CoChat
Sign Up
Cited by 32Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchLiver physiology and pathology

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Present and Future Developments in Hepatic Tissue Engineering for Liver Support Systems: State of the art and future developments of hepatic cell culture techniques for the use in liver support systems

Open access
Diekmann, Sonja, Bader, Augustinus, Schmitmeier, Stephanie·2006·Cytotechnology
DOI 10.1007/s10616-006-6336-4PMC PMC3476010
Open this paper in CoChat — free accountOpen PDF

Abstract

The liver is the most important organ for the biotransformation of xenobiotics, and the failure to treat acute or acute-on-chronic liver failure causes high mortality rates in affected patients. Due to the lack of donor livers and the limited possibility of the clinical management there has been growing interest in the development of extracorporeal liver support systems as a bridge to liver transplantation or to support recovery during hepatic failure. Earlier attempts to provide liver support comprised non-biological therapies based on the use of conventional detoxification procedures, such as filtration and dialysis. These techniques, however, failed to meet the expected efficacy in terms of the overall survival rate due to the inadequate support of several essential liver-specific functions. For this reason, several bioartificial liver support systems using isolated viable hepatocytes have been constructed to improve the outcome of treatment for patients with fulminant liver failure by delivering essential hepatic functions. However, controlled trials (phase I/II) with these systems have shown no significant survival benefits despite the systems' contribution to improvements in clinical and biochemical parameters. For the development of improved liver support systems, critical issues, such as the cell source and culture conditions for the long-term maintenance of liver-specific functions in vitro, are reviewed in this article. We also discuss aspects concerning the performance, biotolerance and logistics of the selected bioartificial liver support systems that have been or are currently being preclinically and clinically evaluated.

