The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Proteolytic interstitial cell migration: a five-step process
Open accessAbstract
Cell migration is a multi-step process that leads to the actin-driven translocation of cells on or through tissue substrate. Basic steps involved in cell migration have been defined for two-dimensional haptokinetic migration which, however, does not provide physical constraints imposed by three-dimensional interstitial tissues. We here describe the process of pericellular proteolysis that leads to extracellular matrix (ECM) degradation and realignment during cell movement and integrate it into established steps of cell migration. After actin-driven leading edge protrusion (step I) and anterior formation of integrin-mediated focal interactions to the substrate (step II), ECM breakdown is focalized towards physical ECM barriers several micrometer rearward of the leading edge (step III). Actomyosin-mediated cell contraction (step IV) then leads to rear-end retraction and forward sliding of cell body and nucleus so that a small tube-like matrix defect bordered by realigned ECM fibers becomes apparent (step V). Pericellular proteolysis is thus integral to the migration cycle and serves to widen ECM gaps and thereby lowers physical stress upon the cell body, which ultimately leads to aligned higher-oder ECM patterns.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cell Migration: Integrating Signals from Front to Back
Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R. A., Ginsberg, M. H., Borisy, G., Parsons, J. T., & Horwitz, A. R. (2003) · Science · doi:10.1126/science.1092053 · Cited by 4,978
Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
Gaggioli, C., Hooper, S., Hidalgo-Carcedo, C., Grosse, R., Marshall, J. F., Harrington, K., & Sahai, E. (2007) · Nature Cell Biology · doi:10.1038/ncb1658 · Cited by 1,589 · cited 1×
“3D cell migration models have allowed to identify the physical and molecular components that determine interstitial migration, including physical resistance imposed by tissue structures, the presence of tissue gaps and trails, and the cellular capability to remodel ECM [9–11].”
BackgroundRapid leukocyte migration by integrin-independent flowing and squeezing
Lämmermann, T., Bader, B. L., Monkley, S. J., Worbs, T., Wedlich-Söldner, R., Hirsch, K., Keller, M., Förster, R., Critchley, D. R., Fässler, R., et al. (2008) · Nature · doi:10.1038/nature06887 · Cited by 1,397
Compensation mechanism in tumor cell migration
Wolf, K., Mazo, I., Leung, H., Engelke, K., von Andrian, U. H., Deryugina, E. I., Strongin, A. Y., Bröcker, E.-B., & Friedl, P. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209006 · Cited by 1,391
Self-citationMicroRNAs: new regulators of immune cell development and function
Baltimore, D., Boldin, M. P., O'Connell, R. M., Rao, D. S., & Taganov, K. D. (2008) · Nature Immunology · doi:10.1038/ni.f.209 · Cited by 1,088
Wolf, K., Wu, Y. I., Liu, Y., Geiger, J., Tam, E., Overall, C., Stack, M. S., & Friedl, P. (2007) · Nature Cell Biology · doi:10.1038/ncb1616 · Cited by 1,010
Self-citationThe biology of cell locomotion within three-dimensional extracellular matrix
Friedl, P., & Br�cker, E.-B. (2000) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050498 · Cited by 656
Self-citationInterstitial leukocyte migration and immune function
Friedl, P., & Weigelin, B. (2008) · Nature Immunology · doi:10.1038/ni.f.212 · Cited by 587
Self-citationEven-Ram, S., & Yamada, K. M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.015 · Cited by 466
Cited by
Collective cell migration in morphogenesis, regeneration and cancer
Friedl, P., & Gilmour, D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2720 · Cited by 2,712
Self-citationConcepts of extracellular matrix remodelling in tumour progression and metastasis
Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J., & Werb, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18794-x · Cited by 2,296
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940
Self-citationWolf, K., te Lindert, M., Krause, M., Alexander, S., te Riet, J., Willis, A. L., Hoffman, R. M., Figdor, C. G., Weiss, S. J., & Friedl, P. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201210152 · Cited by 1,375
Self-citationCancer cell motility: lessons from migration in confined spaces
Paul, C. D., Mistriotis, P., & Konstantopoulos, K. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.123 · Cited by 648
Metadata
- Authors
- Friedl, P., & Wolf, K.
- Venue
- Cancer and Metastasis Reviews
- Published
- 2009-01-21
- Volume
- 28
- Issue
- 1-2
- Pages
- 129-135
- ISSN
- 0167-7659 (ISSN-L)
- 1573-7233
- OpenAlex
- W2133569303
- Cited by
- 288
- References
- 25
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Proteolytic interstitial cell migration: a five-step process. https://app.cochat.ai/papers/10.1007/s10555-008-9174-3
- The paper
- Friedl, P., & Wolf, K. (2009). Proteolytic interstitial cell migration: a five-step process. Cancer and Metastasis Reviews. https://doi.org/10.1007/s10555-008-9174-3
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
