Selenium interactions and toxicity: a review

Zwolak, Iwona; Zaporowska, Halina

doi:10.1007/s10565-011-9203-9

Cited by 326Selenium in Biological SystemsHeavy Metal Exposure and ToxicityTrace Elements in Health

Selenium interactions and toxicity: a review

Zwolak, Iwona, Zaporowska, Halina·2012·Cell Biology and Toxicology

DOI 10.1007/s10565-011-9203-9

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Abstract

Selenium is an essential trace element for mammals. Through selenoproteins, this mineral participates in various biological processes such as antioxidant defence, thyroid hormone production, and immune responses. Some reports indicate that a human organism deficient in selenium may be prone to certain diseases. Adverse health effects following selenium overexposure, although very rare, have been found in animals and people. Contrary to selenium, arsenic and cadmium are regarded as toxic elements. Both are environmental and industrial pollutants, and exposure to excessive amounts of arsenic or cadmium can pose a threat to many people's health, especially those living in polluted regions. Two other elements, vanadium and chromium(III) in trace amounts are believed to play essential physiological functions in mammals. This review summarizes recent studies on selenium interactions with arsenic and cadmium and selenium interactions with vanadium and chromium in mammals. Human studies have demonstrated that selenium may reduce arsenic accumulation in the organism and protect against arsenic-related skin lesions. Selenium was found to antagonise the prooxidant and genotoxic effects of arsenic in rodents and cell cultures. Also, studies on selenium effects against oxidative stress induced by cadmium in various animal tissues produced promising results. Reports suggest that selenium protection against toxicity of arsenic and cadmium is mediated via sequestration of these elements into biologically inert conjugates. Selenium-dependent antioxidant enzymes probably play a secondary role in arsenic and cadmium detoxification. So far, few studies have evaluated selenium effects on chromium(III) and vanadium actions in mammals. Still, they show that selenium may interact with these minerals. Taken together, the recent findings regarding selenium interaction with other elements extend our understanding of selenium biological functions and highlight selenium as a potential countermeasure against toxicity induced by arsenic and cadmium.

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The chemical form, i.e., speciation, of selenium affects its bioavailability and nutritional value.
“Apart from the total Se content of food sources, the chemical form, i.e., speciation, is important, as it affects the bioavailability and nutritional value of Se.”
From Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review (2015) · cites this paper as [15]
The various chemical forms of selenium exhibit highly different properties with regard to sorption, bioavailability, mobility and toxicity.
“The various chemical forms of Se exhibit highly different properties with regard to sorption, bioavailability, mobility and toxicity [12,13,14,15].”
From Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review (2015) · cites this paper as [15]

