The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase
Abstract
p21-activated kinases (PAKs) are implicated in the cytoskeletal changes induced by the Rho family of guanosine triphosphatases. Cytoskeletal dynamics are primarily modulated by interactions of actin and myosin II that are regulated by myosin light chain kinase (MLCK)–mediated phosphorylation of the regulatory myosin light chain (MLC). p21-activated kinase 1 (PAK1) phosphorylates MLCK, resulting in decreased MLCK activity. MLCK activity and MLC phosphorylation were decreased, and cell spreading was inhibited in baby hamster kidney–21 and HeLa cells expressing constitutively active PAK1. These data indicate that MLCK is a target for PAKs and that PAKs may regulate cytoskeletal dynamics by decreasing MLCK activity and MLC phosphorylation.
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Citations
Cites
Rho GTPases and the Actin Cytoskeleton
Hall, A. (1998) · Science · doi:10.1126/science.279.5350.509 · Cited by 6,140
Nobes, C. D., & Hall, A. (1995) · Cell · doi:10.1016/0092-8674(95)90370-4 · Cited by 4,412
Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., et al. (1996) · Science · doi:10.1126/science.273.5272.245 · Cited by 2,884
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
Burridge, K., & Chrzanowska-Wodnicka, M. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.463 · Cited by 1,942
Signal transduction and regulation in smooth muscle
Somlyo, A. P., & Somlyo, A. V. (1994) · Nature · doi:10.1038/372231a0 · Cited by 1,902
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.
Chrzanowska-Wodnicka, M., & Burridge, K. (1996) · The Journal of cell biology · doi:10.1083/jcb.133.6.1403 · Cited by 1,683
Actin-Based Cell Motility and Cell Locomotion
Mitchison, T. J., & Cramer, L. P. (1996) · Cell · doi:10.1016/s0092-8674(00)81281-7 · Cited by 1,532
Regulation of Cell Motility by Mitogen-activated Protein Kinase
Klemke, R. L., Cai, S., Giannini, A. L., Gallagher, P. J., Lanerolle, P. D., & Cheresh, D. A. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.2.481 · Cited by 1,235
Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading
Price, L. S., Leng, J., Schwartz, M. A., & Bokoch, G. M. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.7.1863 · Cited by 644
Self-citationHuman p21-activated kinase (Pak1) regulates actin organization in mammalian cells
Sells, M. A., Knaus, U. G., Bagrodia, S., Ambrose, D. M., Bokoch, G. M., & Chernoff, J. (1997) · Current Biology · doi:10.1016/s0960-9822(97)70091-5 · Cited by 603
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Cited by
Rho GTPases and their effector proteins
BISHOP, A. L., & HALL, A. (2000) · Biochemical Journal · doi:10.1042/bj3480241 · Cited by 2,575
ROCKs: multifunctional kinases in cell behaviour
Riento, K., & Ridley, A. J. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1128 · Cited by 1,941
Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase
Maekawa, M., Ishizaki, T., Boku, S., Watanabe, N., Fujita, A., Iwamatsu, A., Obinata, T., Ohashi, K., Mizuno, K., & Narumiya, S. (1999) · Science · doi:10.1126/science.285.5429.895 · Cited by 1,636
Burridge, K., & Wennerberg, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00003-0 · Cited by 1,578
Cell migration: Rho GTPases lead the way
Raftopoulou, M., & Hall, A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.06.003 · Cited by 1,235
Metadata
- Authors
- Sanders, L. C., Matsumura, F., Bokoch, G. M., & de Lanerolle, P.
- Venue
- Science
- Published
- 1999-03-26
- Volume
- 283
- Issue
- 5410
- Pages
- 2083-2085
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986349419
- Cited by
- 593
- References
- 19
- FWCI
- 19.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sanders, L. C., Matsumura, F., Bokoch, G. M., & de Lanerolle, P. (1999). Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase. Science. https://doi.org/10.1126/science.283.5410.2083
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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