Mesenchymal stem cells maintain their defining stem cell characteristics after treatment with cisplatin
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Mesenchymal stem cells (MSCs) aid the regeneration of tissues damaged by treatment with cisplatin. However, the effects of this cytotoxic drug on the stem cells have been largely unknown. Here we demonstrate that human bone marrow-derived MSCs are relatively resistant to cisplatin treatment and show resistance levels comparable to these of differentiated fibroblasts. Cisplatin did not affect cellular morphology, adhesion or induction of apoptosis in MSCs. The potential for differentiation was preserved after exposure to cisplatin and established MSC surface markers were observed to be stably expressed irrespective of cisplatin treatment. Cytoskeletal rearrangements and high expression levels of individual heat shock proteins were detected in MSCs and may be partly responsible for the observed cisplatin resistance. The cisplatin-resistant phenotype of human MSCs supports the concept of further investigating these stem cells as a potential treatment option for cisplatin-induced tissue damage.
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Cisplatin does not affect BM-MSCs' morphology, adhesion, viability, or differentiation potential.
“For instance, Nicolay et al. studied the effect of cisplatin on BM-MSCs’ characteristics [109,115] and reported that it does not affect MSCs’ morphology, adhesion, viability, or differentiation potential.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [115]
The Results sections report largely unchanged morphology and mostly preserved adhesion, but MSC2 adhesion fell significantly at the high dose. Differentiation was not abolished, yet high-dose cisplatin significantly reduced adipogenic differentiation; the viability results establish relative resistance compared with fibroblasts, not that viability was unaffected. The claim therefore overstates the findings. (LLM, conf=0.90)
Experimental — accuracy not yet measuredTypical MSC-related surface markers CD73, CD90, and CD105 show stable expression levels upon cisplatin exposure.
“Also, typical MSC-related surface markers, CD73, CD90, and CD105, show stable expression levels upon cisplatin exposure [109,115].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [115]
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- Authors
- Nicolay, N. H., Perez, R. L., Rühle, A., Trinh, T., Sisombath, S., Weber, K.-J., Ho, A. D., Debus, J., Saffrich, R., & Huber, P. E.
- Affiliations
- German Cancer Research Center (DE)
- University Hospital Heidelberg (DE)
- Corresponding author
- Nicolay, Nils H.
- ORCID
- Venue
- Scientific Reports
- Published
- 2016-01-25
- Volume
- 6
- Issue
- 1
- Pages
- 20035-20035
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4726328
- OpenAlex
- W2394861557
- Cited by
- 41
- References
- 65
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 9 · 2017: 3 · 2016: 3
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- mesenchymal stem cells, cisplatin, drug resistance, bone marrow-derived stem cells, stem cell maintenance, heat shock proteins, cytoskeletal rearrangement, apoptosis, cell surface markers, tissue regeneration
- MeSH terms
- Bone Marrow Cells, Cell Differentiation, Cells, Cultured, Cisplatin, Drug Resistance, Fibroblasts, Humans, Phenotype, Regeneration, Apoptosis, Cell Proliferation, Mesenchymal Stem Cells
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