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Selenium biochemistry and its role for human health
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Selenium for preventing cancer
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Selenium–Fascinating Microelement, Properties and Sources in Food
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The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature
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Synergistic effect of silicon and selenium on the alleviation of cadmium toxicity in rice plants
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Comprehensive review of the basic chemical behaviours, sources, processes, and endpoints of trace element contamination in paddy soil-rice systems in rice-growing countries
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Selenium Biofortification: Roles, Mechanisms, Responses and Prospects
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Melatonin mediates selenium‐induced tolerance to cadmium stress in tomato plants
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Protective effects of selenium against cadmium induced hematological disturbances, immunosuppressive, oxidative stress and hepatorenal damage in rats
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Arsenic and other elements in drinking water and dietary components from the middle Gangetic plain of Bihar, India: Health risk index
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Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies
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The pathophysiological role of mitochondrial oxidative stress in lung diseases
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Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
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The need for a reassessment of the safe upper limit of selenium in drinking water
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Selenium and Human Health: Witnessing a Copernican Revolution?
Jabłońska, E., & Vinceti, M. (2015) · Journal of Environmental Science and Health Part C · doi:10.1080/10590501.2015.1055163 · Cited by 149 · see citing works
Multielemental speciation analysis by advanced hyphenated technique – HPLC/ICP-MS: A review
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Selenium for preventing cancer
Vinceti, M., Dennert, G., Crespi, C. M., Zwahlen, M., Brinkman, M. T., Zeegers, M. P., Horneber, M., D’Amico, R., & Giovane, C. D. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005195.pub3 · Cited by 149 · see citing works
Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity
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Sulfur and selenium antioxidants: Challenging radical scavenging mechanisms and developing structure–activity relationships based on metal binding
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Toxicity of repeated oral intake of organic selenium, inorganic selenium, and selenium nanoparticles: A review
Hadrup, N., & Ravn‐Haren, G. (2023) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2023.127235 · Cited by 123 · see citing works
Absorption, distribution, metabolism and excretion (ADME) of oral selenium from organic and inorganic sources: A review
Hadrup, N., & Ravn‐Haren, G. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126801 · Cited by 120 · see citing works
Nanoparticle-drug conjugates treating bacterial infections
Jelínková, P., Mazumdar, A., Sur, V. P., Kočiová, S., Dolezelikova, K., Jimenez, A. M. J., Koudelková, Z., Mishra, P. K., Šmerková, K., Heger, Z., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.06.013 · Cited by 113 · see citing works
Selenium-substituted hydroxyapatite nanoparticles and their in vivo antitumor effect on hepatocellular carcinoma
Yanhua, W., Hao, H., Li, Y., & Zhang, S. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.12.056 · Cited by 109 · see citing works
Microbial-enhanced Selenium and Iron Biofortification of Wheat (<i>Triticum aestivum</i>L.) - Applications in Phytoremediation and Biofortification
Yasin, M., El-Mehdawi, A. F., Anwar, A., Pilon-Smits, E. A. H., & Faisal, M. (2015) · International Journal of Phytoremediation · doi:10.1080/15226514.2014.922920 · Cited by 107 · see citing works
Alleviation of lead-induced oxidative stress and immune damage by selenium in chicken bursa of Fabricius
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Serum Antioxidant Nutrients, Vitamin A, and Mortality in U.S. Adults
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Antioxidants for the Treatment of Breast Cancer: Are We There Yet?
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Thyroid Function and Serum Copper, Selenium, and Zinc in General U.S. Population
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Differential effects of amino acid surface decoration on the anticancer efficacy of selenium nanoparticles
Feng, Y., Su, J., Zhao, Z., Zheng, W., Wu, H., Zhang, Y., & Chen, T. (2013) · Dalton Transactions · doi:10.1039/c3dt52468j · Cited by 89 · see citing works
Friend or Foe? The Current Epidemiologic Evidence on Selenium and Human Cancer Risk
Vinceti, M., Crespi, C. M., Malagoli, C., Giovane, C. D., & Krogh, V. (2013) · Journal of Environmental Science and Health Part C · doi:10.1080/10590501.2013.844757 · Cited by 88 · see citing works
Insights into the mechanisms of arsenic-selenium interactions and the associated toxicity in plants, animals, and humans: A critical review
Ali, W., Zhang, H., Junaid, M., Mao, K., Xu, N., Chang, C., Rasool, A., Aslam, M. W., Ali, J., & Yang, Z. (2020) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2020.1740042 · Cited by 90 · see citing works
Comparative responses to silicon and selenium in relation to cadmium uptake, compartmentation in roots, and xylem transport in flowering Chinese cabbage ( Brassica campestris L. ssp. chinensis var. utilis ) under cadmium stress
Wu, Z., Wang, F., Liu, S., Du, Y., Li, F., Du, R., Wen, D., & Zhao, J. (2016) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2016.07.012 · Cited by 85 · see citing works
A comprehensive review on the neuropathophysiology of selenium
Naderi, M., Puar, P., Zonouzi-Marand, M., Chivers, D. P., Niyogi, S., & Kwong, R. W. M. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144329 · Cited by 85 · see citing works
Protective and antioxidant role of selenium on arsenic trioxide–induced oxidative stress and genotoxicity in the fish hepatoma cell line PLHC-1
