Cited by 709Diet, Metabolism, and DiseaseLiver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

The DOI matches its Crossref record; 132 of the 133 references it cites were found in a registry or an index.

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

Open access

Softic, Samir, Cohen, David E., Kahn, C. Ronald·2016·Digestive Diseases and Sciences

DOI 10.1007/s10620-016-4054-0PMC PMC4838515

Open this paper in CoChat — free account

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome. Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened beverages are major risk factors for development of NAFLD. Today the most commonly consumed sugar is high fructose corn syrup. Hepatic lipids may be derived from dietary intake, esterification of plasma free fatty acids (FFA) or hepatic de novo lipogenesis (DNL). A central abnormality in NAFLD is enhanced DNL. Hepatic DNL is increased in individuals with NAFLD, while the contribution of dietary fat and plasma FFA to hepatic lipids is not significantly altered. The importance of DNL in NAFLD is further established in mouse studies with knockout of genes involved in this process. Dietary fructose increases levels of enzymes involved in DNL even more strongly than HFD. Several properties of fructose metabolism make it particularly lipogenic. Fructose is absorbed via portal vein and delivered to the liver in much higher concentrations as compared to other tissues. Fructose increases protein levels of all DNL enzymes during its conversion into triglycerides. Additionally, fructose supports lipogenesis in the setting of insulin resistance as fructose does not require insulin for its metabolism, and it directly stimulates SREBP1c, a major transcriptional regulator of DNL. Fructose also leads to ATP depletion and suppression of mitochondrial fatty acid oxidation, resulting in increased production of reactive oxygen species. Furthermore, fructose promotes ER stress and uric acid formation, additional insulin independent pathways leading to DNL. In summary, fructose metabolism supports DNL more strongly than HFD and hepatic DNL is a central abnormality in NAFLD. Disrupting fructose metabolism in the liver may provide a new therapeutic option for the treatment of NAFLD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s10620-016-4054-0

Cites

132 of 132 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791
Association between Water Intake, Chronic Kidney Disease, and Cardiovascular Disease: A Cross-Sectional Analysis of NHANES Data
Sontrop, J. M., Dixon, S. N., Garg, A. X., Jiménez, I. B., Dohein, O., Huang, S. S., & Clark, W. F. (2013) · American Journal of Nephrology · doi:10.1159/000350377 · Cited by 5,903
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604
Critical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
Self-citation
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075
Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
Targher, G., Day, C. P., & Bonora, E. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0912063 · Cited by 1,907
The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
Chalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.001 · Cited by 1,805
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
Stanhope, K. L., Schwarz, J. M., Keim, N. L., Griffen, S. C., Bremer, A. A., Graham, J. L., Hatcher, B., Cox, C. L., Dyachenko, A., Zhang, W., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37385 · Cited by 1,765
The global NAFLD epidemic
Loomba, R. S., & Sanyal, A. J. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.171 · Cited by 1,732
Insulin Receptor Signaling in Normal and Insulin-Resistant StatesPreprint
Boucher, J., Kleinridders, A., & Kahn, C. R. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009191 · Cited by 1,550
Self-citation

