Human adipose tissue derived mesenchymal stem cells are resistant to several chemotherapeutic agents
Open accessAbstract
Human adipose derived mesenchymal stem cells (ADMSCs) are multipotential stem cells, originated from the vascular stromal compartment of fat tissues which can be used as an alternative cell source for many different cell therapies. However, their response to chemotherapeutic agants remains unknown. Here we assessed the acute direct effects of individual chemotherapeutic drug on ADMSCs. Using an in vitro culture system, the response of ADMSCs to the three chemotherapeutic agents cisplatin, comptothecin and vincristine was determined in comparison with that of testicular germ cell tumour (TGCT) cell line. The recovery of cell numbers following exposure to chemotherapeutic agents were also evaluated. Our results showed that human ADMSCs were resistant to chemo-therapeutic agents which are commonly used in clinic, the full recovery was seen respectively in ADMSCs after the drug treatment. Moreover, ADMSCs maintained their stem cell characteristics in vitro after the exposure to all chemotherapeutic agents.
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Both BM-MSCs and ASCs could be explored further as a combinatory reparative and anti-cancer treatment option for OS.
“The results from these studies suggest that both BM-MSCs and ASCs could be explored further as a combinatory reparative and anti-cancer treatment option for OS (Figure 1).”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [116]
ASCs displayed resistance to cisplatin, camptothecin, and vincristine and fully recovered after treatment.
“ASCs displayed resistance to all the agents used and fully recovered after treatment [109,116].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [116]
ASCs' stem cell properties remained intact in vitro following exposure to cisplatin, camptothecin, and vincristine.
“Furthermore, their stem cell properties remained intact in vitro following the exposure to these drugs [109,116].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [116]
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- Authors
- Liang, W., Xia, H., Li, J., & Zhao, R. C.
- Affiliations
- First Affiliated Hospital of Anhui Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Liang, Wei
- Venue
- Cytotechnology
- Published
- 2011-07-15
- Volume
- 63
- Issue
- 5
- Pages
- 523-530
- ISSN
- 0920-9069 (ISSN-L)
- 1573-0778
- PMC
- PMC3176932
- OpenAlex
- W2021583973
- Cited by
- 47
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cytotechnology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- adipose-derived stem cells, chemoresistance, cisplatin, doxorubicin, vincristine, testicular germ cell tumors, stem cell maintenance, stem cell therapy
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