Overview

Integrity signals

Registry

Crossref · 10.1007/s10616-006-6336-4

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 5 references

Research works printed but not linked: 137

  1. Auth M.K., Okamoto M., Ishida Y., Keogh A., Auth S.H., Gerlach J., Encke A., McMaster P. and Strain A.J. (1998). Maintained function of primary human hepatocytes by cellular interactions in coculture: implications for liver support systems. Transpl. Int. 11: S439–S443 · DOI
  2. Babensee J.E., De Boni U. and Sefton M.V. (1992). Morphological assessment of hepatoma cells (HepG2) microencapsulated in a HEMA-MMA copolymer with and without Matrigel. J. Biomed. Mater. Res. 26: 1401–1418 · DOI
  3. Bader A., Fruhauf N., Zech K., Haverich A. and Borlak J.T. (1998). Development of a small-scale bioreactor for drug metabolism studies maintaining hepatospecific functions. Xenobiotica 28: 815–825 · DOI
  4. Bader A., Knop E., Kern A., Boker K., Fruhauf N., Crome O., Esselmann H., Pape C., Kempka G. and Sewing K.F. (1996). 3-D coculture of hepatic sinusoidal cells with primary hepatocytes-design of an organotypical model. Exp. Cell Res. 226: 223–233 · DOI
  5. Bader A., Rinkes I.H., Closs E.I., Ryan C.M., Toner M., Cunningham J.M., Tompkins R.G. and Yarmush M.L. (1992). A stable long-term hepatocyte culture system for studies of physiologic processes: cytokine stimulation of the acute phase response in rat and human hepatocytes. Biotechnol. Prog. 8: 219–225 · DOI
  6. Baquerizo A., Mhoyan A., Kearns-Jonker M., Arnaout W.S., Shackleton C., Busuttil R.W., Demetriou A.A. and Cramer D.V. (1999). Characterization of human xenoreactive antibodies in liver failure patients exposed to pig hepatocytes after bioartificial liver treatment: an ex vivo model of pig to human xenotransplantation. Transplantation 67: 5–18 · DOI
  7. Ben-Ze’ev A., Robinson G.S., Bucher N.L. and Farmer S.R. (1988). Cell–cell and cell–matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 85: 2161–2165 · DOI
  8. Black D., Lyman S., Heider T.R. and Behrns K.E. (2004). Molecular and cellular features of hepatic regeneration. J. Surg. Res. 117: 306–315 · DOI
  9. Blusch J.H., Patience C. and Martin U. (2002). Pig endogenous retroviruses and xenotransplantation. Xenotransplantation 9: 242–251 · DOI
  10. Braet F., Shleper M., Paizi M., Brodsky S., Kopeiko N., Resnick N. and Spira G. (2004). Liver sinusoidal endothelial cell modulation upon resection and shear stress in vitro. Comp. Hepatol. 3: 7 · DOI
  11. Bucher N.L., Robinson G.S. and Farmer S.R. (1990). Effects of extracellular matrix on hepatocyte growth and gene expression: implications for hepatic regeneration and the repair of liver injury. Semin. Liver Dis. 10: 11–19 · DOI
  12. Canaple L., Nurdin N., Angelova N., Hunkeler D. and Desvergne B. (2001). Development of a coculture model of encapsulated cells. Ann. NY Acad. Sci. 944: 350–361 · DOI
  13. Cascio S.M. (2001). Novel strategies for immortalization of human hepatocytes. Artif. Organs 25: 529–538 · DOI
  14. Costa R.H., Kalinichenko V.V., Holterman A.X. and Wang X. (2003). Transcription factors in liver development differentiation, and regeneration. Hepatology 38: 1331–1347 · DOI
  15. Curcio E., Barbieri G., Rende M., Giorno L., Morelli S. and Drioli E. (2005). Diffusive and convective transport through hollow fiber membranes for liver cell culture. J. Biotechnol. 117: 309–321 · DOI
  16. David B., Dore E., Jaffrin M.Y. and Legallais C. (2004). Mass transfers in a fluidized bed bioreactor using alginate beads for a future bioartificial liver. Int. J. Artif. Organs 27: 284–293 · DOI
  17. De Bartolo L., Bader A. (2001). Review of a flat membrane bioreactor as a bioartificial liver. Ann. Transplant. 6: 40–46
  18. De Bartolo L., Jarosch-Von Schweder G., Haverich A. and Bader A. (2000). A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: cell viability and tissue-specific functions. Biotechnol. Prog. 16: 102–108 · DOI
  19. De Bartolo L., Morelli S., Bader A. and Drioli E. (2002). Evaluation of cell behaviour related to physico-chemical properties of polymeric membranes to be used in bioartificial organs. Biomaterials 23: 2485–2497 · DOI
  20. De Bartolo L., Morelli S., Lopez L.C., Giorno L., Campana C., Salerno S., Rende M., Favia P., Detomaso L., Gristina R., d’Agostino R. and Drioli E. (2005). Biotransformation and liver-specific functions of human hepatocytes in culture on RGD-immobilized plasma-processed membranes. Biomaterials 26: 4432–4441 · DOI