Show all 133 references

Sorted by citations

Items 601–700 of 705

Ipertrigliceridemia: fisiopatologia e significato clinico
Olivieri, C., Pisati, D., Sironi, F. M., Roversi, T., & Magni, P. (2022) · L Endocrinologo · doi:10.1007/s40619-022-01059-8
Foods, 1. Survey
Schieber, A., & Shipe, W. F. (2017) · Ullmann's Encyclopedia of Industrial Chemistry · doi:10.1002/14356007.a11_491.pub3
Fatty Liver Disease
Corte, C. D., Mosca, A., Alterio, A., Comparcola, D., Ferretti, F., & Nobili, V. (2017) · Contemporary Endocrinology · doi:10.1007/978-3-319-68192-4_26
Malus toringoides (Rehd.) Hughes Improves Metabolic Syndrome and Liver Injury in High-Fructose-Induced MicePreprint
Quan, X. H., Guo, Q., Li, X., Yu, L., Cui, M., Li, J., Huang, S., & Li, B. (2020) · Research Square · doi:10.21203/rs.3.rs-89389/v1
Molecular Basis of Liver Disease
Monga, S. P., & Behari, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802761-5.00020-1
Doença hepática gordurosa não alcoólica (DHGNA) e síndrome dos ovários policísticos (SOP): associação do polimorfismo no gene da patatin-like phospholipase domain containing 3 (PNPLA3) e alterações endócrinas e metabólicas
Recuero, A. M. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2022.tde-19072022-163406
Plasma MicroRNA (miRNA)s as Novel Markers of Nonalcoholic Fatty Liver Disease
Akbulut, U. E. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81304-8_30-1
A pilot study to assess the feasibility of a sham anti-inflammatory diet: Can inflammation neutrality and participant blinding be achieved?Preprint
Allison, D. J., Agudelo, A. R., Lawson, A., Gazzellone, G., Ditor, D. S., & Loh, E. (2022) · Research Square · doi:10.21203/rs.3.rs-2109846/v1
A pilot randomized controlled trial to assess the feasibility of a sham anti-inflammatory diet: Can inflammation neutrality and participant blinding be achieved?Preprint
Allison, D. J., Agudelo, A. R., Lawson, A., Gazzellone, G., Ditor, D. S., & Loh, E. (2022) · Research Square · doi:10.21203/rs.3.rs-2155046/v1
Diyabetin Şifresi
Eriş, D. (2023) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.2576
Musculoskeletal and immunological considerations
Fettke, G., Kaplan, B., Baker, S., & Rice, S. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821617-0.00004-8
Frutose e risco cardiometabólico em indivíduos com preservação da cultura germânica: estudo SHIP-BRASIL
Zappa, T. M. A. (2022) · doi:10.11606/d.6.2022.tde-11042023-165437
GalNAc-siRNA Mediated Knockdown of Ketohexokinase Versus Systemic, Small Molecule Inhibition of its Kinase Activity Exert Divergent Effects on Hepatic Metabolism in Mice on a HFDPreprint
Park, S., Fadhul, T., Conroy, L. R., Clarke, H. A., Sun, R. C., Wallenius, K., Boucher, J., O’Mahony, G., Boianelli, A., Persson, M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.14.553218
Self-citation
Hepatic Safety in Rats Fed on Fructose, Glucose, or Sucrose When Combine with A Moderate Fat Diet
Nasr, N., Elkattawy, A. M., Kahilo, K. A., Sadek, K. M., Elhady, S. A., El-Sawy, H. B., & Dorghamm, D. A. (2023) · Egyptian Journal of Veterinary Science · doi:10.21608/ejvs.2023.230165.1563
Exploring the link between fructose intake and Non-Alcoholic Fatty Liver Disease (NAFLD)
Arslanbulut, G., & Çiftçi, S. (2023) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2023.10.004
Evaluantion of the antiobesogenic and anti-inflammatory potential of biotransformed phenolic extracts of grape pomace
Christofoletti, C. R. (2021) · doi:10.47749/t/unicamp.2021.1234403
Pengaruh Pemberian Diet Tinggi Lemak Tinggi Gula terhadap Gambaran Histologi Hati Tikus Wistart Usia Kanak-Kanak
Gusman, M. I., Sari, J. I., Rahim, R., Setiawati, D., & Fatmawati, F. (2023) · Media Publikasi Promosi Kesehatan Indonesia (MPPKI) · doi:10.56338/mppki.v6i12.3996
The Effects of High Calcium and Vitamin D on the Fructose- Induced Lipogenesis Pathway in Rats
Semiha Özge, K. A. R. A., & Yakan, A. (2023) · Kocatepe Veterinary Journal · doi:10.30607/kvj.1319111
