The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake
Open accessAbstract
Extracellular vesicles are a heterogeneous group of membrane-limited vesicles loaded with various proteins, lipids, and nucleic acids. Release of extracellular vesicles from its cell of origin occurs either through the outward budding of the plasma membrane or through the inward budding of the endosomal membrane, resulting in the formation of multivesicular bodies, which release vesicles upon fusion with the plasma membrane. The release of vesicles can facilitate intercellular communication by contact with or by internalization of contents, either by fusion with the plasma membrane or by endocytosis into “recipient” cells. Although the interest in extracellular vesicle research is increasing, there are still no real standards in place to separate or classify the different types of vesicles. This review provides an introduction into this expanding and complex field of research focusing on the biogenesis, nucleic acid cargo loading, content, release, and uptake of extracellular vesicles.
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Citations
Cites
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099
Rab GTPases as coordinators of vesicle traffic
Stenmark, H. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2728 · Cited by 3,413
Routes and mechanisms of extracellular vesicle uptake
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Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
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Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
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“…been classified based on differences in biogenesis, we will focus on the different molecular mechanisms resulting in either the release of vesicles upon the fusion of the MVBs with the plasma membrane or the release via the outward budding and fission of the plasma membrane (Akers et al. 2013).”
Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
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Self-citationExosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311 · cited 1×
“…shown that the release of EVs is also an important mediator of intercellular communication that is involved in normal physiological process as well as in pathological progression (Frühbeis et al. 2012, 2013; Marcilla et al. 2012; Luga et al. 2012; Regev-Rudzki et al. 2013; Barteneva et al. 2013).”
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Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication
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Current and future perspectives of liquid biopsies in genomics-driven oncology
Heitzer, E., Haque, I. S., Roberts, C. E. S., & Speicher, M. R. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0071-5 · Cited by 1,557
Therapeutically harnessing extracellular vesicles
Cheng, L., & Hill, A. F. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00410-w · Cited by 737
Clinical Significance of PD-L1+ Exosomes in Plasma of Head and Neck Cancer Patients
Theodoraki, M.-N., Yerneni, S. S., Hoffmann, T. K., Gooding, W. E., & Whiteside, T. L. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2664 · Cited by 624
Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery
Antimisiaris, S. G., Mourtas, S., & Marazioti, A. (2018) · doi:10.20944/preprints201810.0507.v1 · Cited by 605
Metadata
- Authors
- Abels, E. R., & Breakefield, X. O.
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2016-04
- Volume
- 36
- Issue
- 3
- Pages
- 301-312
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- OpenAlex
- W2330004628
- Cited by
- 1,678
- References
- 17
- FWCI
- 45.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Abels, E. R., & Breakefield, X. O. (2016). Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake. Cellular and Molecular Neurobiology. https://doi.org/10.1007/s10571-016-0366-z
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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