  21. De Bartolo L., Morelli S., Rende M., Gordano A. and Drioli E. (2004). New modified polyetheretherketone membrane for liver cell culture in biohybrid systems: adhesion and specific functions of isolated hepatocytes. Biomaterials 25: 3621–3629 · DOI
  22. De Leeuw A.M., Brouwer A. and Knook D.L. (1990). Sinusoidal endothelial cells of the liver: fine structure and function in relation to age. J. Electron. Microsc. Tech. 14: 218–236 · DOI
  23. De Vos P., De Haan B. and Van Schilfgaarde R. (1997). Effect of the alginate composition on the biocompatibility of alginate-polylysine microcapsules. Biomaterials 18: 273–278 · DOI
  24. Demetriou A.A., Brown R.S., Busuttil R.W., Fair J., McGuire B.M., Rosenthal P., Am Esch J.S., Lerut J., Nyberg S.L., Salizzoni M., Fagan E.A., Broelsch C.E., Muraca M., Salmeron J.M., Rabkin J.M., Metselaar H.J., Pratt D., La Mata M., McChesney L.P., Everson G.T., Lavin P.T., Stevens A.C., Pitkin Z. and Solomon B.A. (2004). Prospectiverandomizedmulticentercontrolled trial of a bioartificial liver in treating acute liver failure. Ann. Surg. 239: 660–667 · DOI
  25. Dixit V., Darvasi R., Arthur M., Lewin K. and Gitnick G. (1993). Cryopreserved microencapsulated hepatocytes–transplantation studies in Gunn rats. Transplantation 55: 616–622 · DOI
  26. Dixit V. and Gitnick G. (1998). The bioartificial liver: state-of-the-art. Eur. J. Surg. 582(Suppl.): S71–S76
  27. Dore E. and Legallais C. (1999). A new concept of bioartificial liver based on a fluidized bed bioreactor. Ther. Apher. 3: 264–267 · DOI
  28. Dou M., de Sousa G., Lacarelle B., Placidi M., la Porte P., Domingo M., Lafont H. and Rahmani R. (1992). Thawed human hepatocytes in primary culture. Cryobiology 29: 454–469 · DOI
  29. Dunn J.C., Tompkins R.G. and Yarmush M.L. (1991). Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol. Prog. 7: 237–245 · DOI
  30. Dunn J.C., Yarmush M.L., Koebe H.G. and Tompkins R.G. (1989). Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration. Faseb. J. 3: 174–177 · DOI
  31. Ellis A.J., Hughes R.D., Wendon J.A., Dunne J., Langley P.G., Kelly J.H., Gislason G.T., Sussman N.L. and Williams R. (1996). Pilot-controlled trial of the extracorporeal liver assist device in acute liver failure. Hepatology 24: 1446–1451 · DOI
  32. Elvevold K.H., Nedredal G.I., Revhaug A. and Smedsrod B. (2004). Scavenger properties of cultivated pig liver endothelial cells. Comp. Hepatol. 3: 4 · DOI
  33. Enomoto K., Nishikawa Y., Omori Y., Tokairin T., Yoshida M., Ohi N., Nishimura T., Yamamoto Y. and Li Q. (2004). Cell biology and pathology of liver sinusoidal endothelial cells. Med. Electron. Microsc. 37: 208–215 · DOI
  34. Eschbach E., Chatterjee S.S., Noldner M., Gottwald E., Dertinger H., Weibezahn K.F. and Knedlitschek G. (2005). Microstructured scaffolds for liver tissue cultures of high cell density: morphological and biochemical characterization of tissue aggregates. J. Cell Biochem. 95: 243–255 · DOI
  35. Evenepoel P., Laleman W., Wilmer A., Claes K., Maes B., Kuypers D., Bammens B., Nevens F. and Vanrenterghem Y. (2005). Detoxifying capacity and kinetics of prometheus — a new extracorporeal system for the treatment of liver failure. Blood Purif. 23: 349–358 · DOI
  36. Fishman J.A. and Patience C. (2004). Xenotransplantation: infectious risk revisited. Am. J. Transplant. 4: 1383–1390 · DOI
  37. Flendrig L.M., Calise F., Di Florio E., Mancini A., Ceriello A., Santaniello W., Mezza E., Sicoli F., Belleza G., Bracco A., Cozzolino S., Scala D., Mazzone M., Fattore M., Gonzales E. and Chamuleau R.A. (1999). Significantly improved survival time in pigs with complete liver ischemia treated with a novel bioartificial liver. Int. J. Artif. Organs 22: 701–709 · DOI
  38. Flendrig L.M., la Soe J.W., Jorning G.G., Steenbeek A., Karlsen O.T., Bovee W.M., Ladiges N.C., te Velde A.A. and Chamuleau R.A. (1997). In vitro evaluation of a novel bioreactor based on an integral oxygenator and a spirally wound nonwoven polyester matrix for hepatocyte culture as small aggregates. J. Hepatol. 26: 1379–1392 · DOI
  39. Fremond B., Malandain C., Guyomard C., Chesne C., Guillouzo A. and Campion J.P. (1993). Correction of bilirubin conjugation in the Gunn rat using hepatocytes immobilized in alginate gel beads as an extracorporeal bioartificial liver. Cell Transplant. 2: 453–460 · DOI