Impacto do receptor de estrogênio alfa na doença hepática gordurosa não alcoólica e metabolismo energético do fígado
SUCUPIRA, F. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2023.tde-10112023-165126
Investigation of Non-alcoholic steatohepatitis development in newly designed short-term insulin resistance-fatty liver rat models. From chronic to acutePreprint
Mohammed, E. D., & Sun, B. (2024) · Research Square · doi:10.21203/rs.3.rs-3810049/v1
Empagliflozin Exacerbated Lipid Metabolism Disorders in Diabetic MicePreprint
Li, J., Xing, B., Xu, M., Zhang, Q., Guo, J., & Duan, J. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4706362
Updates in Pediatric Hepatology and Pancreatology
Oh, T. Y., Palle, S. K., & Freeman, A. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-41542-5_16
COMPORTAMENTO DO AZEITE DE OLIVA EXTRAVIRGEM EM TEMPERATURAS ELEVADAS
Akil, E., Dantas, G., & Vendramini, A. L. D. A. (2024) · doi:10.22533/at.ed.0062415027
DESEQUILIBRIO DIETÉTICO EN EL ESTADO NUTRICIONAL DE UNA POBLACIÓN DE ECUADOR
Galarza, W., Zurita, V. A. R., Arteaga, C., Morales, K. P. H., Ocaña, T. S. M., & Lara, V. E. G. (2024) · doi:10.22533/at.ed.0062415021
Inovações em ciência de alimentos: da produção à nutrição 2
Brasil, C. C. B. (2024) · doi:10.22533/at.ed.006241502
EFEITO IN VITRO DO GUARANÁ (PAULLINIA CUPANA, MART) NA PROTEÇÃO DE CÉLULAS NEURAIS SH-SY5Y EXPOSTAS AO METILMERCÚRIO
da Cruz, S., Azzolin, V. F., Barbisan, F., Sasso, J. S., da Cruz, I. B. M., Ribeiro, E. E., Trombini, F. D. S., Simon, M. F., & Medeiros, C. S. D. S. (2024) · doi:10.22533/at.ed.0062415023
QUALIDADE DO MEL COMERCIALIZADO INFORMALMENTE EM SÃO LUÍS, MARANHÃO
Lima, P. L. A., Lacerda, L. D. M., Ribeiro, A. C., Tenório, E. G., do Rosário, C. J. R. M., Martins, A. G. D. B., Siqueira, C. L. C., Lima, M. D. R., & Costa, L. C. S. (2024) · doi:10.22533/at.ed.0062415029
A INFLUÊNCIA DA SUPLEMENTAÇÃO DE VITAMINA D NO DIABETES MELLITUS
da Silva, M. K., & Fidelix, M. S. P. (2024) · doi:10.22533/at.ed.0062415024
FRUTOSE PROVENIENTE DE FRUTAS, SACAROSE OU DO XAROPE DE MILHO RICO EM FRUTOSE: CULPADA OU INOCENTE NO DESENCADEAMENTO DA DHGNA?
Queiroz, J. M. F., & Queiroz, W. C. (2024) · doi:10.22533/at.ed.0062415026
O EFEITO DA DIETA MEDITERRÂNEA COMO TERAPIA NUTRICIONAL DE PACIENTES COM OBESIDADE E FIBRILAÇÃO ATRIAL: UMA REVISÃO INTEGRATIVA
Noronha, J. A. R., da Silva, S. C., & Neiva, G. S. (2024) · doi:10.22533/at.ed.0062415022
NUTRIÇÃO DE PEITO ABERTO: UM RELATO DE EXPERIÊNCIA ENTRE ALIMENTAÇÃO E CÂNCER DE MAMA
Carvalho, R. F., Carreiro, K. L., Moura, R. S., Fernandes, A. C. D. C., & Caldas, D. R. C. (2024) · doi:10.22533/at.ed.0062415025
LEVEDURAS SELVAGENS NA PRODUÇÃO DE VINHOS: EXPLORAÇÃO PARA O DESENVOLVIMENTO DE NOVOS PRODUTOS
Campos, L. B. (2024) · doi:10.22533/at.ed.0062415028
Alterações do metabolismo lipídico no fígado durante a termogênese adaptativa
Vieira, V. A. (2023) · doi:10.11606/d.17.2023.tde-06022024-102543
NAFLD PATHOGENESIS AND CLINICAL ASSOCIATIONS WITH CARDIOVASCULAR DISEASES
Valaitienė, J. (2024) · Health Sciences · doi:10.35988/sm-hs.2024.129
Fructose consumption in pregnancy and associations with maternal and offspring hepatic and whole-body adiposity: a scoping reviewPreprint
Zhao, G., Chondon, S., Gray, C., Gentili, S., Stanley, M., & Regnault, T. R. H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.02.600389
Metabolic-Dysfunction-Associated Fatty Liver Disease and Hepatic Insulin Resistance: A Type 2 Diabetes Mellitus-like in the liver - A Systematic ReviewPreprint
Andrade, L. J. D. O., de Oliveira, G. C. M., & de Oliveira, L. M. (2024) · Research Square · doi:10.21203/rs.3.rs-4739938/v1
Close association of systemic immune-inflammation index with hepatic steatosis than fibrosis: evidences from NHANES 1999–2018Preprint
Tu, Z., Duan, L., Duan, S., & Tu, R. (2024) · Research Square · doi:10.21203/rs.3.rs-4637173/v1
Fructose, Fatty Liver, and Addiction
