of Advanced Veterinary and Animal Research · doi:10.5455/javar.2023.j709 · Cited by 12
Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma
Rutland, C. S., Cockcroft, J. M., Lothion‐Roy, J. H., Harris, A. E., Jeyapalan, J. N., Simpson, S., Alibhai, A. A., Bailey, C., Ballard-Reisch, A. C., Rizvanov, A. A., et al. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.704598 · Cited by 12
Children's Oncology Group's 2013 blueprint for research: Epidemiology
Spector, L. G., Ross, J. A., & Olshan, A. F. (2012) · Pediatric Blood & Cancer · doi:10.1002/pbc.24434 · Cited by 12
Dog Models of Naturally Occurring Cancer
Fenger, J. M., Rowell, J., Zapata, I., Kisseberth, W. C., London, C. A., & Alvarez, C. E. (2016) · Methods and principles in medicinal chemistry · doi:10.1002/9783527695881.ch9 · Cited by 11
Decoding ferroptosis: transforming orthopedic disease management
Huo, G., Lin, Y., Liu, L., He, Y., Qu, Y., Liu, Y., Zhu, R., Wang, B., Gong, Q., Han, Z., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1509172 · Cited by 10
Roles of Parathyroid Hormone-Related Protein (PTHrP) and Its Receptor (PTHR1) in Normal and Tumor Tissues: Focus on Their Roles in Osteosarcoma
Al-Khan, A. A., Balushi, N. A., Richardson, S. J., & Danks, J. A. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.637614 · Cited by 11
Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk
Zhang, C., Wiemels, J. L., Hansen, H. M., Gonzalez‐Maya, J., Endicott, A. A., de Smith, A. J., Smirnov, I. V., Witte, J. S., Morimoto, L. M., Metayer, C., et al. (2018) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-0306 · Cited by 10
Case–control study of paternal occupational exposures and childhood bone tumours and soft-tissue sarcomas in Great Britain, 1962–2010
Kendall, G. M., Bunch, K. J., Stiller, C. A., Vincent, T. J., & Murphy, M. F. G. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0760-7 · Cited by 10
A Case-Control Study of Fluoridation and Osteosarcoma
Kim, F. M., Hayes, C., Burgard, S. L., Kim, H., Hoover, R. N., National Osteosarcoma Etiology Group, Douglass, C. W., & Couper, D. J. (2020) · Journal of Dental Research · doi:10.1177/0022034520919385 · Cited by 11
Self-citation
Epidemiology of Bone and Soft Tissue Sarcomas
Lupo, P. J., Spector, L. G., O’Brien, S., Schiffman, J. D., & Hettmer, S. (2020) · Pediatric oncology · doi:10.1007/978-3-030-51160-9_1 · Cited by 11
Ubiquitin-specific proteases as therapeutic targets in paediatric primary bone tumours?
Mullard, M., Lavaud, M., Regnier, L., Tesfaye, R. A., Ory, B., Rédiní, F., & Verrecchia, F. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114797 · Cited by 9
Genetic variants associated with osteosarcoma risk: a systematic review and meta-analysis
Hassanain, O., Alaa, M., Khalifa, M. K., Kamal, N., Albagoury, A., & Ghoneimy, A. M. E. (2024) · Scientific Reports · doi:10.1038/s41598-024-53802-w · Cited by 9
Integrative analysis reveals driver long non-coding RNAs in osteosarcoma
Luo, Z., Li, X., Li, J., Dong, B., & Wang, C. (2019) · Medicine · doi:10.1097/md.0000000000014302 · Cited by 10
Identification of a seven-gene prognostic signature using the gene expression profile of osteosarcoma
Liu, Z., Zhong, Y., Meng, S., Liao, Q., & Chen, W. (2022) · Annals of Translational Medicine · doi:10.21037/atm-21-6276 · Cited by 8
Effect of variation of FGF2 genotypes on the risk of osteosarcoma susceptibly: a case control study.
Wang, J., Liu, H., Liu, X., & Qi, X. (2015) · PubMed Central · Cited by 9
Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and susceptibility to osteosarcoma: a meta-analysis and literature review
Jiang, Y.-H., Wang, X., Cheng, Y., Peng, J., Xiao, J., Tang, D., & Yi, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.18813 · Cited by 9
Genetically inferred birthweight, height, and puberty timing and risk of osteosarcoma
Gianferante, D. M., Moore, A. L., Spector, L. G., Wheeler, W., Yang, T., Hubbard, A. K., Gorlick, R. G., Patiño‐García, A., Lecanda, F., Flanagan, A. M., et al. (2023) · Cancer Epidemiology · doi:10.1016/j.canep.2023.102432 · Cited by 8
Self-citation
Frailty modeling of age–incidence curves of osteosarcoma and Ewing sarcoma among individuals younger than 40 years
Valberg, M., Grotmol, T., Tretli, S., Veierød, M. B., Devesa, S. S., & Aalen, O. O. (2012) · Statistics in Medicine · doi:10.1002/sim.5441 · Cited by 8
Osteosarcoma
Hiller, C., Wegler, J. L., & Forest, C. P. (2016) · JAAPA · doi:10.1097/01.jaa.0000508202.17804.4d · Cited by 8
Birth Characteristics and Risk of Early-Onset Synovial Sarcoma
Wiemels, J. L., Wang, R., Feng, Q., Clark, C. J., Amatruda, J. F., Rubin, E. M., Yee, A. C., Morimoto, L. M., Metayer, C., & Ma, X. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0093 · Cited by 7
RETRACTED ARTICLE: Effect of RAB31 silencing on osteosarcoma cell proliferation and migration through the Hedgehog signaling pathway
