The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2
Abstract
Apoptosis of Jurkat T cells induced the caspase-mediated proteolytic cleavage of p21-activated kinase 2 (PAK2). Cleavage occurred between the amino-terminal regulatory domain and the carboxyl-terminal catalytic domain, which generated a constitutively active PAK2 fragment. Stable Jurkat cell lines that expressed a dominant-negative PAK mutant were resistant to the Fas-induced formation of apoptotic bodies, but had an enhanced externalization of phosphatidylserine at the cell surface. Thus, proteolytic activation of PAK2 represents a guanosine triphosphatase–independent mechanism of PAK regulation that allows PAK2 to regulate morphological changes that are seen in apoptotic cells.
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Cites
Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824
Cited by
Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 5,779
Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81589-5 · Cited by 3,626
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
Earnshaw, W. C., Martins, L. M., & Kaufmann, S. H. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.383 · Cited by 2,760
Pyroptosis: Mechanisms and Diseases
Yu, P., Zhang, X., Liu, N., Tang, L., Peng, C., & Chen, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00507-5 · Cited by 2,353
Caspase structure, proteolytic substrates, and function during apoptotic cell death
Nicholson, D. (1999) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400598 · Cited by 1,543
Metadata
- Authors
- Rudel, T., & Bokoch, G. M.
- Venue
- Science
- Published
- 1997-06-06
- Volume
- 276
- Issue
- 5318
- Pages
- 1571-1574
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076398093
- Cited by
- 747
- References
- 1
- FWCI
- 28.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rudel, T., & Bokoch, G. M. (1997). Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2. Science. https://doi.org/10.1126/science.276.5318.1571
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