Lustig, R. H. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780190671051.003.0037
Efectos sistémicos del consumo de sacarosa y su asociación con la respuesta inmunitaria: revisión sistemática
Carrillo, B. E. M., Estrada, F. D. M. C., López, A. L. G., Rillo, A. G., & Ramírez, M. L. P. (2024) · LATAM Revista Latinoamericana de Ciencias Sociales y Humanidades · doi:10.56712/latam.v5i5.2744
Carbohydrate Metabolism in Health and Diseases
Waiz, M., Rehman, K., Ahmad, P., & Khan, M. S. (2024) · Springer eBooks · doi:10.1007/978-981-97-4723-8_2
Omega-3 PUFAs counteracts high fructose diet-induced gonadal impairment via fortified antioxidant defense
Ekhoye, E., Agbonifo‐Chijiokwu, E., & Nwangwa, E. K. (2024) · Physiology and Pharmacology · doi:10.61186/phypha.28.3.282
Interplay between food-associated oxidative stress and NDG disorders
Kapil, L., Kumar, V., Arora, S., Kaur, S., Prasad, S., Singh, C., & Singh, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00025-7
Basic Prehabilitation Pillars
Watson, A., & Bitterman, J. S. (2024) · Springer eBooks · doi:10.1007/978-3-031-72862-4_2
Cloning and sequence analysis of goat GSK3B gene and its effect on lipogenesis in goat intramuscular adipocytes
Gong, C., Chen, D., He, X., Wang, Y., Huang, X., Wang, Y., Xiong, Y., Li, Y., Xing, J., & Li, R. (2025) · Journal of Applied Animal Research · doi:10.1080/09712119.2025.2462577
Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats
Moussa, S. A. A., Ibrahim, F. A. A., Elbaset, M. A., Morsy, F. A., Aziz, S. W., El-Latif, N. A. A., Afifi, S. M., Esatbeyoglu, T., Toumy, S. A. E., Salib, J. Y., et al. (2025) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2025.100235
Investigation of the Effects of Estradiol and Testosterone on the Expression Levels of Genes Involved in Reverse Cholesterol Transport in Palmitate- and Oleate-Treated HepG2 CellsPreprint
Jafarpour, E., Hosseini, M.-S., Mohammadi, Y., Dashtaki, A., & Bahreini, E. (2025) · Research Square · doi:10.21203/rs.3.rs-6234234/v1
Ernährung – Physiologie und Pathophysiologie
Herberhold, M., & Dubbeldam, A. (2025) · Elsevier eBooks · doi:10.1016/b978-3-437-45059-4.00003-2
Investigating the Effect of Interval and Continuous Aerobic Training on Hepatic Expression of CD36 and HSL Genes in Fructose-Fed Male Rats
Nasri, M., Nasiri, K., Akbari, A., & Safarzade, A. (2025) · Zahedan Journal of Research in Medical Sciences · doi:10.5812/zjrms-159143
Anti-inflammatory Diet: An Evidence-Based Understanding
Howard, R., Schulman, A., Perez, A., Levine, J., Yuder, E., & Nwankwo, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-92079-0_2
Metabolic Adaptations of Prostate Cancer Cells Under Chronic Fructose StimulationPreprint
Echeverría, C. E., Oyarzún, V. I., Jara, C., Flores-Faúndez, E., Ramírez, C., Torres-Estay, V. A., Tapia‐Rojas, C., Díaz, J., Meneses, M. F., Cancino, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.07.663510
Basic Aspects of Digestion and Absorption
Duong, J. T., & Green, N. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-11760-2.00002-1
A Plant-Based Strategy for MASLD: Desmodium caudatum (Thunb.) DC. Extract Reduces Hepatic Lipid Accumulation and Improves Glycogen Storage In Vitro and In Vivo
Chen, Y., Liang, Y.-H. C., Wong, Y., Tseng, C.-Y., Chang, C.-W., Lin, H., & Chen, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178442
NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD): DISEASE MECHANISMS AND CONTEMPORARY THERAPEUTIC APPROACHES - A LITERATURE REVIEW
Strużek, K., Kwiatkowska, A., Mączka, E., Tracz, W., Świercz, P., Teper, K., Khiralla-Gawlik, S., Strzelecka, A. A., & Basak, A. E. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(47).2025.3662
Screening Based on Structural and Biological Verification of Stachyose as a PPARγ‐Modulating Ligand for the Treatment of Non‐Alcoholic Fatty Liver Disease
Fang, B., Li, M., Jiang, F., Dong, W., Zhang, W.-Z., Lin, L.-F., Bai, Y., & Zheng, J. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.71009
