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Spermidine Exhibits Protective Effects Against Traumatic Brain Injury

Huang, Jianxing, Zhang, Heping, Zhang, Jinning, Yu, Huiping, Lin, Zhizhong, Cai, Yonghui·2020·Cellular and Molecular Neurobiology
DOI 10.1007/s10571-019-00783-4
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  • Several CR-associated genes, including GPX3, HMGN2, NQO1 and ODC1 (encoding a rate-limiting enzyme of polyamine biosynthesis), possess or promote antioxidant activities.

    “Several CR-associated genes, including GPX3, HMGN2, NQO1 and ODC1 (encoding a rate-limiting enzyme of polyamine biosynthesis), possess or promote antioxidant activities61–66 (Fig. 5c–f and Supplementary Fig. 43a–d).”

    From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [65]

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  7. Johnson VE, Meaney DF, Cullen DK, Smith DH (2015) Animal models of traumatic brain injury. Handb Clin Neurol 127:115-128. https ://doi.org/10.1016/B978-0-444-52892 -6.00008 -8 · DOI
  8. Kang R, Zeh HJ, Lotze MT, Tang D (2011) The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 18(4):571-580. https ://doi.org/10.1038/cdd.2010.191 · DOI · Paper page
  9. Liu F, Liao F, Li W, Han Y, Liao D (2014) Progesterone alters Nogo-A, GFAP and GAP-43 expression in a rat model of traumatic brain injury. Mol Med Rep 9(4):1225-1231. https ://doi.org/10.3892/ mmr.2014.1967
  10. Maas AI, Stocchetti N, Bullock R (2008) Moderate and severe traumatic brain injury in adults. Lancet Neurol 7(8):728-741. https :// doi.org/10.1016/S1474 -4422(08)70164 -9 · DOI
  11. Mondello S, Kobeissy F, Vestri A, Hayes RL, Kochanek PM, Berger RP (2016) Serum concentrations of Ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein after pediatric traumatic brain injury. Sci Rep 6:28203. https ://doi.org/10.1038/srep2 8203 · DOI
  12. Nikolaeva I, Crowell B, Valenziano J, Meaney D, D'Arcangelo G (2016) Beneficial effects of early mTORC1 inhibition after traumatic brain injury. J Neurotrauma 33(2):183-193. https ://doi. org/10.1089/neu.2015.3899 · DOI
  13. Portbury SD, Hare DJ, Finkelstein DI, Adlard PA (2017) Trehalose improves traumatic brain injury-induced cognitive impairment. PLoS ONE 12(8):e0183683. https ://doi.org/10.1371/journ al.pone.01836 83 · DOI
  14. Ridler C (2017) Cardiovascular endocrinology: spermidine enhances cardiovascular health. Nat Rev Endocrinol 13(2):66. https ://doi. org/10.1038/nrend o.2016.203 · DOI
  15. Roozenbeek B, Maas AI, Menon DK (2013) Changing patterns in the epidemiology of traumatic brain injury. Nat Rev Neurol 9(4):231236. https ://doi.org/10.1038/nrneu rol.2013.22 · DOI
  16. Sarkar C, Zhao Z, Aungst S, Sabirzhanov B, Faden AI, Lipinski MM (2014) Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury. Autophagy 10(12):2208-2222. https ://doi.org/10.4161/15548 627.2014.98178 7 · DOI
  17. Schenkel E, Berlaimont V, Dubois J, Helson-Cambier M, Hanocq M (1995) Improved high-performance liquid chromatographic method for the determination of polyamines as their benzoylated derivatives: application to P388 cancer cells. J Chromatogr B, Biomed Appl 668(2):189-197. https ://doi.org/10.1016/03784347(95)00094 -y · DOI
  18. Sharma S, Kumar P, Deshmukh R (2018) Neuroprotective potential of spermidine against rotenone induced Parkinson's disease in rats. Neurochem Int 116:104-111. https ://doi.org/10.1016/j.neuin t.2018.02.010 · DOI
  19. Smith CM, Chen Y, Sullivan ML, Kochanek PM, Clark RS (2011) Autophagy in acute brain injury: feast, famine, or folly? Neurobiol Dis 43(1):52-59. https ://doi.org/10.1016/j.nbd.2010.09.014 · DOI
  20. Tao L, Li D, Liu H, Jiang F, Xu Y, Cao Y, Gao R, Chen G (2018) Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-kappaB and MAPK signaling pathway. Brain Res Bull 140:154-161. https ://doi.org/10.1016/j.brain resbu ll.2018.04.008 · DOI
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  22. Viscomi MT, D'Amelio M, Cavallucci V, Latini L, Bisicchia E, Nazio F, Fanelli F, Maccarrone M, Moreno S, Cecconi F, Molinari M (2012) Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage. Autophagy 8(2):222-235. https ://doi.org/10.4161/auto.8.2.18599 · DOI
  23. Yang Y, Chen S, Zhang Y, Lin X, Song Y, Xue Z, Qian H, Wang S, Wan G, Zheng X, Zhang L (2017) Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage. Cell Death Dis 8(4):e2738. https ://doi. org/10.1038/cddis .2017.161 · DOI
  24. Zhao M, Liang F, Xu H, Yan W, Zhang J (2016) Methylene blue exerts a neuroprotective effect against traumatic brain injury by promoting autophagy and inhibiting microglial activation. Mol Med Rep 13(1):13-20. https ://doi.org/10.3892/mmr.2015.4551 · DOI

Cited by

Sorted by citations

Authors
Huang, J., Zhang, H., Zhang, J., Yu, H., Lin, Z., & Cai, Y.
ORCID
Zhang, Jinning
Venue
Cellular and Molecular Neurobiology
Publisher
Springer Science and Business Media LLC
Published
2020-01-08
Volume
40
Issue
6
Pages
927-937
ISSN
  • 0272-4340
  • 1573-6830
DOI
10.1007/s10571-019-00783-4
Cited by
22
References
3
Language
en
Licence

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