  40. Fruhauf N.R., Oldhafer K.J., Holtje M., Kaiser G.M., Fruhauf J.H., Stavrou G.A., Bader A. and Broelsch C.E. (2004). A bioartificial liver support system using primary hepatocytes: a preclinical study in a new porcine hepatectomy model. Surgery 136: 47–56 · DOI
  41. Gan J.H., Zhou X.Q., Qin A.L., Luo E.P., Zhao W.F., Yu H. and Xu J. (2005). Hybrid artificial liver support system for treatment of severe liver failure. World J. Gastroenterol. 11: 890–894 · DOI
  42. Gerlach J.C. (1996). Development of a hybrid liver support system: a review. Int. J. Artif. Organs 19: 645–654 · DOI
  43. Gerlach J.C., Kloppel K., Muller C., Schnoy N., Smith M.D. and Neuhaus P. (1993). Hepatocyte aggregate culture technique for bioreactors in hybrid liver support systems. Int. J. Artif. Organs 16: 843–846 · DOI
  44. Gerlach J.C., Mutig K., Sauer I.M., Schrade P., Efimova E., Mieder T., Naumann G., Grunwald A., Pless G., Mas A., Bachmann S., Neuhaus P. and Zeilinger K. (2003). Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study. Transplantation 76: 781–786 · DOI
  45. Gimson A.E. (1996). Fulminant and late onset hepatic failure. Br. J. Anaesth. 77: 90–98 · DOI
  46. Glicklis R., Shapiro L., Agbaria R., Merchuk J.C. and Cohen S. (2000). Hepatocyte behavior within three-dimensional porous alginate scaffolds. Biotechnol. Bioeng. 67: 344–353 · DOI
  47. Gregory P.G., Connolly C.K., Toner M. and Sullivan S.J. (2000). In vitro characterization of porcine hepatocyte function. Cell Transplant. 9: 1–10 · DOI
  48. Guillouzo A., Rialland L., Fautrel A. and Guyomard C. (1999). Survival and function of isolated hepatocytes after cryopreservation. Chem. Biol. Interact. 121: 7–16 · DOI
  49. Hasegawa H., Shimada M., Gion T., Ijima H., Nakazawa K., Funatsu K. and Sugimachi K. (1999). Modulation of immunologic reactions between cultured porcine hepatocytes and human sera. ASAIO J. 45: 392–396 · DOI
  50. He Z.P., Tan W.Q., Tang Y.F. and Feng M.F. (2003). Differentiation of putative hepatic stem cells derived from adult rats into mature hepatocytes in the presence of epidermal growth factor and hepatocyte growth factor. Differentiation 71: 281–290 · DOI
  51. Hengstler J.G., Ringel M., Biefang K., Hammel S., Milbert U., Gerl M., Klebach M., Diener B., Platt K.L., Bottger T., Steinberg P. and Oesch F. (2000). Cultures with cryopreserved hepatocytes: applicability for studies of enzyme induction. Chem. Biol. Interact. 125: 51–73 · DOI
  52. Hoekstra R. and Chamuleau R.A. (2002). Recent developments on human cell lines for the bioartificial liver. Int. J. Artif. Organs 25: 182–191 · DOI
  53. Honiger J., Sarkis R., Baudrimont M., Delelo R., Chafai N., Benoist S., Sarkis K., Balladur P., Capeau J. and Nordlinger B. (2000). Semiautomatic macroencapsulation of large numbers of porcine hepatocytes by coextrusion with a solution of AN69 polymer. Biomaterials 21: 1269–1274 · DOI
  54. Hughes R.D., Nicolaou N., Langley P.G., Ellis A.J., Wendon J.A. and Williams R. (1998). Plasma cytokine levels and coagulation and complement activation during use of the extracorporeal liver assist device in acute liver failure. Artif. Organs 22: 854–858 · DOI
  55. Irgang M., Sauer I.M., Karlas A., Zeilinger K., Gerlach J.C., Kurth R., Neuhaus P. and Denner J. (2003). Porcine endogenous retroviruses: no infection in patients treated with a bioreactor based on porcine liver cells. J. Clin. Virol. 28: 141–154 · DOI
  56. Isom H.C., Secott T., Georgoff I., Woodworth C. and Mummaw J. (1985). Maintenance of differentiated rat hepatocytes in primary culture. Proc. Natl. Acad. Sci. U.S.A. 82: 3252–3256 · DOI
  57. Jasmund I., Langsch A., Simmoteit R. and Bader A. (2002). Cultivation of primary porcine hepatocytes in an OXY-HFB for use as a bioartificial liver device. Biotechnol. Prog. 18: 839–846 · DOI
  58. Jauregui H.O., Mullon C.J., Trenkler D., Naik S., Santangini H., Press P., Muller T.E. and Solomon B.A. (1995). In vivo evaluation of a hollow fiber liver assist device. Hepatology 21: 460–469 · DOI
  59. Jauregui H.O., Naik S., Santangini H., Pan J., Trenkler D. and Mullon C. (1994). Primary cultures of rat hepatocytes in hollow fiber chambers. In Vitro Cell Dev Biol. Anim. 30: 23–29 · DOI
  60. Joly A., Desjardins J.F., Fremond B., Desille M., Campion J.P., Malledant Y., Lebreton Y., Semana G., Edwards-Levy F., Levy M.C. and Clement B. (1997). Survival, proliferation, and functions of porcine hepatocytes encapsulated in coated alginate beads: a step toward a reliable bioartificial liver. Transplantation 63: 795–803 · DOI