Selvaraj, V., Armstead, M. Y., & Murray, E. E. (2012) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2022 · Cited by 83 · see citing works
Cd, Pb and Hg Biomonitoring in Fish of the Mediterranean Region and Risk Estimations on Fish Consumption
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Cross-Talk between Cadmium and Selenium at Elevated Cadmium Stress Determines the Fate of Selenium Uptake in Rice
Farooq, M. U., Tang, Z., Zheng, T., Asghar, M. A., Zeng, R., Yang, S., Hla, H., Liang, Y., Zhang, Y., Ye, X., et al. (2019) · Biomolecules · doi:10.3390/biom9060247 · Cited by 79 · see citing works
Helping plants to deal with heavy metal stress: the role of nanotechnology and plant growth promoting rhizobacteria in the process of phytoremediation
Gulzar, A. B. M., & Mazumder, P. B. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-19756-0 · Cited by 78 · see citing works
Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators
Belenichev, I. F., Aliyeva, O. G., Popazova, O., & Bukhtiyarova, N. V. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1131683 · Cited by 78 · see citing works
Associations between toxic and essential trace elements in maternal blood and fetal congenital heart defects
Ou, Y., Bloom, M. S., Nie, Z., Han, F., Mai, J., Chen, J., Lin, S., Liu, X., & Zhuang, J. (2017) · Environment International · doi:10.1016/j.envint.2017.05.017 · Cited by 77 · see citing works
Cadmium, arsenic, selenium and iron– Implications for tumor progression in breast cancer
Jabłońska, E., Socha, K., Reszka, E., Wieczorek, E., Skokowski, J., Kalinowski, L., Fendler, W. M., Seroczyńska, B., Woźniak, M., Borawska, M. H., et al. (2017) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2017.05.014 · Cited by 75 · see citing works
The protection of selenium on cadmium-induced inhibition of spermatogenesis via activating testosterone synthesis in mice
Ren, X., Wang, G., Xu, D., Luo, K., Liu, Y., Zhong, Y., & Cai, Y. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.07.021 · Cited by 73 · see citing works
Kidney function and blood pressure in preschool-aged children exposed to cadmium and arsenic - potential alleviation by selenium
Skröder, H., Hawkesworth, S., Kippler, M. J., Arifeen, S. E., Wagatsuma, Y., Moore, S. E., & Vahter, M. (2015) · Environmental Research · doi:10.1016/j.envres.2015.03.038 · Cited by 70 · see citing works
Interaction between cadmium (Cd), selenium (Se) and oxidative stress biomarkers in healthy mothers and its impact on birth anthropometric measures
Al‐Saleh, I., Al-Rouqi, R., Obsum, C. A., Shinwari, N., Mashhour, A., Billedo, G., Al-Sarraj, Y. A., & Rabbah, A. (2014) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2014.08.001 · Cited by 69 · see citing works
The role of selenium in thyroid gland pathophysiology
Stuss, M., Michalska, M., & Sewerynek, E. (2017) · Endokrynologia Polska · doi:10.5603/ep.2017.0051 · Cited by 68 · see citing works
Selenium intake and multiple health-related outcomes: an umbrella review of meta-analyses
Wang, P., Chen, B., Huang, Y. C., Li, J., Cao, D., Chen, Z., Li, J., Ran, B., Yang, J., Wang, R., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1263853 · Cited by 67 · see citing works
Male infertility: Decreased levels of selenium, zinc and antioxidants
Türk, S., Mändar, R., Mahlapuu, R., Viitak, A., Punab, M., & Kullisaar, T. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2013.12.005 · Cited by 67 · see citing works
The effects of di(2‐ethylhexyl)phthalate on rat liver in relation to selenium status
Erkekoğlu, P., Zeybek, N. D., Giray, B., Rachidi, W., Kızılgün, M., Hininger‐Favier, I., Favier, A. E., Aşan, E., & Hıncal, F. (2013) · International Journal of Experimental Pathology · doi:10.1111/iep.12059 · Cited by 67 · see citing works
Research Progress on the Physiological Mechanism by Which Selenium Alleviates Heavy Metal Stress in Plants: A Review
Yuan, Z., Cai, S., Chang, Y. Z., Rao, S., Cheng, S., Xu, F., & Liu, X. (2024) · Agronomy · doi:10.3390/agronomy14081787 · Cited by 72 · see citing works
Toxicity of Oxidatively Degraded Quantum Dots to Developing Zebrafish (Danio rerio)
Wiecinski, P. N., Metz, K. M., Heiden, T. C. K., Louis, K. M., Mangham, A. N., Hamers, R. J., Heideman, W., Peterson, R. E., & Pedersen, J. A. (2013) · Environmental Science & Technology · doi:10.1021/es304987r · Cited by 64 · see citing works
Localization, ligand environment, bioavailability and toxicity of mercury in Boletus spp. and Scutiger pes-caprae mushrooms
Kavčič, A., Mikuš, K., Debeljak, M., van Elteren, J. T., Arčon, I., Kodre, A., Kump, P., Karydas, A. G., Migliori, A., Czyżycki, M., et al. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.109623 · Cited by 63 · see citing works
Selenium-Induced Toxicity Is Counteracted by Sulfur in Broccoli (Brassica oleracea L. var. italica)
Tian, M., Hui, M., Thannhauser, T. W., Pan, S., & Li, L. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01425 · Cited by 61 · see citing works
Bioaccumulation of Hg in Rice Leaf Facilitates Selenium Bioaccumulation in Rice ( Oryza sativa L .) Leaf in the Wanshan Mercury Mine
Chang, C., Chen, C., Yin, R., Shen, Y., Mao, K., Yang, Z., Feng, X., & Zhang, H. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b06486 · Cited by 60 · see citing works
Selenium biofortification and its effect on multi-element change in Auricularia auricular
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Authors: Zwolak, I., & Zaporowska, H.
Affiliations: John Paul II Catholic University of Lublin (PL)
Corresponding author: Zwolak, Iwona
ORCID: Zwolak, Iwona
Venue: Cell Biology and Toxicology
Publisher: Springer Science and Business Media LLC
Published: 2011-09-14
Volume: 28
Issue: 1
Pages: 31-46
ISSN: 0742-2091 (ISSN-L)
1573-6822
DOI: 10.1007/s10565-011-9203-9
OpenAlex: W1959593972
Cited by: 325
References: 120
Citations by year: 2026: 18 · 2025: 26 · 2024: 22 · 2023: 21 · 2022: 23 · 2021: 33 · 2020: 28 · 2019: 32 · 2018: 16 · 2017: 20 · 2016: 19 · 2015: 22 · 2014: 22 · 2013: 14 · 2012: 8
FWCI: 1.74
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Biology and Toxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: selenium, arsenic, cadmium, vanadium, trivalent chromium, trace element interactions, metal toxicity, arsenic accumulation, oxidative stress, antioxidant enzymes, metal detoxification, selenoproteins, genotoxicity, pro-oxidant activity
MeSH terms: Animals, Antioxidants, Arsenic, Cadmium, Chromium, Drug Interactions, Humans, Inactivation, Metabolic, Selenium, Trace Elements, Vanadium, Selenoproteins

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