The battle over “food addiction”. Translation into Russian
Lustig, R. H. (2025) · Психофармакология и биологическая наркология · doi:10.17816/phbn691855
Diabetes mellitus and hepatosteatosis: a narrative review
Kösekli, M. A. (2025) · Exploration of Endocrine and Metabolic Diseases · doi:10.37349/eemd.2025.101446
Perspective Chapter: Cross-Talk between Genetics and Biochemistry in the Pathogenesis of Hepatic Steatosis
Üçdal, M. T., & Çeltikçi, B. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1011511
Identifying Key Features Associated with Excessive Fructose Intake: A Machine Learning Analysis of a Mexican Cohort
Gutiérrez-Esparza, G. O., Martínez-García, M., Salazar, M., Amezcua-Guerra, L. M., Brianza-Padilla, M., Ramírez-delReal, T. A., & Lemus, E. H. (2025) · Nutrients · doi:10.3390/nu17223623
Additional file 1 of Genistein and exercise modulated lipid peroxidation and improved steatohepatitis in ovariectomized rats
Witayavanitkul, N., Werawatganon, D., Chayanupatkul, M., Klaikeaw, N., Sanguanrungsirikul, S., & Siriviriyakul, P. (2020) · Figshare · doi:10.6084/m9.figshare.12408311
Additional file 1 of Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study
Wang, K., Shi, M., Luk, A. O. Y., Kong, A. P. S., Ronald, C. W., Li, C., Chen, L., Chow, E., & Chan, J. C. N. (2024) · Figshare · doi:10.6084/m9.figshare.26740931
Additional file 1 of Different dietary carbohydrate component intakes and long-term outcomes in patients with NAFLD: results of longitudinal analysis from the UK Biobank
Liu, Z., Huang, H., Xie, J., Hou, L., & Xu, C. (2023) · Figshare · doi:10.6084/m9.figshare.24770264
NAFLD-related SNPs are linked to changes in liver fat, as measured by the CAP score, and serum lipids in response to a 3-week sugar-sweetened beverage intervention: a pilot study
Jeyaraj, F. T., Vennam, S. S., Nelson, K. L., Watts, K., Goss, L. R., Nance, B., Mass, B. B., & Voruganti, V. S. (2026) · Food & Function · doi:10.1039/d5fo03248b
Low-dose galactose rebalances HBP-mTORC1-SREBP-1c signaling to suppress hepatic lipogenesis and protect against early-stage alcohol-related liver disease
Li, Y., Guo, R., Qian, Y., Hawro, I., Córdoba‐Chacón, J., Jiang, Y., & Song, Z. (2026) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00379.2025
Étude des effets des acides gras oméga-3 et de nouvelles bactéries probiotiques pour contrer les désordres associés à l'obésité au niveau métabolique et intestinal
Barz, M. L. (2017) · theses.fr (ABES) · doi:10.70675/d1f0a7a2z6eadz445dzb191za197a6f08824
Diversité des macrophages dans un modèle murin de stéatohépatite non alcoolique
Tran, S. (2019) · theses.fr (ABES) · doi:10.70675/22efc884z2788z43fazabc1zaeb115ea6833
Modèle de carcinomes hépatocellulaires murins induits par l'expression de l'antigène T SV40 : analyse du transcriptome entier du foie et des variations d'expression ARN liées à l'âge et induites par un régime « occidental »
Hobeika, C. (2022) · theses.fr (ABES) · doi:10.70675/4c247323z584fz42b6za12cze7812b01da9e
Rôle de LECT2 dans les maladies stéatosiques non alcooliques du foie
Pham, S. (2020) · theses.fr (ABES) · doi:10.70675/3693bfe6z9d91z4045za9a9zc37497dc9c1b
Rôles des cellules de Kupffer dans la physiopathologie hépatique
Baba, I. (2022) · theses.fr (ABES) · doi:10.70675/eded7312zb940z4cbfz9829za0a5798491d3
Rôle des cellules de Kupffer dans l'homéostasie du cholestérol
Fima, R. (2022) · theses.fr (ABES) · doi:10.70675/57f4dd66z9dc1z45c7z8619z4ddb93538c40
Rôle de la kinase ATR dans la progression de la stéatose hépatique non alcoolique
Saroul-Aïnama, M. (2022) · theses.fr (ABES) · doi:10.70675/1fc5906az1637z451czab81z7529e034be63
D-(-)-Fruktoz’un Sitotoksik ve Genotoksik Potansiyelinin Allium cepa Kök Ucu Hücrelerinde İncelenmesi
Çınar, R. B., Şahan, C., Tuncay, B., Burgazlı, A. Y., Yüzbaşıoğlu, D., & Ünal, F. (2026) · Afyon Kocatepe University Journal of Sciences and Engineering · doi:10.35414/akufemubid.1699269