  61. Kang Y.H., Berthiaume F., Nath B.D. and Yarmush M.L. (2004). Growth factors and nonparenchymal cell conditioned media induce mitogenic responses in stable long-term adult rat hepatocyte cultures. Exp. Cell Res. 293: 239–247 · DOI
  62. King A., Strand B., Rokstad A.M., Kulseng B., Andersson A., Skjak-Braek G. and Sandler S. (2003). Improvement of the biocompatibility of alginate/poly-l-lysine/alginate microcapsules by the use of epimerized alginate as a coating. J. Biomed. Mater. Res. (Part) A. 64: 533–539 · DOI
  63. Kjaergard L.L., Liu J., Als-Nielsen B. and Gluud C. (2003). Artificial and bioartificial support systems for acute and acute-on-chronic liver failure: a systematic review. JAMA 289: 217–222 · DOI
  64. Kmieć Z. (2001). Cooperation of liver cells in health and disease. In: Beck, F., Christ, B., Kriz, W., Kummer, W., Marani, E., Putz, R., Sano, Y., Schiebler, T.H., Schoenwolf, G.C. and Zilles, K. (eds) Advances in Anatomy Embryology and Cell Biology, Vol. 161, pp 1–149. Springer-Verlag, Berlin, Heidelberg, New York
  65. Kobayashi N., Okitsu T., Nakaji S. and Tanaka N. (2003). Hybrid bioartificial liver: establishing a reversibly immortalized human hepatocyte line and developing a bioartificial liver for practical use. J. Artif. Organs 6: 236–244 · DOI
  66. Koide N., Sakaguchi K., Koide Y., Asano K., Kawaguchi M., Matsushima H., Takenami T., Shinji T., Mori M. and Tsuji T. (1990). Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments. Exp. Cell Res. 186: 227–235 · DOI
  67. Koniaris L.G., McKillop I.H., Schwartz S.I. and Zimmers T.A. (2003). Liver regeneration. J. Am. Coll. Surg. 197: 634–659 · DOI
  68. Krisper P., Haditsch B., Stauber R., Jung A., Stadlbauer V., Trauner M., Holzer H. and Schneditz D. (2005). In vivo quantification of liver dialysis: comparison of albumin dialysis and fractionated plasma separation. J. Hepatol. 43: 451–457 · DOI
  69. Kuddus R., Patzer J.F., Lopez R., Mazariegos G.V., Meighen B., Kramer D.J. and Rao A.S. (2002). Clinical and laboratory evaluation of the safety of a bioartificial liver assist device for potential transmission of porcine endogenous retrovirus. Transplantation 73: 420–429 · DOI
  70. Lacik I., Brissova M., Anilkumar A.V., Powers A.C. and Wang T. (1998). New capsule with tailored properties for the encapsulation of living cells. J. Biomed. Mater. Res. 39: 52–60 · DOI
  71. Langsch A. and Bader A. (2001). Longterm stability of phase I and phase II enzymes of porcine liver cells in flat membrane bioreactors. Biotechnol. Bioeng. 76: 115–125 · DOI
  72. Lee K.W., Park J.B., Yoon J.J., Lee J.H., Kim S.Y., Jung H.J., Lee S.K., Kim S.J., Lee H.H., Lee D.S. and Joh J.W. (2004). The viability and function of cryopreserved hepatocyte spheroids with different cryopreservation solutions. Transplant. Proc. 36: 2462–2463 · DOI
  73. Lee W.M. (1993). Acute liver failure. N. Engl. J. Med. 329: 1862–1872 · DOI
  74. Legallais C., Dore E. and Paullier P. (2000). Design of a fluidized bed bioartificial liver. Artif. Organs 24: 519–525 · DOI
  75. Lorenti A., Barbich M., de Santibanes M., Ielpi M., Vazquez J.C., Sorroche P. and Argibay P. (2003). Ammonium detoxification performed by porcine hepatocyte spheroids in a bioartificial liver for pediatric use: preliminary report. Artif. Organs 27: 665–670 · DOI
  76. Louha M., Poussin K., Ganne N., Zylberberg H., Nalpas B., Nicolet J., Capron F., Soubrane O., Vons C., Pol S., Beaugrand M, Berthelot P., Franco D., Trinchet J.C., Brechot C. and Paterlini P. (1997). Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer. Hepatology 26: 998–1005 · DOI
  77. Lowes K.N., Croager E.J., Olynyk J.K., Abraham L.J. and Yeoh G.C. (2003). Oval cell-mediated liver regeneration: Role of cytokines and growth factors. J. Gastroenterol. Hepatol. 18: 4–12 · DOI
  78. Mai G., Huy N.T., Morel P., Mei J., Bosco D., Berney T., Majno P., Mentha G., Trono D. and Buhler L.H. (2005). Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes. Transplant. Proc. 37: 527–529 · DOI
  79. Matsushita T., Yagi T., Hardin J.A., Cragun J.D., Crow F.W., Bergen H.R., Gores G.J. and Nyberg S.L. (2003). Apoptotic cell death and function of cryopreserved porcine hepatocytes in a bioartificial liver. Cell Transplant. 12: 109–121 · DOI