Yu, Q., Li, D., Wang, D., Hu, C., Sun, Y., Tang, Y., & Shi, G. (2018) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-018-0961-9 · Cited by 7
Retracted
Establishment, characterization, and genetic profiling of patient-derived osteosarcoma cells from a patient with retinoblastoma
Thongkumkoon, P., Sangphukieo, A., Tongjai, S., Noisagul, P., Sangkhathat, S., Laochareonsuk, W., Kamolphiwong, R., Budprom, P., Teeyakasem, P., Yongpitakwattana, P., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-60628-z · Cited by 6
Transcriptome Analysis Identifies Novel Prognostic Genes in Osteosarcoma
Chen, J., Guo, X., Zeng, G., Liu, J., & Zhao, B. (2020) · Computational and Mathematical Methods in Medicine · doi:10.1155/2020/8081973 · Cited by 6
Differentiation of human osteosarcoma 3AB-OS stem-like cells in derivatives of the three primary germ layers as a useful in vitro model to develop several purposes
Fiore, R. D., Drago‐Ferrante, R., D’Anneo, A., Blasio, A. D., Santulli, A., Messina, C. M., Carlisi, D., Tesoriere, G., & Vento, R. (2013) · Stem Cell Discovery · doi:10.4236/scd.2013.33024 · Cited by 5
Cancer-Specific Survival after Limb Salvage versus Amputation in Children and Adolescents with Osteosarcoma: A Population-Based Analysis with Propensity Score Matching
Zhen-wei, L., Xu, B., Cai, J., & Zha, Z. (2023) · Journal of Oncology · doi:10.1155/2023/8635829 · Cited by 5
Birth weight and risk of childhood solid tumors in Brazil: a record linkage between population-based data sets.
Silva, N. D. P., Reis, R. D. S., Cunha, R. G., Oliveira, J. F. P., de Lima, F. C. D. S., Pombo‐de‐Oliveira, M. S., Santos, M. D. O., & de Camargo, B. (2017) · Europe PMC (PubMed Central) · doi:10.26633/rpsp.2017.14 · Cited by 5
The Etiology of Cancer
Vail, D. M., Thamm, D. H., & Liptak, J. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-59496-7.00001-3 · Cited by 6
Adverse pregnancy outcomes and multiple cancers risk in both mother and offspring: an umbrella review of systematic reviews with meta-analyses of observational studies
Liu, N., Bao, R.-H., Chang, Y.-J., Liu, F.-H., Wu, L., Wang, J.-Y., Niu, Z.-P., Ma, S., Men, Y.-X., Liu, K.-X., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03680-w · Cited by 4
Linking Environmental Hazards to Osteosarcoma Development: A Comprehensive Review
Wang, Y., Zhang, H., Yao, P., & Teng, S. (2025) · Cancer Management and Research · doi:10.2147/cmar.s542371 · Cited by 3
Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma
de Brot, S., Cobb, J., Alibhai, A. A., Jackson-Oxley, J., Haque, M., Patke, R., Harris, A. E., Woodcock, C. L., Lothion‐Roy, J. H., Varun, D., et al. (2024) · Cancers · doi:10.3390/cancers16101945 · Cited by 3
Comparison of Differentially Expressed Genes in Human and Canine Osteosarcoma
Jackson-Oxley, J., Alibhai, A. A., Guerin, J., Thompson, R., Patke, R., Harris, A. E., Woodcock, C. L., Varun, D., Haque, M., Modikoane, T. K., et al. (2025) · Life · doi:10.3390/life15060951 · Cited by 3
Targeting the Tumor Microenvironment in Osteosarcoma: A Pathway to Overcome Therapeutic Resistance
Pandi, K., Cheriyan, B. V., Sooriyaprakash, R., Sakthivel, P., & Thirupathi, R. (2024) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/3022 · Cited by 3

Authors: Mirabello, L., Pfeiffer, R., Murphy, G., Daw, N. C., Patiño-Garcia, A., Troisi, R. J., Hoover, R. N., Douglass, C., Schüz, J., Craft, A. W., & Savage, S. A.
Affiliations: National Institutes of Health (US)
St. Jude Children's Research Hospital (US)
Harvard University (US)
Johannes Gutenberg University Mainz (DE)
Newcastle University (GB)
Corresponding author: Mirabello, Lisa
ORCID: Mirabello, Lisa
Pfeiffer, Ruth
Murphy, Gwen
Daw, Najat C.
Troisi, Rebecca J.
Hoover, Robert N.
Schüz, Joachim
Craft, Alan W.
Savage, Sharon A.
Venue: Cancer Causes & Control
Publisher: Springer Science and Business Media LLC
Published: 2011-04-05
Volume: 22
Issue: 6
Pages: 899-908
ISSN: 0957-5243 (ISSN-L)
1573-7225
DOI: 10.1007/s10552-011-9763-2
PMC: PMC3494416
OpenAlex: W2107929386
Cited by: 116
References: 74
Citations by year: 2026: 3 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 9 · 2021: 10 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 11 · 2014: 5 · 2013: 7 · 2012: 6
FWCI: 5.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cancer Causes & Control (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
Funders: National Institutes of Health (Z99 CA999999)
National Cancer Institute (Y99 CA999999)
Topics: Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: osteosarcoma, birth weight, tall stature, puberty, cancer risk factors, pooled analysis
MeSH terms: Adolescent, Adult, Birth Weight, Body Height, Bone Neoplasms, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Risk Factors, Osteosarcoma, Case-Control Studies, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Height at diagnosis and birth-weight as risk factors for osteosarcoma

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks