Hepatocellular carcinoma in the setting of non-cirrhotic nonalcoholic fatty liver disease and the metabolic syndrome: US experience
Abstract
Background Type 2 diabetes mellitus, obesity, and the metabolic syndrome (MS) have been growing in prevalence in the USA and are independent risk factors for the development of hepatocellular carcinoma (HCC). Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of the MS, with or without nonalcoholic steatohepatitis (NASH) can predispose to HCC in the absence of cirrhosis or advanced fibrosis. Nevertheless, the US literature investigating non-cirrhotic HCC in the setting of NAFLD/NASH and MS is lacking.Aim To describe a retrospective case series of patients who developed HCC without cirrhosis in the setting of NAFLD/NASH or features of the MS.Methods We identified NAFLD/NASH-associated HCC cases arising in the absence of cirrhosis between January 2010 and September 2012 from a tumor board database at Brooke Army Medical Center (BAMC).Results Of 44 cases of HCC reviewed, six cases of non-cirrhotic HCC associated with NAFLD/NASH and/or MS were identified. Only one patient underwent partial hepatectomy with curative intent. The other five might have been candidates for potential curative partial hepatectomy or liver transplantation had they been diagnosed earlier.Conclusion Our case series highlights the development of NAFLD/NASH and MS-associated HCC in the absence of cirrhosis in the US population and raises the important question of HCC screening for this at-risk group.
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In a case series of 44 individuals who developed MASLD-related HCC between 2010 and 2012, only one individual without cirrhosis out of six underwent liver resection, while late diagnosis impeded curative treatments in the others.
“in another case series of 44 individuals who developed MASLD-related HCC between 2010 and 2012, only one individual without cirrhosis (out of six) underwent liver resection, while the late diagnosis impeded curative treatments in the others. 236”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [236]
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,708 · see citing works
Erdogan, D., Heijnen, B. H. M., Bennink, R. J., Kok, M., Dinant, S., Straatsburg, I. H., Gouma, D. J., & van Gulik, T. M. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.00901.x · Cited by 11,656 · see citing works
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352 · see citing works
Management of Hepatocellular Carcinoma: An Update Δσ
Bruix, J., & Sherman, M. (2011) · Hepatology · doi:10.1002/hep.24199 · Cited by 8,068 · see citing works
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696 · see citing works
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580 · see citing works
Alberti, K. G. M. M., Zimmet, P., & Shaw, J. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01858.x · Cited by 6,597 · see citing works
Management of Hepatocellular Carcinoma *
Bruix, J., & Sherman, M. (2005) · Hepatology · doi:10.1002/hep.20933 · Cited by 5,913 · see citing works
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
El‐Serag, H. B., & Rudolph, K. L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.061 · Cited by 5,401 · see citing works
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769 · see citing works
Chalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · Hepatology · doi:10.1002/hep.25762 · Cited by 3,798 · see citing works
Llovet, J. M., Burroughs, A. K., & Bruix, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14964-1 · Cited by 3,613 · see citing works
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
Sanyal, A. J., Chalasani, N., Kowdley, K. V., McCullough, A., Diehl, A. M., Bass, N. M., Neuschwander-Tetri, B. A., Lavine, J. E., Tonascia, J., Unalp, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907929 · Cited by 3,327 · see citing works
Nonalcoholic Fatty Liver Disease
Rinella, M. E. (2015) · JAMA · doi:10.1001/jama.2015.5370 · Cited by 2,289 · see citing works
Williams, C. D., Stengel, J. Z., Asike, M., Torres, D. M., Shaw, J. C., Contreras, M., Landt, C. L., & Harrison, S. A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.038 · Cited by 2,146 · see citing works
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