  80. Mazariegos G.V., Kramer D.J., Lopez R.C., Shakil A.O., Rosenbloom A.J., DeVera M., Giraldo M., Grogan T.A., Zhu Y., Fulmer M.L., Amiot B.P. and Patzer J.F. (2001). Safety observations in phase I clinical evaluation of the Excorp Medical Bioartificial Liver Support System after the first four patients. ASAIO J. 47: 471–475 · DOI
  81. McClelland R.E., MacDonald J.M. and Coger R.N. (2003). Modeling O2 transport within engineered hepatic devices. Biotechnol. Bioeng. 82: 12–27 · DOI
  82. McLaughlin B.E., Tosone C.M., Custer L.M. and Mullon C. (1999). Overview of extracorporeal liver support systems and clinical results. Ann. NY Acad. Sci. 875: 310–325 · DOI
  83. Michalopoulos G.K., Bowen W.C., Mule K. and Stolz D.B. (2001). Histological organization in hepatocyte organoid cultures. Am. J. Pathol. 159: 1877–1887 · DOI
  84. Michalopoulos G.K. and DeFrances M.C. (1997). Liver regeneration. Science 276: 60–66 · DOI · Paper page
  85. Mitzner S.R., Stange J., Klammt S., Peszynski P. and Schmidt R. (2001). Albumin dialysis using the molecular adsorbent recirculating system. Curr. Opin. Nephrol. Hypertens. 10: 777–783 · DOI
  86. Miura Y., Akimoto T. and Yagi K. (1988). Liver functions in hepatocytes entrapped within calcium alginate. Ann. NY Acad. Sci. 542: 521–532 · DOI
  87. Morsiani E., Brogli M., Galavotti D., Bellini T., Ricci D., Pazzi P. and Puviani A.C. (2001). Long-term expression of highly differentiated functions by isolated porcine hepatocytes perfused in a radial–flow bioreactor. Artif. Organs 25: 740–748 · DOI
  88. Morsiani E., Brogli M., Galavotti D., Pazzi P., Puviani A.C. and Azzena G.F. (2002a). Biologic liver support: optimal cell source and mass. Int. J. Artif. Organs 25: 985–993 · DOI
  89. Morsiani E., Pazzi P., Puviani A.C., Brogli M., Valieri L., Gorini P., Scoletta P., Marangoni E., Ragazzi R., Azzena G., Frazzoli E., Di Luca D. and Cassai E. (2002b). Early experiences with a porcine hepatocyte-based bioartificial liver in acute hepatic failure patients. Int. J. Artif. Organs 25: 192–202 · DOI
  90. Muraca M., Vilei M.T., Zanusso E., Ferraresso C., Granato A., Doninsegna S., Dal Monte R., Carraro P. and Carturan G. (2000). Encapsulation of hepatocytes by SiO(2). Transplant Proc. 32: 2713–2714 · DOI
  91. Muto Y., Nouri-Aria K.T., Meager A., Alexander G.J., Eddleston A.L. and Williams R. (1988). Enhanced tumour necrosis factor and interleukin-1 in fulminant hepatic failure. Lancet 2: 72–74 · DOI
  92. Nagy A. (2000). Cre recombinase: the universal reagent for genome tailoring. Genesis 26: 99–109 · DOI
  93. Nyberg S.L., Hibbs J.R., Hardin J.A., Germer J.J. and Persing D.H. (1999). Transfer of porcine endogenous retrovirus across hollow fiber membranes: significance to a bioartificial liver. Transplantation 67: 1251–1255 · DOI
  94. Nyberg S.L., Mann H.J., Hu M.Y., Payne W.D., Hu W.S., Cerra F.B. and Remmel R.P. (1996). Extrahepatic metabolism of 4-methylumbelliferone and lidocaine in the anhepatic rabbit. Drug Metab. Dispos. 24: 643–648
  95. Nyberg S.L., Platt J.L., Shirabe K., Payne W.D., Hu W.S. and Cerra F.B. (1992a). Immunoprotection of xenocytes in a hollow fiber bioartificial liver. ASAIO J. 38: M463–M467 · DOI
  96. Nyberg S.L., Shatford R.A., Hu W.S., Payne W.D. and Cerra F.B. (1992b). Hepatocyte culture systems for artificial liver support: implications for critical care medicine (bioartificial liver support). Crit. Care Med. 20: 1157–1168 · DOI
  97. Nyberg S.L., Shatford R.A., Payne W.D., Hu W.S. and Cerra F.B. (1992c). Primary culture of rat hepatocytes entrapped in cylindrical collagen gels: an in vitro system with application to the bioartificial liver. Rat hepatocytes cultured in cylindrical collagen gels. Cytotechnology 10: 205–215 · DOI
  98. Nyberg S.L., Shirabe K., Peshwa M.V., Sielaff T.D., Crotty P.L., Mann H.J., Remmel R.P., Payne W.D., Hu W.S. and Cerra F.B. (1993). Extracorporeal application of a gel-entrapmentbioartificial liver: demonstration of drug metabolism and other biochemical functions. Cell Transplant. 2: 441–452 · DOI
  99. Orive G., Hernandez R.M., Gascon A.R., Calafiore R., Chang T.M., De Vos P., Hortelano G., Hunkeler D., Lacik I., Shapiro A.M. and Pedraz J.L. (2003). Cell encapsulation: promise and progress. Nat. Med. 9: 104–107 · DOI
  100. Orive G., Hernandez R.M., Rodriguez Gascon A., Calafiore R., Chang T.M., de Vos P., Hortelano G., Hunkeler D., Lacik I. and Pedraz J.L (2004). History, challenges and perspectives of cell microencapsulation. Trends Biotechnol. 22: 87–92 · DOI
