Impaired Sleep Quality in Crohn’s Disease Depends on Disease Activity
Abstract
Background Little is known concerning the relationship of disease activity and sleep disturbances in inflammatory bowel disease (IBD) and specifically in patients with Crohn's disease.Aim This study examined the prevalence of poor sleep quality in patients with active and inactive Crohn's disease compared with healthy controls.Methods Participants included 108 patients with Crohn's disease attending the IBD clinic of a tertiary medical center in 2009-2010 and 36 healthy volunteers. All prospectively completed a demographic questionnaire and the Pittsburgh sleep quality index (PSQI). Patients with Crohn's disease completed the Crohn's disease activity index (CDAI) and were divided into two groups accordingly: inactive disease (CDAI ≤150) and active disease (CDAI >150). Data on disease duration, medications, complications, and treatment were collected from the medical files.Results Seventy-one patients had inactive Crohn's disease and 37 had active disease. All three groups were similar in mean age, sex distribution, and body mass index. Mean duration of Crohn's disease was 10.22 ± 8.6 years; 40 patients (37 %) had ileal disease, 16 (15 %) colonic disease, and 56 (50 %) ileo-colonic disease. Patients with active disease had a significantly higher mean ± SD global score on the PSQI (8.6 ± 2.4; indicating poorer sleep quality) than patients with inactive disease (4.6 ± 1.9) or control subjects (5.1 ± 1.7) (p < 0.0001 for both), with no significant difference between the inactive-disease and control groups. The correlation between the CDAI and PSQI scores was statistically significant (p < 0.001).Conclusions Impaired sleep quality is associated with active Crohn's disease, but not inactive disease.
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Two recent studies in healthy participants revealed an increase, rather than the expected decrease, in SWA following administration of anakinra and minocycline.
“two recent studies in healthy participants revealed an increase, rather than the expected decrease, in SWA following administration of the anti-inflammatory drugs anakinra, an IL-1ra (495), and minocycline (50)”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [210]
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The Sleep-Immune Crosstalk in Health and Disease
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“In a recent study, half of the IBD patients reported sleep disturbances as assessed by the PSQI (550), with strongest associations in patients with active disease (10, 209).”
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Poor Sleep in Inflammatory Bowel Disease Is Reflective of Distinct Sleep Disorders
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- Authors
- Gingold-Belfer, R., Peled, N., Levy, S., Katz, N., Niv, Y., Fass, R., Fraser, G., & Dickman, R.
- Affiliations
- Tel Aviv University (IL)
- Academic College of Tel Aviv-Yafo (IL)
- Assuta Medical Center (IL)
- MetroHealth Medical Center (US)
- Corresponding author
- Dickman, Ram
- Venue
- Digestive Diseases and Sciences
- Published
- 2013-10-11
- Volume
- 59
- Issue
- 1
- Pages
- 146-151
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2043367863
- Cited by
- 46
- References
- 28
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 5 · 2016: 2 · 2015: 1 · 2014: 2
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- Crohn's disease, sleep quality, sleep disorders, disease activity, inflammatory bowel disease, Pittsburgh Sleep Quality Index, CDAI
- MeSH terms
- Adult, Crohn Disease, Female, Humans, Israel, Male, Middle Aged, Prospective Studies, Sleep Wake Disorders, Prevalence, Case-Control Studies, Young Adult
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