Belfort, R., Harrison, S. A., Brown, K., Darland, C., Finch, J., Hardies, J., Balas, B., Gastaldelli, A., Tio, F., Pulcini, J., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060326 · Cited by 1,827 · see citing works
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · see citing works
Park, E. J., Lee, J. H., Yu, G.-Y., He, G., Ali, S. R., Holzer, R. G., Österreicher, C. H., Takahashi, H., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2009.12.052 · Cited by 1,764 · see citing works
Increasing Prevalence of the Metabolic Syndrome Among U.S. Adults
Ford, E. S., Giles, W. H., & Mokdad, A. H. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2444 · Cited by 1,488 · see citing works
Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma: A Weighty Connection
Starley, B. Q., Calcagno, C. J., & Harrison, S. A. (2010) · Hepatology · doi:10.1002/hep.23594 · Cited by 1,340 · see citing works
Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace
Baffy, G., Brunt, E. M., & Caldwell, S. H. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.10.027 · Cited by 856 · see citing works
White, D. L., Kanwal, F., & El–Serag, H. B. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.10.001 · Cited by 766 · see citing works
Davila, J. A., Morgan, R. O., Shaib, Y. H., McGlynn, K. A., & El‐Serag, H. B. (2005) · Gut · doi:10.1136/gut.2004.052167 · Cited by 703 · see citing works
Marrero, J., Fontana, R. J., Su, G. L., Conjeevaram, H. S., Emick, D. M., & Lok, A. S.-F. (2002) · Hepatology · doi:10.1053/jhep.2002.36939 · Cited by 659 · see citing works
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1
Ben Sahra, I., Regazzetti, C., Robert, G., Laurent, K., Le Marchand-Brustel, Y., Auberger, P., Tanti, J.-F., Giorgetti-Peraldi, S., & Bost, F. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1769 · Cited by 616 · see citing works
Welzel, T. M., Graubard, B. I., Zeuzem, S., El‐Serag, H. B., Davila, J. A., & McGlynn, K. A. (2011) · Hepatology · doi:10.1002/hep.24397 · Cited by 539 · see citing works
Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma
Yasui, K., Hashimoto, E., Komorizono, Y., Koike, K., Arii, S., Imai, Y., Shima, T., Kanbara, Y., Saibara, T., Mori, T., et al. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.01.023 · Cited by 420 · see citing works
Metabolic syndrome and hepatocellular carcinoma: Two growing epidemics with a potential link
Siegel, A. B., & Zhu, A. X. (2009) · Cancer · doi:10.1002/cncr.24687 · Cited by 399 · see citing works
Chen, H.-P., Shieh, J., Chang, C., Chen, T.-T., Lin, J., Wu, M., Lin, J.-H., & Wu, C. (2012) · Gut · doi:10.1136/gutjnl-2011-301708 · Cited by 392 · see citing works
Kawata, S., Yamasaki, E., Nagase, T., Inui, Y., Ito, N., Matsuda, Y., Inada, M., Tamura, S., Noda, S., Imai, Y., et al. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1716 · Cited by 351 · see citing works
Lai, S., Chen, P., Liao, K.-F., Muo, C., Lin, C., & Sung, F.-C. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.384 · Cited by 311 · see citing works
Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma
Hassan, M. M., Curley, S. A., Li, D., Kaseb, A. O., Davila, M. L., Abdalla, E. K., Javle, M. M., Moghazy, D. M., Lozano, R. D., Abbruzzese, J. L., et al. (2010) · Cancer · doi:10.1002/cncr.24982 · Cited by 309 · see citing works
El–Serag, H. B., Johnson, M. L., Hachem, C., & Morgana, R. O. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.053 · Cited by 291 · see citing works
Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease
Torres, D. M., Williams, C. D., & Harrison, S. A. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.03.011 · Cited by 269 · see citing works
Pathology of fatty liver disease
Brunt, E. M. (2007) · Modern Pathology · doi:10.1038/modpathol.3800680 · Cited by 238 · see citing works
Guzman, G., Brunt, E. M., Petrovic, L. M., Chejfec, G., Layden, T. J., & Cotler, S. J. (2008) · Archives of Pathology & Laboratory Medicine · doi:10.5858/132.11.1761 · Cited by 212 · see citing works
Stickel, F., & Hellerbrand, C. (2010) · Gut · doi:10.1136/gut.2009.199661 · Cited by 173 · see citing works
Metformin Prevents Liver Tumorigenesis by Inhibiting Pathways Driving Hepatic Lipogenesis
Bhalla, K., Hwang, B. J., Dewi, R. E., Twaddel, W., Goloubeva, O. G., Wong, K., Saxena, N. K., Biswal, S. S., & Girnun, G. D. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0228 · Cited by 151 · see citing works
Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer
Chang, Q., Zhang, Y., Beezhold, K., Bhatia, D., Zhao, H., Chen, J., Castranova, V., Shi, X., & Chen, F. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.07.037 · Cited by 123 · see citing works
Leptin and liver fibrosis: A matter of fat
Marra, F. (2002) · Gastroenterology · doi:10.1053/gast.2002.33369 · Cited by 91 · see citing works
Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3
Gu, F. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i34.3922 · Cited by 86 · see citing works
Bougoulia, M., Triantos, A., & Koliakos, G. (2006) · HORMONES · doi:10.14310/horm.2002.11190 · Cited by 84 · see citing works
STAT3 activation in monocytes accelerates liver cancer progression
Wu, W., Li, J., Wu, Z., Zhang, C., & Meng, X.-L. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-506 · Cited by 74 · see citing works
Price, J. A., Kovach, S. J., Johnson, T. S., Koniaris, L. G., Cahill, P. A., Sitzmann, J. V., & McKillop, I. H. (2002) · Hepatology · doi:10.1053/jhep.2002.36158 · Cited by 63 · see citing works
Pharmacological characterization of a small molecule inhibitor of c-Jun kinase
Cho, H. K., Black, S. C., Looper, D., Shi, M., Kelly-Sullivan, D., Timofeevski, S. L., Siegel, K., Yu, X., McDonnell, S. R. P., Chen, P., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90298.2008 · Cited by 23 · see citing works
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Sorted by citations
Marrero, J. A., Kulik, L., Sirlin, C. B., Zhu, A. X., Finn, R. S., Abecassis, M. M., Roberts, L. R., & Heimbach, J. K. (2018) · Hepatology · doi:10.1002/hep.29913 · Cited by 4,549 · see citing works
Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210 · see citing works
Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics
Pοlyzos, S. A., Kountouras, J., & Mantzoros, C. S. (2018) · Metabolism · doi:10.1016/j.metabol.2018.11.014 · Cited by 1,221 · see citing works
Loo, T. M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0932 · Cited by 478 · see citing works
(2024) · Obesity Facts · doi:10.1159/000539371 · Cited by 510 · see citing works
New advances in the diagnosis and management of hepatocellular carcinoma
Yang, J. D., & Heimbach, J. K. (2020) · BMJ · doi:10.1136/bmj.m3544 · Cited by 388 · see citing works
Global Epidemiology, Prevention, and Management of Hepatocellular Carcinoma
Mak, L., Cruz-Ramón, V., Chinchilla-López, P., Torres, H. A., LoConte, N. K., Rice, J. P., Foxhall, L. E., Sturgis, E. M., Merrill, J. K., Bailey, H. H., et al. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_200939 · Cited by 237 · see citing works
Orci, L. A., Sanduzzi-Zamparelli, M., Caballol, B., Sapena, V., Colucci, N., Torres, F., Bruix, J., Reig, M., & Toso, C. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.05.002 · Cited by 218 · see citing works
Epidemiology of non-alcoholic fatty liver disease and hepatocellular carcinoma
Younossi, Z. M., & Henry, L. L. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100305 · Cited by 218 · see citing works
Hepatocellular carcinoma surveillance: An evidence-based approach
Harris, P. S., Hansen, R. M., Gray, M. E., Massoud, O. I., McGuire, B. M., & Shoreibah, M. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i13.1550 · Cited by 219 · see citing works
Ohtani, N., & Kawada, N. (2019) · Hepatology Communications · doi:10.1002/hep4.1331 · Cited by 173 · see citing works
Cholankeril, G. T., Patel, R., Khurana, S., & Satapathy, S. K. (2017) · World Journal of Hepatology · doi:10.4254/wjh.v9.i11.533 · Cited by 185 · see citing works
Simon, T. G., Roelstraete, B., Sharma, R., Khalili, H., Hagström, H., & Ludvigsson, J. F. (2021) · Hepatology · doi:10.1002/hep.31845 · Cited by 176 · see citing works
Should we undertake surveillance for HCC in patients with NAFLD?
Younes, R., & Bugianesi, E. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.10.006 · Cited by 174 · see citing works
Non-alcoholic fatty liver disease associated with hepatocellular carcinoma
Dhamija, E., Paul, S. B., & Kedia, S. (2019) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_1456_17 · Cited by 139 · see citing works
Nonalcoholic fatty liver disease and liver transplantation - Where do we stand?
Mikolašević, I., Filipec-Kanižaj, T., Mijić, M., Jakopčić, I., Milić, S., Hrstić, I., Sobočan, N., Štimac, D., & Burra, P. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i14.1491 · Cited by 131 · see citing works
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A Practical Guideline for Hepatocellular Carcinoma Screening in Patients at Risk
Frenette, C. T., Isaacson, A., Bargellini, I., Saab, S., & Singal, A. G. (2019) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2019.04.005 · Cited by 108 · see citing works
Kasmari, A. J., Welch, A. R., Liu, G., LESLIE, D. L., McGarrity, T. J., & Riley, T. (2017) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.12.029 · Cited by 106 · see citing works
Diagnosis of non-alcoholic fatty liver disease (NAFLD)
Yki‐Järvinen, H. (2016) · Diabetologia · doi:10.1007/s00125-016-3944-1 · Cited by 103 · see citing works
Characteristics and outcome of hepatocellular carcinoma in patients with NAFLD without cirrhosis
Bengtsson, B., Stal, P. I., Wåhlin, S., Björkström, N. K., & Hagström, H. (2019) · Liver International · doi:10.1111/liv.14087 · Cited by 97 · see citing works
Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease
Wong, C. R., Nguyen, M., & Lim, J. K. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i37.8294 · Cited by 98 · see citing works
Lee, T., Wu, J., Yu, S., Lin, J., Wu, M., & Wu, C. (2017) · International Journal of Cancer · doi:10.1002/ijc.30784 · Cited by 92 · see citing works
Masarone, M., Rosato, V., Aglitti, A., Bucci, T., Caruso, R., Salvatore, T., Sasso, F. C., Tripodi, M. F., & Persico, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178473 · Cited by 91 · see citing works
Current challenges and future directions for liver transplantation
Toniutto, P., Zanetto, A., Ferrarese, A., & Burra, P. (2016) · Liver International · doi:10.1111/liv.13255 · Cited by 87 · see citing works
Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma
Massoud, O. I., & Charlton, M. (2017) · Clinics in Liver Disease · doi:10.1016/j.cld.2017.08.014 · Cited by 84 · see citing works
Pathogenesis of hypothyroidism-induced NAFLD: Evidence for a distinct disease entity?
Lonardo, A., Ballestri, S., Mantovani, A., Nascimbeni, F., Lugari, S., & Targher, G. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.12.014 · Cited by 76 · see citing works
Nascimbeni, F., Ballestri, S., Machado, M. V., Mantovani, A., Cortez‐Pinto, H., Targher, G., & Lonardo, A. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1415756 · Cited by 60 · see citing works
Liver Resection for Nonalcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma
Koh, Y. X., Tan, H. J., Liew, Y. X., Syn, N. L. X., Teo, J. Y., Lee, S. Y., Goh, B. K. P., Goh, G. B., & Chan, C. Y. (2019) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2019.07.012 · Cited by 55 · see citing works
Torres, M. C. P., Bodini, G., Furnari, M., Marabotto, E., Zentilin, P., Strazzabosco, M., & Giannini, E. G. (2020) · Cancers · doi:10.3390/cancers12061422 · Cited by 53 · see citing works
Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma
Koo, S.-Y., Park, E.-J., & Lee, C.-W. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0480-3 · Cited by 47 · see citing works
Fatty liver disease, an emerging etiology of hepatocellular carcinoma in Argentina
Piñero, F., Pagés, J., Marciano, S., Fernández, N., Silva, J. M. R., Anders, M., Zerega, A. R., Ridruejo, E., Ameigeiras, B., D’Amico, C., et al. (2018) · World Journal of Hepatology · doi:10.4254/wjh.v10.i1.41 · Cited by 47 · see citing works
Epidemiology, pathophysiology and clinical aspects of Hepatocellular Carcinoma in MAFLD patients
Argenziano, M. E., Kim, M. N., Montori, M., Bucchianico, A. D., Balducci, D., Ahn, S. H., & Svegliati‐Baroni, G. (2024) · Hepatology International · doi:10.1007/s12072-024-10692-4 · Cited by 50 · see citing works
TAZ-induced Cybb contributes to liver tumor formation in non-alcoholic steatohepatitis
Wang, X., Zeldin, S. M., Shi, H., Zhu, C., Saito, Y., Corey, K. E., Osganian, S. A., Remotti, H. E., Verna, E. C., Pajvani, U. B., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.11.031 · Cited by 41 · see citing works
Surveillance of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease
Sumida, Y., Yoneda, M., Seko, Y., Ishiba, H., Hara, T., Toyoda, H., Yasuda, S., Kumada, T., Hayashi, H., Kobayashi, T., et al. (2020) · Diagnostics · doi:10.3390/diagnostics10080579 · Cited by 34 · see citing works
Wang, Z., Li, S., Wang, R., Guo, L., Xu, D., Zhang, T., Xu, Y., Wang, W., Wang, M., Gan, Z., et al. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00164-4 · Cited by 34 · see citing works
Fatty Liver Through the Ages: Nonalcoholic Steatohepatitis
Younossi, Z. M., & Henry, L. L. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.12.010 · Cited by 34 · see citing works
Thompson, S. M., Garg, I., Ehman, E. C., Sheedy, S. P., Bookwalter, C. A., Carter, R. E., Roberts, L. R., & Venkatesh, S. K. (2018) · British Journal of Radiology · doi:10.1259/bjr.20180345 · Cited by 33 · see citing works
Chin, K. M., Prieto, M., Cheong, C. K., Martino, M. D., Ielpo, B., Goh, B. K. P., & Koh, Y. X. (2021) · HPB · doi:10.1016/j.hpb.2021.01.009 · Cited by 32 · see citing works
Pellicano, A. J., Spahn, K., Zhou, P., Goldberg, I. D., & Prakash Narayan, A. (2021) · Molecules · doi:10.3390/molecules26113316 · Cited by 32 · see citing works
The Emerging Factors and Treatment Options for NAFLD-Related Hepatocellular Carcinoma
Zhang, C., & Yang, M. J. (2021) · Cancers · doi:10.3390/cancers13153740 · Cited by 34 · see citing works
Aby, E. S., Phan, J., Truong, E., Grotts, J. F., & Saab, S. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001075 · Cited by 26 · see citing works
Piñero, F., Tanno, M., Soteras, G. A. A., Baña, M. T., Dirchwolf, M., Fassio, E., Ruf, A. E., Mengarelli, S., Borzi, S. M., Fernández, N., et al. (2020) · Annals of Hepatology · doi:10.1016/j.aohep.2020.06.003 · Cited by 24 · see citing works
Plasticity, heterogeneity, and multifunctionality of hepatic stellate cells in liver pathophysiology
Du, K., Jun, J. H., Dutta, R. K., & Diehl, A. M. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000411 · Cited by 24 · see citing works
Hwang, A., Shi, C., Zhu, E. Y., Naaz, F., Zhou, P., Rasheed, Z., Liu, X., Jung, L., Duan, B., Li, J., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198937 · Cited by 22 · see citing works
Calitz, C., Pavlović, N., Rosenquist, J., Zagami, C., Samanta, A., & Heindryckx, F. (2020) · Journal of Visualized Experiments · doi:10.3791/61606 · Cited by 22 · see citing works
Hepatocellular carcinoma surveillance in Australia: current and future perspectives
Hui, S., Bell, S., Le, S. T. T., & Dev, A. T. (2023) · The Medical Journal of Australia · doi:10.5694/mja2.52124 · Cited by 23 · see citing works
A practical diagnostic approach to hepatic masses
Jain, D., & Vyas, M. (2018) · Indian Journal of Pathology and Microbiology · doi:10.4103/ijpm.ijpm_578_17 · Cited by 21 · see citing works
Surveillance for hepatocellular carcinoma in chronic viral hepatitis: Is it time to personalize it?
Demirtaş, C. Ö., & Brunetto, M. R. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i33.5536 · Cited by 20 · see citing works
The Current View of Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma
Kogiso, T., & Tokushige, K. (2021) · Cancers · doi:10.3390/cancers13030516 · Cited by 20 · see citing works
Billeter, A. T., Herrera, J. R. D. L. G., Scheurlen, K. M., Nickel, F., Billmann, F. G., & Müller-Stich, B. P. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0009 · Cited by 19 · see citing works
Non-alcoholic steatohepatitis and liver transplantation
Gitto, S., Vukotic, R., Vitale, G., Pirillo, M., Villa, E., & Andreoné, P. (2016) · Digestive and Liver Disease · doi:10.1016/j.dld.2016.02.014 · Cited by 18 · see citing works
Murtha-Lemekhova, A., Fuchs, J., Feiler, S., Schulz, E. R., Teroerde, M., Kalkum, E., Klotz, R., Billeter, A. T., Probst, P., & Hoffmann, K. (2022) · BMC Medicine · doi:10.1186/s12916-022-02239-x · Cited by 18 · see citing works
Deng, L. X., & Mehta, N. J. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06550-6 · Cited by 17 · see citing works
Dakhoul, L., Jones, K. R., Gawrieh, S., Ghabril, M., McShane, C., Vuppalanchi, R., Vilar‐Gómez, E., Nephew, L. D., Chalasani, N., & Lammert, C. S. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5441-5 · Cited by 16 · see citing works
Protein malnutrition during fetal programming induces fatty liver in adult male offspring rats
Campisano, S., Echarte, S. M., Podaza, E., & Chisari, A. N. (2017) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-017-0549-1 · Cited by 15 · see citing works
Liu, Y., Li, H., Ye, N., Luo, C.-J., Hu, Y.-Y., Wu, H., & Gong, J. (2019) · Medical Science Monitor · doi:10.12659/msm.915722 · Cited by 15 · see citing works
van Mourik, H., Li, M., Baumgartner, S., Theys, J., & Shiri‐Sverdlov, R. (2022) · Biomedicines · doi:10.3390/biomedicines10102351 · Cited by 14 · see citing works
Linking Race, Cancer Outcomes, and Tissue Repair
Byun, J. S., Park, S., Caban, A., Jones, A. C., & Gardner, K. L. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.10.009 · Cited by 13 · see citing works
Bissoondial, T. L., Han, Y., Mullan, S., Pabla, A. K., Spahn, K., Shi, S., Zheng, L., Zhou, P., Jiang, K., Prakash, N., et al. (2020) · Diagnostics · doi:10.3390/diagnostics10100784 · Cited by 13 · see citing works
Surveillance for Hepatocellular Carcinoma
Marrero, J. A. (2020) · Clinics in Liver Disease · doi:10.1016/j.cld.2020.07.013 · Cited by 13 · see citing works
Jain, A., Mazer, B. L., Deng, Y., Ciarleglio, M. M., Jain, D., Taddei, T. H., & Zhang, X. (2021) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqab125 · Cited by 12 · see citing works
Samji, N. S., Verma, R., Keri, K., Singal, A. K., Ahmed, A., Rinella, M. E., Bernstein, D., Abdelmalek, M. F., & Satapathy, S. K. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05716-1 · Cited by 12 · see citing works
Demirtaş, C. Ö., Tolu, T., Keklikkıran, Ç., Özdoğan, O. C., & Gündüz, F. (2021) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2021.20677 · Cited by 12 · see citing works
Calitz, C., Pavlović, N., Rosenquist, J., Zagami, C., Samanta, A., & Heindryckx, F. (2020) · Journal of Visualized Experiments · doi:10.3791/61606-v · Cited by 12 · see citing works
Outcomes Following Resection of Hepatocellular Carcinoma in the Absence of Cirrhosis
Lewis, R. H., Glazer, E. S., Bittenbinder, D. M., O’Brien, T., Deneve, J. L., Shibata, D., Behrman, S. W., Vanatta, J. M., Satapathy, S. K., & Dickson, P. V. (2018) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-018-0152-x · Cited by 12 · see citing works
Hepatocellular carcinoma in non-alcoholic fatty liver disease with and without cirrhosis
Onzi, G., Moretti, F., Balbinot, S. S., Balbinot, R. Â., & Soldera, J. (2019) · Hepatoma Research · doi:10.20517/2394-5079.2018.114 · Cited by 11 · see citing works
Mrzljak, A., Berković, M. C., Giovanardi, F., & Lai, Q. (2022) · Croatian Medical Journal · doi:10.3325/cmj.2022.63.176 · Cited by 10 · see citing works
Farrell, A., Ryan, M. C., & Howell, J. A. (2020) · Hepatoma Research · doi:10.20517/2394-5079.2019.019 · Cited by 10 · see citing works
Tian, Y., Li, T., Qi, S., Alhourani, H., Luo, B., Chenqin, J., Fu, Q., Peng, Y., & Wu, J. (2020) · Journal of Surgical Oncology · doi:10.1002/jso.26055 · Cited by 9 · see citing works
Liao, K., Pellicano, A. J., Jiang, K., Prakash, N., Li, J., Bhutkar, S. P., Hu, Z., Ali, Q., Goldberg, I. D., & Prakash Narayan, A. (2020) · ACS Omega · doi:10.1021/acsomega.0c02350 · Cited by 9 · see citing works
[11C]acetate PET as a tool for diagnosis of liver steatosis
Nejabat, M., Leisser, A., Karanikas, G., Wadsak, W., Mitterhauser, M., Mayerhoefer, M. E., Kienbacher, C., Trauner, M. A., Hacker, M., & Haug, A. R. (2018) · Abdominal Radiology · doi:10.1007/s00261-018-1558-4 · Cited by 8 · see citing works
Lin, P., Chen, C., Wallace, C. G., Chen, K., Chang, C., Chen, H., Sung, P., Lin, K., Ko, S., Sun, C., et al. (2017) · PubMed Central · Cited by 8 · see citing works
Role of Hepatocyte Nuclear Factor 4 Alpha in Liver Cancer
Kotulkar, M., Paine‐Cabrera, D., & Apte, U. M. (2024) · Seminars in Liver Disease · doi:10.1055/a-2349-7236 · Cited by 7 · see citing works
Bai, J., Lei, P., Zhao, C., Wang, Y., Yan, D., & Yang, S. (2015) · Toxicology Reports · doi:10.1016/j.toxrep.2015.12.005 · Cited by 7 · see citing works
Large hepatocellular carcinoma: Does fibrosis really impact prognosis after resection?
Golse, N., Bouyousfi, A. E., Marques, F., Bancel, B., Mohkam, K., Ducerf, C., Merle, P., Sebagh, M., Castaing, D., Cunha, A. S., et al. (2018) · Journal of Visceral Surgery · doi:10.1016/j.jviscsurg.2017.10.015 · Cited by 6 · see citing works
Perception of Non-Alcoholic Fatty Liver Disease: Real-Life Experience From Pakistan
Butt, N., Khan, M. A., Rai, L., Channa, R. H., Khemani, H., & Abbasi, A. (2021) · Cureus · doi:10.7759/cureus.16029 · Cited by 5 · see citing works
Non-Alcoholic Fatty Pancreas Disease: The Unsung Disease
Sevim, B. C., Chela, H. K., Ertugrul, H., Malik, L. S., Malik, S., Başar, Ö., Daglilar, E. S., Samiullah, S., Gaballah, A. H., & Tahan, V. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220929142905 · Cited by 5 · see citing works
Clinical Epidemiology of Chronic Liver Disease: Hepatocellular Carcinoma
Suraweera, D., Konyn, P., Vu, T., & Saab, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-94355-8_15 · Cited by 7 · see citing works
D’Silva, M., Na, H. Y., Cho, J. Y., Han, H., Yoon, Y., Lee, H. W., Lee, J. S., Lee, B., & Kim, M. (2021) · Translational Cancer Research · doi:10.21037/tcr-21-707 · Cited by 5 · see citing works
Peretinoin as an adjuvant therapy for hepatocellular carcinoma
Tan, C. (2016) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2016.1238303 · Cited by 5 · see citing works
Bissoondial, T. L., Pellicano, A. J., Goldberg, I. D., & Prakash Narayan, A. (2021) · Molecular Omics · doi:10.1039/d1mo00274k · Cited by 4 · see citing works
Umasankari, S., Aishwarya, S., Aishwarya, S. K., Bhardwaj, S., Pavithra, R., Ray, S., & Vinodhini, V. M. (2024) · Metabolism Open · doi:10.1016/j.metop.2024.100325 · Cited by 4 · see citing works
How useful is the machine perfusion in liver transplantation? An answer from a national survey
Scalera, I., Carlis, R. D., Patrono, D., Gringeri, E., Olivieri, T., Pagano, D., Lai, Q., Rossi, M., Gruttadauria, S., Benedetto, F. D., et al. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.975150 · Cited by 4 · see citing works
Jasty, V. S. J., Urias, E., Tiong, K. L. A., Aboona, M. B., Song, M. W., Faulkner, C., Devan, P., Neo, J. E., Wijarnpreecha, K., Wong, Y. J., et al. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08635-y · Cited by 4 · see citing works
Watanabe, Y., Aikawa, M., Oshima, Y., Kato, T., Takase, K., Watanabe, Y., Okada, K., Okamoto, K., & Koyama, I. (2024) · Surgical Endoscopy · doi:10.1007/s00464-024-10937-1 · Cited by 3 · see citing works
Risk of Hepatocellular Carcinoma in Patients With Nonalcoholic Steatohepatitis.