  101. Pahernik S.A., Thasler W.E., Doser M., Gomez-Lechon M.J., Castell M.J., Planck H. and Koebe H.G. (2001). High density culturing of porcine hepatocytes immobilized on nonwoven polyurethane-based biomatrices. Cells Tissues Organs 168: 170–177 · DOI
  102. Pitkin Z. and Mullon C. (1999). Evidence of absence of porcine endogenous retrovirus (PERV) infection in patients treated with a bioartificial liver support system. Artif. Organs 23: 829–833 · DOI
  103. Quek C.H., Li J., Sun T., Chan M.L., Mao H.Q., Gan L.M., Leong K.W. and Yu H. (2004). Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation. Biomaterials 25: 3531–3540 · DOI
  104. Rahman T. and Hodgson H. (2001). Clinical management of acute hepatic failure. Intensive Care Med. 27: 467–476 · DOI
  105. Ramadori G. and Armbrust T. (2001). Cytokines in the liver. Eur. J. Gastroenterol. Hepatol. 13: 777–784 · DOI
  106. Rifai K., Bahr M., Schneider A., Ott M. and Mann M. (2003). Neue Verfahren in der Leberersatztherapie. Medizinische Klinik 98: 750–753 · DOI
  107. Runge D., Runge D.M., Jager D., Lubecki K.A., Beer Stolz D., Karathanasis S., Kietzmann T., Strom S.C., Jungermann K., Fleig W.E. and Michalopoulos G.K. (2000). Serum-freelong-term cultures of human hepatocytes: maintenance of cell morphology, transcription factors, and liver-specific functions. Biochem. Biophys. Res. Commun. 269: 46–53 · DOI
  108. Saad B., Scholl F.A., Thomas H., Schawalder H., Streit V., Waechter F. and Maier P. (1993). Crude liver membrane fractions and extracellular matrix components as substrata regulate differentially the preservation and inducibility of cytochrome P-450 isoenzymes in cultured rat hepatocytes. Eur. J. Biochem. 213: 805–814 · DOI
  109. Sakai Y., Naruse K., Nagashima I., Muto T. and Suzuki M. (1996). Large-scale preparation and function of porcine hepatocyte spheroids. Int. J. Artif. Organs 19: 294–301 · DOI
  110. Sato Y., Tsukada K. and Hatakeyama K. (1999). Role of shear stress and immune responses in liver regeneration after a partial hepatectomy. Surg. Today 29: 1–9 · DOI
  111. Sauer I.M. and Gerlach J.C. (2002). Modular extracorporeal liver support. Artif. Organs 26: 703–706 · DOI
  112. Sauer I.M., Kardassis D., Zeillinger K., Pascher A., Gruenwald A., Pless G., Irgang M., Kraemer M., Puhl G., Frank J., Muller A.R., Steinmuller T., Denner J., Neuhaus P. and Gerlach J.C. (2003). Clinical extracorporeal hybrid liver support–phase I study with primary porcine liver cells. Xenotransplantation 10: 460–469 · DOI
  113. Sauer I.M., Obermeyer N., Kardassis D., Theruvath T. and Gerlach J.C. (2001). Development of a hybrid liver support system. Ann. NY Acad. Sci. 944: 308–319 · DOI
  114. Sauer I.M., Zeilinger K., Obermayer N., Pless G., Grunwald A., Pascher A., Mieder T., Roth S., Goetz M., Kardassis D., Mas A., Neuhaus P. and Gerlach J.C. (2002). Primary human liver cells as source for modular extracorporeal liver support–a preliminary report. Int. J. Artif. Organs 25: 1001–1005 · DOI
  115. Schoen J.M., Wang H.H., Minuk G.Y. and Lautt W.W. (2001). Shear stress-induced nitric oxide release triggers the liver regeneration cascade. Nitric Oxide 5: 453–464 · DOI · Paper page
  116. Schuetz E.G., Li D., Omiecinski C.J., Muller-Eberhard U., Kleinman H.K., Elswick B. and Guzelian P.S. (1988). Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix. J. Cell Physiol. 134: 309–323 · DOI
  117. Semino C.E., Merok J.R., Crane G.G., Panagiotakos G. and Zhang S. (2003). Functional differentiation of hepatocyte-like spheroid structures from putative liver progenitor cells in three-dimensional peptide scaffolds. Differentiation 71: 262–270 · DOI
  118. Seo S.J., Akaike T., Choi Y.J., Shirakawa M., Kang I.K. and Cho C.S. (2005). Alginate microcapsules prepared with xyloglucan as a synthetic extracellular matrix for hepatocyte attachment. Biomaterials 26: 3607–3615 · DOI
  119. Serandour A.L., Loyer P., Garnier D., Courselaud B., Theret N., Glaise D., Guguen-Guillouzo C. and Corlu A. (2005). TNFα-mediated extracellular matrix remodeling is required for multiple division cycles in rat hepatocytes. Hepatology 41: 478–486 · DOI
  120. Shito M., Tilles A.W., Tompkins R.G., Yarmush M.L. and Toner M. (2003). Efficacy of an extracorporeal flat-plate bioartificial liver in treating fulminant hepatic failure. J. Surg. Res. 111: 53–62 · DOI
  121. Sielaff T.D., Hu M.Y., Rao S., Groehler K., Olson D., Mann H.J., Remmel R.P., Shatford R.A., Amiot B. and Hu W.S. (1995). A technique for porcine hepatocyte harvest and description of differentiated metabolic functions in static culture. Transplantation 59: 1459–1463 · DOI
  122. Stange J. and Mitzner S. (1996). Hepatocyte encapsulation–initial intentions and new aspects for its use in bioartificial liver support. Int. J. Artif. Organs 19: 45–48 · DOI
  123. Sussman N.L., Chong M.G., Koussayer T., He D.E., Shang T.A., Whisennand H.H. and Kelly J.H. (1992). Reversal of fulminant hepatic failure using an extracorporeal liver assist device. Hepatology 16: 60–65 · DOI
  124. Sussman N.L. and Kelly J.H. (1993). Improved liver function following treatment with an extracorporeal liver assist device. Artif. Organs 17: 27–30 · DOI
  125. Suzuki A., Iwama A., Miyashita H., Nakauchi H. and Taniguchi H. (2003). Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells. Development 130: 2513–2524 · DOI
  126. te Velde A.A., Ladiges N.C., Flendrig L.M. and Chamuleau R.A. (1995). Functional activity of isolated pig hepatocytes attached to different extracellular matrix substrates. Implication for application of pig hepatocytes in a bioartificial liver. J. Hepatol. 23: 184–192
  127. Tong J.Z., Sarrazin S., Cassio D., Gauthier F. and Alvarez F. (1994). Application of spheroid culture to human hepatocytes and maintenance of their differentiation. Biol. Cell 81: 77–81 · DOI
  128. Tsiaoussis J., Newsome P.N., Nelson L.J., Hayes P.C. and Plevris J.N. (2001). Which hepatocyte will it be? Hepatocyte choice for bioartificial liver support systems. Liver Transpl. 7: 2–10 · DOI
  129. Uludag H., De Vos P. and Tresco P.A. (2000). Technology of mammalian cell encapsulation. Adv. Drug Deliv. Rev. 42: 29–64 · DOI
  130. van de Kerkhove M.P., Germans M.R., Deurholt T., Hoekstra R., Joziasse D.H., van Wijk A.C., van Gulik T.M., Chamuleau R.A. and Roos A. (2005a). Evidence for Galα (1–3)Gal expression on primary porcine hepatocytes: implications for bioartificial liver systems. J. Hepatol. 42: 541–547 · DOI
  131. van de Kerkhove M.P., Hoekstra R., Chamuleau R.A. and van Gulik T.M. (2004). Clinical application of bioartificial liver support systems. Ann. Surg. 240: 216–230 · DOI
  132. van de Kerkhove M.P. and Poyck P.P. (2005b). Liver support therapy: an overview of the AMC-bioartificial liver research. Dig. Surg. 22: 254–264 · DOI
  133. (1999). Cell-cell organization and functions of ‘sinusoids’ in liver microcirculation system. J. Electron. Microsc. (Tokyo) 48: 89–98 · DOI
  134. (1999). Cultivation and characterization of a new immortalized human hepatocyte cell lineHepZ, for use in an artificial liver support system. Ann. NY Acad. Sci. 875: 364–368 · DOI
  135. (2003). Biochemical and functional changes of rat liver spheroids during spheroid formation and maintenance in culture: II. nitric oxide synthesis and related changes. J. Cell Biochem. 90: 1176–1185 · DOI
  136. (2001). Self-organization of liver constitutive cells mediated by artificial matrix and improvement of liver functions in long-term culture. Biochem. Eng. J. 8: 135–143 · DOI
  137. (2003). Efficacy of a larger version of the hybrid artificial liver support system using a polyurethane foam/spheroid packed-bed module in a warm ischemic liver failure pig model for preclinical experiments. Cell Transplant. 12: 101–107 · DOI

Cited by

Sorted by citations

See all 32

Metadata

Authors
Diekmann, S., Bader, A., & Schmitmeier, S.
Affiliations
Leipzig University (DE)
Corresponding author
Schmitmeier, Stephanie
Venue
Cytotechnology
Publisher
Springer Science and Business Media LLC
Published
2006-01-03
Volume
50
Issue
1-3
Pages
163-179
ISSN
  • 0920-9069 (ISSN-L)
  • 1573-0778
DOI
10.1007/s10616-006-6336-4
PMC
PMC3476010
OpenAlex
W2091933158
Cited by
32
References
5
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2020: 1 · 2018: 1 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 1
FWCI
2.04
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Cytotechnology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
liver tissue engineering, bioartificial liver, extracorporeal liver support, acute-on-chronic liver failure, acute liver failure, cell sources, bridge to liver transplantation, xenobiotic detoxification

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review