The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
Pak protein kinases and their role in cancer
Open accessAbstract
Some of the characteristics of cancer cells are high rates of cell proliferation, cell survival, and the ability to invade surrounding tissue. The cytoskeleton has an essential role in these processes. Dynamic changes in the cytoskeleton are necessary for cell motility and cancer cells are dependent on motility for invasion and metastasis. The signaling pathways behind the reshaping and migrating properties of the cytoskeleton in cancer cells involve a group of Ras-related small GTPases and their effectors, including the p21-activated kinases (Paks). Paks are a family of serine/threonine protein kinases comprised of six isoforms (Pak 1–6), all of which are direct targets of the small GTPases Rac and Cdc42. Besides their role in cytoskeletal dynamics, Paks have recently been shown to regulate various other cellular activities, including cell survival, mitosis, and transcription. Paks are overexpressed and/or hyperactivated in several human tumors and their role in cell transformation makes them attractive therapeutic targets. Pak-targeted therapeutics may efficiently inhibit certain types of tumors and efforts to identify selective Pak-inhibitors are underway.
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Cites
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PI3K signaling in cancer: beyond AKT
Lien, E. C., Dibble, C. C., & Toker, A. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.02.007 · Cited by 451
Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase
Montalvo-Ortiz, B. L., Castillo-Pichardo, L., Hernández, E., Humphries-Bickley, T., De La Mota-Peynado, A., Cubano, L. A., Vlaar, C. P., & Dharmawardhane, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.334524 · Cited by 213
RAC1 P29S is a spontaneously activating cancer-associated GTPase
Davis, M. J., Ha, B. H., Holman, E. C., Halaban, R., Schlessinger, J., & Boggon, T. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220895110 · Cited by 180
Cellular landscaping of cisplatin resistance in cervical cancer
Bhattacharjee, R., Dey, T., Kumar, L., Kar, S., Sarkar, R., Ghorai, M., Malik, S., Jha, N. K., Vellingiri, B., Kesari, K. K., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113345 · Cited by 93
Metadata
- Authors
- Dummler, B., Ohshiro, K., Kumar, R., & Field, J.
- Venue
- Cancer and Metastasis Reviews
- Published
- 2009-01-23
- Volume
- 28
- Issue
- 1-2
- Pages
- 51-63
- ISSN
- 0167-7659 (ISSN-L)
- 1573-7233
- OpenAlex
- W1996245793
- Cited by
- 259
- References
- 140
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- green
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