Charlton, M. (2018) · Europe PMC (PubMed Central) · Cited by 3 · see citing works
Long-term surgical outcomes of Non alcoholic fatty liver disease associated hepatocellular carcinoma
D’Silva, M., Cho, J. Y., Han, H., Yoon, Y., Lee, H. W., Lee, J. S., Lee, B., & Kim, M. (2022) · Surgical Oncology · doi:10.1016/j.suronc.2022.101730 · Cited by 3 · see citing works
Izzo, F., Mason, M. C., Silberfein, E. J., Massarweh, N. N., Hsu, C., Cao, H. S. T., Palaia, R., Piccirillo, M., Belli, A., Patrone, R., et al. (2022) · Biology · doi:10.3390/biology11111597 · Cited by 3 · see citing works
Etiology and Pathogenesis of Hepatocellular Carcinoma
Brar, T. S., Hilgenfeldt, E., & Soldevila‐Pico, C. (2017) · Molecular pathology library · doi:10.1007/978-3-319-68082-8_1 · Cited by 3 · see citing works
Hepatocellular Carcinoma Screening and Nonalcoholic Fatty Liver Disease: How is it Different?
Acharya, S. K., & Bopanna, S. (2020) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2020.04.004 · Cited by 3 · see citing works
Calitz, C., Pavlovic, N., Rosenquist, J., Zagami, C., Samanta, A., & Heindryckx, F. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.30.069823 · Cited by 3 · see citing works
Integrating diagnosis and therapy in hepatocellular carcinoma: advances in nanotheranostics
Shen, J., Wen, Y., Wu, S., & Tian, W. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1793834 · Cited by 2 · see citing works
Nonalcoholic Steatohepatitis and Liver Transplantation
Younossi, Z. M., & Henry, L. L. (2016) · Current Hepatology Reports · doi:10.1007/s11901-016-0298-6 · Cited by 2 · see citing works
Nonalcoholic Fatty Pancreatic Disease (NAFPD)
Juboori, A. A., Chela, H. K., Samiullah, S., & Tahan, V. (2020) · Springer eBooks · doi:10.1007/978-3-030-53370-0_25 · Cited by 2 · see citing works
[Medical-historical survey on epilepsy and older concepts about the therapy of epilepsy].
Vencovský, E. (1972) · PubMed · Cited by 1 · see citing works
Hepatocellular Carcinoma in Nonalcoholic Steatohepatitis
Koppe, S., & Arshad, H. M. S. (2017) · Digestive Disease Interventions · doi:10.1055/s-0037-1603572
Golse, N., Bouyousfi, A. E., Marques, F., Bancel, B., Mohkam, K., Ducerf, C., Merle, P., Sebagh, M., Castaing, D., Cunha, A. S., et al. (2018) · Journal de Chirurgie Viscérale · doi:10.1016/j.jchirv.2017.09.005
Hepatocellular Cancer Induced by Infection
Kaplan, D. E., Chang, K.-M., & Sanyal, A. (2019) · Microbiome and Cancer · doi:10.1007/978-3-030-04155-7_12
Choi, W. Y., Jang, B. K., Chung, W. J., & Hwang, J. S. (2015) · Journal of Liver Cancer · doi:10.17998/jlc.15.2.112
- Authors
- Perumpail, R. B., Wong, R. J., Ahmed, A., & Harrison, S. A.
- Affiliations
- Stanford Medicine (US)
- Alameda Health System (US)
- Brooke Army Medical Center (US)
- Corresponding author
- Perumpail, Ryan B.
- Venue
- Digestive Diseases and Sciences
- Published
- 2015-08-07
- Volume
- 60
- Issue
- 10
- Pages
- 3142-3148
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W1901124675
- Cited by
- 111
- References
- 45
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 9 · 2023: 2 · 2022: 9 · 2021: 16 · 2020: 19 · 2019: 13 · 2018: 16 · 2017: 14 · 2016: 6 · 2015: 2
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- hepatocellular carcinoma, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, metabolic syndrome, non-cirrhotic liver cancer, type 2 diabetes, obesity, liver cirrhosis, partial hepatectomy, liver transplantation, HCC screening
- MeSH terms
- Aged, Female, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Male, Middle Aged, Prognosis, Retrospective Studies, United States, Cohort Studies, Comorbidity, Incidence, Survival Rate, Databases, Factual, Age Distribution, Sex Distribution, Risk Assessment, Metabolic Syndrome, Non-alcoholic Fatty Liver Disease
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