Fructose metabolism as an adaptive survival axis in pancreatic cancer: mechanistic insights and therapeutic implications
Zhang, Y., & Zhang, Y. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1794440
High-fat diet, gut dysbiosis, and oxidative stress: A synergistic triangle in metabolic dysfunction-associated steatotic liver disease pathogenesis
Zhang, Z.-R., She, L., Cao, Y., & Chen, Y.-W. (2026) · World Journal of Hepatology · doi:10.4254/wjh.v18.i4.116074
Reprogramming of hepatic BCAA metabolism by fructose exacerbates hepatic steatosis
Zhong, M., Luo, X., Shi, M., Zhang, W. J., Niu, W., Sun, H., & Zhang, X. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153999
When sweetness overflows: fructose influences microbial and metabolic dysregulation
Cheikh, M., & Anhê, F. F. (2026) · Biochemical Journal · doi:10.1042/bcj20250136
Cardioprotective effects of acetate supplementation against fructose-induced cardiac injury in pregnant Wistar rats
Oyabambi, A. O., Agbaraolorunpo, F. M., Oguntebi, E. E., Oyakojo, B. C., & Abena, E. (2026) · Current Research in Physiology · doi:10.1016/j.crphys.2026.100186
Subchronic low dose dioxin exposure disrupts hepatic and metabolic homeostasis in a sex- and diet-dependent manner
Bolatimi, O. E., Hua, Y., Phillips, G. J., Ekuban, A., Brizendine/Ames, P. M., Watson, W. H., Banerjee, M., Ekuban, F. A., & Wahlang, B. (2026) · Current Research in Toxicology · doi:10.1016/j.crtox.2026.100311
Dapagliflozin attenuates hepatic steatosis and induces a fasting-mimicking metabolic state in C57BL/6 mice
Gomes-Filho, P. F., Valentim, C. D. S., de Andrade, C. B. V., Pinto, V. A. D. M., Cunha, R. L. D. C. D. S., de Paiva-Júnior, P. R. S., Guedes, R. R. D. C. S., Amparo, J. L. D. C., Ramos, I. P., Alves, L. L., et al. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05723-w
Dexpanthenol Attenuates High-Fructose Corn Syrup-Induced Hepatic Injury in Young Adult Rats by Modulating Oxidative Stress, Apoptosis, and Inflammasome-Associated Pyroptotic Signaling
Elmas, A., Asci, H., Tepebaşı, M. Y., Selver, M. B., İlhan, İ., Akçam, M., & Özmen, Ö. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156828
MASLD: Spatial Mechanisms and New Therapeutics
Stoess, C., Onyuru, J., Hu, Y., Jiang, Y., Xin, Z., Panchal, A., & Hartmann, P. (2026) · Biomolecules · doi:10.3390/biom16081129
The MASLD–Cardio-Oncology Triangle: Dietary Patterns, Metabolic Remodelling and Implications for Cancer Therapy Tolerance
Rocca, F. L., Privitera, G., Geraci, C., Morello, V., Geraci, G., Paternò, V., Santoro, C., & Esposito, R. (2026) · Nutrients · doi:10.3390/nu18152527
Context-dependent effects of β-estradiol and testosterone on lipid accumulation and reverse cholesterol transport in palmitate- and palmitate/oleate-induced HepG2 steatosis
Jafarpour, E., Hosseini, M.-S., Mohammadi, Y., Pashaei‐Asl, R., & Bahreini, E. (2026) · Gene Reports · doi:10.1016/j.genrep.2026.102605
From fructose to steatosis, fructose-induced inflammation as a driver of hepatic injury and MAFLD progression: a systematic review of preclinical studies
Arifin, M., Jannah, W., Latarissa, I. R., Zakiyah, N., Meiliana, A., Barliana, M. I., & Lestari, K. (2026) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2025-001416
Histopathology and NF-κB/Caspase-3 Expression in High Fructose Corn Syrup–Induced Lung Injury: Protective Effect of Dexpanthenol
Taşan, Ş., Aslankoç, R., & Aslan, C. (2026) · Düzce Tıp Fakültesi Dergisi · doi:10.18678/dtfd.1843989
Dietary Reactive Oxygen Species and Oxidative Stress: Pathogenic Mechanisms Linking Food and Feed Exposure to Disease in Humans and Companion Animals
Park, H.-J., & Kim, H.-M. (2026) · Biology · doi:10.3390/biology15171519
Fructose and Alcohol Hepatotoxicity: Demographic Overlap and Mechanistic Interactions
Stem, A. D., Lisgara, A., Alayyoub, M., Berardi, D., Aladelokun, O. B., Johnson, C. H., Johnson, R. J., & Vasiliou, V. (2026) · Livers · doi:10.3390/livers6050092
Decoding dysbiosis: the role of gut microbiota in MASLD progression and emerging therapeutic interventions
Swamikkannu, D. M., Dasarapu, S., Mohan, K. D., & Shanmugam, A. (2026) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-026-01199-7
Total ultra-processed food intake and selected food-group exposures in relation to non-alcoholic fatty liver disease: a systematic review and meta-analysis
Chen, D., Li, L., & Zhang, C. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1876449
Oxazolidine derivative ameliorates diet-induced non-alcoholic fatty liver disease by modulating PI3K/AKT signaling and metabolic homeostasis
Nayak, S. P. R. R., Devadoss, T., Chitra, V., Almutairi, B. O., Almutairi, M. H., Balasubramanian, B., Arasu, M. V., Kumaradoss, K. M., Palaniappan, S., Namasivayam, S. K. R., et al. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118451
Pharmacological preconditioning with cilostazol reverses steatosis and protects the liver against ischemia-reperfusion injury in steatotic rats
Holländer, S., Von Heesen, M., Gäbelein, G., Mercier, J., Laschke, M. W., Spiliotis, A. E., Alic, M., & Glanemann, M. (2026) · Scientific Reports · doi:10.1038/s41598-026-70871-1
Eighty Years After Vague: Advances in Understanding Ectopic Fat and Metabolic Dysfunction
Conte, C., Sumithran, P., le Roux, C. W., Miras, A. D., & Gaal, L. V. (2026) · Obesity Reviews · doi:10.1111/obr.70229
Chitosan Supplementation Improves Hepatic Steatosis, Liver Stiffness, and Body Composition in Patients with Metabolic Dysfunction–Associated Steatotic Liver Disease: A Randomized, Double-Blind, Placebo-Controlled TrialPreprint
Javaheri, F. S. H., Rouini, M., Nematy, M., & Falahi, E. (2026) · Research Square · doi:10.21203/rs.3.rs-10243768/v1
Alcohol consumption: from biochemistry to behavior, health, and beyond
Pechkovsky, E., Kershengoltz, B., Vlassov, V. V., Vlassov, V., & Turchinovich, A. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1876876
Evaluation of hepatoprotective effect of Acacia catechu stem bark extract on high fat and high fructose diet induced metabolic dysfunction-associated steatotic liver disease in experimental animals
Vhanale, D. C., Bandawane, D. D., & Hajare, P. K. (2026) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2026-0258
СТАН МЕТАБОЛІЧНИХ ПРОЦЕСІВ У ЩУРІВ ЗА УМОВ НАДМІРНОГО СПОЖИВАННЯ ФРУКТОЗИ
Melnykivska, N. V., Kudria, M. Y., Ustenko, N. V., Misiura, K. V., & Морозюк, А. Ю. (2026) · Medical and Clinical Chemistry · doi:10.11603/mcch.2410-681x.2026.i3.16595
Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management
Qi, S., Chen, W., Chen, K., Yang, S., Wang, S., Ni, T., Xu, D., Mao, E., Chen, E., & Chen, Y. (2026) · MedComm · doi:10.1002/mco2.70956
Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis (MASLD/MASH) and Cardiovascular Risk: Emerging Therapeutic Strategies at the Interface of Liver and Cardiometabolic Disease
Boutari, C., Charalampidis, K., Sideras, L., Sinakos, E., & Goulis, I. (2026) · Life · doi:10.3390/life16101656
Restricted ovulator hens as a novel experimental model of fatty liver disease
Lee, D. J., Keshavareddy, V. P. R., Goo, D., Katha, H. R., Choppa, V. S. R., Rafieian-Naeini, H. R., Gyawali, I., Ragyari, S. K. R., Paneru, D., Williams, S. M., et al. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107891
Fructose Promotes Oxidative Stress, Sphingolipid Remodelling and Transient Intestinal Barrier Dysfunction in Differentiated Caco-2 Cells
Serreli, G., Melis, M. P., Guerriero, C., Manis, C., Tolle, G., Sanna, G., Orrù, G., Fais, S., Caboni, P., & Deiana, M. (2026) · Nutrients · doi:10.3390/nu18203359
Sex-Specific Associations of Added Sugars and Fructose Exposure Across the First 1,000 Days With Body Composition at 24 MonthsPreprint
Fortin-Miller, S. A., Gajewski, B. J., Carlson, S. E., Colombo, J. A., Christifano, D. N., Sullivan, D. K., & Hull, H. R. (2026) · medRxiv · doi:10.64898/2026.10.16.26365755

Authors: Softic, S., Cohen, D. E., & Kahn, C. R.
Affiliations: Boston Children's Hospital (US)
Brigham and Women's Hospital (US)
Joslin Diabetes Center (US)
Corresponding author: Kahn, C. Ronald
ORCID: Softic, Samir
Cohen, David E.
Kahn, C. Ronald
Venue: Digestive Diseases and Sciences
Publisher: Springer Science and Business Media LLC
Published: 2016-02-08
Volume: 61
Issue: 5
Pages: 1282-1293
ISSN: 0163-2116 (ISSN-L)
1573-2568
DOI: 10.1007/s10620-016-4054-0
PMC: PMC4838515
OpenAlex: W2286797029
Cited by: 709
References: 133
Citations by year: 2026: 52 · 2025: 76 · 2024: 88 · 2023: 78 · 2022: 92 · 2021: 79 · 2020: 88 · 2019: 57 · 2018: 44 · 2017: 42 · 2016: 13
FWCI: 7.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Digestive Diseases and Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK031036, R01 DK033201, K12 HD000850, R37 DK048873, R01 DK056626, R01 DK103046)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: non-alcoholic fatty liver disease, dietary fructose, hepatic de novo lipogenesis, high fructose corn syrup, high-fat diet, sugar-sweetened beverages, insulin resistance, SREBP-1c, endoplasmic reticulum stress, uric acid, mitochondrial fatty acid oxidation, reactive oxygen species, hepatic lipid metabolism, metabolic syndrome
MeSH terms: Diet, Fructose, Humans, Liver, Lipogenesis, Non-alcoholic Fatty Liver Disease, High Fructose Corn Syrup

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks