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Cited by 89Inflammatory Bowel DiseaseMedication Adherence and ComplianceOcular Diseases and Behçet’s Syndrome

Predictors of health-related quality of life and adherence in Crohn's disease and ulcerative colitis: implications for clinical management

Tabibian, Anilga, Tabibian, James H., Beckman, Linda J., Raffals, Laura L., Papadakis, Konstantinos A., Kane, Sunanda V.·2015·Digestive Diseases and Sciences
DOI 10.1007/s10620-014-3471-1
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Abstract

Background and aims Inflammatory bowel disease (IBD) is associated with impaired health-related quality of life (HRQOL) and adherence. Our aim was to identify demographic, clinical, and psychosocial predictors of impaired HRQOL and non-adherence to provider recommendations.Methods Adults with Crohn's disease (CD) or ulcerative colitis (UC) residing within the USA were recruited from online IBD support groups for participation in this cross-sectional study. Data were collected online through standardized instruments, including the Inflammatory Bowel Disease Questionnaire and the Medical Outcomes Study (MOS) general adherence scale. Bivariate analyses and multivariate linear regression were used to assess predictors of HRQOL and adherence.Results We recruited 136 individuals, among whom median age was 35 years (range 18-75), and 82 % were female. 57 % had CD, and 43 % had UC. Predictors of lower HRQOL among CD patients were perceived stress (p < 0.0001), number of CD relapses (p < 0.0001), and female gender (p = 0.0015), while among UC patients they were perceived stress (p < 0.0001) and number of UC relapses (p = 0.0017). Predictors of lower adherence to provider recommendations in CD were perceived stress (p = 0.0007) and older age (p = 0.041), while in UC, perceived stress was the only predictor of lower adherence (p = 0.022).Conclusions Among patients with IBD, a higher level of perceived stress is a strong predictor of lower HRQOL and lower adherence to provider recommendations. Additionally, females with CD and patients with higher number of IBD relapses may be at risk of lower HRQOL. Psychological interventions, including physician-facilitated conversations, psychological screeners, and a multidisciplinary approach, may help address impaired HRQOL and adherence and merit further study.

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  • An increased level of perceived stress, as judged by a 10-item Perceived Stress Scale, is one of the most predictive factors of reduced HRQOL.

    “The data showed that an increased level of perceived stress, as judged by a 10-item Perceived Stress Scale, is one of the most predictive factors of reduced HRQOL (102).”

    From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [102]

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Authors
Tabibian, A., Tabibian, J. H., Beckman, L. J., Raffals, L. L., Papadakis, K. A., & Kane, S. V.
Affiliations
  • Alliant University (US)
  • Mayo Clinic (US)
Corresponding author
Kane, Sunanda V.
ORCID
Venue
Digestive Diseases and Sciences
Publisher
Springer Science and Business Media LLC
Published
2015-01-06
Volume
60
Issue
5
Pages
1366-1374
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
DOI
10.1007/s10620-014-3471-1
OpenAlex
W2093224787
Cited by
89
References
48
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 14 · 2021: 15 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 12 · 2015: 3
FWCI
7.29
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
Crohn's disease, ulcerative colitis, inflammatory bowel disease, health-related quality of life, medication adherence, perceived stress, IBD relapse, sex differences, predictors of quality of life, psychological intervention, clinical management
MeSH terms
Adolescent, Adult, Aged, Colitis, Ulcerative, Crohn Disease, Cross-Sectional Studies, Female, Humans, Health Knowledge, Attitudes, Practice, Male, Middle Aged, Patient Compliance, Quality of Life, Surveys and Questionnaires, Recurrence, Risk Factors, Sex Factors, Stress, Psychological, United States, Multivariate Analysis, Linear Models, Treatment Outcome, Young Adult

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